CN108911965A - The preparation method of 2- methoxy benzoyl chloride - Google Patents
The preparation method of 2- methoxy benzoyl chloride Download PDFInfo
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- CN108911965A CN108911965A CN201810874138.2A CN201810874138A CN108911965A CN 108911965 A CN108911965 A CN 108911965A CN 201810874138 A CN201810874138 A CN 201810874138A CN 108911965 A CN108911965 A CN 108911965A
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- benzoyl chloride
- methoxy benzoyl
- room temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/58—Preparation of carboxylic acid halides
- C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Title of the invention is the preparation method of 2- methoxy benzoyl chloride.Affiliated technical field is medical science.The technical problems to be solved by the invention are to be related to a kind of preparation method of more advanced 2- methoxy benzoyl chloride.The main points of the technical solution of the technical problems to be solved by the invention are the new preparation methods of one kind of the compound.
Description
Technical field
The present invention relates to pharmaceutical technology fields, specifically, the present invention relates to the preparation methods of 2- methoxy benzoyl chloride.
Background technique
2- methoxy benzoyl chloride is a kind of intermediate feed of important synthesis medical product.
The preparation method yield of existing 2- methoxy benzoyl chloride is not high, and synthesis technology is complicated, and yield is unstable, needs
A kind of new preparation method is invented, to overcome the shortcomings of prior art, to achieve the purpose that energy-saving and environmental protection, green.
Summary of the invention
The present invention uses a kind of new technology, not high for the preparation method yield of existing 2- methoxy benzoyl chloride, closes
At complex process, yield is unstable, and the high disadvantage of the purchase cost of required raw material has invented one kind by long-term research and development
New preparation method has established good technical foundation to overcome the shortcomings of prior art for later industrial production.
The technical scheme is that：
1521 milligrams of O-Anisic Acids are added in the reactor, are added 40 milliliters of tetrahydrofuran, in stirring, in room temperature
0.5 milliliter of n,N-Dimethylformamide is added, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, then continues
It is stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 2- methoxybenzoyl
Chlorine, yield 87.7%.
Specific embodiment
Embodiment 1：The preparation of 2- methoxy benzoyl chloride：
1521 milligrams of O-Anisic Acids are added in the reactor, are added 40 milliliters of tetrahydrofuran, in stirring, in room temperature
0.5 milliliter of n,N-Dimethylformamide is added, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, then continues
It is stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 2- methoxybenzoyl
Chlorine, yield 87.7%.
Embodiment 2：The preparation of 2- methoxy benzoyl chloride：
1521 milligrams of O-Anisic Acids are added in the reactor, are added 40 milliliters of tetrahydrofuran, in stirring, in room temperature
0.5 milliliter of n,N-Dimethylformamide is added, is then stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, then continues
It is stirred to react at room temperature 8 hours.After completion of the reaction, post-treated and purification process obtains compound 2- methoxybenzoyl
Chlorine, yield 87.9%.
The present invention can be summarized with others without prejudice to the concrete form of spirit or essential characteristics of the invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair
It is bright.
Claims (2)
1. a kind of preparation method of 2- methoxy methyl acyl chlorides, it is characterized in that：
1521 milligrams of O-Anisic Acids are added in the reactor, is added 40 milliliters of tetrahydrofuran, in stirring, is added in room temperature
Then 0.5 milliliter of n,N-Dimethylformamide is stirred at room temperature 0.5 hour, 3 grams of thionyl chloride is added dropwise, and then continues in room
Middle benefit gas is stirred to react 8 hours.After completion of the reaction, post-treated and purification process obtains compound 2- methoxy benzoyl chloride, receives
Rate is 87.7%.
2. according to the method described in claim 1, it is characterized in that:
It needs that compound N, dinethylformamide is added in reaction solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810874138.2A CN108911965A (en) | 2018-08-03 | 2018-08-03 | The preparation method of 2- methoxy benzoyl chloride |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810874138.2A CN108911965A (en) | 2018-08-03 | 2018-08-03 | The preparation method of 2- methoxy benzoyl chloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108911965A true CN108911965A (en) | 2018-11-30 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810874138.2A Pending CN108911965A (en) | 2018-08-03 | 2018-08-03 | The preparation method of 2- methoxy benzoyl chloride |
Country Status (1)
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004053140A2 (en) * | 2002-12-12 | 2004-06-24 | Jawaharlal Nehru Centre For Advanced Scientific Research | Modulators (inhibitors/activators) of histone acetyltransferases |
| CN103044336A (en) * | 2012-12-28 | 2013-04-17 | 中国农业大学 | Acylthiourea compound, preparation method and application thereof |
| CN105294637A (en) * | 2015-08-08 | 2016-02-03 | 沈阳药科大学 | Derivatives containing nitrogen xanthone, as well as preparation method and application of derivatives |
| WO2016016728A2 (en) * | 2014-07-31 | 2016-02-04 | University College Cardiff Consultants Limited | Bcl-3 inhibitors |
| CN106866419A (en) * | 2017-04-14 | 2017-06-20 | 石河子大学 | One terpenoid ester compounds and its production and use |
| CN107892690A (en) * | 2017-11-30 | 2018-04-10 | 江苏杏睿生物科技有限公司 | Fascaplysin derivative and preparation method and purposes |
-
2018
- 2018-08-03 CN CN201810874138.2A patent/CN108911965A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004053140A2 (en) * | 2002-12-12 | 2004-06-24 | Jawaharlal Nehru Centre For Advanced Scientific Research | Modulators (inhibitors/activators) of histone acetyltransferases |
| CN103044336A (en) * | 2012-12-28 | 2013-04-17 | 中国农业大学 | Acylthiourea compound, preparation method and application thereof |
| WO2016016728A2 (en) * | 2014-07-31 | 2016-02-04 | University College Cardiff Consultants Limited | Bcl-3 inhibitors |
| CN105294637A (en) * | 2015-08-08 | 2016-02-03 | 沈阳药科大学 | Derivatives containing nitrogen xanthone, as well as preparation method and application of derivatives |
| CN106866419A (en) * | 2017-04-14 | 2017-06-20 | 石河子大学 | One terpenoid ester compounds and its production and use |
| CN107892690A (en) * | 2017-11-30 | 2018-04-10 | 江苏杏睿生物科技有限公司 | Fascaplysin derivative and preparation method and purposes |
Non-Patent Citations (2)
| Title |
|---|
| LONG WANG等: "Catalytic aza-Wittig Reaction of Acid Anhydride for the Synthesis of 4H‑Benzo[d][1,3]oxazin-4-ones and 4‑Benzylidene-2-aryloxazol-5(4H)‑ones", 《ACS CATAL.》 * |
| SHANG-SHI ZHANG等: "Mild Rhodium(III)-Catalyzed C−H Allylation with 4‑Vinyl-1,3-dioxolan-2-ones: Direct and Stereoselective Synthesis of (E)‑Allylic Alcohols", 《ORGANIC LETTERS》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
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Application publication date: 20181130 |