CN108484425A - A kind of polishing purification method of natural levodopa - Google Patents
A kind of polishing purification method of natural levodopa Download PDFInfo
- Publication number
- CN108484425A CN108484425A CN201810529969.6A CN201810529969A CN108484425A CN 108484425 A CN108484425 A CN 108484425A CN 201810529969 A CN201810529969 A CN 201810529969A CN 108484425 A CN108484425 A CN 108484425A
- Authority
- CN
- China
- Prior art keywords
- natural
- levodopa
- purification method
- polishing purification
- tyrosine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The title of the present invention is a kind of polishing purification method of natural levodopa.Affiliated technical field is medical science.The technical problems to be solved by the invention are to be related to a kind of polishing purification method of more advanced natural levodopa.The main points of the technical solution of the technical problems to be solved by the invention are a kind of completely new polishing purification methods of the compound.
Description
Technical field
The present invention relates to pharmaceutical technology fields, specifically, the present invention relates to a kind of polishing purifications of natural levodopa
Method.
Background technology
Natural levodopa is a kind of important medical product raw material.Especially impurity tyrosine content is less than 0.1%
Natural levodopa product.
The polishing purification method yield of existing natural levodopa is not high, and complex process, yield is unstable, needs to invent
A kind of completely new polishing purification method, to overcome the shortcomings of prior art.
Invention content
The present invention uses a kind of new technology, work not high for the polishing purification method yield of existing natural levodopa
Skill is complicated, and yield is unstable, disadvantage of high cost, by long-term research and development, has invented a kind of completely new polishing purification method, comes
Overcome the shortcomings of prior art, good technical foundation has been established for later industrialized production.
The technical scheme is that：
(HPLC contents are 98.3% to the natural levodopa of 1000 milligrams of addition, wherein tyrosine HPLC in the reactor
Content is 0.18%), 15 milliliters of deionized water to be added, and in stirring, oil bath is warming up to 60 DEG C of interior temperature, then in 60 DEG C of lasting stirrings
One hour, when being cooled to white solid precipitation, fast filtering obtained the natural left side that impurity tyrosine HPLC contents are less than 0.10%
Revolve 824 milligrams of DOPA.
Specific implementation mode
Embodiment 1：
(HPLC contents are 98.3% to the natural levodopa of 1000 milligrams of addition, wherein tyrosine HPLC in the reactor
Content is 0.18%), 15 milliliters of deionized water to be added, and in stirring, oil bath is warming up to 60 DEG C of interior temperature, then in 60 DEG C of lasting stirrings
One hour, when being cooled to white solid precipitation, fast filtering obtained the natural left side that impurity tyrosine HPLC contents are less than 0.10%
Revolve 824 milligrams of DOPA.
Embodiment 2：
(HPLC contents are 98.3% to the natural levodopa of 1000 milligrams of addition, wherein tyrosine HPLC in the reactor
Content is 0.18%), 15 milliliters of deionized water to be added, and in stirring, oil bath is warming up to 60 DEG C of interior temperature, then in 60 DEG C of lasting stirrings
One hour, when being cooled to white solid precipitation, fast filtering obtained the natural left side that impurity tyrosine HPLC contents are less than 0.10%
Revolve 852 milligrams of DOPA.
The present invention can be summarized with others without prejudice to the concrete form of the spirit or essential characteristics of the present invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair
It is bright.
Claims (1)
1. a kind of polishing purification method of natural levodopa, it is characterized in that：
(HPLC contents are 98.3%, wherein tyrosine HPLC contents to the natural levodopa of 1000 milligrams of addition in the reactor
0.18%), 15 milliliters of deionized water to be added, in stirring, oil bath is warming up to 60 DEG C of interior temperature, and it is small then persistently to stir one at 60 DEG C
When, when being cooled to white solid precipitation, it is natural left-handed more less than 0.10% to obtain impurity tyrosine HPLC contents for fast filtering
Bars 824 milligrams.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810529969.6A CN108484425A (en) | 2018-05-29 | 2018-05-29 | A kind of polishing purification method of natural levodopa |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810529969.6A CN108484425A (en) | 2018-05-29 | 2018-05-29 | A kind of polishing purification method of natural levodopa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108484425A true CN108484425A (en) | 2018-09-04 |
Family
ID=63351218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810529969.6A Pending CN108484425A (en) | 2018-05-29 | 2018-05-29 | A kind of polishing purification method of natural levodopa |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108484425A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109485581A (en) * | 2018-11-19 | 2019-03-19 | 广西壮族自治区中医药研究院 | A method of purification levodopa |
| CN111116393A (en) * | 2020-01-03 | 2020-05-08 | 海山都(上海)生物技术有限公司 | Method for removing overproof tyrosine in levodopa by resin method |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102557975A (en) * | 2010-12-29 | 2012-07-11 | 庞宝艳 | Chemical synthesizing method for levodopa bulk pharmaceutical |
| CN106117071A (en) * | 2016-07-08 | 2016-11-16 | 长兴制药股份有限公司 | A kind of membrane filtration isolation and purification method of levodopa conversional solution |
| CN106117072A (en) * | 2016-07-08 | 2016-11-16 | 长兴制药股份有限公司 | A kind of levodopa crystalline powder and manufacture method thereof |
| CN106946721A (en) * | 2017-03-30 | 2017-07-14 | 湖南华诚生物资源股份有限公司 | A kind of method for extracting high-purity tyrosine and levodopa in the beans from cat simultaneously |
| CN107141229A (en) * | 2017-06-30 | 2017-09-08 | 山东鲁抗医药股份有限公司 | A kind of method that levodopa is extracted from conversion fluid |
| CN108033893A (en) * | 2017-12-25 | 2018-05-15 | 北京颐方生物科技有限公司 | The method that continuous flow upstream ultrasonic technique extracts levodopa from cat beans |
-
2018
- 2018-05-29 CN CN201810529969.6A patent/CN108484425A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102557975A (en) * | 2010-12-29 | 2012-07-11 | 庞宝艳 | Chemical synthesizing method for levodopa bulk pharmaceutical |
| CN106117071A (en) * | 2016-07-08 | 2016-11-16 | 长兴制药股份有限公司 | A kind of membrane filtration isolation and purification method of levodopa conversional solution |
| CN106117072A (en) * | 2016-07-08 | 2016-11-16 | 长兴制药股份有限公司 | A kind of levodopa crystalline powder and manufacture method thereof |
| CN106946721A (en) * | 2017-03-30 | 2017-07-14 | 湖南华诚生物资源股份有限公司 | A kind of method for extracting high-purity tyrosine and levodopa in the beans from cat simultaneously |
| CN107141229A (en) * | 2017-06-30 | 2017-09-08 | 山东鲁抗医药股份有限公司 | A kind of method that levodopa is extracted from conversion fluid |
| CN108033893A (en) * | 2017-12-25 | 2018-05-15 | 北京颐方生物科技有限公司 | The method that continuous flow upstream ultrasonic technique extracts levodopa from cat beans |
Non-Patent Citations (3)
| Title |
|---|
| 王熙卿: "左旋多巴的合成", 《医药工业》 * |
| 赵小超 等: "左旋多巴的生产工艺及相关物质研究概况", 《中国民族民间医药》 * |
| 马强强 等: "左旋多巴合成研究进展", 《化工进展》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109485581A (en) * | 2018-11-19 | 2019-03-19 | 广西壮族自治区中医药研究院 | A method of purification levodopa |
| CN109485581B (en) * | 2018-11-19 | 2021-07-09 | 广西壮族自治区中医药研究院 | Method for refining levodopa |
| CN111116393A (en) * | 2020-01-03 | 2020-05-08 | 海山都(上海)生物技术有限公司 | Method for removing overproof tyrosine in levodopa by resin method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108484425A (en) | A kind of polishing purification method of natural levodopa | |
| CN104709990A (en) | Special poly aluminum chloride for municipal water supply and preparation method of poly aluminum chloride | |
| CN109096091A (en) | The preparation method of cinnamic acid | |
| CN110885095B (en) | Method for preparing porous calcium titanate based on eutectic solvent | |
| CN108794337A (en) | A kind of new preparation process of 3,4- dihydroxy-beta-nitrostyrene | |
| CN105503774B (en) | A kind of preparation method of S-1574 intermediate | |
| CN108821953A (en) | A kind of polishing purification method of natural resveratrol | |
| CN108794317A (en) | The preparation method of 2,3- dimethoxy benzaldehydes | |
| CN108863773A (en) | The preparation method of 3- methoxy cinnamic acid | |
| KR102458994B1 (en) | Method for producing dicarboxylic acid crystals | |
| CN102417527A (en) | Method for synthesizing sucralose-6-ethyl ester | |
| CN108314651A (en) | A kind of new preparation process of huperzine | |
| CN108059590A (en) | A kind of preparation method of 3- trifluoromethoxies -4- chlorobenzaldehydes | |
| CN108752187A (en) | A kind of new preparation process of 2,4- dihydroxy-benzoic acids | |
| CN108794326A (en) | The preparation method of 3- methoxy benzoyl chlorides | |
| CN108863772A (en) | The preparation method of 4- methoxy cinnamic acid | |
| CN104003936B (en) | A kind of refining purification process of dextromethorphan hydrobromide | |
| CN108689835A (en) | A kind of new preparation process of 3- hydroxybenzoyl chlorides | |
| CN108752214A (en) | A kind of new preparation process of 2- hydroxy-betas-nitrostyrolene | |
| CN104628627A (en) | Method for synthesizing 1-boc-4-aminopiperidine | |
| CN108658778A (en) | A kind of new preparation process of 3,4- dimethoxys-beta-nitrostyrene | |
| CN109020793A (en) | The preparation method of 4- hydroxycinnamaldehyde | |
| CN108689856A (en) | A kind of new preparation process of 3- hydroxy-betas-nitrostyrolene | |
| CN108586259A (en) | A kind of new preparation process of 2- methoxyl groups-beta-nitrostyrene | |
| CN108863745A (en) | The preparation method of 3- hydroxycinnamaldehyde |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180904 |