CN108752187A - A kind of new preparation process of 2,4- dihydroxy-benzoic acids - Google Patents
A kind of new preparation process of 2,4- dihydroxy-benzoic acids Download PDFInfo
- Publication number
- CN108752187A CN108752187A CN201810787654.1A CN201810787654A CN108752187A CN 108752187 A CN108752187 A CN 108752187A CN 201810787654 A CN201810787654 A CN 201810787654A CN 108752187 A CN108752187 A CN 108752187A
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- CN
- China
- Prior art keywords
- dihydroxy
- benzoic acids
- added
- new preparation
- preparation process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
Abstract
The title of the present invention is a kind of 2,4- dihydroxy-benzoic acids new preparation process.Affiliated technical field is medical science.The technical problems to be solved by the invention are to be related to a kind of new preparation process of more advanced 2,4- dihydroxy-benzoic acids.The main points of the technical solution of the technical problems to be solved by the invention are a kind of new preparation methods of the compound.
Description
Technical field
The present invention relates to pharmaceutical technology fields, specifically, the present invention relates to the brand-news of one kind 2,4- dihydroxy-benzoic acids
Preparation Method.
Background technology
2,4- dihydroxy-benzoic acids are a kind of intermediate feeds of important medicines and health protection product.
The preparation method yield of existing 2,4- dihydroxy-benzoic acids is not high, and synthesis technology is complicated, and yield is unstable, especially
It needs to invent a kind of new preparation method, to overcome the shortcomings of prior art, to achieve the purpose that energy-saving and environmental protection, green.
Invention content
The present invention uses a kind of new technology, not high for the preparation method yield of existing 2,4- dihydroxy-benzoic acids, closes
At complex process, yield is unstable, and the disadvantage that the purchase cost of required raw material is high has invented one kind by long-term research and development
New preparation method has established good technical foundation to overcome the shortcomings of prior art for later industrial production.
The technical scheme is that：
1821 milligrams of 2,4- dimethoxybenzoic acids are added in the reactor, 50 milliliters of toluene are added, in stirring, in room temperature
3444 milligrams of p-methyl benzenesulfonic acid is added, is then stirred at room temperature 20 minutes, then oil bath is warming up to 70 DEG C and stirs 4 hours.After
Processing, vacuum drying, obtains compound 2,4- dihydroxy-benzoic acids, yield 96.7%.
Specific implementation mode
Embodiment 1：The preparation of 2,4- dihydroxy-benzoic acids：
1821 milligrams of 2,4- dimethoxybenzoic acids are added in the reactor, 50 milliliters of toluene are added, in stirring, in room temperature
3444 milligrams of p-methyl benzenesulfonic acid is added, is then stirred at room temperature 20 minutes, then oil bath is warming up to 70 DEG C and stirs 4 hours.After
Processing, vacuum drying, obtains compound 2,4- dihydroxy-benzoic acids, yield 96.7%.
Embodiment 2：The preparation of 2,4- dihydroxy-benzoic acids：
1821 milligrams of 2,4- dimethoxybenzoic acids are added in the reactor, 50 milliliters of toluene are added, in stirring, in room temperature
3444 milligrams of p-methyl benzenesulfonic acid is added, is then stirred at room temperature 20 minutes, then oil bath is warming up to 70 DEG C and stirs 4 hours.After
Processing, vacuum drying, obtains compound 2,4- dihydroxy-benzoic acids, yield 97.3%.
The present invention can be summarized with others without prejudice to the concrete form of the spirit or essential characteristics of the present invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair
It is bright.
Claims (2)
1. one kind 2, the new preparation process of 4- dihydroxy-benzoic acids, it is characterized in that：
1821 milligrams of 2,4- dimethoxybenzoic acids are added in the reactor, 50 milliliters of toluene is added, in stirring, is added in room temperature
Then 3444 milligrams of p-methyl benzenesulfonic acid is stirred at room temperature 20 minutes, then oil bath is warming up to 70 DEG C and stirs 4 hours.It is post-treated,
Vacuum drying, obtains compound 2,4- dihydroxy-benzoic acids, yield 96.7%.
2. according to the method described in claim 1, it is characterized in that:
It needs that compound p-methyl benzenesulfonic acid is added in reaction solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810787654.1A CN108752187A (en) | 2018-07-18 | 2018-07-18 | A kind of new preparation process of 2,4- dihydroxy-benzoic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810787654.1A CN108752187A (en) | 2018-07-18 | 2018-07-18 | A kind of new preparation process of 2,4- dihydroxy-benzoic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108752187A true CN108752187A (en) | 2018-11-06 |
Family
ID=63970507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810787654.1A Pending CN108752187A (en) | 2018-07-18 | 2018-07-18 | A kind of new preparation process of 2,4- dihydroxy-benzoic acids |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108752187A (en) |
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2018
- 2018-07-18 CN CN201810787654.1A patent/CN108752187A/en active Pending
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181106 |