CN108752168A - A kind of new preparation process of oxidation Stilbene triphenol - Google Patents
A kind of new preparation process of oxidation Stilbene triphenol Download PDFInfo
- Publication number
- CN108752168A CN108752168A CN201810781173.XA CN201810781173A CN108752168A CN 108752168 A CN108752168 A CN 108752168A CN 201810781173 A CN201810781173 A CN 201810781173A CN 108752168 A CN108752168 A CN 108752168A
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- CN
- China
- Prior art keywords
- added
- triphenol
- new preparation
- preparation process
- oxidation stilbene
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
Abstract
The title of the present invention is a kind of new preparation process of oxidation Stilbene triphenol.Affiliated technical field is medical science.The technical problems to be solved by the invention are to be related to a kind of new preparation process of more advanced oxidation Stilbene triphenol.The main points of the technical solution of the technical problems to be solved by the invention are a kind of new preparation methods of the compound.
Description
Technical field
The present invention relates to pharmaceutical technology fields, specifically, the present invention relates to a kind of new preparation process of oxidation Stilbene triphenol.
Background technology
It is a kind of raw material of important medicines and health protection product to aoxidize Stilbene triphenol.
The preparation method yield of existing oxidation Stilbene triphenol is not high, and synthesis technology is complicated, and yield is unstable, needs invention one
The new preparation method of kind, to overcome the shortcomings of prior art, to achieve the purpose that energy-saving and environmental protection, green.
Invention content
The present invention uses a kind of new technology, not high for the preparation method yield of existing oxidation Stilbene triphenol, synthesis technology
Complexity, yield is unstable, and the disadvantage that the purchase cost of required raw material is high has invented a kind of new system by long-term research and development
Preparation Method has established good technical foundation to overcome the shortcomings of prior art for later industrial production.
The technical scheme is that：
3003 milligram 2,3' is added in the reactor, 50 milliliters of toluene, stirring is added in 4,5'- tetramethoxy talan
In, 3444 milligrams of p-methyl benzenesulfonic acid is added in room temperature, is then stirred at room temperature 20 minutes, then stirs 4 hours for 70 DEG C.Through later
Processing, vacuum drying, obtains compound oxidation Stilbene triphenol, yield 90.7%.
Specific implementation mode
Embodiment 1：Aoxidize the preparation of Stilbene triphenol：
3003 milligram 2,3' is added in the reactor, 50 milliliters of toluene, stirring is added in 4,5'- tetramethoxy talan
In, 3444 milligrams of p-methyl benzenesulfonic acid is added in room temperature, is then stirred at room temperature 20 minutes, then stirs 4 hours for 70 DEG C.Through later
Processing, vacuum drying, obtains compound oxidation Stilbene triphenol, yield 90.7%.
Embodiment 2：Aoxidize the preparation of Stilbene triphenol：
3003 milligram 2,3' is added in the reactor, 50 milliliters of toluene, stirring is added in 4,5'- tetramethoxy talan
In, 3444 milligrams of p-methyl benzenesulfonic acid is added in room temperature, is then stirred at room temperature 20 minutes, then stirs 4 hours for 70 DEG C.Through later
Processing, vacuum drying, obtains compound oxidation Stilbene triphenol, yield 91.9%.
The present invention can be summarized with others without prejudice to the concrete form of the spirit or essential characteristics of the present invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair
It is bright.
Claims (2)
1. a kind of new preparation process of oxidation Stilbene triphenol, it is characterized in that：
3003 milligram 2,3' is added in the reactor, 50 milliliters of toluene, in stirring, room is added in 4,5'- tetramethoxy talan
3444 milligrams of p-methyl benzenesulfonic acid is added in middle benefit gas, is then stirred at room temperature 20 minutes, then stirs 4 hours for 70 DEG C.By post-processing,
Vacuum drying, obtains compound oxidation Stilbene triphenol, yield 90.7%.
2. according to the method described in claim 1, it is characterized in that:
It needs that compound p-methyl benzenesulfonic acid is added in reaction solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810781173.XA CN108752168A (en) | 2018-07-17 | 2018-07-17 | A kind of new preparation process of oxidation Stilbene triphenol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810781173.XA CN108752168A (en) | 2018-07-17 | 2018-07-17 | A kind of new preparation process of oxidation Stilbene triphenol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108752168A true CN108752168A (en) | 2018-11-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810781173.XA Pending CN108752168A (en) | 2018-07-17 | 2018-07-17 | A kind of new preparation process of oxidation Stilbene triphenol |
Country Status (1)
| Country | Link |
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| CN (1) | CN108752168A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7253324B1 (en) * | 2007-01-23 | 2007-08-07 | Sami Labs Limited | Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers |
| CN101633606A (en) * | 2009-08-13 | 2010-01-27 | 河北科技大学 | Method for synthesizing stilbenoids by hydrochloric acid heterogeneous chlorination |
| CN101838173A (en) * | 2010-05-07 | 2010-09-22 | 河北科技大学 | Method for synthesizing stilbene compound by utilizing Kornblum oxidation reaction |
| CN102369223A (en) * | 2009-01-29 | 2012-03-07 | 国家科学和工业研究组织 | Molecularly imprinted polymers |
| CN103172499A (en) * | 2013-03-07 | 2013-06-26 | 康宝莱蕾硕（湖南）天然产物有限公司 | Oxyresveratrol synthesis method |
| CN104447218A (en) * | 2014-12-01 | 2015-03-25 | 广西民族大学 | Method for preparing resveratrol and derivative of resveratrol |
| CN105418381A (en) * | 2015-12-04 | 2016-03-23 | 陕西嘉禾生物科技股份有限公司 | Oxyresveratrol synthesis method |
-
2018
- 2018-07-17 CN CN201810781173.XA patent/CN108752168A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7253324B1 (en) * | 2007-01-23 | 2007-08-07 | Sami Labs Limited | Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers |
| CN102369223A (en) * | 2009-01-29 | 2012-03-07 | 国家科学和工业研究组织 | Molecularly imprinted polymers |
| CN101633606A (en) * | 2009-08-13 | 2010-01-27 | 河北科技大学 | Method for synthesizing stilbenoids by hydrochloric acid heterogeneous chlorination |
| CN101838173A (en) * | 2010-05-07 | 2010-09-22 | 河北科技大学 | Method for synthesizing stilbene compound by utilizing Kornblum oxidation reaction |
| CN103172499A (en) * | 2013-03-07 | 2013-06-26 | 康宝莱蕾硕（湖南）天然产物有限公司 | Oxyresveratrol synthesis method |
| CN104447218A (en) * | 2014-12-01 | 2015-03-25 | 广西民族大学 | Method for preparing resveratrol and derivative of resveratrol |
| CN105418381A (en) * | 2015-12-04 | 2016-03-23 | 陕西嘉禾生物科技股份有限公司 | Oxyresveratrol synthesis method |
Non-Patent Citations (3)
| Title |
|---|
| AKIRA SAKAKURA等: "Chiral Lewis Base-Assisted Brønsted Acid (LBBA)-Catalyzed Enantioselective Cyclization of 2-Geranylphenols", 《ORG. LETT.》 * |
| JOHN G. KODET等: "Synthesis of Indole Analogues of the Natural Schweinfurthins", 《J. ORG. CHEM.》 * |
| 顾烨: "白藜芦醇的合成", 《华东理工大学硕士论文》 * |
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Application publication date: 20181106 |