CN109096091A - The preparation method of cinnamic acid - Google Patents
The preparation method of cinnamic acid Download PDFInfo
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- CN109096091A CN109096091A CN201810977307.5A CN201810977307A CN109096091A CN 109096091 A CN109096091 A CN 109096091A CN 201810977307 A CN201810977307 A CN 201810977307A CN 109096091 A CN109096091 A CN 109096091A
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- CN
- China
- Prior art keywords
- cinnamic acid
- preparation
- added
- milligrams
- milliliters
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/353—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
Title of the invention is the preparation method of cinnamic acid.Affiliated technical field is medical science.The technical problems to be solved by the invention are to be related to a kind of preparation method of more advanced cinnamic acid.The main points of the technical solution of the technical problems to be solved by the invention are the new preparation methods of one kind of the compound.
Description
Technical field
The present invention relates to pharmaceutical technology fields, specifically, the present invention relates to a kind of preparation methods of cinnamic acid.
Background technique
Cinnamic acid is a kind of intermediate feed of important synthesis medical product.
The preparation method yield of existing cinnamic acid is not high, and synthesis technology is complicated, and yield is unstable, needs to invent a kind of new
Preparation method, to overcome the shortcomings of prior art.
Summary of the invention
The present invention uses a kind of new technology, not high for the preparation method yield of existing cinnamic acid, and synthesis technology is complicated,
Yield is unstable, and the high disadvantage of the purchase cost of required raw material has invented a kind of new preparation side by long-term research and development
Method has established good technical foundation to overcome the shortcomings of prior art for later industrial production.
The technical scheme is that
1061 milligrams of benzaldehydes are added in the reactor, are added 20 milliliters of dimethylbenzene, in stirring, 3 milliliters are added in room temperature
Malonic acid, be then stirred at room temperature 30 minutes, add 1000 milligrams of pyridine, then continue in 80 DEG C to be stirred to react 2 small
When.After completion of the reaction, post-treated and purification process obtains compound cinnamic acid, yield 97.3%.
Specific embodiment
Embodiment 1: the preparation of cinnamic acid:
1061 milligrams of benzaldehydes are added in the reactor, are added 20 milliliters of dimethylbenzene, in stirring, 3 milliliters are added in room temperature
Malonic acid, be then stirred at room temperature 30 minutes, add 1000 milligrams of pyridine, then continue in 80 DEG C to be stirred to react 2 small
When.After completion of the reaction, post-treated and purification process obtains compound cinnamic acid, yield 97.3%.
Embodiment 2: the preparation of cinnamic acid:
1061 milligrams of benzaldehydes are added in the reactor, are added 20 milliliters of dimethylbenzene, in stirring, 3 milliliters are added in room temperature
Malonic acid, be then stirred at room temperature 30 minutes, add 1000 milligrams of pyridine, then continue in 80 DEG C to be stirred to react 2 small
When.After completion of the reaction, post-treated and purification process obtains compound cinnamic acid, yield 94.8%.
The present invention can be summarized with others without prejudice to the concrete form of spirit or essential characteristics of the invention.Therefore, nothing
By from the point of view of which point, the embodiment above of the invention can only all be considered the description of the invention and cannot limit this hair
It is bright.
Claims (2)
1. the preparation method of cinnamic acid, it is characterized in that:
1061 milligrams of benzaldehydes are added in the reactor, are added 20 milliliters of dimethylbenzene, in stirring, the third of 3 milliliters is added in room temperature
Then diacid is stirred at room temperature 30 minutes, adds 1000 milligrams of pyridine, then continue to be stirred to react in 80 DEG C 2 hours.Instead
After answering, post-treated and purification process obtains compound cinnamic acid, yield 97.3%.
2. according to the method described in claim 1, it is characterized in that:
It needs that compound pyridine is added in reaction solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810977307.5A CN109096091A (en) | 2018-08-27 | 2018-08-27 | The preparation method of cinnamic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810977307.5A CN109096091A (en) | 2018-08-27 | 2018-08-27 | The preparation method of cinnamic acid |
Publications (1)
| Publication Number | Publication Date |
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| CN109096091A true CN109096091A (en) | 2018-12-28 |
Family
ID=64851028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810977307.5A Pending CN109096091A (en) | 2018-08-27 | 2018-08-27 | The preparation method of cinnamic acid |
Country Status (1)
| Country | Link |
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| CN (1) | CN109096091A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110317136A (en) * | 2019-07-17 | 2019-10-11 | 华中师范大学 | A kind of cinnamic acid derivative and its preparation method and application |
| CN115433082A (en) * | 2022-08-15 | 2022-12-06 | 南京远淑医药科技有限公司 | Synthetic method of cinnamic acid |
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| CN108164410A (en) * | 2018-01-03 | 2018-06-15 | 辽宁石油化工大学 | The method that Water-Soluble Calixarenes phenates catalyzes and synthesizes cinnamic acid |
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2018
- 2018-08-27 CN CN201810977307.5A patent/CN109096091A/en active Pending
Patent Citations (2)
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| CN106146450A (en) * | 2015-04-20 | 2016-11-23 | 南京华迈生物医药科技有限公司 | Formoononetin derivant, its preparation method and medical usage |
| CN108164410A (en) * | 2018-01-03 | 2018-06-15 | 辽宁石油化工大学 | The method that Water-Soluble Calixarenes phenates catalyzes and synthesizes cinnamic acid |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110317136A (en) * | 2019-07-17 | 2019-10-11 | 华中师范大学 | A kind of cinnamic acid derivative and its preparation method and application |
| CN115433082A (en) * | 2022-08-15 | 2022-12-06 | 南京远淑医药科技有限公司 | Synthetic method of cinnamic acid |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181228 |
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| WD01 | Invention patent application deemed withdrawn after publication |