CN108837149A - A kind of composition with wound repair function - Google Patents
A kind of composition with wound repair function Download PDFInfo
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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Abstract
The present invention relates to a kind of compositions with wound repair function, belong to field of medicaments.In order to overcome the wound repair function of hemorrhoid treating medicine in the prior art bad, the poor technical deficiency of analgesic effect, the present invention provides a kind of hemorrhoid composition with wound repair function, including chitosan 0.5%-5%, chitosan quaternary ammonium salt 0.1%-2%, menthol 0.5%-5%, polyvinyl alcohol 10%-40%, sodium alginate 0.5%-3%, povidone iodine 1%~5%, collagen 0.5~5% and 50-80% water.Composition each component provided by the invention is repairing the hemorrhoid surface of a wound and ease pain with significant synergistic effect, and drug safety acts on comprehensively, is appropriate for promoting and applying.
Description
Technical field
The present invention relates to a kind of compositions with wound repair function, belong to field of medicaments.
Background technique
The main clinical manifestation of hemorrhoid is hematochezia, and the property of hematochezia can be painless, intermittent, blood after an action of the bowels, just when bleed
Or band blood, constipation are drunk or are aggravated after feeding irritable food on toilet paper.The only falling inflation sense of pure internal piles without pain, can bleeding,
It is developed to prolapsus, pain just occurs when merging thrombosis, incarceration, infection.Usually without characteristic symptom, thrombus and inflammation occur for external piles
Can there are swelling, pain when disease.Internal piles is divided into 4 degree.1. bleeding when I degree of defecation, bleeding can voluntarily stop after an action of the bowels, and hemorrhoid do not deviate from anus
Door；2. II degree often has hematochezia；Deviate from anus when defecation, is also received automatically after defecation；3. needing Hand supplementary also to receive after III degree of hemorrhoid abjection；④
IV degree of hemorrhoid outside anus, cannot also be received for a long time；Wherein, II degree or more of internal piles multiform shows as internal piles and external piles at mixed hemorrhoid
Symptom exist simultaneously, may occur in which that pain is uncomfortable, itch, wherein itch often due to when hemorrhoid are deviate from toughness secretion flow out, after
At mixed hemorrhoid more than three degree.
Externally applied drug occupies certain scale in hospital market.Wherein, suppository is that specific gravity is maximum in the market for external application drug for haemorrhoid
Dosage form, main cause are that suppository administration is convenient, can directly act on hemorrhoid position, absorption is fast and comprehensive, there is the effect of moisturizing, effect
Bigger performance can be obtained, therefore, hemorrhoid suppositories are commonplace in clinical use.Other than suppository, ointment and cream pair
External piles effect preferably, alsies occupy one seat, and the two accounts for 35.20%, 12.24% respectively on the market, and it is opposite to belong to sale
Popular dosage form.Ten kinds are before sales volume in the market：Horse-chestnut seed extract piece, diosmin piece, compound folium ginkgo extraction
Composite capsule, the immersion liquid of sweet clover stream, compound carraghenates, PuJi BenShi Fang, bismuth subgallate, MAYINGLONGZHICHUANGGAO, White Cloud Mountain
Respect and repairs a HUAZHI SHUAN, Mayinglong musk hemorrhoids suppository.Preceding ten kind occupies 98% or so share of sample hospital hemorrhoid medicine market.Additionally
There are inactivation angstrom uncommon pine, Jiuhua Zhichuang Shuan, Indomethacin Roptazol suppository, xiaozhiling injection, the jiuhua plaster etc. of German doctor Ka De.But
The external application Chinese medicine suppository of existing market lacks the repair to the surface of a wound based on moisturizing, and these drug ingedients are complicated, past
It is past to bring some negative consequences.It is therefore desirable to develop a kind of wound repair effect preferably and the hemorrhoid of definite ingredients,
Therefore propose the present invention.
Chinese invention patent 201310355429.8 is related to the formula and preparation process of a kind of chitosan iodine bolt, and feature exists
In：By weight, formula includes consisting of：Chitosan iodine 8~15%, Potassiumiodate 0.1~2%, chitosan 0.1~1%,
Hydrophilic matrix 20~50%, hydroxyethyl cellulose 1~10%, glacial acetic acid 0.05~0.5%, purified water 30~70%.The hair
The more other dosage form effects of bright chitosan iodine suppository are more effective lasting, but it is bad for the therapeutic effect of hemorrhoid.
Summary of the invention
In order to overcome the wound repair function of hemorrhoid treating medicine in the prior art bad, the poor technology of analgesic effect is not
Foot, the present invention provide a kind of composition with wound repair function, and a variety of drug components are as its active constituent, wherein each group
/ there is significant synergistic effect repairing the hemorrhoid surface of a wound and ease pain, drug safety, effect comprehensively, be suitble into
Row promotes and applies.
The present invention provides a kind of composition with wound repair function comprising the component of following weight percentage：
Chitosan 0.5%-5%, chitosan quaternary ammonium salt 0.1%-2%, menthol 0.5%-5%, polyvinyl alcohol 10%-40%, seaweed
Sour sodium 0.5%-3%, povidone iodine 1%~5%, collagen 0.5~5% and 50-80% water.
Preferably, the hemorrhoid composition with wound repair function includes the component of following weight percentage：
Chitosan 1-3%, chitosan quaternary ammonium salt 0.5-1%, menthol 2-4%, polyvinyl alcohol 15-25%, sodium alginate 1-2%, gather
Tie up ketone iodine 2-3%, collagen 2-4% and 60-70% water.
Preferably, the hemorrhoid composition with wound repair function by following weight percentage component：Shell
Glycan 2.75%, chitosan quaternary ammonium salt 1%, menthol 2.75%, polyvinyl alcohol 25%, sodium alginate 1.75%, povidone iodine
4%, the water of collagen 2.75% and 60%.
The composition with wound repair function can also contain Angelica Dahurica extract, wherein the Angelica Dahurica extract
In preparation method be：40 meshes will be crossed after angelica root dries pulverizing, 3-5 times that angelica root quality is added thereto measures body
Reaction, mistake after hydrolysis 4-6 hours is hydrolyzed controlled at 50-70 DEG C in the sodium hydroxide solution of 3% long-pending mass concentration
Filter, using drinking water wash filtered angelica root until water lotion pH value be 7-8, angelica root after washing is dried
Afterwards, 4-6 times of its quality aqueous acetone solution refluxing extraction 2-3 time for measuring 30% volumetric concentration of volume is added thereto, extracts
Liquid is concentrated under reduced pressure into paste after merging, and the 6-8 times of dehydrated alcohol reflux for measuring volume that its quality is added is dissolved, and discards after filtering
Filter residue, phegma is concentrated under reduced pressure into paste, dry to get Angelica Dahurica extract.
The weight ratio of composition as described above with wound repair function, chitosan and Angelica Dahurica extract is 1:1~
3, it is highly preferred that the weight ratio of chitosan and Angelica Dahurica extract is 1:2.The addition of Angelica Dahurica extract so that suppository wound repair
Significant effect enhancing, and there is significant analgesic effect.
On the other hand, the present invention also provides a kind of suppository containing the composition with wound repair function, in suppository
Comprising matrix, the dosage of the matrix can be added according to pharmaceutical quantities, and content does not have an impact the therapeutic effect of drug.Institute
The matrix stated is semi-synthetic fatty glyceride, cocoa butter, Myrj 45, hydrogenated vegetable oil, glycerin gelatine, gathers
One of glycols is a variety of, it is preferable to use cocoa butter.
The preparation method of the suppository is：Weigh the chitosan, chitosan quaternary ammonium salt, menthol of recipe quantity, polyethylene
Alcohol, sodium alginate, povidone iodine, collagen, Angelica Dahurica extract and water grind well to obtain drug after mixing in mortar molten
Liquid, water-bath make matrix, and drug solution is added, and mix, and cool to slightly sticky thick, injection bolt mould, place solidification and are placed on refrigerator cold-storage,
Scraping is taken out, is demoulded to get suppository.Chitosan, menthol and Angelica Dahurica extract can play significantly in prescription of the present invention
Wound repair effect is cooperateed with, and there is significant analgesic activity.The hemorrhoid composition being prepared according to the above-mentioned technique not only surface of a wound
It repairs and analgesic effect is good, and property is stablized, it is easy to carry, it is very suitable to promote and apply.
The present invention provides a kind of compositions with wound repair function to prepare the application in medicine for treaching hemorrhoie.This
Inventive composition, there is certain analgesic activity, and analgesic effect repairs product better than existing chitosan wound.
The present invention achieves following technical effect compared with the existing technology：
1) chitosan and Angelica Dahurica extract can play significant collaboration wound repair effect in prescription of the present invention, wherein shell
Glycan and Angelica Dahurica extract optimum proportioning are 1:It can the maximum synergic antalgic repairing effect for playing the two when 2.
2) present invention has the hemorrhoid composition analgesic effect of wound repair function good, can play treating both manifestation and root cause of disease to hemorrhoid
Effect, it is highly-safe, effect comprehensively, can be used for a long time.
Specific embodiment
The present invention is further described below by way of specific embodiment, but the embodiment does not limit this hair in any way
Bright scope of patent protection.
Embodiment 1, the composition with wound repair function
It is grouped as by the group of following weight percentage：Chitosan 2.75%, chitosan quaternary ammonium salt 1%, menthol
2.75%, polyvinyl alcohol 25%, sodium alginate 1.75%, povidone iodine 3%, collagen 2.75% and excess water.
Embodiment 2, the composition with wound repair function
It is grouped as by the group of following weight percentage：Chitosan 0.5%, chitosan quaternary ammonium salt 0.1%, menthol
0.5%, polyvinyl alcohol 10%, sodium alginate 0.5%, povidone iodine 1%, collagen 0.5% and excess water.
Embodiment 3, the composition with wound repair function
It is prepared by the component of following weight percentage：Chitosan 5%, chitosan quaternary ammonium salt 2%, menthol 5%,
Polyvinyl alcohol 40%, sodium alginate 3%, povidone iodine 5%, collagen 5% and excess water.
Embodiment 4, the composition with wound repair function
It is grouped as by the group of following weight percentage：Chitosan 2.75%, chitosan quaternary ammonium salt 1%, menthol
2.75%, polyvinyl alcohol 25%, sodium alginate 1.75%, povidone iodine 3%, collagen 2.75%, Angelica Dahurica extract 5.5%
And excess water.
Wherein the preparation method in the Angelica Dahurica extract is：40 meshes will be crossed after angelica root dries pulverizing, thereto
The sodium hydroxide solution of 3% mass concentration of 3 times of amount volumes of angelica root quality is added, is hydrolyzed controlled at 50 DEG C
Reaction, hydrolysis 4 hours after filter, using drinking water wash filtered angelica root until water lotion pH value be 7, will wash
Afterwards after angelica root drying, the aqueous acetone solution reflux that 30% volumetric concentration of 4 times of amount volumes of its quality is added thereto is mentioned
It takes 2 times, extracting solution is concentrated under reduced pressure into paste after merging, and the dehydrated alcohol reflux dissolution of 6 times of amount volumes of its quality, mistake is added
Filter residue is discarded after filter, phegma is concentrated under reduced pressure into paste, dry to get Angelica Dahurica extract.
Embodiment 5, the composition with wound repair function
It is grouped as by the group of following weight percentage：Chitosan 0.5%, chitosan quaternary ammonium salt 0.1%, menthol
0.5%, polyvinyl alcohol 10%, sodium alginate 0.5%, povidone iodine 1%, collagen 0.5%, 0.5% and of Angelica Dahurica extract
Excess water.
Embodiment 6, the composition with wound repair function
It is grouped as by the group of following weight percentage：Chitosan 5%, chitosan quaternary ammonium salt 2%, menthol 5%, poly- second
Enol 40%, sodium alginate 3%, povidone iodine 5%, collagen 5%, Angelica Dahurica extract 15% and excess water.
Embodiment 7, suppository L1~L6 with wound repair function
The composition of Example 1~6 respectively, grinds well to obtain drug solution, 80 DEG C of water after mixing in mortar
Bath melts its cocoa butter, and drug solution is added, and mixes, and cools to slightly sticky thick, injection bolt mould, places solidification and is placed on refrigerator
20min is refrigerated, scraping is taken out, demoulding is to get suppository L1~L6, the wherein weight ratio of composition and cocoa butter：1:3.
Comparative example 1, the composition with wound repair function
Difference with embodiment 4 is, does not include chitosan, remaining is the same as embodiment 4.
Comparative example 2, the composition with wound repair function
Difference with embodiment 4 is, does not include menthol, remaining is the same as embodiment 4.
Comparative example 3, the suppository with wound repair function
The chitosan iodine bolt being prepared according to 201310355429.8 embodiment 1 of Chinese patent application.
The influence of rat anus ulcer caused by test example one, suppository L1~L6 Dichlorodiphenyl Acetate
Take rat 100, half male and half female, 200~250g of weight.Take filter paper that size is made with the punch that internal diameter is 6mm
Equal filter paper is put into 99.0% acetum and sufficiently impregnates, and the filter paper after immersion is put into perianal, makes filter paper
Piece is in close contact anal skin and mucous membrane, and every time with a piece of filter paper, when every rat l min, 0.5min changes a filter paper.The
Rat is randomly divided into 10 groups by 2d, and Ma Yinglong, suppository L1~L6 are administered respectively, and dosage is 5g/kg, and administration group is used
The dissolution of 0.5%CMC-Na solution, control group give isometric 0.5%CMC-Na solution.Each group be rectally 0.6mL. in
The 3rd, 5,7,9d observation rat ulcer healing state is administered, evaluates ulcer level.Standards of grading：There is ulcer sepage 1 to divide；It is a little to burst
Ulcer sepage 2 divides；There is eschar, basic 3 points of healing；4 points of healing completely.
Note：Compared with the control group,*P < 0.05,**P < 0.01；Compared with suppository L4,#P < 0.05,##P < 0.01.
The result shows that：Compared with the control group, rat Perianal ulceration caused by composition group Dichlorodiphenyl Acetate of the invention has significantly
Therapeutic effect (P<0.05), especially suppository L4~L6 group containing Angelica Dahurica extract has extremely significant difference with control group
(P<, and the obtained chitosan iodine bolt of effect prior art preparation 0.05).It should be pointed out that being added without compared with suppository L4
There is significant difference, especially 5d compared with suppository L4 in the ulcer level of the 3rd, 5,7 and 9d in suppository made from chitosan
Afterwards, there are extremely significant differences.And it is added without suppository made from menthol, there is conspicuousness compared with suppository L4 in the 5th and 9d
Difference shows significantly to act synergistically.
Test example two, suppository L1~L6 influence mouse hot-plate analgesic
The production of 2.1 mouse hot-plate pain models
Weight 20g or so female mice is placed on hot plate pain threshold detector, screens qualified female mice 120 (when licking metapedes
Between<5s or>30s is thrown aside, and to prevent foot from scalding, should also set deadline, generally 60s), the latent of metapedes reaction is added with mouse
The volt phase is pain indicator, takes 110 jennies, is divided into 11 groups, 10/group, each group smears administration, blank in addition to model group
Control group is without any processing, and 60mi n, 120min add the time reacted enough after measurement administration.
Influence of 2.2 suppositorys of the present invention to the sufficient response latency is licked in mouse hot-plate analgesic experiment
Mouse licks sufficient response latency time showing, compared with model group, after suppository L1~L6 administration after 1h and 2h, respectively gives
The mouse of medicine group adds the incubation period reacted enough and is all larger than model group, illustrates that the suppository L1~L6 of the present invention is able to extend mouse to heat
Plate stimulation adds the sufficient response latency, there is certain analgesic activity.This shows that hemorrhoid composition each component is used in combination and is easing pain
Aspect has significant synergistic effect.The analgesic effect of suppository L1~L6 of the present invention is produced better than existing chitosan wound reparation
Product.It the results are shown in Table 2.
2 mouse of table licks sufficient response latency timetable
| Group | 1h(s) | 2h(s) |
| Blank control group | 40.25±8.2 | 39.12±5.7 |
| Model group | 22.5±3.9** | 23.5±3.7** |
| Suppository L1 | 30.7±4.6# | 28.1±5.2# |
| Suppository L2 | 28.5±5.9# | 27.3±3.8# |
| Suppository L3 | 30.2±5.8# | 27.7±4.5# |
| Suppository L4 | 36.8±5.4## | 36.3±3.8## |
| Suppository L5 | 34.7±6.5## | 35.5±3.4## |
| Suppository L6 | 35.9±5.2## | 35.2±4.7## |
| Comparative example 1 | 24.7±1.9# | 25.6±1.5# |
| Comparative example 2 | 26.3±1.3# | 27.4±2.7# |
| Comparative example 3 | 30.5±5.1## | 28.6±3.3# |
Note：Compared with blank control group,*P < 0.05,**P < 0.01；Compared with model group,#P < 0.05,##P < 0.01.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology all without departing from the spirit and scope of the present invention, carries out modifications and changes to above-described embodiment.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should be covered by the claims of the present invention.
Claims (10)
1. a kind of composition with wound repair function comprising the component of following weight percentage：Chitosan 0.5%-
5%, chitosan quaternary ammonium salt 0.1%-2%, menthol 0.5%-5%, polyvinyl alcohol 10%-40%, sodium alginate 0.5%-
3%, povidone iodine 1%~5%, collagen 0.5~5% and 50-80% water.
2. the composition according to claim 1 with wound repair function, which is characterized in that including following weight percent
The component of content：Chitosan 1-3%, chitosan quaternary ammonium salt 0.5-1%, menthol 2-4%, polyvinyl alcohol 15-25%, alginic acid
Sodium 1-2%, povidone iodine 2-3%, collagen 2-4% and 60-70% water.
3. the composition according to claim 2 with wound repair function, which is characterized in that including following weight percent
The component of content：Chitosan 2.75%, chitosan quaternary ammonium salt 1%, menthol 2.75%, polyvinyl alcohol 25%, sodium alginate
1.75%, povidone iodine 4%, the water of collagen 2.75% and 60%.
4. the composition according to claim 1 with wound repair function, which is characterized in that also wrapped in the composition
Include Angelica Dahurica extract.
5. the composition according to claim 4 with wound repair function, which is characterized in that the Angelica Dahurica extract
Preparation method is：
40 meshes will be crossed after angelica root dries pulverizing, 3-5 times of addition angelica root quality measures 3% mass of volume thereto
Reaction is hydrolyzed controlled at 50-70 DEG C in the sodium hydroxide solution of concentration, and hydrolysis is filtered after 4-6 hours, uses drinking water
Filtered angelica root is washed until the pH value of water lotion is that it is added after drying angelica root after washing in 7-8 thereto
4-6 times of quality measures aqueous acetone solution refluxing extraction 2-3 times of 30% volumetric concentration of volume, and extracting solution is concentrated under reduced pressure after merging
To paste, the 6-8 times of dehydrated alcohol reflux for measuring volume that its quality is added is dissolved, and filter residue, phegma decompression are discarded after filtering
It is concentrated into paste, it is dry to get Angelica Dahurica extract.
6. the composition according to claim 4 or 5 with wound repair function, which is characterized in that the chitosan
Weight fraction ratio with Angelica Dahurica extract is 1:1~3.
7. the composition according to claim 6 with wound repair function, which is characterized in that the chitosan with it is white
The weight fraction ratio of root of Dahurian angelica extract is 1:2.
8. a kind of suppository containing the described in any item compositions of claim 1-7, it is characterised in that：The suppository includes base
Matter, the matrix are that semi-synthetic fatty glyceride, cocoa butter, Myrj 45, hydrogenated vegetable oil, glycerol are bright
One of glue and polyethylene glycols are a variety of.
9. the preparation method of suppository according to any one of claims 8, it is characterised in that：Weigh recipe quantity with wound repair function
Composition each component grinds well to obtain drug solution after mixing in mortar, and water-bath melts matrix, and drug solution is added, and mixes
It is even, it cools to slightly sticky thick, injection bolt mould, places solidification and be placed on refrigerator cold-storage, take out scraping, demould to get suppository.
10. the described in any item compositions with wound repair function of claim 1-7 are in preparing medicine for treaching hemorrhoie
Using.
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|---|---|---|---|
| CN201811075627.8A CN108837149B (en) | 2018-09-14 | 2018-09-14 | Composition with wound repair function |
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| CN201811075627.8A CN108837149B (en) | 2018-09-14 | 2018-09-14 | Composition with wound repair function |
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| CN108837149B CN108837149B (en) | 2021-11-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113144281A (en) * | 2021-04-19 | 2021-07-23 | 深圳市安多福消毒高科技股份有限公司 | Wound surface disinfection gel and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN108837149B (en) | 2021-11-30 |
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