CN108813598A - A kind of food materials composition eradicating hypertension and cardiovascular and cerebrovascular disease - Google Patents

A kind of food materials composition eradicating hypertension and cardiovascular and cerebrovascular disease Download PDF

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Publication number
CN108813598A
CN108813598A CN201810732438.7A CN201810732438A CN108813598A CN 108813598 A CN108813598 A CN 108813598A CN 201810732438 A CN201810732438 A CN 201810732438A CN 108813598 A CN108813598 A CN 108813598A
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food materials
materials composition
cardiovascular
cerebrovascular disease
parts
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马凤强
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
    • A61K36/9068Zingiber, e.g. garden ginger
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses a kind of radical cure hypertension and the food materials composition of cardiovascular and cerebrovascular disease, the food materials composition to be made of apple vinegar, lemon, ginger.The invention also discloses a kind of radical cure hypertension and the preparation methods of the food materials composition of cardiovascular and cerebrovascular disease, include the following steps:1) after cleaning lemon, ginger, slice is added in apple vinegar, and high fire is boiled, and small fire closes fire after enduring half an hour slowly after boiling;2) it filters, is saved in the cooling postposition refrigerator of resulting filtrate.The present invention carries out compatibility with apple vinegar, lemon, ginger special ratios, synergistic function enhancing, it is verified through clinical test, food materials composition of the invention has radical cure effect well to hypertension and cardiovascular and cerebrovascular disease, has the advantages that significant in efficacy, safe without toxic side effect, can take for a long time.Preparation process of the invention is simple, and strong operability, production cost is low, is suitable for being mass produced.

Description

A kind of food materials composition eradicating hypertension and cardiovascular and cerebrovascular disease
Technical field
The present invention relates to technical field of health care food, and in particular to a kind of food materials for eradicating hypertension and cardiovascular and cerebrovascular disease Composition.
Background technique
Cardiovascular and cerebrovascular disease is the general designation of cardiovascular disease and cranial vascular disease, refer to due to hyperlipidemia, blood is sticky, The common name of ischemic or hemorrhagic disease occurs for heart caused by atherosclerosis, hypertension etc., brain and body tissue.
With the quickening of continuous improvement of people's living standards and work rhythm, the illness rate of cardiovascular and cerebrovascular disease increases year by year Add, and some cardiovascular and cerebrovascular diseases, if hypertension is because of incidence of occult, thus it is ignored, often just found in health examination.Separately Outside since the big diet of people's psychology stress is unbalanced, environmental pollution does not get enough athletic exercise, and a large amount of lipid material can not generation It thanks, has then resulted in the accumulation of internal lipid material, so that hyperlipidemia, hypertension, hyperglycemia, obesity etc. are further obvious, this And the main reason for causing cardiovascular and cerebrovascular disease incidence persistently to rise.
Once this kind of disease must be gone up, less serious case needs maintenance of taking medicine for a long time, and severe one needs to spend a large amount of money that hospital is gone to rescue It controls, very big financial burden and psychological pressure is caused to family.In order to prevent and treat above-mentioned disease, there are many related in recent years Drug is increasingly developed, and so-called there's no such thing as a totally safe medicine, and many drugs, not only expensive price, but also effect is unknown after taking It is aobvious.
Summary of the invention
Of the existing technology in order to solve the problems, such as, the purpose of the present invention is to provide a kind of radical cure hypertension and heart and brain blood The food materials composition of pipe disease, the food materials composition have significant in efficacy, safe without toxic side effect, at low cost, production method is simple The advantages that single easy to operate.
To achieve the above object, the first aspect of the present invention provides a kind of food for eradicating hypertension and cardiovascular and cerebrovascular disease Material composition, the food materials composition are made of apple vinegar, lemon, ginger.
Further, according to parts by weight, the food materials composition is by 500 parts of apple vinegar, 100-200 parts of lemon, ginger 20-60 parts are made.
Further, according to parts by weight, the food materials composition is by 500 parts of apple vinegar, 120-160 parts of lemon, ginger 30-50 parts are made.
Further, according to parts by weight, the food materials composition is by 500 parts of apple vinegar, 140 parts of lemon, 40 parts of ginger It is made.
The second aspect of the present invention provides a kind of preparation of food materials composition for eradicating hypertension and cardiovascular and cerebrovascular disease Method the described method comprises the following steps:
1) after cleaning lemon, ginger, slice is added in apple vinegar, high fire is boiled, and small fire endures half an hour slowly after boiling Fire is closed afterwards;
2) it filters, is saved in the cooling postposition refrigerator of resulting filtrate.
Further, 500 parts by weight of apple vinegar, lemon 100-200 parts by weight, ginger 20-60 parts by weight.
The third aspect of the present invention provides above-mentioned food materials composition in preparation radical cure hypertension and cardiovascular and cerebrovascular disease Health care product in application.
The fourth aspect of the present invention provides above-mentioned food materials composition in preparation radical cure hypertension and cardiovascular and cerebrovascular disease Drug in application.
The effect for each raw material that the present invention uses is as follows:
Apple vinegar:It is the product of apple deep processing, it is using apple as raw material, through alcoholic fermentation, acetic fermentation brew At one kind is full of nutrition, flavorful acid health care condiment.Tart flavour in apple vinegar is rich in organic in vinegar liquid Acid also contains malic acid, succinic acid, lactic acid, citric acid, hydroxyacetic acid in addition to acetic acid.Studies have shown that apple vinegar is in addition to its crowd Well known antibacterial activity effect is outer, can also reduce blood pressure, anti-oxidant, and mitigating diabetes influences, and prevents cardiovascular disease, promotees Into metabolism etc..
Lemon:Rich in vitamin C, carbohydrate, calcium, phosphorus, iron, vitamin B1, vitamin B2, niacin, quininic acid, citric acid, Malic acid, aurantiamarin, aurantiin, coumarin, a large amount potassium element and low amounts sodium element etc., it is highly beneficial to human body.Vitamin C energy The generation of human body various tissues and cytoplasm is maintained, and keeps their normal physiological functions.The intracorporal matrix of people, bonding and Collagen etc. requires vitamin C to protect.When vitamin C lacks, the interstitial jelly between cell also just and then becomes It is few.In this way, cell tissue will become fragile, the ability for resisting external force is lost, human body is easy for scurvy occur, it is used there are also more On the way, such as the effects of preventing cold, stimulation hematopoiesis and anticancer.It is early on the books in ancient medical book.Written by pharmacy man of Ming Dynasty Li Shizhen (1518-1593 A.D.)《Book on Chinese herbal medicine Detailed outline》Middle record lemon has the function of to promote the production of body fluid, quench the thirst, driving away summer heat etc..Lemon juice is bitter in taste, warm, nontoxic.《Luchuan book on Chinese herbal medicine》It says Citron fruit, skin juice etc., which have, to be dredged stagnant, stomach invigorating, relieves pain, controls the efficiency such as stasis abdominal pain do not feel like eating.Modern medicine thinks that lemon is The medicine food for preventing cardiovascular disease.Due to citric acid in human body and calcium binding is at a kind of soluble complexes, to alleviate Calcium ion plays the role of promoting blood clotting.Therefore, hypertension, Patients With Myocardial Infarction often drink lemonade, have very to symptom is improved Big benefit.
Ginger:Belong to Zingiber zingiber herbaceos perennial and annual vegetable crop.Ginger is full of nutrition, and has Unique flavor can be used as a kind of important flavouring.Nature and flavor are pungent, tepor.Contain pungent and fragrance ingredient.Piquancy component is one " zingerone " in kind armaticity stearopten.Wherein it is mainly ginger oil terpene, phellandium, camphor terpene, gingerol, folium eucalypti olein, forms sediment Powder, mucus.The secretion that can be promoted blood circulation with digestive juice has cold dispelling and orectic effect, while having town to spit, town Bitterly, anti-inflammation detumescence, expelling parasite and antiviral effect.Can assist in the treatment of influenza, pneumonia, bronchiectasis, pertussis, Acute tonsillitis, the illnesss such as thick phlegm, trichomonas vaginitis, irregular menstruation, skin tinea of coughing.Terpenoid in ginger, Such as ginger oil alcohol, zingerone, borneol citral, they all have stronger bactericidal effect.
The invention has the advantages that:
1, the present invention carries out compatibility with apple vinegar, lemon, ginger special ratios, and synergistic function enhancing is tried through clinic Verifying, food materials composition of the invention to hypertension and cardiovascular and cerebrovascular disease have well radical cure effect, have it is significant in efficacy, Safe without toxic side effect, the advantages of can taking for a long time.
2, preparation process of the invention is simple, and strong operability, production cost is low, is suitable for being mass produced.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
Embodiment 1
A kind of radical cure hypertension of the present embodiment and the food materials composition of cardiovascular and cerebrovascular disease, by 500 grams of apple vinegar, lemon 100 grams, ginger 20 restrain at.
The preparation method of the food materials composition is:
1) after cleaning lemon, ginger, slice is added in apple vinegar, high fire is boiled, and small fire endures half an hour slowly after boiling Fire is closed afterwards;
2) it filters, is saved in the cooling postposition refrigerator of resulting filtrate.
Embodiment 2
A kind of radical cure hypertension of the present embodiment and the food materials composition of cardiovascular and cerebrovascular disease, by 500 grams of apple vinegar, lemon 150 grams, ginger 60 restrain at.
The preparation method is the same as that of Example 1 for the food materials composition.
Embodiment 3
A kind of radical cure hypertension of the present embodiment and the food materials composition of cardiovascular and cerebrovascular disease, by 500 grams of apple vinegar, lemon 180 grams, ginger 30 restrain at.
The preparation method is the same as that of Example 1 for the food materials composition.
Embodiment 4
A kind of radical cure hypertension of the present embodiment and the food materials composition of cardiovascular and cerebrovascular disease, by 500 grams of apple vinegar, lemon 140 grams, ginger 40 restrain at.
The preparation method is the same as that of Example 1 for the food materials composition.
Embodiment 5
A kind of radical cure hypertension of the present embodiment and the food materials composition of cardiovascular and cerebrovascular disease, by 500 grams of apple vinegar, lemon 200 grams, ginger 20 restrain at.
The preparation method is the same as that of Example 1 for the food materials composition.
Embodiment 6
A kind of radical cure hypertension of the present embodiment and the food materials composition of cardiovascular and cerebrovascular disease, by 500 grams of apple vinegar, lemon 100 grams, ginger 25 restrain at.
The preparation method is the same as that of Example 1 for the food materials composition.
Test example
In order to illustrate the effect of food materials composition of the invention in terms of radical cure hypertension and cardiovascular and cerebrovascular disease, the present invention Following clinical trial is carried out.
1, general information
It chooses voluntary receiving food materials composition of the present invention nearly ten years to be treated, is diagnosed as hypertension and cardiovascular and cerebrovascular disease Patient is used as research object for totally 167, wherein and hypertension 45, coronary heart disease 21, pulmonary heart disease 17, cerebral thrombosis 47, the heart Muscle infarction 37, it is randomly divided into treatment group (n=83) and control group (n=84).The bases such as gender, age, the course of disease of two groups of patients Not statistically significant (the P of this data comparing difference>0.05) it, is comparable.
2, treatment method
Treatment group:It gives food materials composition, warm water made from the present embodiment 2 to take, proper honey flavor adjustment can be added, 2 times a day.
Contrast groups:Hypertensive patient takes captopril, each 12.5-25mg, once a day;Patients with Cardiovascular/Cerebrovascular Diseases Dosed herself with aspirin, each 50-150mg, once a day.
2 months as a treatment course, and all patients eat the acidic materials such as fish, meat, egg in treatment stage less, forbids edible fertilizer Meat, cream, sweet food and pluck etc. be high-fat, high sugar, high-cholesterol diet.The alkalinity foods such as more feed coarse food grains, veterinary antibiotics Object, and cooperate and take exercise.
3, curative effect determinate standard
It is effective:Patient by treatment after, hypertensive patient's diastole drops 10mmHg or more, and reach normal range (NR) and/ Or diastole drops 20mmHg or more, but it is not up to normal;Patients with Cardiovascular/Cerebrovascular Diseases is uncomfortable in chest, shortness of breath, cardio palmus shape disappear.
Effectively:For patient after treatment, hypertensive patient's diastolic pressure is declined by less than 10mmHg, but has reached normal range (NR) And/or diastole drops 10-19mmHg, but decline 30mmHg or more before the relatively treatment of not up to normal and/or systolic pressure;Heart and brain blood Pipe Disease is uncomfortable in chest, shortness of breath, cardio palmus shape are alleviated.
In vain:For patient after treatment, hypertensive patient is not up to the above standard;Patients with Cardiovascular/Cerebrovascular Diseases symptom is without bright It is aobvious to improve.
4, result
Two groups of patients are after 1 course of therapy, effective 35 for the treatment of group, and effective 40, invalid 8, treatment is total effective Rate is 90.36%;Control group effective 28, effective 33, invalid 23, treatment total effective rate is 72.62%;Treatment group's effect Better than control group, difference has statistical significance.
Typical case:
1, Liu, male 51 years old, suffer from hypertension 8 years, throughout the year giddy dizziness, and indistinctly, body is tired out of strength, lassitude for headache, Few gas uncomfortable in chest, blood pressure 160/100mmHg once took captopril depressor, more felt dizzy uncomfortable, took orally the embodiment of the present invention 1 Food materials composition obtained even served 2 months 2 times a day, and the symptoms such as dizziness disappear, and blood pressure is normal, and follow-up half a year does not recur.
2, what certain, female, precordialgia before 48 years old, 1 year cannot be alleviated after rest, be diagnosed as coronary heart disease, take orally on the market Drug without good curative effect, food materials composition made from the oral embodiment of the present invention 3 even served 1 week, pareordia 2 times a day It pain lasts 3-5 minutes, can voluntarily alleviate after rest, continue to take 2 months, pain of the heart area disappears, and follow-up half a year does not recur.
3, Lee, male, 45 years old, 1 month previous lateral deviation paralysis, the basic imperception of limbs was diagnosed as cerebral thrombosis, takes orally the present invention Food materials composition made from embodiment 5 even served 2 months 2 times a day, and can get up alone walking, continue to take 2 months, symptom is complete It totally disappeared mistake, suitable manual labor can be carried out, follow-up half a year does not recur.
4, Zhang, male, 55 years old, bored pain after half a year os presternum was in duration, radiates with back part, be diagnosed as myocardial infarction. Food materials composition made from the present embodiment 6 is taken, is taken 1 week, pectoralgia is substantially reduced, continues to take 1 month, symptom disappears completely It removes, does not occur any discomfort when patient takes.
Although above having used general explanation and specific embodiment, the present invention is described in detail, at this On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore, These modifications or improvements without departing from theon the basis of the spirit of the present invention are fallen within the scope of the claimed invention.

Claims (8)

1. the food materials composition of a kind of radical cure hypertension and cardiovascular and cerebrovascular disease, which is characterized in that the food materials composition is by apple Fruit vinegar, lemon, ginger are made.
2. the food materials composition of radical cure hypertension according to claim 1 and cardiovascular and cerebrovascular disease, which is characterized in that by weight Number meter is measured, the food materials composition is made of 500 parts of apple vinegar, 100-200 parts of lemon, 20-60 parts of ginger.
3. the food materials composition of radical cure hypertension according to claim 2 and cardiovascular and cerebrovascular disease, which is characterized in that by weight Number meter is measured, the food materials composition is made of 500 parts of apple vinegar, 120-160 parts of lemon, 30-50 parts of ginger.
4. the food materials composition of radical cure hypertension according to claim 2 and cardiovascular and cerebrovascular disease, which is characterized in that by weight Number meter is measured, the food materials composition is made of 500 parts of apple vinegar, 140 parts of lemon, 40 parts of ginger.
5. a kind of preparation method of the food materials composition of radical cure hypertension and cardiovascular and cerebrovascular disease, which is characterized in that the method Include the following steps:
1) after cleaning lemon, ginger, slice is added in apple vinegar, high fire is boiled, and small fire is closed after enduring half an hour slowly after boiling Fire;
2) it filters, is saved in the cooling postposition refrigerator of resulting filtrate.
6. the preparation method of the food materials composition of radical cure hypertension according to claim 5 and cardiovascular and cerebrovascular disease, special Sign is, 500 parts by weight of apple vinegar, lemon 100-200 parts by weight, ginger 20-60 parts by weight.
7. food materials composition described in claim 1 answering in the health care product of preparation radical cure hypertension and cardiovascular and cerebrovascular disease With.
8. application of the food materials composition described in claim 1 in the drug of preparation radical cure hypertension and cardiovascular and cerebrovascular disease.
CN201810732438.7A 2018-07-05 2018-07-05 A kind of food materials composition eradicating hypertension and cardiovascular and cerebrovascular disease Pending CN108813598A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103260431A (en) * 2010-12-08 2013-08-21 雀巢产品技术援助有限公司 Food ingredient comprising hydrolyzed whole grain
CN105853948A (en) * 2015-01-20 2016-08-17 牙生·玉苏甫 Health product for preventing and treating cardio-cerebral vascular embolism
CN106620629A (en) * 2017-02-20 2017-05-10 王智 Xuesaitong combination drug and preparation method thereof
CN107279613A (en) * 2017-06-27 2017-10-24 丁保群 A kind of cerebral thrombus Dietotherapy health drink
CN107737321A (en) * 2017-11-28 2018-02-27 无限极(中国)有限公司 A kind of Chinese medicine composition of the promoting flow of qi and blood circulation and its preparation method and application

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103260431A (en) * 2010-12-08 2013-08-21 雀巢产品技术援助有限公司 Food ingredient comprising hydrolyzed whole grain
CN105853948A (en) * 2015-01-20 2016-08-17 牙生·玉苏甫 Health product for preventing and treating cardio-cerebral vascular embolism
CN106620629A (en) * 2017-02-20 2017-05-10 王智 Xuesaitong combination drug and preparation method thereof
CN107279613A (en) * 2017-06-27 2017-10-24 丁保群 A kind of cerebral thrombus Dietotherapy health drink
CN107737321A (en) * 2017-11-28 2018-02-27 无限极(中国)有限公司 A kind of Chinese medicine composition of the promoting flow of qi and blood circulation and its preparation method and application

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
周晓博: "验方十二则", 《开卷有益—求医问药》 *

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Application publication date: 20181116