CN108795646A - A kind of hemostasis health liquor and preparation method thereof - Google Patents

A kind of hemostasis health liquor and preparation method thereof Download PDF

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Publication number
CN108795646A
CN108795646A CN201810713979.5A CN201810713979A CN108795646A CN 108795646 A CN108795646 A CN 108795646A CN 201810713979 A CN201810713979 A CN 201810713979A CN 108795646 A CN108795646 A CN 108795646A
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parts
hemostasis
liquor
health
health liquor
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不公告发明人
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Guangzhou Poly Health Industry Research Institute Co Ltd
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Guangzhou Poly Health Industry Research Institute Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/02—Preparation of other alcoholic beverages by fermentation

Abstract

The invention discloses a kind of hemostasis health liquors and preparation method thereof, wherein hemostasis health liquor is made of the raw material of following parts by weight：0.5~1.5 part of red halloysite powder, 15~20 parts of Peony Root, 5~6 parts of honey-fried licorice root, 35~45 parts of jujube, 25~35 parts of maltose, 4~12 parts of gekko leaching liquor, 3~7 parts of Rhizoma imperatae polysaccharides, 0.05~1.15 part of citric acid, 1~5 part of pectin；The present invention stops blooding, and health liquor aroma is strong, sour and sweet palatability, medicine cordiale perfume (or spice) are coordinated, and there is hemostasis to enrich blood, reduce the health-care efficacy of present situation in poor health.

Description

A kind of hemostasis health liquor and preparation method thereof
Technical field
The invention belongs to health liquor preparation fields, and in particular to a kind of hemostasis health liquor and preparation method thereof.
Background technology
The big health industry of traditional Chinese medicine is related to the two big field of production and health service of health-oriented products, the wherein life of health-oriented products Production includes the manufacture of drug, health products, green organic food, wine, water, tea, daily chemical product and traditional medical instrument etc..Medicinal liquor is made There is long history in China for important one kind in the big health-oriented products of traditional Chinese medicine, and type is various, since medicinal liquor is being made The ingredients such as Chinese medicine are added during making, therefore are had the function of disease preventing and treating and kept fit and healthy.The wine of modern health wine System inherits the production method and experience of traditional medicinal liquor, and has merged modern advanced science and technology, this makes health liquor industry Great development is obtained.But current market sales of health liquor single varieties, the health care range having is smaller, this cannot Meets the needs of people are growing.
Invention content
To solve the above-mentioned problems, it is strong, sour and sweet palatability that the present invention provides a kind of aroma, has hemostasis to enrich blood, salubrity The health liquor of effect of being healthy and strong.
The present invention can be realized by following technical scheme：
A kind of hemostasis health liquor, is made of the raw material of following parts by weight：0.5~1.5 part of red halloysite powder, Peony Root 15~ 20 parts, 5~6 parts of honey-fried licorice root, 35~45 parts of jujube, 25~35 parts of maltose, 4~12 parts of gekko leaching liquor, Rhizoma imperatae polysaccharides 3~7 Part, 0.05~1.15 part of citric acid, 1~5 part of pectin.
Preferably, a kind of hemostasis health liquor of the present invention, is made of the raw material of following parts by weight：Red halloysite powder 0.75~ 1.25 parts, 16.25~18.75 parts of Peony Root, 5.25~5.75 parts of honey-fried licorice root, 37.5~42.5 parts of jujube, maltose 27.5~ 32.5 parts, 6~10 parts of gekko leaching liquor, 4~6 parts of Rhizoma imperatae polysaccharides, 0.325~0.875 part of citric acid, 2~4 parts of pectin.
It is highly preferred that a kind of hemostasis health liquor of the present invention, is made of the raw material of following parts by weight：1 part of red halloysite powder, Chinese herbaceous peony 17.5 parts of medicine root, 5.5 parts of honey-fried licorice root, 40 parts of jujube, 30 parts of maltose, 16 parts of gekko leaching liquor, 5 parts of Rhizoma imperatae polysaccharides, citric acid 0.6 part, 3 parts of pectin.
A kind of hemostasis health liquor of the present invention, the preparation method of the red halloysite powder are：It is ground into fine powder, with vinegar and even, Rubbing segment, is dried, and is set in crucible, is forged and is popular in smokeless stove fire, is taken out, cool.
A kind of hemostasis health liquor of the present invention, the preparation method of the Rhizoma imperatae polysaccharides are：
A. it takes dry rhizoma imperatae to crushed 50~70 mesh sieve, is 1 by solid-liquid ratio:2~3 are added 95% ethyl alcohol, 24~ 20~28h, then 2~4h of refluxing extraction in 45~55 DEG C of water-baths, filtering are stood at 28 DEG C；
B. filter residue dries, and is 1 by solid-liquid ratio:4~5 addition pure water extract 2~3h in 90~100 DEG C of water-baths, filter Filtrate is collected, filter residue repeats extracting in water 1 time, merges 2 filtrates, is concentrated under reduced pressure into the 1/10~2/5 of original volume, centrifugation removes 95% ethyl alcohol is added in clear liquid and carries out alcohol precipitation, stands overnight, filters, vacuum freeze drying obtains white in -4~-2 DEG C for decontamination Lalang grass rhizome Thick many candies；
C. obtained rhizoma imperatae Thick many candies are dissolved, chloroform is added:N-butanol=4:1 Sevag reagents take off albumen, repeatedly De- albumen collects water phase to no albuminate, and 95% ethyl alcohol is added and carries out alcohol precipitation, stands overnight, filters in -4~-2 DEG C, freezing Dry Rhizoma imperatae polysaccharides.
A kind of hemostasis health liquor of the present invention, the preparation method of the gekko leaching liquor are：Gekko is cut out into eyeball, in removing It is dirty, it cleans, big fire in Chinese herbal medicine leaching liquor is put into after chopping and boils 45~55min, filter and remove residue obtains gekko leaching liquor.
The present invention prepares a kind of method of hemostasis health liquor, includes the following steps：
(1) dry Peony Root and honey-fried licorice root are crushed by weight, it is 1 to cross after 400 mesh sieve and press solid-liquid ratio:15~20 add Enter pure water, saccharification enzymatic conversion is added after 30~40min of ultrasonic extraction, through 4~6 layers of filtered through gauze after completion, removes filter residue and obtain Medicinal material enzymolysis liquid；
(2) it is 1 by solid-liquid ratio:7~9 jujube and pure water is mixed with beating, and jujube liquid is after pectinase enzymatic hydrolysis with 4~6 layers Filtered through gauze removes pomace and obtains jujube enzymolysis liquid；
(3) it is for use that active dry yeasr is activated with 4~6 times of 2% sucrose water at 35~40 DEG C to 25~35min, by weight Part meter mixing medicinal material enzymolysis liquid, jujube enzymolysis liquid, Rhizoma imperatae polysaccharides, gekko leaching liquor, red halloysite powder, maltose, after stirring completely Filtrate is filtered to take with citric acid tune pH value to 4.8~5.2；
(4) fermentation by saccharomyces cerevisiae is added, gelatin clarification is added after fermentation and through 8 layers of filtered through gauze, removing filter residue is Wine liquid is obtained, being cooled to 10~15 DEG C rapidly after the 9~10min that sterilizes at 70~80 DEG C preserves to get health liquor finished product.
Further, the addition of the carbohydrase is 150~250U/mL, and saccharification temperature is 55~65 DEG C, the time 10 ~14h；The addition of the pectase is 100~150U/mL, and hydrolysis temperature is 40~50 DEG C, and the time is 6~10h；The ferment In the fermentation process of mother's fermentation, yeast-inoculated amount is 9~13%, and fermentation temperature is 22~30 DEG C, and fermentation time is 8~10d.
The related introduction of the part raw material of present invention hemostasis health liquor is as follows：
Red halloysite powder is the powder that a kind of red blocks of silicates mineral is process, and warm-natured, sweet-puckery flavor has The function of hemostasis and protection blood vessel mucous membrane.
Peony Root contains Paeoniflorin and benzoic acid, and it is a variety of that honey-fried licorice root contains glycyrrhizin, enoxolone, licorice polysaccharide etc. Chemical composition has anti-inflammatory and anti-allergy action, and body's immunity, antitumor and analgesic effect is adjusted.In curing mainly The burnt cold of insufficiency type, incoordination between the liver and the spleen, spiritlessness and weakness, deficiency of vital energy anaemia, restless fever of hands and feet, dry throat.
Rhizoma imperatae polysaccharides are taken from the grass with cooling blood and hemostasis, reducing fever and causing diuresis, clearing heat and promoting fluid, liver protection and other effects The dry rhizome of cogongrass has hypoglycemic, protect liver, antioxygen because having the function of anti-oxidant, elimination free radical, anti-aging The multiple efficacies such as change, antibacterial.
Gekko leaching liquor contains abundant carnosine, choline, carnitine, guanine, protein, fat, inorganic salts etc., has only Blood is enriched blood, improves the effects of the five internal organs.
Advantageous effect：The present invention stops blooding, and health liquor aroma is strong, sour and sweet palatability, medicine cordiale perfume (or spice) are coordinated, and there is hemostasis to enrich blood, Reduce the health-care efficacy of present situation in poor health.
Specific implementation mode
In order to make the technical means, the creative features, the aims and the efficiencies achieved by the present invention be easy to understand, tie below Specific embodiment is closed, the present invention is further explained.
Embodiment 1
A kind of hemostasis health liquor, is made of the raw material of following parts by weight：1 part of red halloysite powder, 17.5 parts of Peony Root, toast are sweet 5.5 parts of grass, 40 parts of jujube, 30 parts of maltose, 16 parts of gekko leaching liquor, 5 parts of Rhizoma imperatae polysaccharides, 0.6 part of citric acid, 3 parts of pectin.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the red halloysite powder are：Be ground into fine powder, with vinegar and Even, rubbing segment is dried, is set in crucible, is forged and is popular in smokeless stove fire, is taken out, cool.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the Rhizoma imperatae polysaccharides are：
A. it takes dry rhizoma imperatae to crushed 60 mesh sieve, is 1 by solid-liquid ratio:2.5 are added 95% ethyl alcohol, are stood at 26 DEG C For 24 hours, the refluxing extraction 3h then in 50 DEG C of water-baths, filtering；
B. filter residue dries, and is 1 by solid-liquid ratio:4.5 addition pure water extract 2.5h in 95 DEG C of water-baths, and filter is collected by filtration Liquid, filter residue repeat extracting in water 1 time, merge 2 filtrates, are concentrated under reduced pressure into the 1/4 of original volume, are centrifuged off impurity, clear 95% ethyl alcohol is added in liquid and carries out alcohol precipitation, stands overnight, filters in -3 DEG C, vacuum freeze drying obtains rhizoma imperatae Thick many candies；
C. obtained rhizoma imperatae Thick many candies are dissolved, chloroform is added:N-butanol=4:1 Sevag reagents take off albumen, repeatedly De- albumen collects water phase to no albuminate, and 95% ethyl alcohol is added and carries out alcohol precipitation, stands overnight, filters in -3 DEG C, freeze-drying Obtain Rhizoma imperatae polysaccharides.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the gekko leaching liquor are：Gekko is cut out into eyeball, is removed Internal organ are cleaned, big fire in Chinese herbal medicine leaching liquor are put into after chopping and boils 50min, filter and remove residue obtains gekko leaching liquor.
The present embodiment prepares a kind of method of hemostasis health liquor, includes the following steps：
(1) dry Peony Root and honey-fried licorice root are crushed by weight, it is 1 to cross after 400 mesh sieve and press solid-liquid ratio:17.5 are added Saccharification enzymatic conversion is added after ultrasonic extraction 35min for pure water, through 5 layers of filtered through gauze after completion, removes filter residue and obtains medicinal material enzymolysis Liquid；
(2) it is 1 by solid-liquid ratio:8 jujube and pure water is mixed with beating, and jujube liquid is after pectinase enzymatic hydrolysis with 5 layers of gauze mistake Filter removes pomace and obtains jujube enzymolysis liquid；
(3) it is for use that active dry yeasr is activated with 5 times of 2% sucrose water at 37.5 DEG C to 30min, mixes medicine by weight Material enzymolysis liquid, jujube enzymolysis liquid, Rhizoma imperatae polysaccharides, gekko leaching liquor, red halloysite powder, maltose filter to take filtrate after stirring completely With citric acid tune pH value to 5；
(4) fermentation by saccharomyces cerevisiae is added, gelatin clarification is added after fermentation and through 8 layers of filtered through gauze, removing filter residue is Wine liquid is obtained, being cooled to 12.5 DEG C rapidly after the 9.5min that sterilizes at 75 DEG C preserves to get health liquor finished product.
In above method step, the addition of the carbohydrase is 200U/mL, and saccharification temperature is 60 DEG C, time 12h； The addition of the pectase is 125U/mL, and hydrolysis temperature is 45 DEG C, time 8h；In the yeast-leavened fermentation process, Yeast-inoculated amount is 11%, and fermentation temperature is 26 DEG C, fermentation time 9d.
Embodiment 2
A kind of hemostasis health liquor, is made of the raw material of following parts by weight：0.5 part of red halloysite powder, 15 parts of Peony Root, toast are sweet 5 parts of grass, 35 parts of jujube, 25 parts of maltose, 4 parts of gekko leaching liquor, 3 parts of Rhizoma imperatae polysaccharides, 0.05 part of citric acid, 1 part of pectin.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the red halloysite powder are：Be ground into fine powder, with vinegar and Even, rubbing segment is dried, is set in crucible, is forged and is popular in smokeless stove fire, is taken out, cool.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the Rhizoma imperatae polysaccharides are：
A. it takes dry rhizoma imperatae to crushed 50 mesh sieve, is 1 by solid-liquid ratio:2 are added 95% ethyl alcohol, are stood at 24 DEG C 20h, then the refluxing extraction 2h in 45 DEG C of water-baths, filtering；
B. filter residue dries, and is 1 by solid-liquid ratio:4 addition pure water extract 2h in 90 DEG C of water-baths, and filtrate is collected by filtration, filters Slag repeats extracting in water 1 time, merges 2 filtrates, is concentrated under reduced pressure into the 1/10 of original volume, is centrifuged off impurity, in clear liquid 95% ethyl alcohol is added and carries out alcohol precipitation, stands overnight, filters in -4 DEG C, vacuum freeze drying obtains rhizoma imperatae Thick many candies；
C. obtained rhizoma imperatae Thick many candies are dissolved, chloroform is added:N-butanol=4:1 Sevag reagents take off albumen, repeatedly De- albumen collects water phase to no albuminate, and 95% ethyl alcohol is added and carries out alcohol precipitation, stands overnight, filters in -2 DEG C, freeze-drying Obtain Rhizoma imperatae polysaccharides.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the gekko leaching liquor are：Gekko is cut out into eyeball, is removed Internal organ are cleaned, big fire in Chinese herbal medicine leaching liquor are put into after chopping and boils 45min, filter and remove residue obtains gekko leaching liquor.
The present embodiment prepares a kind of method of hemostasis health liquor, includes the following steps：
(1) dry Peony Root and honey-fried licorice root are crushed by weight, it is 1 to cross after 400 mesh sieve and press solid-liquid ratio:15 additions are pure Saccharification enzymatic conversion is added after ultrasonic extraction 30min for water purification, through 4 layers of filtered through gauze after completion, removes filter residue and obtains medicinal material enzymolysis liquid；
(2) it is 1 by solid-liquid ratio:7 jujube and pure water is mixed with beating, and jujube liquid is after pectinase enzymatic hydrolysis with 4 layers of gauze mistake Filter removes pomace and obtains jujube enzymolysis liquid；
(3) it is for use that active dry yeasr is activated with 4 times of 2% sucrose water at 35 DEG C to 25min, mixes medicinal material by weight Enzymolysis liquid, jujube enzymolysis liquid, Rhizoma imperatae polysaccharides, gekko leaching liquor, red halloysite powder, maltose filter to take filtrate use after stirring completely Citric acid tune pH value is to 4.8；
(4) fermentation by saccharomyces cerevisiae is added, gelatin clarification is added after fermentation and through 8 layers of filtered through gauze, removing filter residue is Wine liquid is obtained, being cooled to 10 DEG C rapidly after the 9min that sterilizes at 70 DEG C preserves to get health liquor finished product.
In above method step, the addition of the carbohydrase is 150U/mL, and saccharification temperature is 55 DEG C, time 10h； The addition of the pectase is 100U/mL, and hydrolysis temperature is 40 DEG C, time 6h；In the yeast-leavened fermentation process, Yeast-inoculated amount is 9%, and fermentation temperature is 22 DEG C, fermentation time 8d.
Embodiment 3
A kind of hemostasis health liquor, is made of the raw material of following parts by weight：1.5 parts of red halloysite powder, 20 parts of Peony Root, toast are sweet 6 parts of grass, 45 parts of jujube, 35 parts of maltose, 12 parts of gekko leaching liquor, 7 parts of Rhizoma imperatae polysaccharides, 1.15 parts of citric acid, 5 parts of pectin.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the red halloysite powder are：Be ground into fine powder, with vinegar and Even, rubbing segment is dried, is set in crucible, is forged and is popular in smokeless stove fire, is taken out, cool.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the Rhizoma imperatae polysaccharides are：
A. it takes dry rhizoma imperatae to crushed 70 mesh sieve, is 1 by solid-liquid ratio:3 are added 95% ethyl alcohol, are stood at 28 DEG C 28h, then the refluxing extraction 4h in 55 DEG C of water-baths, filtering；
B. filter residue dries, and is 1 by solid-liquid ratio:5 addition pure water extract 3h in 100 DEG C of water-baths, and filtrate is collected by filtration, filters Slag repeats extracting in water 1 time, merges 2 filtrates, is concentrated under reduced pressure into the 2/5 of original volume, is centrifuged off impurity, adds in clear liquid Enter 95% ethyl alcohol and carry out alcohol precipitation, stands overnight, filter in -2 DEG C, vacuum freeze drying obtains rhizoma imperatae Thick many candies；
C. obtained rhizoma imperatae Thick many candies are dissolved, chloroform is added:N-butanol=4:1 Sevag reagents take off albumen, repeatedly De- albumen collects water phase to no albuminate, and 95% ethyl alcohol is added and carries out alcohol precipitation, stands overnight, filters in -4 DEG C, freeze-drying Obtain Rhizoma imperatae polysaccharides.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the gekko leaching liquor are：Gekko is cut out into eyeball, is removed Internal organ are cleaned, big fire in Chinese herbal medicine leaching liquor are put into after chopping and boils 55min, filter and remove residue obtains gekko leaching liquor.
The present embodiment prepares a kind of method of hemostasis health liquor, includes the following steps：
(1) dry Peony Root and honey-fried licorice root are crushed by weight, it is 1 to cross after 400 mesh sieve and press solid-liquid ratio:20 additions are pure Saccharification enzymatic conversion is added after ultrasonic extraction 40min for water purification, through 6 layers of filtered through gauze after completion, removes filter residue and obtains medicinal material enzymolysis liquid；
(2) it is 1 by solid-liquid ratio:9 jujube and pure water is mixed with beating, and jujube liquid is after pectinase enzymatic hydrolysis with 6 layers of gauze mistake Filter removes pomace and obtains jujube enzymolysis liquid；
(3) it is for use that active dry yeasr is activated with 6 times of 2% sucrose water at 40 DEG C to 35min, mixes medicinal material by weight Enzymolysis liquid, jujube enzymolysis liquid, Rhizoma imperatae polysaccharides, gekko leaching liquor, red halloysite powder, maltose filter to take filtrate use after stirring completely Citric acid tune pH value is to 5.2；
(4) fermentation by saccharomyces cerevisiae is added, gelatin clarification is added after fermentation and through 8 layers of filtered through gauze, removing filter residue is Wine liquid is obtained, being cooled to 15 DEG C rapidly after the 10min that sterilizes at 80 DEG C preserves to get health liquor finished product.
In above method step, the addition of the carbohydrase is 250U/mL, and saccharification temperature is 65 DEG C, time 14h； The addition of the pectase is 150U/mL, and hydrolysis temperature is 50 DEG C, time 10h；The yeast-leavened fermentation process In, yeast-inoculated amount is 13%, and fermentation temperature is 30 DEG C, fermentation time 10d.
Embodiment 4
A kind of hemostasis health liquor, is made of the raw material of following parts by weight：0.75 part of red halloysite powder, 16.25 parts of Peony Root, 5.25 parts of honey-fried licorice root, 37.5 parts of jujube, 27.5 parts of maltose, 6 parts of gekko leaching liquor, 4 parts of Rhizoma imperatae polysaccharides, 0.325 part of citric acid, 2 parts of pectin.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the red halloysite powder are：Be ground into fine powder, with vinegar and Even, rubbing segment is dried, is set in crucible, is forged and is popular in smokeless stove fire, is taken out, cool.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the Rhizoma imperatae polysaccharides are：
A. it takes dry rhizoma imperatae to crushed 55 mesh sieve, is 1 by solid-liquid ratio:2.25 are added 95% ethyl alcohol, quiet at 25 DEG C 22h, then the refluxing extraction 2.5h in 47.5 DEG C of water-baths are set, is filtered；
B. filter residue dries, and is 1 by solid-liquid ratio:4.25 addition pure water extract 2.25h in 92.5 DEG C of water-baths, are collected by filtration Filtrate, filter residue repeat extracting in water 1 time, merge 2 filtrates, are concentrated under reduced pressure into the 9/40 of original volume, are centrifuged off impurity, 95% ethyl alcohol is added in clear liquid and carries out alcohol precipitation, stands overnight, filters in -3.5 DEG C, vacuum freeze drying obtains rhizoma imperatae Thick many candies；
C. obtained rhizoma imperatae Thick many candies are dissolved, chloroform is added:N-butanol=4:1 Sevag reagents take off albumen, repeatedly De- albumen collects water phase to no albuminate, and 95% ethyl alcohol is added and carries out alcohol precipitation, stands overnight, filters in -2.5 DEG C, freezing is dry It is dry to obtain Rhizoma imperatae polysaccharides.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the gekko leaching liquor are：Gekko is cut out into eyeball, is removed Internal organ are cleaned, big fire in Chinese herbal medicine leaching liquor are put into after chopping and boils 47.5min, filter and remove residue obtains gekko leaching liquor.
The present embodiment prepares a kind of method of hemostasis health liquor, includes the following steps：
(1) dry Peony Root and honey-fried licorice root are crushed by weight, it is 1 to cross after 400 mesh sieve and press solid-liquid ratio:16.25 add Enter pure water, saccharification enzymatic conversion is added after ultrasonic extraction 32.5min, through 5 layers of filtered through gauze after completion, removes filter residue and obtain medicinal material enzyme Solve liquid；
(2) it is 1 by solid-liquid ratio:7.5 jujube and pure water is mixed with beating, and jujube liquid is after pectinase enzymatic hydrolysis with 5 layers of gauze Filtering removes pomace and obtains jujube enzymolysis liquid；
(3) it is for use that active dry yeasr is activated with 4.5 times of 2% sucrose water at 36 DEG C to 27.5min, is mixed by weight Medicinal material enzymolysis liquid, jujube enzymolysis liquid, Rhizoma imperatae polysaccharides, gekko leaching liquor, red halloysite powder, maltose filter to take filter after stirring completely Liquid citric acid tune pH value to 4.9；
(4) fermentation by saccharomyces cerevisiae is added, gelatin clarification is added after fermentation and through 8 layers of filtered through gauze, removing filter residue is Wine liquid is obtained, being cooled to 12 DEG C rapidly after the 9.5min that sterilizes at 72.5 DEG C preserves to get health liquor finished product.
In above method step, the addition of the carbohydrase is 175U/mL, and saccharification temperature is 57.5 DEG C, and the time is 11h；The addition of the pectase is 112U/mL, and hydrolysis temperature is 42.5 DEG C, time 7h；The yeast-leavened fermentation In the process, yeast-inoculated amount is 10%, and fermentation temperature is 24 DEG C, fermentation time 8.5d.
Embodiment 5
A kind of hemostasis health liquor, is made of the raw material of following parts by weight：1.25 parts of red halloysite powder, 18.75 parts of Peony Root, 5.75 parts of honey-fried licorice root, 42.5 parts of jujube, 32.5 parts of maltose, 10 parts of gekko leaching liquor, 6 parts of Rhizoma imperatae polysaccharides, citric acid 0.875 Part, 4 parts of pectin.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the red halloysite powder are：Be ground into fine powder, with vinegar and Even, rubbing segment is dried, is set in crucible, is forged and is popular in smokeless stove fire, is taken out, cool.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the Rhizoma imperatae polysaccharides are：
A. it takes dry rhizoma imperatae to crushed 65 mesh sieve, is 1 by solid-liquid ratio:2.75 are added 95% ethyl alcohol, quiet at 27 DEG C 26h, then the refluxing extraction 3.5h in 52.5 DEG C of water-baths are set, is filtered；
B. filter residue dries, and is 1 by solid-liquid ratio:4.75 addition pure water extract 2.5h in 97.5 DEG C of water-baths, are collected by filtration Filtrate, filter residue repeat extracting in water 1 time, merge 2 filtrates, are concentrated under reduced pressure into the 1/5 of original volume, are centrifuged off impurity, 95% ethyl alcohol is added in clear liquid and carries out alcohol precipitation, stands overnight, filters in -2.5 DEG C, vacuum freeze drying obtains rhizoma imperatae Thick many candies；
C. obtained rhizoma imperatae Thick many candies are dissolved, chloroform is added:N-butanol=4:1 Sevag reagents take off albumen, repeatedly De- albumen collects water phase to no albuminate, and 95% ethyl alcohol is added and carries out alcohol precipitation, stands overnight, filters in -3.5 DEG C, freezing is dry It is dry to obtain Rhizoma imperatae polysaccharides.
A kind of hemostasis health liquor of the present embodiment, the preparation method of the gekko leaching liquor are：Gekko is cut out into eyeball, is removed Internal organ are cleaned, big fire in Chinese herbal medicine leaching liquor are put into after chopping and boils 52.5min, filter and remove residue obtains gekko leaching liquor.
The present embodiment prepares a kind of method of hemostasis health liquor, includes the following steps：
(1) dry Peony Root and honey-fried licorice root are crushed by weight, it is 1 to cross after 400 mesh sieve and press solid-liquid ratio:19 additions are pure Saccharification enzymatic conversion is added after ultrasonic extraction 37.5min for water purification, through 5 layers of filtered through gauze after completion, removes filter residue and obtains medicinal material enzymolysis Liquid；
(2) it is 1 by solid-liquid ratio:8.5 jujube and pure water is mixed with beating, and jujube liquid is after pectinase enzymatic hydrolysis with 5 layers of gauze Filtering removes pomace and obtains jujube enzymolysis liquid；
(3) it is for use that active dry yeasr is activated with 5.5 times of 2% sucrose water at 37.5 DEG C to 32.5min, it is mixed by weight Medicinal material enzymolysis liquid, jujube enzymolysis liquid, Rhizoma imperatae polysaccharides, gekko leaching liquor, red halloysite powder, maltose are closed, is filtered to take after stirring completely Filtrate citric acid tune pH value to 5.1；
(4) fermentation by saccharomyces cerevisiae is added, gelatin clarification is added after fermentation and through 8 layers of filtered through gauze, removing filter residue is Wine liquid is obtained, being cooled to 14 DEG C rapidly after the 9.5min that sterilizes at 77.5 DEG C preserves to get health liquor finished product.
In above method step, the addition of the carbohydrase is 225U/mL, and saccharification temperature is 62.5 DEG C, and the time is 13h；The addition of the pectase is 137U/mL, and hydrolysis temperature is 47.5 DEG C, time 9h；The yeast-leavened fermentation In the process, yeast-inoculated amount is 12%, and fermentation temperature is 28 DEG C, fermentation time 9.5d.
Related part person on probation situation and trial effect are as follows：
1. Miss Huang, 35 years old, dysmenorrhoea, hypogastralgia had vomiting phenomenon on the day of a couple of days and menstruation before menstruation, vomit to Complexion is whitened, and is that blood stasis causes blockage of main and collateral channels, obstructed algesiogenic reason.Take hemostasis health liquor, daily two or three mouthful, 12 Dysmenorrhoea disappears after week, and vomiting, complexion state of blush make moderate progress.
2. Miss Wu, 40 years old, menstruation was delayed 12 days, amount is few, and menses color is deep, has clot, is in poor health cause Menstruation delay.Hemostasis health liquor is taken, menstruation recovery is normal after 12 weeks, and color is also restored normally, and clot disappears.
3. Mr. Chen, 37 years old, complexion was gloomy, lip color is deep, often thinks that air lift is not come up, very tired, takes Stop blooding health liquor, has rosy cheeks after eight weeks, and lip color restores normal, and gas is smooth.
4. Miss Zhang, 30 years old, menstrual period were unstable, shifted to an earlier date sometimes, postponed sometimes.Intermenstrual period is liable to fits of temper, vexed Meaning is disorderly, interior showing tremendous enthusiasm heavy, takes hemostasis health liquor, menstruation recovery is normal after 12 weeks, and menstrual period are emotionally stable, meaning vexed never again Random feeling.
5. Mr. Yang, threescore, blood fat and blood pressure is higher, palm is red, takes hemostasis health liquor, palm color is extensive after 12 weeks Multiple normal, the higher situation of blood fat and blood pressure makes moderate progress.
6. Mrs deer, 25 years old, there was bruise in injured leg of running, takes hemostasis health liquor and simultaneously wipes health liquor On bruise skin, bruise improves after five weeks.
It the above is only the briefing and trial effect of some of the staff's hemostasis health liquor on probation, personnel's situation as above and on probation Effect is also very much, does not enumerate one by one.
Pass through the explanation on probation of above section personnel：
(1) present invention makes blood in arteries and veins to prevent or prevent internal external hemorrhage, keeps fit and healthy and improves the state of mind, slows down Menstrual period caused by weak, blood stasis in advance or postpone and unstable and menstrual period easily fly into a rage and upset, the blood fat of blood stasis Slight Hypertension and palm is red, palpitaition of having palpitation caused by blood stasis and the cold obesity symptoms such as with hand and foot numbness, all has and significantly controls It treats and conditioning effect.
(2) present invention no matter men and women, no matter be engaged in what industry, no matter what season can be used, adaptation population is wide Broad spectrum activities general, convenient to carry out and at low cost, with popularization and application.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention Protect range.

Claims (10)

1. a kind of hemostasis health liquor, which is characterized in that be made of the raw material of following parts by weight：0.5~1.5 part of red halloysite powder, 15~20 parts of Peony Root, 5~6 parts of honey-fried licorice root, 35~45 parts of jujube, 25~35 parts of maltose, 4~12 parts of gekko leaching liquor, cogongrass 3~7 parts of root polysaccharide, 0.05~1.15 part of citric acid, 1~5 part of pectin.
2. a kind of hemostasis health liquor according to claim 1, which is characterized in that be made of the raw material of following parts by weight： 0.75~1.25 part of red halloysite powder, 16.25~18.75 parts of Peony Root, 5.25~5.75 parts of honey-fried licorice root, jujube 37.5~42.5 Part, 27.5~32.5 parts of maltose, 6~10 parts of gekko leaching liquor, 4~6 parts of Rhizoma imperatae polysaccharides, 0.325~0.875 part of citric acid, 2~4 parts of pectin.
3. a kind of hemostasis health liquor according to claim 2, which is characterized in that be made of the raw material of following parts by weight： 1 part of red halloysite powder, 17.5 parts of Peony Root, 5.5 parts of honey-fried licorice root, 40 parts of jujube, 30 parts of maltose, 16 parts of gekko leaching liquor, rhizoma imperatae 5 parts of polysaccharide, 0.6 part of citric acid, 3 parts of pectin.
4. according to a kind of hemostasis health liquor of claims 1 to 3 any one of them, which is characterized in that the system of the red halloysite powder Preparation Method is：It is ground into fine powder, with vinegar and even, rubbing segment is dried, set in crucible, is forged and is popular in smokeless stove fire, takes Go out, cool.
5. according to a kind of hemostasis health liquor of claims 1 to 3 any one of them, which is characterized in that the Rhizoma imperatae polysaccharides Preparation method is：
A. it takes dry rhizoma imperatae to crushed 50~70 mesh sieve, is 1 by solid-liquid ratio:2~3 are added 95% ethyl alcohol, at 24~28 DEG C 20~28h of lower standing, then 2~4h of refluxing extraction in 45~55 DEG C of water-baths, filtering；
B. filter residue dries, and is 1 by solid-liquid ratio:4~5 addition pure water extract 2~3h in 90~100 DEG C of water-baths, are collected by filtration Filtrate, filter residue repeat extracting in water 1 time, merge 2 filtrates, are concentrated under reduced pressure into the 1/10~2/5 of original volume, are centrifuged off miscellaneous 95% ethyl alcohol is added in clear liquid and carries out alcohol precipitation, stands overnight, filters in -4~-2 DEG C, vacuum freeze drying obtains rhizoma imperatae for matter Thick many candies；
C. obtained rhizoma imperatae Thick many candies are dissolved, chloroform is added:N-butanol=4:1 Sevag reagents take off albumen, take off egg repeatedly Bai Zhiwu albuminates collect water phase, and 95% ethyl alcohol is added and carries out alcohol precipitation, stands overnight, filters in -4~-2 DEG C, freeze-drying Obtain Rhizoma imperatae polysaccharides.
6. according to a kind of hemostasis health liquor of claims 1 to 3 any one of them, which is characterized in that the gekko leaching liquor Preparation method is：Gekko is cut out into eyeball, removes internal organ, is cleaned, be put into after chopping big fire in Chinese herbal medicine leaching liquor boil 45~ 55min, filter and remove residue obtain gekko leaching liquor.
7. a kind of prepare such as a kind of method of hemostasis health liquor of claim 1~6 any one of them, which is characterized in that including Following steps：
(1) dry Peony Root and honey-fried licorice root are crushed by weight, it is 1 to cross after 400 mesh sieve and press solid-liquid ratio:15~20 additions are pure Saccharification enzymatic conversion is added after 30~40min of ultrasonic extraction for water purification, through 4~6 layers of filtered through gauze after completion, removes filter residue and obtains medicinal material Enzymolysis liquid；
(2) it is 1 by solid-liquid ratio:7~9 jujube and pure water is mixed with beating, and jujube liquid is after pectinase enzymatic hydrolysis with 4~6 layers of gauze Filtering removes pomace and obtains jujube enzymolysis liquid；
(3) it is for use that active dry yeasr is activated with 4~6 times of 2% sucrose water at 35~40 DEG C to 25~35min, by weight Medicinal material enzymolysis liquid, jujube enzymolysis liquid, Rhizoma imperatae polysaccharides, gekko leaching liquor, red halloysite powder, maltose are mixed, filtering after stirring completely Take filtrate with citric acid tune pH value to 4.8~5.2；
(4) fermentation by saccharomyces cerevisiae is added, gelatin clarification is added after fermentation and through 8 layers of filtered through gauze, removes filter residue up to wine Liquid is cooled to rapidly 10~15 DEG C of preservations to get health liquor finished product at 70~80 DEG C after 9~10min of sterilizing.
8. according to claim 7 prepare a kind of method of hemostasis health liquor, which is characterized in that the addition of the carbohydrase Amount is 150~250U/mL, and saccharification temperature is 55~65 DEG C, and the time is 10~14h.
9. according to claim 7 prepare a kind of method of hemostasis health liquor, which is characterized in that the addition of the pectase Amount is 100~150U/mL, and hydrolysis temperature is 40~50 DEG C, and the time is 6~10h.
10. according to claim 7 prepare a kind of method of hemostasis health liquor, which is characterized in that described yeast-leavened In fermentation process, yeast-inoculated amount is 9~13%, and fermentation temperature is 22~30 DEG C, and fermentation time is 8~10d.
CN201810713979.5A 2018-07-03 2018-07-03 A kind of hemostasis health liquor and preparation method thereof Pending CN108795646A (en)

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Application publication date: 20181113