CN109876053A - A kind of acne-removing inflammation-diminishing, removing toxic substances of clearing liver prescription and its preparation method - Google Patents
A kind of acne-removing inflammation-diminishing, removing toxic substances of clearing liver prescription and its preparation method Download PDFInfo
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Abstract
The present invention relates to a kind of acne-removing inflammation-diminishings, the prescription and its preparation method of removing toxic substances of clearing liver, the acne-removing inflammation-diminishing, the prescription to detoxify that clears liver use Fructificatio Tricholomatis Matsutakis extract, dandelion, black sesame powder, peanut powder, honey peach powder, bamboo salt for major ingredient, the root of Dahurain angelica, loquat, Fructus Forsythiae, honeysuckle, cordate houttuynia, Radix Salviae Miltiorrhizae, wild chrysanthemum, pachyrhizus, fructus arctii, almond powder, isomalt, Sucralose are auxiliary material and carry out appropriate weight proportion, and being finally prepared has effects that anti-acne, removing toxic substances, lipid-loweringing and the prescription to purify the blood.There is synergistic effect between each raw material contained by the present invention, between each ingredient interaction can maximum the effect of playing acne-removing inflammation-diminishing, and the present invention carries out different extraction processes for different material, so that each raw material effect is played to the greatest extent.Acne-removing inflammation-diminishing of the present invention, removing toxic substances of clearing liver prescription preparation method it is simple, high-efficient, pollution-free, meet large-scale production and require, be easy to implement.
Description
Technical field
The invention belongs to technical field of health care, and in particular to a kind of acne-removing inflammation-diminishing, removing toxic substances of clearing liver prescription and its system
Method.
Background technique
Whelk is medically acne, is a kind of chronic inflammatory skin of pilosebaceous unit, is mainly apt to occur in
Teenager, but not puberty is peculiar, and many adults also like long acne.Serious acne has inflammatory response, can be on the skin
Existing red granular measles, and may after symptom disappearance scar.Fifty percent or more whelk appears in face, and shirtfront with
Also there is three one-tenth of disease hair probability behind.Whelk not only influences appearance, it is also possible to the psychological condition for influencing patient, bring anxiety with
It is dejected.The problem of whelk, affects the middle school student more than ninety percent, after the whelk problem of many people even more continues to adult,
It is least ready the reality faced on the face as many young men and women.Even if whelk has been fully recovered, the enlarged pores and powder that leave
Thorn even pox spots or acne scar even more allow many people Hua Liao great money on relevant skin care products and doctor's U.S. treatment.Research hair
Existing, for the erroneous cognition of whelk and whelk treatment and maintenance, the pass of whelk can not be got rid of by being only many people for a long time
Key.
Liver is important removing toxic substances organ, liver toxin expelling time at night 11 points to 3:00 AM, while the toxin expelling of liver need to be
Middle progress of sleeping soundly not stay up late so should sleep soundly in this period.When liver toxin expelling is bad, it will usually some diseases occur
Shape, such as constipation, halitosis, chloasma, acne and complexion obfuscation etc..It as the saying goes, " liver failure first goes up face ".Liver is as human body
" chemical plant ", usually the harmful components in diet or drug are all needed in vivo by liver detoxification for we.If the poison in liver
Element can not normally be discharged, and be detained in vivo, will issue on the face " signal ".The toxin of liver excessively also results in endocrine disorder,
And then cause skin problem, such as acne, acne, skin allergy.
Prescription refers to sugar, cream and dairy products, egg or egg products, fruit juice or alimentary vegetable extracts etc. for primary raw material,
It adds suitable adjuvant or food additives is made.Because its is easy to carry, be easy to save, it is small in size, be readily transported, edible side
Just, full of nutrition, unique flavor, it is numerous in variety the features such as by consumer favor.
There are oral medicine or the ointment of many treatment whelks in the market, but effect is unobvious, side effect is big, high recurrence rate.
Cosmetics also all only temporarily play the role of concealing, palliative, can not tackle the problem at its root.If using Chinese medicine
It improves somagenic need and expends people's plenty of time and energy, so needing a kind of drink convenient for the daily carrying of modern and can be pre-
Prevent and treat the drink of whelk.
Summary of the invention
In order to solve the above problems existing in the present technology, the present invention provides it is a kind of it is easy to carry, drink conveniently, and have
There are the prescription and its preparation method of the acne-removing inflammation-diminishing of anti-acne, removing toxic substances, lipid-loweringing and the effect that purifies the blood, removing toxic substances of clearing liver.Anti-acne described in long-term drinking
Anti-inflammatory, the prescription to detoxify that clears liver can effectively adjust human body mechanism, play the effect of good anti-acne, anti-inflammatory, health care.
The technical scheme adopted by the invention is as follows:
A kind of acne-removing inflammation-diminishing, removing toxic substances of clearing liver prescription, raw material components include:
Fructificatio Tricholomatis Matsutakis extract 0.5-1.5 parts by weight, dandelion 3-7 parts by weight, root of Dahurain angelica 0.3-0.8 parts by weight, loquat 0.2-
0.4 parts by weight, Fructus Forsythiae 0.3-0.5 parts by weight, honeysuckle 0.1-0.4 parts by weight, cordate houttuynia 0.2-0.4 parts by weight, Radix Salviae Miltiorrhizae 0.1-
0.3 parts by weight, wild chrysanthemum 0.2-0.4 parts by weight, pachyrhizus 0.1-0.3 parts by weight, fructus arctii 0.2-0.3 parts by weight, almond powder 1-3
Parts by weight, black sesame powder 8-12 parts by weight, peanut powder 8-12 parts by weight, honey peach powder 30-36.5 parts by weight, isomalt
30-50 parts by weight, Sucralose 0.4-0.6 parts by weight, bamboo salt 0.4-0.6 parts by weight.
The further preferred acne-removing inflammation-diminishing, removing toxic substances of clearing liver the raw material components of prescription include:
0.75 parts by weight of Fructificatio Tricholomatis Matsutakis extract, 5 parts by weight of dandelion, 0.5 parts by weight of the root of Dahurain angelica, 0.3 parts by weight of loquat, Fructus Forsythiae
0.4 parts by weight, 0.2 parts by weight of honeysuckle, 0.3 parts by weight of cordate houttuynia, 0.2 parts by weight of Radix Salviae Miltiorrhizae, 0.3 parts by weight of wild chrysanthemum, pachyrhizus
0.2 parts by weight, 0.25 parts by weight of fructus arctii, 2 parts by weight of almond powder, 10 parts by weight of black sesame powder, 10 parts by weight of peanut powder, honey peach powder
33.25 parts by weight, 40 parts by weight of isomalt, 0.5 parts by weight of Sucralose, 0.5 parts by weight of bamboo salt.
Further, the preparation method of the Fructificatio Tricholomatis Matsutakis extract, includes the following steps:
(1) it will be crushed after matsutake drying, obtain matsutake powder；The matsutake powder is mixed with distilled water, is stirred after standing
It mixes uniformly, obtains matsutake homogenate；The matsutake is homogenized and is centrifuged, takes supernatant to be digested, obtains matsutake enzymolysis liquid；
(2) it after saccharomycete activation, is cultivated, obtains seed liquor；Step (1) described matsutake is added into the seed liquor
Enzymolysis liquid, fermented culture obtain fermentation liquid；The fermentation liquid is separated by solid-liquid separation, supernatant and yeast thallus are obtained；It will
The supernatant is successively spray-dried, is sterilized to get the extract of the promotion Liver Lipid Metabolism, anti-inflammatory drop enzyme.
Further, in step (1), the temperature of the drying is 60-90 DEG C, and the time of the drying is 2-4h；It is described
The mass ratio of matsutake powder and the distilled water is 2-4:1-3；The time of the standing is 10-14h, and the temperature of the standing is 4-
6℃；The revolving speed of the stirring is 40-60r/min, and the time of the stirring is 1-3h；The revolving speed of the centrifugation is 5000-
7000rpm, the time of the centrifugation are 35-55min.
Further, in step (1), the enzyme for carrying out the enzymatic hydrolysis is the mixed of papain, cellulase and pectase
Close object；The time for carrying out the enzymatic hydrolysis is 2-3h, and the temperature for carrying out the enzymatic hydrolysis is 35-40 DEG C；The papain, fiber
The mass ratio of plain enzyme and pectase is 1-2:1-2:1-2.
Further, in step (2), the ratio between volume of the seed liquor and the matsutake enzymolysis liquid is 1-2:1-2；It is described
The temperature of fermented and cultured is 28-32 DEG C, and the speed of agitator of the fermented and cultured is 150-250rpm, the time of the fermented and cultured
For 32-40h；The inlet air temperature of the spray drying is 70-80 DEG C, water drip rate 25-35mL/min, and hot air flowrate is
30-40m/h, compressed air require 450-530L/h, charging rate are 3.0 × 180-5.0 × 180mL/h, and leaving water temperature is
75-80℃。
A method of the prescription preparing the acne-removing inflammation-diminishing, removing toxic substances of clearing liver includes the following steps:
(1) dandelion is taken by above-mentioned parts by weight, is successively cleaned, cleaned, is dried；It is carried out after addition Extraction solvent pan-fried
It boils；It is then filtered, obtains filtrate；Filtrate is concentrated, concentrate is obtained；
(2) gained concentrate in step (1) is subjected to alcohol precipitation, obtains sediment；Gained sediment is spray-dried,
It crushes, obtains dandelion extract；
(3) root of Dahurain angelica, loquat, Fructus Forsythiae, honeysuckle, cordate houttuynia, Radix Salviae Miltiorrhizae, wild chrysanthemum, pachyrhizus, fructus arctii are taken by above-mentioned parts by weight,
It successively cleaned, cleaned, dried, crushed respectively, obtain each raw material fine powder, each raw material fine powder is mixed, soaking in Chinese liquor is added
After filter, then steamed, obtain steaming material；
(4) addition distiller's yeast in expecting is steamed to the middle gained of step (3) to be fermented, distilled, and the extracting solution of each raw material is obtained；
(5) extracting solution, the matsutake of the middle each raw material of gained of gained dandelion extract, step (4) in step (2) are extracted
Object, almond powder, black sesame powder, peanut powder, honey peach powder, isomalt, Sucralose and bamboo salt mixing, stirring, dry, powder
It is broken, obtain the prescription of the acne-removing inflammation-diminishing, removing toxic substances of clearing liver.
Further, in step (1), the Extraction solvent is any in ethyl alcohol, ether, chloroform, acetone or petroleum ether
Kind.
Further, in step (1), the additional amount of the Extraction solvent is 3-5 times of dandelion quality, when the decoction
Between be 1.5-2 hours.
Further, in step (2), the alcohol precipitation time is 2-3 hours.
Further, in step (3), the partial size of each raw material fine powder is 80-120 mesh, the alcoholic strength of the white wine
Number is 55-65 degree, and the temperature of the immersion is 25-28 DEG C, and the time of the immersion is 3-5 days.
Further, in step (3), the temperature steamed is 150-180 DEG C, and the time steamed is 40-80 points
Clock.
Further, in step (4), the additive amount of the distiller's yeast is the 1-3wt% for steaming material, the fermentation time
It is 20-30 days, the temperature of the fermentation is 25-28 DEG C.
Further, in step (5), the smashed partial size is 100-300 mesh.
It underdraws below to effect caused by raw material in the present invention.
Fructificatio Tricholomatis Matsutakis extract, Fructificatio Tricholomatis Matsutakis extract promote liver fat metabolism function, can reducing blood lipid, adjust blood lipid composition
(i.e. raising free unsaturated fatty acid ratio), anti-oxidant and promotion fat transfer, prevents fatty excessive oxidation and in liver cell
Infiltration accumulation, mitigates hepatic steatosis；The hormone metabolism and function of detoxification for promoting liver enhance its removing toxic substances and the inactivation of hormone
Effect reduces poisonous substance to histiocytic damage；Promote inactivation of the liver to the androgen of puberty excessive secretion, and can subtract
The excessive keratinization of light pilosebaceous duct, therefore have significant curative effect to acne；There is pole to chemically (including Alcoholic) hepatic injury
Its significant protective effect, due to significantly improving reduced glutathione in liver cell (GSH) and superoxide dismutase (SOD)
Content and its expression, Fructificatio Tricholomatis Matsutakis extract can improve skin quality (i.e. Whitening, spot, firm skin).
Dandelion contains a variety of health such as taraxol, taraxacin, choline, organic acid, synanthrin in dandelion plant
Nutritional ingredient.It can be used for treating liver and gall-bladder obstruction, improve liver function, promote bile secretion and used as diuretics；Also
It can be applied to liver inflammation and hyperemia, as one of most effective removing toxic substances herbal medicine, play in filtration blood flow, gall-bladder, liver and kidney
The effect of toxin and waste；Bile secretion can be stimulated, and body is helped to exclude the excessive moisture that damaged liver manufactures；Dandelion
Extract flavonoids can be such that bile flow doubles, and it is very crucial in the process that this acts on exclusion toxin；Dandelion extract can be extensive
Multiple gallbladder function, choleretic effect remove gall stone and hyperemia and jaundice are very useful for liver and gall-bladder inflammation；Solution
Malicious protect liver helps toxin to excrete, and reduces intracorporal toxin, the skin problem for causing toxin obtain it is effective improve and
It solves；Dandelion extract can reduce alanine aminotransferase (ALT) and improve liver function, reduce the accumulative of vivotoxin.
The root of Dahurain angelica, warm-natured, acrid flavour return stomach, large intestine, lung channel.Major function: relieve heat dehumidifies, and sensible analgesic, detumescence and apocenosis.With
In cold headache, pain in the supra-orbital bone, nasal obstruction, nasosinusitis, toothache, leukorrhea, sore swell and ache curative.
Loquat, cool in nature, sweet in flavor, sour, returns spleen, lung, it is simultaneous enter Liver Channel.Major function: moistening lung, quenches the thirst, lower gas.Control consumptive lung disease cough
It spits blood, bleeding from five sense organs or subcutaneous tissue is dry thirsty, vomits inverse.
Fructus Forsythiae, cold nature, bitter, return lung, the heart, small intestinl channel.Major function: clearing heat and detoxicating, dispersing swelling and dissipating binds.For ulcer,
Scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of warm is joined the army, hyperpyrexia polydipsia, coma macular eruption, heat gonorrhea renal shutdown.
Honeysuckle, cold in nature, sweet in flavor, return lung, the heart, stomach meridian.Major function: clearing heat and detoxicating, wind-heat dissipating.For carbuncle swells malignant boil
Sore, sore throat, erysipelas, toxic-heat and blood stasis, wind-heat cold, warm disease and fever.
Cordate houttuynia, cold nature, acrid flavour are distributed in lung channel.Major function: clearing heat and detoxicating, the carbuncle that disappears apocenosis, inducing diuresis for treating strangurtia.For lung
Carbuncle pyemesis, phlegm heat panting cough, hot dysentery, heat gonorrhea, carbuncle sore tumefacting virus.
Radix Salviae Miltiorrhizae, cold nature, bitter, converge to heart and liver channels.Major function: stasis-dispelling and pain-killing, blood circulation, relieving restlessness and restlessness.For the moon
Through uncomfortable, amenorrhea and algomenorrhea, a lump in the abdomen causing distension and pain, chest and abdomen shouting pain, hot numbness pain, sore and ulcer, swelling and pain, upset and sleepless, hepatosplenomegaly, angina pectoris.
Wild chrysanthemum, cold nature is bitter, pungent, returns liver, the heart channel of Hang-Shaoyin.Major function: clearing heat and detoxicating.For furunculosis carbuncle swells, hot eyes is swollen
Bitterly, headache and dizziness.
Pachyrhizus, cool in nature, sweet in flavor, returns spleen, kidney channel.Major function: bowl spares and blood, nourishing generate fluid, wide stomach, defaecation are secret.
Fructus arctii, cold in nature, bitter, pungent, channel tropism.Major function: clearing heat and detoxicating, dispelling wind relieving sore-throat.For anemopyretic cold, cough,
Abscess of throat, boil swelling and pain, the ringworm of the foot, eczema.
Almond, warm-natured, bitter, return lung, large intestine channel.Major function: expelling phlegm and arresting coughing, relievings asthma, ease constipation.Exogenous cough is controlled, is breathed heavily
It is full, sore throat, dry constipation of intestines.
Sesame contains vitamin E abundant, and vitamin E is anti-oxidant, can prevent to generate lipid peroxide in vivo, to tie up
The complete and function of holding the cell membrane for comparing concentration containing unsaturated fatty acid is normal, and internal other ingredients can be prevented by lipid
The injury of peroxide；The lecithin and linoleic acid abundant contained in sesame, can not only treat atherosclerosis, cerebrum tonifying,
Enhance memory, and prevents hair from bleaching too early, falling off and beauty moisturizing, keep and vigor of renewing one's youth；Sesame
Numb element can reduce the content of lipid in fatty liver liver, hinder the effect hit formed to fatty liver for the first time, while can significantly increase
Strong SOD activity, reduces oxidation metabolites MDA content, significantly reduces the expression of CYP2E1mRNA, improve the oxidation resistant energy of body
Power blocks second strike to the progress of liver cell fat lesion, and sesamin can protect liver, caused by reducing because of liver damage
Liver function decline and toxin blocking pore caused by whelk and skin problem.
Peanut contains protein, fat, carbohydrate, vitamin A, vitamin B6, vitamin E, vitamin K and minerals
The nutritional ingredients such as calcium, phosphorus, iron, amino acid and unsaturated fatty acid containing 8 kinds of needed by human body contain lecithin, choline, carrot
The substances such as element, crude fibre, vitamin B2 rich in, PP, A, D, E, calcium and iron etc., and contain thiamine, riboflavin, Buddhist nun
The multivitamins such as gram acid.There is the brain cell development for promoting people, anti-aging, blood coagulation hemostasis, enhancing memory, reduces cholesterol, is pre-
The effect of anti-kind of tumor.
Honey peach powder, honey peach have the functions such as skin makeup, clearing stomach, moistening lung, eliminating the phlegm.The content of its protein is than apple, Portugal
Grape double, and seven times more than pear, the content of iron is three times more than apple, five times more than pear, are known as the good reputation of " queen in fruit ".
Honey peach energy inducing diuresis for treating strangurtia, removing jaundice, which is reduced swelling, contains phenol in peach blossom, has diuresis, can remove aqueous vapor, detumescence is full, cures Huang
Subcutaneous ulcer, stranguria etc..Peach blossom energy catharsis simultaneously, and have no stimulation to intestinal wall；Energy anti-anemia action promotes blood to generate and contains in peach pulp
Iron is higher, is only second to cherry in various fruit.Since iron participates in the synthesis of blood of human body, so food peach has promotion blood red
The ability of protein renaturation, anaemia caused by can preventing and treating because of iron deficiency；Can in cancer-resisting peach kernel contained semen armeniacae amarae at hydrolysate
Hydrogen cyanide and benzaldehyde have a collaboration destruction to cancer cell, and the further metabolite of hydrogen cyanide and benzaldehyde, right respectively
Improve the anaemia of tumor patient and relieves pain certain effect；Honey peach energy anticoagulant pharmacological research shows the alcohol extracting of peach kernel
It takes object that can improve in blood platelet (AMP) level, inhibits platelet aggregation, show that there is certain anticoagulant effect and weaker molten
Blood effect；Honey peach can substances such as contained semen armeniacae amarae formula, emulsin in relieving cough and asthma peach kernel, have town to respiratory apparatus after hydrolysis
Quiet effect, can be relieving cough and asthma；Honey peach energy anti-hepatic fibrosis, portal vein in the expansible liver of cholagogue Semen Persicae extract promote liver blood
Circulation and raising hepatic tissue collagenase activity, and can promote the catabolism of clostridiopetidase A in liver, have to cirrhosis, liver fibrosis good
Good therapeutic effect；Red blood cell velocity in liver microcirculation can also be made to increase, promote bile secretion.
The invention has the benefit that
Acne-removing inflammation-diminishing of the present invention, removing toxic substances of clearing liver prescription using Fructificatio Tricholomatis Matsutakis extract, dandelion, black sesame powder, peanut powder,
Honey peach powder, bamboo salt are major ingredient, the root of Dahurain angelica, loquat, Fructus Forsythiae, honeysuckle, cordate houttuynia, Radix Salviae Miltiorrhizae, wild chrysanthemum, pachyrhizus, fructus arctii, almond
Powder, isomalt, Sucralose are auxiliary material and carry out appropriate weight proportion, are finally prepared with anti-acne, removing toxic substances, drop
The prescription of rouge and the effect that purifies the blood.The present invention is based on matsutake and dandelion protect liver, toxin expelling, drop enzyme, diuresis, black sesame powder antioxygen in addition
Change, improve liver metabolism, is aided with bamboo salt, peanut powder, honey peach powder and assigns skin repair.Have between each raw material contained by the present invention
Have a synergistic effect, between each ingredient interaction can maximum the effect of playing acne-removing inflammation-diminishing, and the present invention is directed to different originals
Material carries out different extraction processes, so that each raw material effect is played to the greatest extent.Acne-removing inflammation-diminishing of the present invention, clearing liver
The preparation method of the prescription of removing toxic substances is simple, high-efficient, pollution-free, meets large-scale production and requires, and is easy to implement.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
Embodiment 1
The present embodiment provides a kind of acne-removing inflammation-diminishing, the prescription for removing toxic substances of clearing liver, raw material components include:
Fructificatio Tricholomatis Matsutakis extract 0.5g, dandelion 3g, root of Dahurain angelica 0.3g, loquat 0.2g, Fructus Forsythiae 0.3g, honeysuckle 0.1g, cordate houttuynia
0.2g, Radix Salviae Miltiorrhizae 0.1g, wild chrysanthemum 0.2g, pachyrhizus 0.1g, fructus arctii 0.2g, almond powder 1g, black sesame powder 8g, peanut powder 8g, honey peach
Powder 30g, isomalt 30g, Sucralose 0.4g, bamboo salt 0.4g.
Further, the preparation method of the Fructificatio Tricholomatis Matsutakis extract, comprising the following steps:
(1) matsutake enzymolysis liquid is prepared
Matsutake is crushed after dry 4h under the conditions of temperature is 60 DEG C, obtains matsutake powder；By the matsutake powder and steam
Distilled water is mixed by the mass ratio of 2:1, after 4 DEG C of standing 10h, is stirred 3h with the revolving speed of 40r/min, is obtained matsutake homogenate；By institute
It states matsutake homogenate and 55min is centrifuged with the revolving speed of 5000rpm, papain, cellulase and pectase are added into supernatant
The mixture mixed with the mass ratio of 1:1:1 digests 3h under conditions of temperature is 35 DEG C, obtains matsutake enzymolysis liquid；
(2) preparation promotes the extract of Liver Lipid Metabolism, anti-inflammatory drop enzyme
After saccharomycete activation, is cultivated, obtain seed liquor；2000mL step (1) is added into seed liquor described in 1000mL
The matsutake enzymolysis liquid is 28 DEG C in temperature, and fermented and cultured 32h obtains fermentation liquid under the stirring condition that revolving speed is 150rpm；It will
The fermentation liquid is separated by solid-liquid separation, and supernatant and yeast thallus are obtained；By the supernatant inlet air temperature be 70 DEG C, water droplet
Speed is 25mL/min, hot air flowrate 30m/h, compressed air require 450L/h, and charging rate is 3.0 × 180mL/h,
Leaving water temperature is spray-dried under conditions of being 75 DEG C, to get the promotion Liver Lipid Metabolism, anti-inflammatory drop enzyme after sterilization
Extract.
Further, the present embodiment provides the preparation methods of the acne-removing inflammation-diminishing, the prescription for removing toxic substances of clearing liver, including walk as follows
It is rapid:
(1) dandelion is taken by above-mentioned parts by weight, is successively cleaned, cleaned, is dried；It is decocted after the ethyl alcohol of 3 times of quality is added
It boils 1.5 hours；It is then filtered, obtains filtrate；Filtrate is concentrated, concentrate is obtained；
(2) gained concentrate in step (1) is carried out alcohol precipitation 2 hours, obtains sediment；Gained sediment is sprayed
Dry, crushing, obtains dandelion extract；
(3) root of Dahurain angelica, loquat, Fructus Forsythiae, honeysuckle, cordate houttuynia, Radix Salviae Miltiorrhizae, wild chrysanthemum, pachyrhizus, fructus arctii are taken by above-mentioned parts by weight,
Successively being cleaned, cleaned respectively, being dry, pulverize to partial size is 80 mesh, obtains each raw material fine powder, each raw material fine powder is mixed,
It is added after 55 degree of white wine impregnate 3 days at 25 DEG C and filters, steamed at subsequent 150 DEG C 40 minutes, obtain steaming material；
(4) distiller's yeast that gained steams addition 1wt% in material into step (3) ferments 20 days at 25 DEG C, obtains after distillation
The extracting solution of each raw material；
(5) extracting solution, the matsutake of the middle each raw material of gained of gained dandelion extract, step (4) in step (2) are extracted
Object, almond powder, black sesame powder, peanut powder, honey peach powder, isomalt, Sucralose and bamboo salt mixing, stirring, dry, powder
Being broken to partial size is 100 mesh, obtains the prescription of the acne-removing inflammation-diminishing, removing toxic substances of clearing liver.
Embodiment 2
The present embodiment provides a kind of acne-removing inflammation-diminishing, the prescription for removing toxic substances of clearing liver, raw material components include:
Fructificatio Tricholomatis Matsutakis extract 1.5g, dandelion 7g, root of Dahurain angelica 0.8g, loquat 0.4g, Fructus Forsythiae 0.5g, honeysuckle 0.4g, cordate houttuynia
0.4g, Radix Salviae Miltiorrhizae 0.3g, wild chrysanthemum 0.4g, pachyrhizus 0.3g, fructus arctii 0.3g, almond powder 3g, black sesame powder 12g, peanut powder 12g, water honey
Peach powder 36.5g, isomalt 50g, Sucralose 0.6g, bamboo salt 0.6g.
Further, the preparation method of the Fructificatio Tricholomatis Matsutakis extract, comprising the following steps:
(1) matsutake enzymolysis liquid is prepared
Matsutake is crushed after dry 2h under the conditions of temperature is 90 DEG C, obtains matsutake powder；By the matsutake powder and steam
Distilled water is mixed by the mass ratio of 4:3, after 6 DEG C of standing 14h, is stirred 1h with the revolving speed of 60r/min, is obtained matsutake homogenate；By institute
It states matsutake homogenate and 35min is centrifuged with the revolving speed of 7000rpm, papain, cellulase and pectase are added into supernatant
The mixture mixed with the mass ratio of 1:2:2 digests 2h under conditions of temperature is 40 DEG C, obtains matsutake enzymolysis liquid；
(2) preparation promotes the extract of Liver Lipid Metabolism, anti-inflammatory drop enzyme
After saccharomycete activation, is cultivated, obtain seed liquor；1000mL step (1) is added into seed liquor described in 500mL
The matsutake enzymolysis liquid is 32 DEG C in temperature, and fermented and cultured 40h obtains fermentation liquid under the stirring condition that revolving speed is 250rpm；It will
The fermentation liquid is separated by solid-liquid separation, and supernatant and yeast thallus are obtained；By the supernatant inlet air temperature be 80 DEG C, water droplet
Speed is 35mL/min, hot air flowrate 40m/h, compressed air require 530L/h, and charging rate is 5.0 × 180mL/h,
Leaving water temperature is spray-dried under conditions of being 75 DEG C, to get the promotion Liver Lipid Metabolism, anti-inflammatory drop enzyme after sterilization
Extract.
Further, the present embodiment provides the preparation methods of the acne-removing inflammation-diminishing, the prescription for removing toxic substances of clearing liver, including walk as follows
It is rapid:
(1) dandelion is taken by above-mentioned parts by weight, is successively cleaned, cleaned, is dried；It is decocted after the chloroform of 5 times of quality is added
It boils 2 hours；It is then filtered, obtains filtrate；Filtrate is concentrated, concentrate is obtained；
(2) gained concentrate in step (1) is carried out alcohol precipitation 3 hours, obtains sediment；Gained sediment is sprayed
Dry, crushing, obtains dandelion extract；
(3) root of Dahurain angelica, loquat, Fructus Forsythiae, honeysuckle, cordate houttuynia, Radix Salviae Miltiorrhizae, wild chrysanthemum, pachyrhizus, fructus arctii are taken by above-mentioned parts by weight,
Successively being cleaned, cleaned respectively, being dry, pulverize to partial size is 120 mesh, obtains each raw material fine powder, each raw material fine powder is mixed,
It is added after 65 degree of white wine impregnate 5 days at 28 DEG C and filters, steamed at subsequent 180 DEG C 80 minutes, obtain steaming material；
(4) distiller's yeast that gained steams addition 3wt% in material into step (3) ferments 30 days at 28 DEG C, obtains after distillation
The extracting solution of each raw material；
(5) extracting solution, the matsutake of the middle each raw material of gained of gained dandelion extract, step (4) in step (2) are extracted
Object, almond powder, black sesame powder, peanut powder, honey peach powder, isomalt, Sucralose and bamboo salt mixing, stirring, dry, powder
Being broken to partial size is 300 mesh, obtains the prescription of the acne-removing inflammation-diminishing, removing toxic substances of clearing liver.
Embodiment 3
The present embodiment provides a kind of acne-removing inflammation-diminishing, the prescription for removing toxic substances of clearing liver, raw material components include:
Fructificatio Tricholomatis Matsutakis extract 0.75g, dandelion 5g, root of Dahurain angelica 0.5g, loquat 0.3g, Fructus Forsythiae 0.4g, honeysuckle 0.2g, fish raw meat
Careless 0.3g, Radix Salviae Miltiorrhizae 0.2g, wild chrysanthemum 0.3g, pachyrhizus 0.2g, fructus arctii 0.25g, almond powder 2g, black sesame powder 10g, peanut powder 10g, water
Honey peach powder 33.25g, isomalt 40g, Sucralose 0.5g, bamboo salt 0.5g.
Further, the preparation method of the Fructificatio Tricholomatis Matsutakis extract, comprising the following steps:
(1) matsutake enzymolysis liquid is prepared
Matsutake is crushed after dry 3h under the conditions of temperature is 80 DEG C, obtains matsutake powder；By the matsutake powder and steam
Distilled water is mixed by the mass ratio of 3:2, after 5 DEG C of standing 12h, is stirred 2h with the revolving speed of 50r/min, is obtained matsutake homogenate；By institute
It states matsutake homogenate and 45min is centrifuged with the revolving speed of 6000rpm, papain, cellulase and pectase are added into supernatant
The mixture mixed with the mass ratio of 1:2:1 digests 2.5h under conditions of temperature is 38 DEG C, obtains matsutake enzymolysis liquid；
(2) preparation promotes the extract of Liver Lipid Metabolism, anti-inflammatory drop enzyme
After saccharomycete activation, is cultivated, obtain seed liquor；1000mL step (1) is added into seed liquor described in 500mL
The matsutake enzymolysis liquid is 30 DEG C in temperature, and fermented and cultured 36h obtains fermentation liquid under the stirring condition that revolving speed is 200rpm；It will
The fermentation liquid is separated by solid-liquid separation, and supernatant and yeast thallus are obtained；By the supernatant inlet air temperature be 80 DEG C, water droplet
Speed is 30mL/min, hot air flowrate 36m/h, compressed air require 490L/h, and charging rate is 4.0 × 180mL/h,
Leaving water temperature is spray-dried under conditions of being 80 DEG C, to get the promotion Liver Lipid Metabolism, anti-inflammatory drop enzyme after sterilization
Extract.
Further, the present embodiment provides the preparation methods of the acne-removing inflammation-diminishing, the prescription for removing toxic substances of clearing liver, including walk as follows
It is rapid:
(1) dandelion is taken by above-mentioned parts by weight, is successively cleaned, cleaned, is dried；It is decocted after the ether of 4 times of quality is added
It boils 1.75 hours；It is then filtered, obtains filtrate；Filtrate is concentrated, concentrate is obtained；
(2) gained concentrate in step (1) is carried out alcohol precipitation 2.5 hours, obtains sediment；Gained sediment is sprayed
Mist is dry, crushes, and obtains dandelion extract；
(3) root of Dahurain angelica, loquat, Fructus Forsythiae, honeysuckle, cordate houttuynia, Radix Salviae Miltiorrhizae, wild chrysanthemum, pachyrhizus, fructus arctii are taken by above-mentioned parts by weight,
Successively being cleaned, cleaned respectively, being dry, pulverize to partial size is 100 mesh, obtains each raw material fine powder, each raw material fine powder is mixed,
It is added after 60 degree of white wine impregnate 4 days at 26 DEG C and filters, steamed at subsequent 165 DEG C 60 minutes, obtain steaming material；
(4) distiller's yeast that gained steams addition 2wt% in material into step (3) ferments 25 days at 26 DEG C, obtains after distillation
The extracting solution of each raw material；
(5) extracting solution, the matsutake of the middle each raw material of gained of gained dandelion extract, step (4) in step (2) are extracted
Object, almond powder, black sesame powder, peanut powder, honey peach powder, isomalt, Sucralose and bamboo salt mixing, stirring, dry, powder
Being broken to partial size is 200 mesh, obtains the prescription of the acne-removing inflammation-diminishing, removing toxic substances of clearing liver.
Comparative example 1
It is only that the processing mode of dandelion is different from embodiment 3, dandelion is successively cleaned in this comparative example, clearly
After washing, drying plus water is decocted, is filtered, and in triplicate, heating concentration is carried out after merging filtrate, is obtained dandelion extracting solution.
Comparative example 2
The place of the root of Dahurain angelica, loquat, Fructus Forsythiae, honeysuckle, cordate houttuynia, Radix Salviae Miltiorrhizae, wild chrysanthemum, pachyrhizus, fructus arctii is only that with embodiment 3
Reason mode is different, and after the above raw material is successively cleaned, cleans, dry in this comparative example plus water is decocted, filtered, and repeats
Three times, heating concentration is carried out after merging filtrate, obtains the extracting solution of each raw material.
Experimental example
One, the effect test of embodiment 3 and comparative example 1-2 gained prescription
1, subjects: patients with acne 93, of all ages, gender is divided into three groups of (corresponding embodiment 3 and comparative examples
1-2)。
2, it tests process: drinking prescription obtained by embodiment 3 and comparative example 1-2 respectively, allow subject to drink 30 days, then
Check subjects skin's acne situation.
3, test result judgment criteria: (1) effectively: acne mitigates；(2) effective: acne disappears；(3) invalid: acne is without appointing
What improves.
4, test result: it is shown in Table 1.
| Group | Effectively (number) | Effective (number) | (number) in vain | Efficient (%) |
| Embodiment 3 | 14 | 16 | 1 | 96.8 |
| Comparative example 1 | 8 | 4 | 19 | 38.7 |
| Comparative example 2 | 5 | 4 | 22 | 29.0 |
From table 1 it follows that prescription described in the embodiment of the present invention 3 has preferable therapeutic effect to acne, it is efficient
It is 96.8%, fully confirms the prescription therapeutic effect exact for acne of acne-removing inflammation-diminishing of the present invention, removing toxic substances of clearing liver.
Two, shadow of Fructificatio Tricholomatis Matsutakis extract, dandelion extract and the sesamin in prescription described in embodiment 1-3 to serum composition
It rings
1, process is tested
100 male mouse of kunming, 6 week old are chosen, 20~25g of weight was numbered with basal feed adaptive feeding 1 week
After be randomly divided into 5 groups, every group 20, respectively following group:
First group: Normal group (n=20): feeding basal feed.
Second group: hyperlipidemia model group (n=20): feeding high lipid food.
Third group: Fructificatio Tricholomatis Matsutakis extract group (n=20): feeding high lipid food, Fructificatio Tricholomatis Matsutakis extract suspension 20mgkg-1。
4th group: dandelion extract group (n=20): feeding high lipid food, dandelion extract suspension 20mgkg-1。
5th group: sesamin group (n=20): feeding high lipid food, sesamin suspension 20mgkg-1。
Testing 10 weeks terminates, and jugular vein blood collection separates serum according to a conventional method, carries out biochemical measurement.
2, test result
Table 2: the influence of matsutake, dandelion extract and sesamin to serum composition
Note: compared with model control group: p < 0.01 * p < 0.05, * *, compared with Normal group: #p < 0.05.
It can be obtained by data in table 2, be mentioned in Fructificatio Tricholomatis Matsutakis extract group, dandelion extract group, sesamin group and matsutake, dandelion
Under taking object and sesame promotor composition group to treat, the content of TC, LDL-C, MDA and ALT in serum is decreased obviously, wherein matsutake,
Dandelion extract and sesame promotor composition group effect are best, and show there is apparent synergistic effect.Compared with hyperlipidemia model group,
It is treated in Fructificatio Tricholomatis Matsutakis extract group, dandelion extract group, sesamin group and matsutake, dandelion extract and sesame promotor composition group
Lower SOD obviously rises, and is also improved compared with Normal group.Wherein matsutake, dandelion extract and sesame promotor composition group
Effect it is best, have apparent synergistic effect.
Typical case
1, Tang so-and-so, female, 32 years old, because of facial red papules 3 years, diagnosis are as follows: " acne " is looked into liver function and is shown: ALT185IU/
L, AST98IU/L；This composition is given, after taking four weeks, liver function is looked into and shows: ALT78IU/L, AST62IU/L；Acne, hence it is evident that
It improves；Continuing to take surrounding, acne subsides substantially, and it looks into liver function and shows no obvious abnormalities, follow-up half a year, no relapse.
2, Zheng, male, 25 years old, because work relationship often needs to stay up late, drink and treat with courtesy.In face of the worry and image of acne
Puzzlement.After taking this composition one month, the problem of acne, obtains effective solution, and self-confidence also increases.
3, Huang, female 13 years old, sock and stay up late.Because of the scar that whelk and whelk leave, school by
It is insulted to despot and suffers from slight depression.After taking this composition one month, whelk and skin condition are improved, and self-confident
The heart also increases.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, and should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention should be based on the protection scope of the described claims.
Claims (10)
1. the prescription of a kind of acne-removing inflammation-diminishing, removing toxic substances of clearing liver, which is characterized in that raw material components include:
Fructificatio Tricholomatis Matsutakis extract 0.5-1.5 parts by weight, dandelion 3-7 parts by weight, root of Dahurain angelica 0.3-0.8 parts by weight, loquat 0.2-0.4 weight
Part, Fructus Forsythiae 0.3-0.5 parts by weight, honeysuckle 0.1-0.4 parts by weight, cordate houttuynia 0.2-0.4 parts by weight, Radix Salviae Miltiorrhizae 0.1-0.3 weight
Part, wild chrysanthemum 0.2-0.4 parts by weight, pachyrhizus 0.1-0.3 parts by weight, fructus arctii 0.2-0.3 parts by weight, almond powder 1-3 parts by weight, sesame
Numb powder 8-12 parts by weight, peanut powder 8-12 parts by weight, honey peach powder 30-36.5 parts by weight, isomalt 30-50 weight
Part, Sucralose 0.4-0.6 parts by weight, bamboo salt 0.4-0.6 parts by weight.
2. the prescription of acne-removing inflammation-diminishing according to claim 1, removing toxic substances of clearing liver, which is characterized in that raw material components include:
0.75 parts by weight of Fructificatio Tricholomatis Matsutakis extract, 5 parts by weight of dandelion, 0.5 parts by weight of the root of Dahurain angelica, 0.3 parts by weight of loquat, 0.4 weight of Fructus Forsythiae
Measure part, 0.2 parts by weight of honeysuckle, 0.3 parts by weight of cordate houttuynia, 0.2 parts by weight of Radix Salviae Miltiorrhizae, 0.3 parts by weight of wild chrysanthemum, 0.2 weight of pachyrhizus
Measure part, 0.25 parts by weight of fructus arctii, 2 parts by weight of almond powder, 10 parts by weight of black sesame powder, 10 parts by weight of peanut powder, honey peach powder 33.25
Parts by weight, 40 parts by weight of isomalt, 0.5 parts by weight of Sucralose, 0.5 parts by weight of bamboo salt.
3. the preparation method of any one of the claim 1-2 acne-removing inflammation-diminishing, the prescription to detoxify that clears liver, which is characterized in that including
Following steps:
(1) dandelion is taken by above-mentioned parts by weight, is successively cleaned, cleaned, is dried；It is decocted after Extraction solvent is added；With
After be filtered, obtain filtrate；Filtrate is concentrated, concentrate is obtained；
(2) gained concentrate in step (1) is subjected to alcohol precipitation, obtains sediment；Gained sediment is spray-dried, powder
It is broken, obtain dandelion extract；
(3) root of Dahurain angelica, loquat, Fructus Forsythiae, honeysuckle, cordate houttuynia, Radix Salviae Miltiorrhizae, wild chrysanthemum, pachyrhizus, fructus arctii are taken by above-mentioned parts by weight, respectively
It successively cleaned, cleaned, dried, crushed, obtain each raw material fine powder, each raw material fine powder is mixed, mistake after soaking in Chinese liquor is added
Filter, is then steamed, obtains steaming material；
(4) addition distiller's yeast in expecting is steamed to the middle gained of step (3) to be fermented, distilled, and the extracting solution of each raw material is obtained；
(5) by extracting solution, Fructificatio Tricholomatis Matsutakis extract, the apricot of the middle each raw material of gained of gained dandelion extract, step (4) in step (2)
Benevolence powder, black sesame powder, peanut powder, honey peach powder, isomalt, Sucralose and bamboo salt mixing, are successively stirred, do
Dry, crushing obtains the prescription of the acne-removing inflammation-diminishing, removing toxic substances of clearing liver.
4. the preparation method of acne-removing inflammation-diminishing, the prescription to detoxify that clears liver according to claim 3, which is characterized in that step (1)
In, the Extraction solvent is any one of ethyl alcohol, ether, chloroform, acetone or petroleum ether.
5. the preparation method of acne-removing inflammation-diminishing, the prescription to detoxify that clears liver according to claim 3, which is characterized in that step (1)
In, the additional amount of the Extraction solvent is 3-5 times of dandelion quality, and the decocting time is 1.5-2 hours.
6. the preparation method of acne-removing inflammation-diminishing, the prescription to detoxify that clears liver according to claim 3, which is characterized in that step (2)
In, the alcohol precipitation time is 2-3 hours.
7. the preparation method of acne-removing inflammation-diminishing, the prescription to detoxify that clears liver according to claim 3, which is characterized in that step (3)
In, the partial size of each raw material fine powder is 80-120 mesh, and the Alcohol degree of the white wine is 55-65 degree, the temperature of the immersion
Degree is 25-28 DEG C, and the time of the immersion is 3-5 days.
8. the preparation method of acne-removing inflammation-diminishing, the prescription to detoxify that clears liver according to claim 3, which is characterized in that step (3)
In, the temperature steamed is 150-180 DEG C, and the time steamed is 40-80 minutes.
9. the preparation method of acne-removing inflammation-diminishing, the prescription to detoxify that clears liver according to claim 3, which is characterized in that step (4)
In, the additive amount of the distiller's yeast is the 1-3wt% for steaming material, and the fermentation time is 20-30 days, the temperature of the fermentation
It is 25-28 DEG C.
10. the preparation method of acne-removing inflammation-diminishing, the prescription to detoxify that clears liver according to claim 3, which is characterized in that step (5)
In, the smashed partial size is 100-300 mesh.
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Application publication date: 20190614 |