CN108760659A - It donates blood primary dcreening operation analyzer and its application method - Google Patents
It donates blood primary dcreening operation analyzer and its application method Download PDFInfo
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- CN108760659A CN108760659A CN201810933717.XA CN201810933717A CN108760659A CN 108760659 A CN108760659 A CN 108760659A CN 201810933717 A CN201810933717 A CN 201810933717A CN 108760659 A CN108760659 A CN 108760659A
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- reagent
- blood
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- 210000004369 blood Anatomy 0.000 title claims abstract description 73
- 239000008280 blood Substances 0.000 title claims abstract description 73
- 238000000034 method Methods 0.000 title claims abstract description 20
- 239000000523 sample Substances 0.000 claims abstract description 220
- 238000001514 detection method Methods 0.000 claims abstract description 78
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 71
- 206010018910 Haemolysis Diseases 0.000 claims abstract description 48
- 230000008588 hemolysis Effects 0.000 claims abstract description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 238000012360 testing method Methods 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 239000012530 fluid Substances 0.000 claims description 31
- 238000010438 heat treatment Methods 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 17
- 239000010453 quartz Substances 0.000 claims description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 14
- 230000003321 amplification Effects 0.000 claims description 13
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 13
- 210000003743 erythrocyte Anatomy 0.000 claims description 9
- 239000003814 drug Substances 0.000 claims description 8
- 229940079593 drug Drugs 0.000 claims description 8
- 102000001554 Hemoglobins Human genes 0.000 claims description 7
- 108010054147 Hemoglobins Proteins 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000009413 insulation Methods 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 4
- 238000004737 colorimetric analysis Methods 0.000 claims description 4
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims description 4
- 238000007689 inspection Methods 0.000 claims description 4
- 238000004879 turbidimetry Methods 0.000 claims description 4
- 238000002835 absorbance Methods 0.000 claims description 3
- 210000001268 chyle Anatomy 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- 239000006228 supernatant Substances 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 238000004458 analytical method Methods 0.000 claims 1
- 230000005611 electricity Effects 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 5
- 238000010586 diagram Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 4
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 description 2
- 108010082126 Alanine transaminase Proteins 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000003708 ampul Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 238000000703 high-speed centrifugation Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Abstract
The present invention relates to the field of medical instrument technology, donate blood primary dcreening operation analyzer and its application method more particularly, to one kind.Primary dcreening operation analyzer of donating blood includes：Mounting bracket, sample disk module, probe module, haemolysis, chylemia colorimetric module, reagent refrigerating module and detection module；It is provided on mounting bracket for installing probe module and haemolysis, the locating piece of chylemia colorimetric mould, locating piece can be moved relative to the transverse reciprocating of mounting bracket, make locating piece that there is the first traffic direction and the second traffic direction, when being moved along the first traffic direction, probe module can successively in pipette samples disk module sample and reagent refrigerating mould reagent in the block, and the mixture of sample and reagent is injected into detection module；When being moved along the second traffic direction, probe module can inject pure water into sample disk module, and the mixed liquor of pure water and sample is drawn and detected.To alleviate cumbersome, the time-consuming and laborious technical problem of blood testing process existing in the prior art.
Description
Technical field
The present invention relates to the field of medical instrument technology, donate blood primary dcreening operation analyzer and its application method more particularly, to one kind.
Background technology
The voluntary blood donation of China is the process to the blood collection of healthy population, and blood donor will first pass through at the beginning of one before donating blood
The blood testing screening of step, wherein at least comprising three glutamic-pyruvic transaminase in blood of human body, hemoglobin and chylemia indexs
Detection cannot then donate blood if there is one of which is not met.The prior art uses one for the detection of glutamic-pyruvic transaminase
Platform Dry-type biochemical analyzer, sampling whole blood 30ul, which is added to after dry type strip to be put into instrument about 120 seconds, goes out testing result.It is right
It is generally estimated using copper sulphate titration in hemoglobin, i.e., the one big about 50ul that bleeds, which is added dropwise in copper-bath, to be seen
Examine blood be sink to bottom of bottle be also suspended in solution interpretation whether blood donor whether anaemia.Or use hemoglobin detector
It is detected.
The prior art is detected donor blood with the presence or absence of haemolysis currently without means.Due to individual difference,
Erythrocyte fragility also has different degrees of difference, erythrocyte fragility to increase in blood of human body, and red blood cell is easy to destroy, and makes red blood cell
The lost of life, the blood adopted in blood bag is not easy to maintain, easy tos produce haemolysis, causes useless blood.If sent out in time during primary dcreening operation
Now then avoid the generation of such case.
Chylemia is detected observed after centrifuge 2--3 minutes after general venous blood samples blood plasma whether chyle, but due to by
Influence to ambient light and the subjective sensation of people is often led to divergence.
So each single item is separate detection or cannot detect that detection process is cumbersome, time-consuming and laborious, there is use
The problems such as blood excessively and repeatedly heals detection.
Invention content
It donates blood primary dcreening operation analyzer the purpose of the present invention is to provide one kind, to alleviate blood testing existing in the prior art
Process is cumbersome, time-consuming and laborious, there is technical issues that excessively and repeatedly to heal using blood.
One kind provided by the invention is donated blood primary dcreening operation analyzer, including：Mounting bracket, sample disk module, probe module, haemolysis,
Chylemia colorimetric module, reagent refrigerating module and detection module；
The sample disk module, reagent refrigerating module and detection module are spaced apart and arranged in the one of the mounting bracket successively
Side is provided with locating piece on the other side of the mounting bracket, and the probe module and the haemolysis, chylemia colorimetric module are all provided with
It sets on the locating piece, the probe module is connected to the haemolysis, chylemia colorimetric module, and the probe module can lean on
One end of the nearly mounting bracket side extends, and the locating piece can be moved relative to the other side transverse reciprocating of the mounting bracket,
So that the probe module can draw sample and the reagent refrigerating mould reagent in the block in the sample disk module successively,
And the mixture of sample after detection and reagent is injected into detection module and is detected.
Further, the probe module includes link block, sample reagent probe, into liquid drugs injection and drain needle；
Setting is there are three through-hole on the link block, three through-holes be respectively used to install the sample reagent probe,
Into liquid drugs injection and drain needle, one end of the sample reagent probe is for the haemolysis, one end connection of chylemia colorimetric module.
Further, the probe module further includes having plunger pump and triple valve；
The plunger pump and the triple valve are arranged at side of the mounting bracket far from the locating rack, the plunger
Pump connect with the first interface of the triple valve, the second interface of the triple valve and the haemolysis, chylemia colorimetric module
The other end connects, and the third interface of the triple valve is for connecting pure water water pipe.
Further, further include having probe service sink；
The probe service sink includes main tank body, water inlet pipe and drainpipe, and the water inlet pipe is positioned close to the main pond
The open end of body, the drainpipe are positioned close to the bottom end of the main tank body.
Further, further include the first diaphragm fluid pump, the second diaphragm fluid pump, third diaphragm fluid pump and the 4th diaphragm fluid pump；
First diaphragm fluid pump is connect with described one end into liquid drugs injection, second diaphragm fluid pump and the drain needle
One end connects, and the third diaphragm fluid pump is connect with the water inlet pipe, and the 4th diaphragm fluid pump is connect with the drainpipe.
Further, the detection module includes measuring circuit plate and four road detector bars；
There are four cuvette and LED light sources, four cuvettes to be examined along four tunnel for setting on the detector bar of four road
The extending direction for surveying item is spaced setting successively, is arranged on LED light source described in the measuring circuit plate and is correspondingly arranged on photoelectric sensing
Device, the photoelectric sensor are used to mixture absorbance information in cuvette that LED light source absorbs feeding back to the measurement electric
Road plate.
Further, insulation heating cushion, the measurement are provided between the measuring circuit plate and four road detector bar
The heating zone for being heated to four road detector bar is provided on circuit board, the heating zone is used for four road detector bar
It is heated.
Further, it is additionally provided with temperature sensor in the detector bar of four road, is provided with and adds in the measuring circuit plate
Thermal control circuit, the heating control circuit are electrically connected with the temperature sensor, to control the temperature of the cuvette.
Further, the haemolysis, chylemia colorimetric module include main casing, hemolysis test LED light source, chylemia detection
LED light source, quartz cuvette and signal amplification circuit plate；
The quartz cuvette passes through the main casing, one end of the quartz cuvette to connect with the sample reagent probe
It connects, the hemolysis test LED light source and chylemia detection LED light source are arranged in the side of the main casing, the main casing
Another side is equipped with corresponding photoelectric sensor；The other end of the quartz cuvette and the second interface of the triple valve connect
It connects, the signal amplification circuit plate is arranged is provided with light source control in the bottom end of the main casing, the signal amplification circuit plate
Circuit, the first signal amplification circuit and second signal amplifying circuit processed, the hemolysis test LED light source and chylemia detect led
Light source is connect with the control circuit for light source.
A kind of application method for primary dcreening operation analyzer of donating blood has donate blood primary dcreening operation analyzer, including following step as described above
Suddenly：
Detection module starts, and detection module is made to reach scheduled temperature；
30 μ l of blood are taken to be put into the centrifuge tube equipped with quantitative cell-preservation liquid, with high-speed micro centrifuge
Second, the sample centrifuged to be put into the position of sample disk module hole, sample disk module rotates to fixed position, sample disk module
Rotate to fixed position, locating piece is moved to sample disk module upper end, by the sample after centrifugation draw its supernatant to haemolysis,
In chylemia colorimetric module, sample is detected 4--5 seconds, after the completion of detection using colorimetric method and turbidimetry, locating piece movement
To above reagent refrigerating module, after probe module draws reagent, locating piece moves again, and probe module is made to be moved to detection mould
Above block, reagent and sample mixture are injected in detection module, are detected using performance rate method by probe, and detection time is about
120 seconds；
For probe module by after in reagent and sample injection to detection module, locating piece drives probe module to turn again to sample
Above product disk module, pure water is injected into the centrifuge tube of sample disk module, so that the red blood cell rupture of the sample in pipe, and
Mixture stirring to pure water and sample, probe module are drawn in the sample to haemolysis, chylemia colorimetric module after stirring, inspection
It surveys 6~10 seconds, is detected with the content to hemoglobin in sample.
One kind provided by the invention is donated blood primary dcreening operation analyzer, including：Mounting bracket, sample disk module, probe module, haemolysis,
Chylemia colorimetric module, reagent refrigerating module and detection module；The sample disk module, reagent refrigerating module and detection module according to
Minor tick it is arranged on the side of the mounting bracket, the other side of the mounting bracket and is provided with locating piece, the probe module
And the haemolysis, chylemia colorimetric module are arranged on the locating piece, the probe module and the haemolysis, chylemia ratio
Color module is connected to, and the probe module can extend to one end close to the mounting bracket side, and the locating piece can be opposite
The other side transverse reciprocating movement of the mounting bracket, so that the locating piece has the first traffic direction and the second traffic direction,
When being moved along the first traffic direction, the probe module can draw sample and the examination in the sample disk module successively
Agent refrigerates mould reagent in the block, and the mixture of sample after detection and reagent is injected into detection module and is detected；Work as edge
When second traffic direction moves, the probe module can inject pure water into the sample disk module, and by pure water and
The mixing of sample is drawn and is detected.Using above-mentioned scheme, probe module is arranged on the positioning element, and locating piece being capable of opposite peace
Movement is shelved, so that probe module can draw the sample after centrifuge, while reagent refrigerating module can also be drawn
In reagent, and by the sample and reagent injector to detection module after detection, due to the reciprocating motion of locating piece, additionally it is possible to make
Probe module moves to the top of sample disk module again after the mixture of sample and reagent is injected into detection module,
And be detected again to injecting after pure water to suck in sample, and the sample after absorption is detected, to alleviate existing skill
Blood testing process present in art is cumbersome, time-consuming and laborious, there is the technology that detection excessively and is repeatedly healed using blood
Problem.
A kind of application method of primary dcreening operation analyzer of donating blood provided by the invention has such as above-mentioned primary dcreening operation analyzer of donating blood,
Include the following steps：Detection module starts, and detection module is made to reach scheduled temperature；It takes 30 μ l of blood to be put into protect equipped with quantitative cell
In the centrifuge tube of liquid storage, with high-speed micro centrifugeSecond, the sample centrifuged is put into sample disk module hole
In position, sample disk module rotates to fixed position, and locating piece is moved to sample disk module upper end, and the sample after centrifugation is drawn it
In supernatant to haemolysis, chylemia colorimetric module, sample is detected 4--5 seconds using colorimetric method and turbidimetry, detection is completed
Afterwards, locating piece is moved to above reagent refrigerating module, and after probe module draws reagent, locating piece moves again, makes probe mould
Block is moved to above detection module, and reagent and sample mixture are injected in detection module, are examined using performance rate method by probe
It surveys, detection time about 120 seconds；For probe module by after in reagent and sample injection to detection module, locating piece drives probe
Module turns again to above sample disk module, pure water is injected into the centrifuge tube of sample disk module, so that the sample in pipe
Red blood cell rupture, and the mixture of pure water and sample is stirred, probe module draws the sample after stirring to haemolysis, chyle
In blood colorimetric module, detects 6~10 seconds, be detected with the content to hemoglobin in sample.Using above-mentioned application method,
The speed that blood testing can be improved reduces the fussy degree of blood testing.
Description of the drawings
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art are briefly described, it should be apparent that, in being described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, other drawings may also be obtained based on these drawings.
Fig. 1 is the structural schematic diagram of primary dcreening operation analyzer provided in an embodiment of the present invention of donating blood；
Fig. 2 is the rearview of primary dcreening operation analyzer provided in an embodiment of the present invention of donating blood；
Fig. 3 is the structural schematic diagram of primary dcreening operation analyzer detection module provided in an embodiment of the present invention of donating blood；
Fig. 4 is the structural schematic diagram that primary dcreening operation analyzer provided in an embodiment of the present invention of donating blood examines probe service sink；
Fig. 5 is the structural schematic diagram of primary dcreening operation analyzer probe module provided in an embodiment of the present invention of donating blood；
Fig. 6 be primary dcreening operation analyzer haemolysis provided in an embodiment of the present invention of donating blood, chylemia colorimetric module structural schematic diagram.
Icon：1- mounting brackets；2- sample disk modules；3- probe modules；4- reagent refrigerating modules；5- detection modules；6- is visited
Needle service sink；The first diaphragm fluid pumps of 7-；The second diaphragm fluid pumps of 8-；9- third diaphragm fluid pumps；The 4th diaphragm fluid pumps of 10-；11- is molten
Blood, chylemia colorimetric module；110- main casings；111- hemolysis test LED light sources；112- chylemias detect LED light source；113- stones
English colorimetric cylinder；114- signal amplification circuit plates；310- link blocks；320- sample reagent probes；330- is into liquid drugs injection；340- drains
Needle；350- plunger pumps；360- triple valves；510- measuring circuit plates；Tetra- road detector bars of 520-；521- cuvettes；522-LED light
Source；610- main tank bodies；620- water inlet pipes；630- drainpipes.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
The every other embodiment that personnel are obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term "center", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, merely to
Convenient for the description present invention and simplify description, do not indicate or imply the indicated device or element must have a particular orientation,
With specific azimuth configuration and operation, therefore it is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is used for description purposes only, and is not understood to indicate or imply relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
Can also be electrical connection to be mechanical connection；It can be directly connected, can also indirectly connected through an intermediary, Ke Yishi
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood at this with concrete condition
Concrete meaning in invention.
Fig. 1 is the structural schematic diagram of primary dcreening operation analyzer provided in an embodiment of the present invention of donating blood；Fig. 2 carries for the embodiment of the present invention
The rearview of the primary dcreening operation analyzer of donating blood supplied.As illustrated in fig. 1 and 2, one kind provided by the invention is donated blood primary dcreening operation analyzer, including：
Mounting bracket 1, sample disk module 2, probe module 3, haemolysis, chylemia colorimetric module 11, reagent refrigerating module 4 and detection module 5；
The sample disk module 2, reagent refrigerating module 4 and detection module 5 are spaced apart and arranged in the mounting bracket 1 successively
Side is provided with locating piece, the probe module 3 and the haemolysis, chylemia colorimetric module on the other side of the mounting bracket 1
11 are arranged on the locating piece, and the probe module 3 is connected to the haemolysis, chylemia colorimetric module 11, the probe
Module 3 can extend to one end close to 1 side of the mounting bracket, and the locating piece is capable of the another of the mounting bracket 1 relatively
Side transverse reciprocating movement, so that the probe module 3 can draw sample and the reagent in the sample disk module 2 successively
The reagent in module 4 is refrigerated, and the mixture of sample after detection and reagent is injected into detection module 5 and is detected.
Wherein, sample disk module 2 include multiple centrifuge tubes, sample before detection it is a certain amount of (such as：30ul) whole blood is added
Into centrifuge tube, after the upper cover for buckling centrifuge tube, use descends mixing several times on hand, is put into 7000 revs/min of rotating speed or more high speed centrifugation
After machine centrifuges 8~10 seconds, the bottom of centrifuge tube is red blood cell.
Wherein, mounting bracket 1 may include that bottom plate and riser, riser are vertically set on transverse slat, and riser is arranged in transverse slat
Center, be arranged in the side of riser in locating piece, and be additionally provided with transversal driving mechanism in the side of locating piece and longitudinal drive
Motivation structure, transversal driving mechanism are used to drive locating piece to be moved back and forth along the width direction of riser, and longitudinal driving mechanism is used for band
Dynamic probe module 3 is moved back and forth along the short transverse of riser.
Using above-mentioned scheme, probe module 3 is arranged on the positioning element, and locating piece can be moved relative to mounting bracket 1, with
So that probe module 3 is drawn the sample after centrifuge, while the reagent in reagent refrigerating module 4 can also be drawn,
And by the sample and reagent injector to detection module 5 after detection, due to the reciprocating motion of locating piece, additionally it is possible to make probe module
3 after being injected into the mixture of sample and reagent in detection module 5, moves to the top of sample disk module 2 again, and to sample
It sucks after injection pure water in product and is detected again, and the sample after absorption is detected, deposited in the prior art with alleviating
Blood testing process it is cumbersome, it is time-consuming and laborious, there is technical issues that using blood excessively and repeatedly heal.
Fig. 5 is the structural schematic diagram of primary dcreening operation analyzer probe module provided in an embodiment of the present invention of donating blood.As shown in figure 5,
On the basis of the above embodiments, further, the probe module 3 includes link block 310, sample reagent probe 320, water inlet
Needle 330 and drain needle 340；
There are three through-hole, three through-holes are respectively used to install the sample reagent spy for setting on the link block 310
Needle 320, into liquid drugs injection 330 and drain needle 340, one end of the sample reagent probe 320 is for the haemolysis, chylemia colorimetric mould
One end of block 11 is connected to.
Further, the probe module 3 further includes having plunger pump 350 and triple valve 360；
The plunger pump 350 and the triple valve 360 are arranged at side of the mounting bracket 1 far from the locating rack,
The plunger pump 350 is connect with the first interface of the triple valve 360, the second interface of the triple valve 360 and the haemolysis,
The other end of chylemia colorimetric module 11 connects, and the third interface of the triple valve 360 is for connecting pure water water pipe.
Fig. 4 is the structural schematic diagram that primary dcreening operation analyzer provided in an embodiment of the present invention of donating blood examines probe service sink.Such as Fig. 4 institutes
Show, further includes having probe service sink 6 further；
The probe service sink 6 includes main tank body 610, water inlet pipe 620 and drainpipe 630, and the setting of the water inlet pipe 620 exists
Close to the open end of the main tank body 610, the drainpipe 630 is positioned close to the bottom end of the main tank body 610.
Further, further include the first diaphragm fluid pump 7, the second diaphragm fluid pump 8, third diaphragm fluid pump 9 and the 4th diaphragm liquid
Pump 10；
First diaphragm fluid pump 7 is connect with described one end into liquid drugs injection 330, second diaphragm fluid pump 8 and the row
One end of liquid needle 340 connects, and the third diaphragm fluid pump 9 is connect with the water inlet pipe 620, the 4th diaphragm fluid pump 10 and institute
State the connection of drainpipe 630.
In the present embodiment, the first interface of triple valve 360 is connect with plunger pump 350, the second interface of triple valve 360 and
Three interfaces are connected with pure water water pipe and haemolysis, chylemia colorimetric module 11 respectively, haemolysis, chylemia colorimetric module 11 it is another
End connect with sample reagent probe 320, plunger pump 350 work so that sample reagent probe 320 absorb a certain amount of sample or
The setting of reagent, plunger pump 350 can absorb sample and the amount of reagent is more accurate, and sample reagent probe 320 needs after use
Enter in probe service sink 6 and cleaned, the water inlet pipe 620 and drainpipe 630 of main tank body 610 respectively with third diaphragm liquid
Pump 9 and the 4th diaphragm fluid pump 10 connect, and third diaphragm fluid pump 9 and the 4th diaphragm fluid pump 10 in main tank body 610 respectively to injecting liquid
Simultaneously liquid in main tank body 610 is discharged for body, sample reagent probe 320 is cleaned, and in the inner wall to sample reagent probe 320
When cleaning, the third interface being connect with pure water in triple valve 360 is first in the state opened, and plunger pump 350 is drawn centainly
After the pure water of amount, the third interface of triple valve 360 is closed, and second interface is opened, and plunger pump 350 works, and pure water is made to pass through
Sample reagent probe 320 is discharged, and sample reagent probe 320 is cleaned, when being cleaned to the cuvette 521 in detection module 5,
Second diaphragm fluid pump 8 and the work of the first diaphragm fluid pump 7, first 521 water filling of contrastive colours cup are discharged by the water in cuvette 521, with
Cuvette 521 is cleaned.
Fig. 3 is the structural schematic diagram of primary dcreening operation analyzer detection module provided in an embodiment of the present invention of donating blood.As shown in figure 3,
On the basis of the above embodiments, further, the detection module 5 includes measuring circuit plate 510 and four road detector bars 520；
There are four cuvette 521 and LED light source 522, four cuvettes 521 for setting on four road detector bar 520
It is spaced setting successively along the extending direction of four road detector bar 520, is set on LED light source 522 described in the measuring circuit plate 510
It sets and is correspondingly arranged on photoelectric sensor, mixture in the cuvette 521 that the photoelectric sensor is used to absorb LED light source 522
Absorbance information feeds back to the measuring circuit plate 510.
In the present embodiment, it is provided with four road detector bars 520 in detection module 5, four ratios are provided on four road detector bars 520
Color cup 521, each cuvette 521 correspond to LED light source 522 and photoelectric sensor, can be by sample reagent probe 320 by sample and examination
The mixture of agent is put into one of cuvette 521, and corresponding LED light source 522 and photoelectric transfer device can be by the results of detection
It is converted into electric signal to be transferred in measuring circuit plate 510, the form of electric current either voltage is converted to by measuring circuit plate 510
It feeds back.
On the basis of the above embodiments, further, the measuring circuit plate 510 and four road detector bar 520 it
Between be provided with insulation heating cushion, the heating for being heated to four road detector bar 520 is provided in the measuring circuit plate 510
Area, the heating zone is for heating four road detector bar 520.
Further, it is additionally provided with temperature sensor in four road detector bar 520, is set in the measuring circuit plate 510
It is equipped with heating control circuit, the heating control circuit is electrically connected with the temperature sensor, to control the cuvette 521
Temperature.
In the present embodiment, insulation heating cushion is heated in the heating zone in measuring circuit plate 510, and insulation heating cushion will be warm
Amount is transmitted in four road detector bars 520, while also having set temperature sensor in four road detector bars 520, and temperature sensor can
Incude the temperature in four road detector bars 520, and temperature information is fed back in heating control circuit, so that setting detects on four tunnels
Cuvette 521 on item 520 is in default range.
Fig. 6 be primary dcreening operation analyzer haemolysis provided in an embodiment of the present invention of donating blood, chylemia colorimetric module structural schematic diagram.
As shown in fig. 6, on the basis of the above embodiments, further, the haemolysis, chylemia colorimetric module 11 include main casing
110, hemolysis test LED light source 111, chylemia detection LED light source 112, quartz cuvette 113 and signal amplification circuit plate 114；
The quartz cuvette 113 passes through the main casing 110, one end of the quartz cuvette 113 and the sample
Reagent probe 320 connects, and the hemolysis test LED light source 111 and chylemia detection LED light source 112 are arranged in the main casing
The another side of 110 side, the main casing is equipped with corresponding photoelectric sensor；The other end of the quartz cuvette 113
It being connect with the second interface of the triple valve 360, the signal amplification circuit plate 114 is arranged in the bottom end of the main casing 110,
Control circuit for light source, the first signal amplification circuit and second signal amplifying circuit are provided in the signal amplification circuit plate 114,
The hemolysis test LED light source 111 and chylemia detection LED light source 112 are connect with the control circuit for light source.
In the present embodiment, quartz cuvette 113 runs through main casing 110, after 350 pipette samples of plunger pump are either broken
Sample when, hemolysis test LED light source 111 and chylemia detection LED light source 112 sample in quartz ampoule is detected, with
Obtain the result of detection.
A kind of application method of primary dcreening operation analyzer of donating blood provided by the invention has such as above-mentioned primary dcreening operation analyzer of donating blood,
Include the following steps：Detection module 5 starts, and detection module 5 is made to reach scheduled temperature；Sample disk module 2 to sample carry out from
Heart processing, locating piece are moved to 2 upper end of sample disk module, the sample after centrifugation are drawn to haemolysis, chylemia colorimetric module 11
In, sample is detected 4--5 seconds, after the completion of detection using colorimetric method and turbidimetry, locating piece is moved to reagent refrigerating module
4 tops, after probe module 3 draws reagent, locating piece moves again, so that probe module 3 is moved to 5 top of detection module, visits
Reagent and sample mixture are injected in detection module 5 by needle, are detected using performance rate method, detection time about 120 seconds；It visits
For pin module 3 by after in reagent and sample injection to detection module 5, locating piece drives probe module 3 to turn again to sample disc mould
2 top of block, pure water is injected into the centrifuge tube of sample disk module 2, so that the red blood cell rupture of the sample in pipe, and to pure
The mixture of water purification and sample stirs, and probe module 3 is drawn in the sample to haemolysis, chylemia colorimetric module 11 after stirring, inspection
It surveys 6~10 seconds, is detected with the content to hemoglobin in sample.Using above-mentioned application method, blood inspection can be improved
The speed of survey, by the fussy degree of low blood testing.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
- The primary dcreening operation analyzer 1. one kind is donated blood, which is characterized in that including：Mounting bracket, sample disk module, probe module, haemolysis, chyle Blood colorimetric module, reagent refrigerating module and detection module；The sample disk module, reagent refrigerating module and detection module are spaced apart and arranged in the side of the mounting bracket, institute successively It states and is provided with locating piece on the other side of mounting bracket, the probe module and the haemolysis, chylemia colorimetric module are arranged at On the locating piece, the probe module is connected to the haemolysis, chylemia colorimetric module, and the probe module can be to close One end of the mounting bracket side extends, and the locating piece can be moved relative to the other side transverse reciprocating of the mounting bracket, with Make the locating piece that there is the first traffic direction and the second traffic direction, when being moved along the first traffic direction, the probe mould Block can draw sample and the reagent refrigerating mould reagent in the block in the sample disk module successively, and will sample after detection It is injected into detection module and is detected with the mixture of reagent；When being moved along the second traffic direction, the probe module can inject pure water into the sample disk module, and will The mixing of pure water and sample is drawn and is detected.
- 2. primary dcreening operation analyzer according to claim 1 of donating blood, which is characterized in that the probe module includes link block, sample Product reagent probe, into liquid drugs injection and drain needle；There are three through-hole, three through-holes are respectively used to install the sample reagent probe, water inlet for setting on the link block Needle and drain needle, one end of the sample reagent probe is for the haemolysis, one end connection of chylemia colorimetric module.
- 3. primary dcreening operation analyzer according to claim 2 of donating blood, which is characterized in that the probe module further includes having plunger pump And triple valve；The plunger pump and the triple valve are arranged at side of the mounting bracket far from the locating piece, the plunger pump with The first interface of the triple valve connects, the second interface of the triple valve and the haemolysis, chylemia colorimetric module it is another End connection, the third interface of the triple valve is for connecting pure water water pipe.
- 4. primary dcreening operation analyzer according to claim 3 of donating blood, which is characterized in that further include having probe service sink；The probe service sink includes main tank body, water inlet pipe and drainpipe, and the water inlet pipe is positioned close to the main tank body Open end, the drainpipe are positioned close to the bottom end of the main tank body.
- 5. primary dcreening operation analyzer according to claim 4 of donating blood, which is characterized in that further include the first diaphragm fluid pump, second every Film liquid pump, third diaphragm fluid pump and the 4th diaphragm fluid pump；First diaphragm fluid pump is connect with described one end into liquid drugs injection, one end of second diaphragm fluid pump and the drain needle Connection, the third diaphragm fluid pump are connect with the water inlet pipe, and the 4th diaphragm fluid pump is connect with the drainpipe.
- 6. primary dcreening operation analyzer according to claim 5 of donating blood, which is characterized in that the detection module includes measuring circuit plate With four road detector bars；There are four cuvette and LED light sources for setting on the detector bar of four road, and four cuvettes are along four road detector bar Extending direction be spaced setting successively, on LED light source described in the measuring circuit plate setting be correspondingly arranged on photoelectric sensor, institute Photoelectric sensor is stated for mixture absorbance information in cuvette that LED light source absorbs to be fed back to the measuring circuit plate.
- 7. primary dcreening operation analyzer according to claim 6 of donating blood, which is characterized in that the measuring circuit plate and four tunnel inspection It is provided with insulation heating cushion between survey item, the heating for being heated to four road detector bar is provided in the measuring circuit plate Area, the heating zone is for heating four road detector bar.
- 8. primary dcreening operation analyzer according to claim 7 of donating blood, which is characterized in that be additionally provided with temperature in the detector bar of four road Sensor is spent, heating control circuit, the heating control circuit and the temperature sensor are provided in the measuring circuit plate Electrical connection, to control the temperature of the cuvette.
- 9. primary dcreening operation analyzer according to claim 8 of donating blood, which is characterized in that the haemolysis, chylemia colorimetric module packet Include main casing, hemolysis test LED light source, chylemia detection LED light source, quartz cuvette and signal amplification circuit plate；The quartz cuvette passes through the main casing, one end of the quartz cuvette to be connect with the sample reagent probe, The hemolysis test LED light source and chylemia detection LED light source are arranged in the side of the main casing, the main casing it is another Side is equipped with corresponding photoelectric sensor；The other end of the quartz cuvette is connect with the second interface of the triple valve, institute State signal amplification circuit plate be arranged be provided in the bottom end of the main casing, the signal amplification circuit plate light source control electricity Road, the first signal amplification circuit and second signal amplifying circuit, the hemolysis test LED light source and chylemia detect LED light source It is connect with the control circuit for light source.
- 10. a kind of application method for primary dcreening operation analyzer of donating blood has the mesh analysis as at the beginning of donating blood claim 1-9 any one of them Instrument, which is characterized in that include the following steps：Detection module starts, and detection module is made to reach scheduled temperature；30 μ l of blood are taken to be put into the centrifuge tube equipped with quantitative cell-preservation liquid, with high-speed micro centrifugeSecond, The sample centrifuged is put into the Kong Weizhong of sample disk module, and sample disk module rotates to fixed position, the rotation of sample disk module To fixed position, locating piece is moved to sample disk module upper end, and the sample after centrifugation is drawn its supernatant to haemolysis, chylemia In colorimetric module, sample is detected 4--5 seconds, after the completion of detection using colorimetric method and turbidimetry, locating piece is moved to reagent It refrigerates above module, after probe module draws reagent, locating piece moves again, and probe module is made to be moved on detection module Reagent and sample mixture are injected in detection module, are detected using performance rate method by side, probe, detection time about 120 Second；For probe module by after in reagent and sample injection to detection module, locating piece drives probe module to turn again to sample disc Above module, pure water is injected into the centrifuge tube of sample disk module, so that the red blood cell rupture of the sample in pipe, and to pure The mixture of water purification and sample stirs, and probe module is drawn in the sample to haemolysis, chylemia colorimetric module after stirring, detection 6 It~10 seconds, is detected with the content to hemoglobin in sample.
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| CN108760659B (en) | 2024-03-22 |
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