CN108752218A - 一种度鲁特韦关键中间体2,4-二氟苄胺制备的新路线 - Google Patents
一种度鲁特韦关键中间体2,4-二氟苄胺制备的新路线 Download PDFInfo
- Publication number
- CN108752218A CN108752218A CN201810791781.9A CN201810791781A CN108752218A CN 108752218 A CN108752218 A CN 108752218A CN 201810791781 A CN201810791781 A CN 201810791781A CN 108752218 A CN108752218 A CN 108752218A
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- CN
- China
- Prior art keywords
- difluorobenzene
- difluorobenzylamines
- lutewei
- key intermediates
- variation route
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZZAJFWXXFZTTLH-UHFFFAOYSA-N Cc(cc(cc1)Cl)c1C#N Chemical compound Cc(cc(cc1)Cl)c1C#N ZZAJFWXXFZTTLH-UHFFFAOYSA-N 0.000 description 1
- QDZZDVQGBKTLHV-UHFFFAOYSA-N NCc(c(F)c1)ccc1F Chemical compound NCc(c(F)c1)ccc1F QDZZDVQGBKTLHV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
- C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
- C07C51/23—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of oxygen-containing groups to carboxyl groups
- C07C51/235—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of oxygen-containing groups to carboxyl groups of —CHO groups or primary alcohol groups
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201810791781.9A CN108752218B (zh) | 2018-07-18 | 2018-07-18 | 一种度鲁特韦关键中间体2,4-二氟苄胺制备的路线 |
Applications Claiming Priority (1)
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CN201810791781.9A CN108752218B (zh) | 2018-07-18 | 2018-07-18 | 一种度鲁特韦关键中间体2,4-二氟苄胺制备的路线 |
Publications (2)
Publication Number | Publication Date |
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CN108752218A true CN108752218A (zh) | 2018-11-06 |
CN108752218B CN108752218B (zh) | 2021-03-19 |
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CN201810791781.9A Active CN108752218B (zh) | 2018-07-18 | 2018-07-18 | 一种度鲁特韦关键中间体2,4-二氟苄胺制备的路线 |
Country Status (1)
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CN (1) | CN108752218B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109761764A (zh) * | 2019-02-16 | 2019-05-17 | 安徽华胜医药科技有限公司 | 一种四步法合成2-溴-2-(2-氟-3-甲氧基苯基)乙酸乙酯的方法 |
Citations (9)
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---|---|---|---|---|
CN101250090A (zh) * | 2008-03-25 | 2008-08-27 | 盐城市绿叶化工有限公司 | 一种对氯苯乙醇的合成方法 |
CN103613591A (zh) * | 2012-09-29 | 2014-03-05 | 天津滨江药物研发有限公司 | 作为cMet抑制剂的化合物及其制备方法和用途 |
WO2015001572A2 (en) * | 2013-07-04 | 2015-01-08 | Hetero Research Foundation | Process for the preparation of intermediate of dolutegravir |
CN105017026A (zh) * | 2015-07-02 | 2015-11-04 | 南京杰运医药科技有限公司 | 2,4-二氟苯甲胺的合成方法 |
CN106565747A (zh) * | 2016-11-10 | 2017-04-19 | 顾世海 | 一种制备度鲁特韦的新方法 |
CN106810460A (zh) * | 2016-12-30 | 2017-06-09 | 苏州诚和医药化学有限公司 | 一种4‑[2‑(二甲基氨基)乙氧基]苄胺的制备方法 |
CN107778161A (zh) * | 2016-10-29 | 2018-03-09 | 江苏沙星化工有限公司 | 一种制备2,3,4,5‑四氟苯甲酸的工艺方法 |
CN108137532A (zh) * | 2015-08-07 | 2018-06-08 | Viiv保健英国第五有限公司 | 作为人免疫缺陷病毒复制的抑制剂的吡啶-3-基乙酸衍生物 |
CN108250087A (zh) * | 2018-03-15 | 2018-07-06 | 常州大学 | 一种4-异丁氧基苄胺的合成方法 |
-
2018
- 2018-07-18 CN CN201810791781.9A patent/CN108752218B/zh active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101250090A (zh) * | 2008-03-25 | 2008-08-27 | 盐城市绿叶化工有限公司 | 一种对氯苯乙醇的合成方法 |
CN103613591A (zh) * | 2012-09-29 | 2014-03-05 | 天津滨江药物研发有限公司 | 作为cMet抑制剂的化合物及其制备方法和用途 |
WO2015001572A2 (en) * | 2013-07-04 | 2015-01-08 | Hetero Research Foundation | Process for the preparation of intermediate of dolutegravir |
CN105017026A (zh) * | 2015-07-02 | 2015-11-04 | 南京杰运医药科技有限公司 | 2,4-二氟苯甲胺的合成方法 |
CN108137532A (zh) * | 2015-08-07 | 2018-06-08 | Viiv保健英国第五有限公司 | 作为人免疫缺陷病毒复制的抑制剂的吡啶-3-基乙酸衍生物 |
CN107778161A (zh) * | 2016-10-29 | 2018-03-09 | 江苏沙星化工有限公司 | 一种制备2,3,4,5‑四氟苯甲酸的工艺方法 |
CN106565747A (zh) * | 2016-11-10 | 2017-04-19 | 顾世海 | 一种制备度鲁特韦的新方法 |
CN106810460A (zh) * | 2016-12-30 | 2017-06-09 | 苏州诚和医药化学有限公司 | 一种4‑[2‑(二甲基氨基)乙氧基]苄胺的制备方法 |
CN108250087A (zh) * | 2018-03-15 | 2018-07-06 | 常州大学 | 一种4-异丁氧基苄胺的合成方法 |
Non-Patent Citations (1)
Title |
---|
荣国斌,等: "《大学有机化学基础 上》", 31 March 2006, 华东理工大学出版社 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109761764A (zh) * | 2019-02-16 | 2019-05-17 | 安徽华胜医药科技有限公司 | 一种四步法合成2-溴-2-(2-氟-3-甲氧基苯基)乙酸乙酯的方法 |
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CN108752218B (zh) | 2021-03-19 |
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Address after: Huangjiao Yantou, Yongquan Town, Linhai City, Taizhou City, Zhejiang Province Patentee after: Zhejiang Shaxing Technology Co.,Ltd. Address before: Huangjiao Yantou, Yongquan Town, Linhai City, Taizhou City, Zhejiang Province Patentee before: ZHEJIANG SHAXING TECHNOLOGY Co.,Ltd. |
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Application publication date: 20181106 Assignee: Zhejiang Shaxing Bohai Technology Co.,Ltd. Assignor: Zhejiang Shaxing Technology Co.,Ltd. Contract record no.: X2023330000338 Denomination of invention: A route for the preparation of 2,4-difluorobenzylamine, a key intermediate of Dulutevir Granted publication date: 20210319 License type: Common License Record date: 20230613 |