CN108744027A - A kind of protein-based liquid adhesive bandage and preparation method thereof - Google Patents
A kind of protein-based liquid adhesive bandage and preparation method thereof Download PDFInfo
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- CN108744027A CN108744027A CN201810722458.6A CN201810722458A CN108744027A CN 108744027 A CN108744027 A CN 108744027A CN 201810722458 A CN201810722458 A CN 201810722458A CN 108744027 A CN108744027 A CN 108744027A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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Abstract
The present invention discloses a kind of protein fluid adhesive bandage and preparation method thereof, protein fluid adhesive bandage is by the way that keratin, glycerine, Radix Notoginseng powder, decanoy acetaldehyde, ethyl alcohol, ethyl acetate and isoamyl acetate to be mixed to prepare, the present invention uses keratin as film forming agent, it is with good biological degradability and biocompatibility and excellent water resistance and toughness.The protein fluid adhesive bandage has no toxic side effect, and does not have any irritation to skin.It is convenient that the protein fluid adhesive bandage is smeared, and can form a film in 1~2min after being coated on wound, can be used for the protection of various wounds.And the protein fluid adhesive bandage soft texture and with elasticity, there is good stickiness with skin, arbitrary bending motion can be carried out with skin, and not easily to fall off.In addition, such protein fluid adhesive bandage water proof good permeability, additionally it is possible to play the role of hemostasis, analgesic and sterilization, at the same time can be effectively facilitated the healing of wound.
Description
Technical field
The invention belongs to medical dressing field, it is related to a kind of protein fluid adhesive bandage and preparation method thereof.
Background technology
Wound will appear inflammation and fester etc. symptoms after contact bacterium and water, therefore critically important to the protection of wound.
People's generally use adhesive bandage protects wound, however adhesive bandage poor air permeability currently on the market, and poor sealing, water and
Bacterium etc. can penetrate into wound by adhesive bandage, be easy to cause wound infection.In addition, for irregular wound, adhesive bandage makes
Use inconvenience.Therefore, the market demand for having the adhesive bandage of excellent waterproof and gas permeability increasingly increases.
Occurs liquid adhesive bandage in existing market, liquid adhesive bandage can quickly form one layer of guarantor after being applied to above wound
Film is protected, can achieve the purpose that the anti-inflammatory that sterilizes, can such as kill Escherichia coli, staphylococcus glucose coccus and Candida albicans
Deng.The shortcomings that liquid adhesive bandage can carry out the wound covering of large area, effective solution traditional adhesive bandage.However, at present
The film-formation result of some liquid adhesive bandage products is poor in the market, irritation is big, is easy to fall off, and with ventilative and anti-infection
The shortcomings of ineffective.Therefore developing natural no stimulation, hemostasis bactericidal effect, good liquid adhesive bandage is still one urgent
The problem of.
Invention content
It is an object of the invention to prepare a kind of smearable liquid using the protein with good biocompatibility
Adhesive bandage, the adhesive bandage have film forming speed fast, and soft texture, quick-acting haemostatic powder is nonirritant, good gas permeability, with skin
There is good stickiness, the excellent properties such as arbitrary bending motion can be carried out with skin, in addition, the adhesive bandage is by being added additionally
Drug and nutriment can effectively completely cut off the invasion of moisture and bacterium, and can effectively promote wound healing, and
Without scar after healing.
The present invention solves its technical problem using following technical scheme to realize：
A kind of preparation method of liquid adhesive bandage, percentage, including keratin 5 %~10%, glycerine 2%~5%, Radix Notoginseng
Powder 1%~1.5%, decanoy acetaldehyde 0.5%~1%, ethyl alcohol 20%~30%, ethyl acetate 25%~35%, isoamyl acetate 30%~40%.
The preparation method of aforesaid liquid adhesive bandage, by the keratolysis in ethanol solution, in 50 DEG C of thermostatted waters
It is persistently stirred in bath, glycerine, Radix Notoginseng powder, decanoy acetaldehyde, ethyl acetate and isoamyl acetate, mixing speed is added after dissolving completely
Protein fluid adhesive bandage is made after mixing for 800rpm.
Each raw material role is as follows in above-mentioned liquid adhesive bandage：
Keratin：It is a kind of good film forming matter not having skin with good biological degradability and biocompatibility
Any irritation has excellent water resistance and toughness.
Glycerine：It is a kind of plasticizer, the toughness and water-resisting property of keratin can be enhanced after addition.In addition glycerine can play
The effect for moisturizing the skin and being retained can be such that healing rate accelerates, mitigate feeling of pain pain.
Radix Notoginseng powder：It is a kind of Chinese medicine, has the function of hemostasis, dissipates the stasis of blood, analgesic.
Decanoy acetaldehyde has the function of antibacterial, can such as kill Escherichia coli, golden Huang staphylococcus etc..
Ethyl alcohol, ethyl acetate, isoamyl acetate：For excellent organic solvent and volatilizer, keratin, sweet can be made
Oil, Radix Notoginseng powder and decanoy acetaldehyde are completely dissolved, and the film-forming that can quickly volatilize after smearing.
Advantageous effect：A kind of protein fluid adhesive bandage and preparation method thereof, including keratin, glycerine, Radix Notoginseng powder, fish raw meat
Careless element, ethyl alcohol, ethyl acetate, isoamyl acetate.
The materials safety that the protein fluid adhesive bandage uses is nontoxic, non-stimulated to skin.Moreover, the protein fluid is created
It can paste with good stickiness, it is not easily to fall off, smooth protective film is formed after smearing on wound.Its film forming speed is very
Soon, after being coated on wound can in 1~2min film-forming, and there is good air permeable waterproof effect, and can rise
To the effect of quick-acting haemostatic powder and antibacterial, the speed to cicatrize a wound is accelerated.
Specific implementation mode
1 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 10g keratolysis in 42g ethyl alcohol
It in solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 4g glycerine, 3.0g Radix Notoginseng powders, 1.0g cordate houttuynias is added after dissolving completely
Element, 60g ethyl acetate and 80g isoamyl acetates, mixing speed 800rpm obtain fluid present invention wound after mixing
It can paste.
The measurement of the liquid adhesive bandage film formation time of preparation, test method are:Choose the experimenter of 16~50 years old age bracket
10 people take the 0.5g adhesive bandage samples of preparation, are applied to the skin surface of volunteer's arm respectively, record the time to form a film every time simultaneously
Calculate average film formation time.
The liquid adhesive bandage hemostasis of preparation, the measurement of antibacterial effect, test method are：10 healthy mices are chosen, are used
Scalpel scratches the leg muscle of mouse, is handled immediately with the liquid adhesive bandage prepared after scuffing, and mouse is observed
The bleeding stopping period of wound and the bacterium infection situation being subject to simultaneously are recorded.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 1 is averaged
Film formation time is 83s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 1 to mouse
After wound is handled, bleeding stopping period 28s, and there are infection phenomenons without any mouse.
2 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 11g keratolysis in 60g ethyl alcohol
It in solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 5g glycerine, 2.9g Radix Notoginseng powders, 1.1g cordate houttuynias is added after dissolving completely
Element, 60g ethyl acetate and 60g isoamyl acetates, mixing speed 800rpm obtain fluid present invention wound after mixing
It can paste.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 2 is averaged
Film formation time is 85s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 2 to mouse
After wound is handled, bleeding stopping period 31s, and there are infection phenomenons without any mouse.
3 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 12g keratolysis in 56g ethyl alcohol
It in solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 6g glycerine, 2.8g Radix Notoginseng powders, 1.2g cordate houttuynias is added after dissolving completely
Element, 62g ethyl acetate and 60g isoamyl acetates, mixing speed 800rpm obtain fluid present invention wound after mixing
It can paste.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 3 is averaged
Film formation time is 81s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 3 to mouse
After wound is handled, bleeding stopping period 35s, and there are infection phenomenons without any mouse.
4 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 13g keratolysis in 56g ethyl alcohol
It in solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 7g glycerine, 2.7g Radix Notoginseng powders, 1.3g cordate houttuynias is added after dissolving completely
Element, 50g ethyl acetate and 70g isoamyl acetates, mixing speed 800rpm obtain fluid present invention wound after mixing
It can paste.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 4 is averaged
Film formation time is 78s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 4 to mouse
After wound is handled, bleeding stopping period 29s, and there are infection phenomenons without any mouse.
5 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 14g keratolysis in 54g second
It in alcoholic solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 10g glycerine, 2.6g Radix Notoginseng powders, 1.4g fish raw meats is added after dissolving completely
Careless element, 52g ethyl acetate and 72g isoamyl acetates, mixing speed 800rpm obtain fluid present invention after mixing
Adhesive bandage.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 5 is averaged
Film formation time is 79s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 5 to mouse
After wound is handled, bleeding stopping period 43s, and there are infection phenomenons without any mouse.
6 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 16g keratolysis in 50g second
It in alcoholic solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 8g glycerine, 2.4g Radix Notoginseng powders, 1.6 g fishes is added after dissolving completely
Raw meat grass element, 52g ethyl acetate and 66g isoamyl acetates, mixing speed 800rpm obtain liquid of the present invention after mixing
Body adhesive bandage.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 6 is averaged
Film formation time is 78s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 6 to mouse
After wound is handled, bleeding stopping period 47s, and there are infection phenomenons without any mouse.
7 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 15g keratolysis in 48g second
It in alcoholic solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 5g glycerine, 2.5g Radix Notoginseng powders, 1.5g fish raw meats is added after dissolving completely
Careless element, 50g ethyl acetate and 78g isoamyl acetates, mixing speed 800rpm obtain fluid present invention after mixing
Adhesive bandage.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 7 is averaged
Film formation time is 83s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 7 to mouse
After wound is handled, bleeding stopping period 33s, and there are infection phenomenons without any mouse.
8 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 17g keratolysis in 46g ethyl alcohol
It in solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 7g glycerine, 2.2g Radix Notoginseng powders, 1.8g cordate houttuynias is added after dissolving completely
Element, 54g ethyl acetate and 78g isoamyl acetates, mixing speed 800rpm obtain fluid present invention wound after mixing
It can paste.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 8 is averaged
Film formation time is 69s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 8 to mouse
After wound is handled, bleeding stopping period 43s, and there are infection phenomenons without any mouse.
9 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 19g keratolysis in 44 g second
It in alcoholic solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 9 g glycerine, 2.3g Radix Notoginseng powders, 1.7g fish raw meats is added after dissolving completely
Careless element, 62g ethyl acetate and 62g isoamyl acetates, mixing speed 800rpm obtain fluid present invention after mixing
Adhesive bandage.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 9 is averaged
Film formation time is 65s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 9 to mouse
After wound is handled, bleeding stopping period 52s, and there are infection phenomenons without any mouse.
10 a kind of protein fluid adhesive bandage of embodiment and preparation method thereof is as follows：By 20g keratolysis in 50g second
It in alcoholic solution, is persistently stirred in 50 DEG C of waters bath with thermostatic control, 10g glycerine, 2.0 g Radix Notoginseng powders, 2.0g fishes is added after dissolving completely
Raw meat grass element, 56g ethyl acetate and 60g isoamyl acetates, mixing speed 800rpm obtain liquid of the present invention after mixing
Body adhesive bandage.
With the test method of liquid adhesive bandage film formation time in embodiment 1, the liquid adhesive bandage that is prepared in example 10 it is flat
Equal film formation time is 63s.
With the test method of hemostasis, antibacterial effect in embodiment 1, with the liquid adhesive bandage prepared in example 10 to mouse
After wound is handled, bleeding stopping period 46s, and there are infection phenomenons without any mouse.
Claims (5)
1. a kind of protein fluid adhesive bandage and preparation method thereof, which is characterized in that including film forming agent, plasticizer, hemostat, resist
Microbial inoculum, solvent；
The film forming agent is keratin, and plasticizer is glycerine, and hemostat is Radix Notoginseng powder, and antiseptic is decanoy acetaldehyde, and solvent is
Ethyl alcohol, ethyl acetate, isoamyl acetate.
2. protein fluid adhesive bandage according to claim 1, which is characterized in that the step of preparation and condition is as follows:
A kind of preparation method of liquid adhesive bandage, percentage, including keratin 5 %~10%, glycerine 2%~5%, Radix Notoginseng
Powder 1%~1.5%, decanoy acetaldehyde 0.5%~1%, ethyl alcohol 20%~30%, ethyl acetate 25%~35%, isoamyl acetate 30%~40%；
It by the keratolysis in ethanol solution, persistently stirs in 50 DEG C of waters bath with thermostatic control, adds after its dissolving completely
Enter glycerine, Radix Notoginseng powder, decanoy acetaldehyde, ethyl acetate and isoamyl acetate, mixing speed 800rpm is made after mixing
Protein fluid adhesive bandage.
3. protein fluid adhesive bandage according to claim 1 and preparation method thereof, which is characterized in that the protein
The step of liquid adhesive bandage and preparation method thereof and condition are as follows:
It by 10g keratolysis in 42g ethanol solutions, persistently stirs in 50 DEG C of waters bath with thermostatic control, is added after dissolving completely
4.0g glycerine, 3.0g Radix Notoginseng powders, 1.0g decanoy acetaldehydes, 60g ethyl acetate and 80g isoamyl acetates, mixing speed 800rpm,
After mixing, the protein fluid adhesive bandage of the present invention is obtained.
4. protein fluid adhesive bandage according to claim 1 and preparation method thereof, which is characterized in that the protein
The step of liquid adhesive bandage and preparation method thereof and condition are as follows:
It by 16g keratolysis in 50g ethanol solutions, persistently stirs in 50 DEG C of waters bath with thermostatic control, is added after dissolving completely
8.0g glycerine, 2.4g Radix Notoginseng powders, 1.6g decanoy acetaldehydes, 52g ethyl acetate and 66g isoamyl acetates, mixing speed 800rpm,
After mixing, the protein fluid adhesive bandage of the present invention is obtained.
5. protein fluid adhesive bandage according to claim 1 and preparation method thereof, which is characterized in that the protein
The step of liquid adhesive bandage and preparation method thereof and condition are as follows:
It by 20g keratolysis in 50g ethanol solutions, persistently stirs in 50 DEG C of waters bath with thermostatic control, is added after dissolving completely
10g glycerine, 2.0g Radix Notoginseng powders, 2.0g decanoy acetaldehydes, 56g ethyl acetate and 60g isoamyl acetates, mixing speed 800rpm,
After mixing, the protein fluid adhesive bandage of the present invention is obtained.
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| CN201810722458.6A CN108744027A (en) | 2018-07-04 | 2018-07-04 | A kind of protein-based liquid adhesive bandage and preparation method thereof |
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| CN201810722458.6A CN108744027A (en) | 2018-07-04 | 2018-07-04 | A kind of protein-based liquid adhesive bandage and preparation method thereof |
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Cited By (3)
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| CN110859989A (en) * | 2019-10-25 | 2020-03-06 | 天津冠勤医药科技有限公司 | Liquid band-aid and preparation method thereof |
| CN113679693A (en) * | 2021-07-28 | 2021-11-23 | 长春工业大学 | Preparation method of atomization type soluble antibacterial anti-inflammation microneedle patch |
| WO2022133628A1 (en) * | 2020-12-21 | 2022-06-30 | 江苏奇力康皮肤药业有限公司 | Degradable liquid band-aid and preparation method therefor |
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| CN110859989A (en) * | 2019-10-25 | 2020-03-06 | 天津冠勤医药科技有限公司 | Liquid band-aid and preparation method thereof |
| WO2022133628A1 (en) * | 2020-12-21 | 2022-06-30 | 江苏奇力康皮肤药业有限公司 | Degradable liquid band-aid and preparation method therefor |
| CN113679693A (en) * | 2021-07-28 | 2021-11-23 | 长春工业大学 | Preparation method of atomization type soluble antibacterial anti-inflammation microneedle patch |
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