CN109157673A - A kind of liquid adhesive bandage - Google Patents
A kind of liquid adhesive bandage Download PDFInfo
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- CN109157673A CN109157673A CN201811253243.0A CN201811253243A CN109157673A CN 109157673 A CN109157673 A CN 109157673A CN 201811253243 A CN201811253243 A CN 201811253243A CN 109157673 A CN109157673 A CN 109157673A
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- liquid adhesive
- adhesive bandage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention provides a kind of liquid adhesive bandages, each component comprising following parts by weight: 1-8 parts of matrine, 1-8 parts of propolis, 5-20 parts of film forming agent, 50-150 parts of solvent, 0.1-18 parts of bioactivity glass, and disclose the preparation method of the liquid adhesive bandage: (1) being uniformly mixed the film forming agent of formula ratio and solvent, forms film-forming composition；(2) matrine, propolis, bioactivity glass, borneol and the transdermal enhancer that formula ratio is added into step (1) resulting film-forming composition, are uniformly mixed and form liquid adhesive bandage.Liquid adhesive bandage film formation time prepared by the present invention is short, and resilience performance is good after forming a film, and satisfied comfort can be brought to user.In addition, liquid adhesive bandage prepared by the present invention while physical barrier moisture content and harmful substance, containing the drug ingedient that can largely promote wound healing, can promote wound healing.
Description
Technical field
The invention belongs to medical domains, and in particular to a kind of adhesive bandage is more particularly to a kind of liquid with water-proof function
Body adhesive bandage.
Background technique
Skin is the maximum organ of human body, in body defenses be used as structural barriers, pathogen can be prevented to invade, it
Protect body from also playing vital effect in excess water loss.Skin wound may be one of lysis
Point, it is also possible to the cause of disease of disease.When skin is by various damages, various kinds of cell and extracellular access are activated, with stringent
Supervision and the mode coordinated, the integrality of recovery organization.Conventionally, the process of wound healing is divided into four different stages:
Hemostasis, inflammation, proliferation and remodeling.In view of the complexity of healing cascade, many factors can intervene agglutination, lead to wound healing
Delay, patient morbidity and the death rate increase, cosmetic result is poor.
In wound healing process, the activities such as bathing, outdoor activities, wound contact can adversely affect wound, because
This, it is particularly important to the nursing of wound.Wound protection film with block water, hinder bacterium, ventilative, transparent performance, such as adhesive bandage, it is right
Wound has good protective effect.Although the traditional adhesive bandage for occupying most of share in market is met to a certain extent
Clinic needs, but its curative effect is unsatisfactory, and there is many problems in use process, such as: adhesion wound, and when replacement leads to machinery
Property is damaged again, dressing bleeding pain；Absorbability is limited；Not waterproof or waterproof is airtight；Bacterium easily penetrates easy infection, incrustation
Hinder wound healing；Large area covering and moving part are limited；Replacement is frequent, dressing heavy workload, easy Remaining debris；Wound table
Face serious dehydration, wound healing time length etc..Liquid adhesive bandage has compared with traditional adhesive bandage as a kind of novel adhesive bandage
There are waterproof, permeability good, moving part limited degree is small, replaces the advantages that convenient and efficient.
Chinese patent announces CN104998295A and discloses a kind of liquid adhesive bandage and preparation method thereof, the liquid adhesive bandage
Raw material composition are as follows: matrine 1%-5%, oxymatrine 1%-5%, setose thistle 10%-15%, borneol 1%-2%, glycerol
0.5%-2%, transdermal enhancer 0.5%-5%, filmogen 3%-8%, remaining is ethyl alcohol, by percentage to the quality.The hair
Bright liquid adhesive bandage, which has, promotes the treatment function such as wound healing, sterilization, antibacterial, reduction pain, can form one in human body surface
Layer film is not afraid of after smearing into water, membrane body tightly flap coverage, easy to use, and safer guarantor is provided than common adhesive bandage
Shield.But the adhesive bandage contains a large amount of alcohol, is also easy to produce feeling of pain in the moment of coating, and the liquid adhesive bandage does not have
Special technology is used to improve the gas permeability of coating film.
Chinese patent announces CN107693840A and discloses a kind of liquid adhesive bandage and preparation method thereof, and the liquid wound can
Patch includes film forming agent, solvent and bioactivity glass.The invention is mainly adjusted by the waterproof of coating film, ventilative and resistance bacterium property
Can, to provide suitable healing environment for wound, but the invention is in the preparation process of liquid adhesive bandage, suitable there is no being added
The drug ingedient of amount, to promote wound healing.
So it is desirable to a kind of not only contain active drug ingredient, but also can effectively waterproof, resistance bacterium, ventilative liquid wound can
Patch.
Summary of the invention
The present invention provides a kind of liquid adhesive bandage, the both Chinese medicine containing anti-inflammatory, antibacterial, moisturizing myogenic in the liquid adhesive bandage
Ingredient, and external environment can effectively be blocked to adversely affect wound bring, the healing rate of wound can be significantly improved.
The present invention provides a kind of liquid adhesive bandage, each component comprising following parts by weight: 1-8 parts of matrine, propolis 1-8
Part, 5-20 parts of film forming agent, 50-150 parts of solvent, 0.1-18 parts of bioactivity glass.
Preferably, the liquid adhesive bandage contains each component of following parts by weight: 1-5 parts of matrine, 1-5 parts of propolis, at
5-14 parts of film, 50-130 parts of solvent, 1-14 parts of bioactivity glass.
The film forming agent is one in nitrocotton, polyacrylic resin, polyvinyl alcohol, collagen, chitosan or gelatin
Kind is a variety of.
The solvent is one of ethyl alcohol, isoamyl acetate, ethyl acetate or a variety of.
Borneol of the liquid adhesive bandage also containing 0.5-1.5 parts by weight in some preferred embodiments.
The liquid adhesive bandage also contains transdermal enhancer in some preferred embodiments.
The transdermal enhancer is azone or Sodium Laurylsulfate.
The parts by weight of the transdermal enhancer are 0.5-1.5 parts.
The weight ratio of the propolis and bioactivity glass is 1:0.1-4；Preferably 1:1-4；More preferably 1:1-3.
The weight ratio of the matrine and solvent is 0.01-0.1；Preferably 0.05-0.09.
The preparation method of the liquid adhesive bandage, comprising the following steps:
(1) film forming agent of formula ratio and solvent are uniformly mixed, form film-forming composition；
(2) matrine, propolis, bioactivity glass, the ice of formula ratio are added into step (1) resulting film-forming composition
Piece and transdermal enhancer are uniformly mixed and form liquid adhesive bandage.
The liquid adhesive bandage is preparing the application in wound reparation product.
Compared with prior art, the invention has the benefit that
(1) liquid adhesive bandage prepared by the present invention both contained have effects that anti-inflammatory, sterilization, moisturizing myogenic traditional Chinese medicine ingredients,
Again containing the regulator for adjusting coating film gas permeability, a peace can be provided for wound while extraneous poor environment is isolated
Complete efficient healing environment.
(2) present invention it has unexpectedly been discovered that, on the basis of inventive formulation, matrine not only has anti-inflammation and sterilization
Effect, additive amount number the film formation time of coating film can also be had an impact.
(3) addition of propolis and bioactive fiber can all have an impact the permeability of coating film, and the present invention passes through connection
It closes and uses propolis and bioactive fiber, not only obtain good ventilative, waterproof effect, also effectively increase the healing of wound
Speed.
(4) the application it has unexpectedly been discovered that, it is different that the pairs of propolis of the group of film forming agent promotes the effect of wound healing to have
It influences, wherein when using polyacrylic resin as film forming agent, optimal healing effect can be obtained.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
A kind of liquid adhesive bandage of embodiment 1
Contain by weight: 1 part of matrine, 8 parts of propolis, 5 parts of film forming agent nitrocotton, 150 parts of solvent, bioactivity
18 parts of glass, the solvent is ethyl alcohol.
A kind of liquid adhesive bandage of embodiment 2
Contain by weight: 8 parts of matrine, 8 parts of propolis, 20 parts of film forming agent polyvinyl alcohol, 50 parts of solvent, biology are living
Property 0.1 part of glass, the solvent be ethyl alcohol and ethyl acetate mixture, and the weight ratio of ethyl alcohol and ethyl acetate be 1:1.
Implement a kind of 3 liquid adhesive bandages
Contain by weight: 3 parts of matrine, 4 parts of propolis, 15 parts of film forming agent chitosan, 60 parts of solvent, bioactivity
3 parts of glass, the mixture for being dissolved as ethyl alcohol and isoamyl acetate, and the weight ratio of ethyl alcohol and isoamyl acetate is 1:0.5.
Implement a kind of 4 liquid adhesive bandages
Contain by weight: 4 parts of matrine, 2 parts of propolis, 18 parts of film forming agent gelatin, 100 parts molten, bioactivity glass
0.5 part of glass, 1.0 parts of borneol, the mixture for being dissolved as ethyl alcohol and isoamyl acetate, and the weight of ethyl alcohol and isoamyl acetate
Than for 1:1.
Implement a kind of 5 liquid adhesive bandages
Contain by weight: 3 parts of matrine, 4 parts of propolis, 20 parts of film forming agent collagen, 80 parts of solvent, biology are living
16 parts of glass of property, 0.5 part of borneol, the mixture for being dissolved as ethyl alcohol and isoamyl acetate, and ethyl alcohol and isoamyl acetate
Weight ratio is 1:0.5.
Implement a kind of 6 liquid adhesive bandages
Contain by weight: 3 parts of matrine, 4 parts of propolis, 20 parts of film forming agent collagen, 80 parts of solvent, biology are living
16 parts of glass of property, it is 1.5 parts of borneol, 1.5 parts of transdermal enhancer azone, described to be dissolved as ethyl alcohol.
Implement a kind of 7 liquid adhesive bandages
Contain by weight: 6 parts of matrine, 5 parts of propolis, 10 parts of film forming agent collagen, 60 parts of solvent, biology are living
15 parts of glass of property, it is 1.0 parts of borneol, 1.5 parts of transdermal enhancer Sodium Laurylsulfate, described to be dissolved as ethyl alcohol.
A kind of liquid adhesive bandage of embodiment 8
Difference with embodiment 5 is only that using polyacrylic resin as film forming agent.
A kind of liquid adhesive bandage of embodiment 9
Difference with embodiment 5 is only that using chitosan as film forming agent.
A kind of liquid adhesive bandage of embodiment 10
It is only that with the difference for implementing 5 using polyvinyl alcohol as film forming agent.
Implement a kind of 11 liquid adhesive bandages
The parts by weight of matrine are changed to 1 part by 3 parts on the basis of identical with embodiment 3.
A kind of liquid adhesive bandage of comparative example 1
The parts by weight of matrine are changed to 10 parts by 3 parts on the basis of identical with embodiment 3.
A kind of liquid adhesive bandage of comparative example 2
The addition of bioactivity glass is omitted on the basis of embodiment 3.
A kind of liquid adhesive bandage of comparative example 3
On the basis of embodiment 2, the addition of propolis is omitted.
A kind of liquid adhesive bandage of comparative example 4
Chinese patent announces the liquid adhesive bandage that in CN107693840A prepared by embodiment 7.
Experimental example 1
According to the permanent deformation of the measurement liquid adhesive bandage of method as defined in comfort in YY/T 0471.4-2004, answer≤
10%；According to the time of pressure filter paper method measurement liquid adhesive bandage drying and forming-film specified in GB/T 1728-1979 (1989).It is real
Test that the results are shown in Table 1.
Table 1
| Permanent deformation/% | Film formation time/s | |
| Embodiment 1 | 5.2 | 25 |
| Embodiment 2 | 5.1 | 26 |
| Embodiment 3 | 5.8 | 21 |
| Embodiment 4 | 5.5 | 29 |
| Embodiment 5 | 6.0 | 22 |
| Embodiment 6 | 6.1 | 26 |
| Embodiment 7 | 5.1 | 30 |
| Embodiment 8 | 5.9 | 22 |
| Embodiment 9 | 6.1 | 21 |
| Embodiment 10 | 5.9 | 23 |
| Embodiment 11 | 8.5 | 30 |
| Comparative example 1 | 11.1 | 36 |
Experimental data in table 1 shows, permanent deformation≤10% of liquid adhesive bandage prepared by the present invention, in use process
In have preferable resilience.The experimental data of embodiment 3, embodiment 11 and comparative example 1 can be sent out in further comparison sheet 1
Film formation time and the resilience performance after its drying existing, that the additive amount of matrine can influence liquid adhesive bandage.By matrine
After additive amount becomes 1 part (embodiment 11) by 3 parts (embodiments 3), the film formation time of liquid adhesive bandage has extended to 30s by 21s,
Permanent deformation has extended to 8.5% by 5.8%.After the additive amount of matrine is become 10 parts (comparative examples 1) by 3 parts (implementing 3),
The film formation time of liquid adhesive bandage has extended to 36s by 21s, and permanent deformation has risen to 11.1% by 5.8%.
Experimental example 2
The effect of model verifies liquid adhesive bandage in different embodiment and comparative examples is cut off by ICR mouse full thickness skin.
1. buying ICR male mice 150 (avoiding influence of the Female Rats oestrus to wound), adapt to environment 7 days, padding
Sterilizing, provides standard rodent food, and water is freely eaten.The intraperitoneal injection of 1.5% Nembutal sodium solution, dosage (1.0ml/
Kg), pet cuts shaving, applies depilatory cream, and the direction after 2min with cotton against hair growth gently wipes, then is removed with clear water residual
It stays.
2. after for 24 hours, being randomly divided into 15 groups (embodiment 1-11 group and comparative example 1-4 groups), every group 10.1.5% penta bars of ratios
Appropriate sodium anesthesia utilizes the identical wound of diameter 8mm punch (75% ethanol disinfection) manufacture size, Right Wound administration, left side
Wound is without any processing, the 4d after wound, 10d, and 16d euthanasia takes tissue and takes pictures.Wound area is calculated using PS software,
Wherein wound healing rate=(wound area when initial wound area-execution)/initial wound area × 100%.Experimental result is such as
Shown in table 2.
Table 2
Experimental data in table 2 shows that liquid adhesive bandage prepared by the present invention can effectively facilitate wound healing, promotes
The effect of wound healing, hence it is evident that announce the prior art (comparative example 4) in CN107693840A better than Chinese patent.Further compare
Compared with the experimental data for implementing 5 and embodiment 8-10 in table 2, it is found that the type of film forming agent significantly affects the 4th day and the 10th day
Wound healing rate, wherein when using polyacrylic resin as film forming agent (embodiment 8), on day 4, the 10th day and the 16th
It, can obtain maximum wound healing rate.By embodiment 3, embodiment 2 experimental data with comparative example 2, comparative example 3 respectively
It is compared, it is found that in this application, bioactivity glass and propolis have forward direction in terms of promoting wound healing
Interaction, when the two exists simultaneously, can make wound faster heal.
Claims (10)
1. a kind of liquid adhesive bandage, it is characterised in that: each component comprising following parts by weight: 1-8 parts of matrine, 1-8 parts of propolis,
5-20 parts of film forming agent, 50-150 parts of solvent, 0.1-18 parts of bioactivity glass.
2. liquid adhesive bandage according to claim 1, it is characterised in that: each component containing following parts by weight: matrine
1-5 parts, 1-5 parts of propolis, 5-14 parts of film forming agent, 50-130 parts of solvent, 1-14 parts of bioactivity glass.
3. liquid adhesive bandage according to claim 1, it is characterised in that: the film forming agent is nitrocotton, polyacrylic acid tree
One of rouge, polyvinyl alcohol, collagen, chitosan or gelatin are a variety of.
4. liquid adhesive bandage according to claim 1, it is characterised in that: the solvent is ethyl alcohol, isoamyl acetate, acetic acid
One of ethyl ester is a variety of.
5. liquid adhesive bandage according to claim 1, it is characterised in that: the liquid adhesive bandage also contains 0.5-1.5 weight
Measure the borneol of part.
6. liquid adhesive bandage according to claim 1, it is characterised in that: the liquid adhesive bandage also contains transdermal promotion
Agent.
7. liquid adhesive bandage according to claim 6, it is characterised in that: the transdermal enhancer is azone or laurel sulfuric acid
Sodium.
8. liquid adhesive bandage according to claim 6, it is characterised in that the parts by weight of the transdermal enhancer are 0.5-1.5
Part.
9. the preparation method of liquid adhesive bandage according to claim 1-8, it is characterised in that: including following step
It is rapid:
(1) film forming agent of formula ratio and solvent are uniformly mixed, form film-forming composition；
(2) added into step (1) resulting film-forming composition the matrine of formula ratio, propolis, bioactivity glass, borneol and
Transdermal enhancer is uniformly mixed and forms liquid adhesive bandage.
10. liquid adhesive bandage according to claim 1 is preparing the application in wound reparation product.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811253243.0A CN109157673A (en) | 2018-10-25 | 2018-10-25 | A kind of liquid adhesive bandage |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811253243.0A CN109157673A (en) | 2018-10-25 | 2018-10-25 | A kind of liquid adhesive bandage |
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| CN109157673A true CN109157673A (en) | 2019-01-08 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111012945A (en) * | 2020-01-06 | 2020-04-17 | 辽宁中医药大学 | Novel waterproof traditional Chinese medicine liquid band-aid and preparation method thereof |
| CN112245652A (en) * | 2020-10-16 | 2021-01-22 | 合肥贝壳派创新科技有限公司 | Bacteriostatic liquid band-aid capable of quickly forming film and preparation method thereof |
| CN114470311A (en) * | 2021-12-31 | 2022-05-13 | 泰州市榕兴医疗用品股份有限公司 | Liquid band-aid and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5568369A (en) * | 1978-11-15 | 1980-05-23 | Max Planck Gesellschaft | Transparent liquid bandage material and its preparation |
| CN104998295A (en) * | 2015-07-03 | 2015-10-28 | 宁夏职业技术学院 | Liquid woundplast, and preparation method thereof |
| US20150343112A1 (en) * | 2014-06-02 | 2015-12-03 | Problem Solving Products, Llc | Liquid bandage |
| KR20160036943A (en) * | 2014-09-26 | 2016-04-05 | 안용훈 | Manufacturing method about a liquid band containing a herb extracts |
| CN105688270A (en) * | 2016-01-07 | 2016-06-22 | 王清清 | Liquid band-aid and preparing method thereof |
| CN105797202A (en) * | 2016-03-23 | 2016-07-27 | 广州瑞辉生物科技股份有限公司 | Liquid band-aid and preparing method thereof |
| CN107693840A (en) * | 2016-08-09 | 2018-02-16 | 北京纳通医学科技研究院有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
-
2018
- 2018-10-25 CN CN201811253243.0A patent/CN109157673A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5568369A (en) * | 1978-11-15 | 1980-05-23 | Max Planck Gesellschaft | Transparent liquid bandage material and its preparation |
| US20150343112A1 (en) * | 2014-06-02 | 2015-12-03 | Problem Solving Products, Llc | Liquid bandage |
| KR20160036943A (en) * | 2014-09-26 | 2016-04-05 | 안용훈 | Manufacturing method about a liquid band containing a herb extracts |
| CN104998295A (en) * | 2015-07-03 | 2015-10-28 | 宁夏职业技术学院 | Liquid woundplast, and preparation method thereof |
| CN105688270A (en) * | 2016-01-07 | 2016-06-22 | 王清清 | Liquid band-aid and preparing method thereof |
| CN105797202A (en) * | 2016-03-23 | 2016-07-27 | 广州瑞辉生物科技股份有限公司 | Liquid band-aid and preparing method thereof |
| CN107693840A (en) * | 2016-08-09 | 2018-02-16 | 北京纳通医学科技研究院有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111012945A (en) * | 2020-01-06 | 2020-04-17 | 辽宁中医药大学 | Novel waterproof traditional Chinese medicine liquid band-aid and preparation method thereof |
| CN111012945B (en) * | 2020-01-06 | 2022-02-15 | 辽宁中医药大学 | Waterproof traditional Chinese medicine liquid band-aid and preparation method thereof |
| CN112245652A (en) * | 2020-10-16 | 2021-01-22 | 合肥贝壳派创新科技有限公司 | Bacteriostatic liquid band-aid capable of quickly forming film and preparation method thereof |
| CN114470311A (en) * | 2021-12-31 | 2022-05-13 | 泰州市榕兴医疗用品股份有限公司 | Liquid band-aid and preparation method thereof |
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