KR101858835B1 - composition of an aerosol formulation for spray band and method for preparing the same - Google Patents

Abstract

The present invention relates to a composition for a spray band of an aerosol formulation and a process for producing the composition, and more particularly, to a composition for spray bands of an aerosol formulation and a process for producing the composition, which comprises 5 to 10 wt% of an acrylic copolymer, 10 to 25 wt% of 1,3- 1 to 5 wt%, mastic oil 0.5 to 3 wt%, and spraying agent 25 to 50 wt%. The present invention also relates to a composition for a spray band of an aerosol formulation and a method for preparing the same.

Description

Compositions for spray bands of aerosol formulations and methods of preparing the same

The present invention relates to a composition for a spray band and a process for producing the same. More specifically, the present invention relates to an acrylic copolymer, 1,3-dioxolane, a volatile solvent, a tackifier, a propellant, The present invention relates to a composition for an aerosol-type spray band and a method for manufacturing the same, which are capable of protecting wounds at a bent portion and being excellent in stretchability, ventilation and waterproofing, thereby protecting wounds in daily life and in water.

Skin wound protection materials have been in use since the early days of artificial skin research and have been used up to now, and they are mainly used for treatment such as burns and trauma. If a skin injury occurs, a temporary protective film, such as silicone or dressing, is attached until it is newly grown or the skin of the patient's skin is transplanted to protect the affected part temporarily until the damaged skin is recovered. And to absorb the exudate (liquid collected outside the blood vessels when inflammation is present) and prevents infestation and infection from outside. In addition to the gel application, it is made of a porous film using a polyurethane film or chitin, or a freeze-dried product of pig leather.

In other words, the skin wound protection material is a medical device that touches directly to wounded skin for the purpose of preventing and protecting the wounds. It protects wounds including biosynthesis, prevents contamination and prevents the absorption of effusion, loss of blood or loss of body fluids To be able to do so. The method of using the skin wound protecting material may vary depending on the form of the product such as a sheet, a gel, a spray, and the like. Currently, the skin wound care materials currently in circulation are manufactured in various forms such as polyurethane foam, sheet and liquid.

The dual liquid type skin wound protection material can be used simultaneously to protect and treat wound area, can be recovered quickly, and can be made into a spray formulation, etc., so that technology development and cost reduction can be realized. It is one of the areas where research is being actively carried out because it has the merit of being able to treat.

For example, Patent Document 1 discloses a liquid band for protecting skin and wounds, and a method for producing the same, which comprises a polyurethane and a volatile solvent and is made of a pressure sensitive adhesive, a fragrance, a moisturizer, a skin sedative, a local anesthetic, Patent Document 2 discloses a fluid composition such as an aerosol spray which is applied as a fluid to a surface but then dried to form a cover element such as a patch, And patent document 3 discloses a method of spraying a skin aerosol composition composed of a stock solution containing an acrylic resin, a plasticizer and an alcohol and a spray agent (propellant) onto human skin and drying the same in a flat membrane state. A method for producing a film, a method for producing a human skin Membrane and is the human skin discloses aerosol compositions used for the production method.

However, such conventional liquid bands are inconvenient to use a separate brush when applied to a wound, and may cause pain when the brush is in contact with the wound. In order to protect the wound or to form a wound, There is a problem that the elasticity and water resistance of the film are not very easy due to the nature of the film, and thus the mobility thereof is not easy. In the case where the film is used for wounds having curved portions such as joints, the stretchability and the movability of the liquid bands are poor, There is a problem that causes pain, and since the water band is easily detached from the water due to lack of waterproof property, it is not possible to protect 100% of the wound and it is troublesome to repeatedly apply it.

Registration No. 10-1125162 (Published on September 29, 2010) Registered Patent No. 10-0604295 (issued on September 09, 2001) Japanese Patent No. 3805521 (published on October 27, 1998)

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems, and its object is to provide a composition for a spray band of an aerosol formulation, which can be used in a bent region, is convenient to use, And the like.

In order to accomplish the above object, the present invention provides an aerosol formulation for a spray band comprising 5 to 10 wt% of an acrylic copolymer, 10 to 25 wt% of 1,3-dioxolane, 15 to 55 wt% of a volatile solvent, 1 to 5 wt% of an enhancer, 0.5 to 3 wt% of a mastic oil, and 25 to 50 wt% of a propellant (propellant).

number
Composition
Permissible composition range (wt%)
One
Acrylic copolymer
5 to 10
2
1,3-dioxolan
10-25
3
Volatile solvent
15 ~ 55
4
Adhesion enhancer
1-5
5
Mastic oil (flavoring agent)
0.5 to 3
6
Propellant (propellant)
25 to 50
Sum
100

Also, the acrylic copolymer may be prepared by mixing 30 to 80 wt% of ethyl acrylate (EA) and 20 to 70 wt% of methyl methacrylate (MMA), and the acrylic copolymer may include 1,3- 30 wt%.

The volatile solvent may be at least one selected from the group consisting of ethanol, benzyl alcohol, isopropyl alcohol, ethyl acetate and acetone.

Further, the adhesion-enhancing agent is characterized by being at least one selected from the group consisting of polyvinylpyrrolidone, silicone and Luvimer 100P.

The propellant may be at least one selected from the group consisting of dimethyl ether (DME), LPG, air, carbon dioxide, nitrogen, and pouch.

The spray band may further include at least one of a fragrance, a moisturizer, and a disinfectant.

The perfume may be at least one selected from the group consisting of lemon fragrance, lavender fragrance, citrus fragrance, menthol, and methyl salicylate. The humectant may be at least one selected from petrolatum or glycerin, and the disinfectant may be at least one selected from ethanol, isopropanol or camphor .

The method for preparing a composition for a spray band of an aerosol formulation of the present invention comprises the steps of preparing an acrylic copolymer containing 30 to 80 wt% of ethyl acrylate (EA) and 20 to 70 wt% of methyl methacrylate (MMA) ; Dissolving the acrylic copolymer in a weight ratio of 3: 7 to 1,3-dioxolane to prepare an acrylic copolymer stock solution; Dissolving the stock solution in ethanol; Adding an adhesion-promoting agent, stirring the mixture for 30 minutes, and then adding mastic oil to prepare a liquid band of an aerosol formulation; And filling the liquid band with a jetting agent (propellant).

According to the composition for a spray band of the aerosol formulation of the present invention, it is a composition for a spray band which applies a polymer material secure to the skin. It is convenient to apply to a wound site due to a method of spraying on a wound site, The elasticity, the ventilation and the waterproofing are excellent, so that it does not fall well in everyday life and under water, and the wound can be well protected.

1 is a schematic view of a waterproof test apparatus.
FIG. 2A is a filter paper view of a spray band of an aerosol formulation according to the present invention before water resistance test, and FIG. 2B is a filter paper view after a water resistance test.

Hereinafter, the present invention will be described in detail.

The present invention relates to a composition for a spray band of an aerosol formulation and a method for producing the same, and more particularly, to a composition for a spray band of an aerosol formulation and a process for producing the same. The composition includes an acrylic copolymer, 1,3-dioxolane, a volatile solvent, a tack strength improving agent, a mastic oil and a propellant .

The acrylic copolymer is preferably composed of 30 to 80 wt% of ethyl acrylate (EA) and 20 to 70 wt% of methyl methacrylate (MMA).

When the ethyl acrylate (EA) and the methyl methacrylate (MMA) are out of the allowable range, the glass transition temperature (Tg) is changed. When the glass transition temperature is elevated, so-called plasticization occurs. When the glass transition temperature is lowered, If it goes down too much, the viscosity will be very low.

Generally, when the content of ethyl acrylate (EA) is increased, the rubberization proceeds, and when the content of methyl methacrylate (MMA) is increased, curing (plasticization) occurs, % And methyl methacrylate in an amount of 40 wt%.

In addition, although it is preferable to use the above-mentioned acrylic copolymer, since the acrylic copolymer is very difficult to be used immediately by itself due to its high viscosity, the acrylic copolymer can be dissolved and used in a material .

For example, it is preferable that 1,3-dioxolane is mixed with about 30 wt% of an acrylic copolymer, that is, an acrylic copolymer is mixed and dissolved in 1,3-dioxolane at a weight ratio of 3: 7 .

When the amount of the acrylic polymer is more than 30 wt%, the concentration of the acrylic polymer is increased. When the amount of the acrylic polymer is less than 30 wt%, the quality of the acrylic polymer may be deteriorated.

The volatile solvent may be at least one selected from the group consisting of ethanol, benzyl alcohol, isopropyl alcohol, ethyl acetate and acetone, and may be used alone or in combination.

The film-forming agent may include an adhesion-promoting agent. The adhesion-promoting agent may be at least one selected from the group consisting of polyvinylpyrrolidone, silicone, and Luvimer 100P, and may be used alone or in combination.

In addition, the adhesion-promoting agent can be mixed with alcohol or the like, and is easy to adhere to the skin in terms of adhesive strength, so that it can be usefully used as an additive in the production of bands.

On the other hand, the mastic oil used in the present invention is a mastic oil, which is formed only in the Greek island of Pichia lentis, When it is collected, it becomes mastic resin or mastic gum or mastic oil which is dissolved in vegetable oil.

The mastic oil is also referred to as mastic resin or mastic gum. It is used as medicine or quasi-drug. When used as a quasi-drug, mastic oil or mastic gum is extracted with high purity and used do.

In addition to possessing strong antibacterial activity against Helicobacter pylori, which is generally caused by mastic oil or mastic resin or mastic black coloring agent and stomach and duodenal ulcer (New England journal of medicine, vol. 339-1946, No. 26, 12.24.1998) and antibiotics against common bacteria (Escherichia coli, Staphylococcus aureus, and Bacillus subtilis) (Japanese University of Kanagawa Dental Bacteriology Laboratory and J. Asri. (20), 7681-5, 2005), periodontal disease, wound, and acne. It is also known to be effective in food products (Jinju, No. 2014-50) or cosmetics CAS No. 61789-92-2), and the like.

The composition for a spray band of the aerosol formulation of the present invention can use 1 to 3 wt% of mastic oil as a flavoring agent. If the content is less than 1 wt%, the effect is deteriorated. If the content is more than 3 wt%, the flavoring effect may be improved. However, since the mastic oil is an expensive raw material, the manufacturing cost is increased.

The propellant may be at least one selected from the group consisting of Dimethyl Ether (DME), LPG, Air, Carbon dioxide, Nitrogen, and Pouch. have.

The present invention may further include at least one of a fragrance, a moisturizing agent or a disinfecting agent, if necessary.

The perfume may be at least one selected from the group consisting of lemon, lavender, citrus, menthol, and methyl salicylate.

The moisturizing agent may be at least one selected from petrolatum or glycerin, and may be used in an amount of about 1 to 5 wt%, preferably about 5 wt%, alone or in combination.

The disinfecting agent may be at least one selected from ethanol, isopropanol or camphor, and may be used in an amount of about 1 to 5 wt%, preferably about 5 wt%, alone or in combination.

In a preferred embodiment of the present invention, the composition for a spray band comprises 5 to 10 wt% of an acrylic copolymer, 10 to 25 wt% of 1,3-dioxolane, 15 to 55 wt% of a volatile solvent, 1 to 5 wt% An aerosol formulation consisting of 1.5 to 2.5 wt% of a stick oil and 25 to 50 wt% of a propellant (propellant).

If the content of 1,3-dioxolane is less than 10 wt%, which is a function of dissolving the acrylic copolymer, the acrylic copolymer and the 1,3- -Dioxolane mixture is highly viscous and may cause inconvenience of poor spraying when used as an aerosol type spray band, and if it exceeds 25 wt%, the viscosity of the mixture of acrylic copolymer and 1,3-dioxolane It is not easy to use it because it is injected so as to spread widely rather than being concentrated injection at a wound site.

The present invention is preferably used as a spray band of an aerosol formulation, and it is preferable that the aerosol formulation is dried within about 3 minutes after spraying to form a film-like film.

However, when the volatile solvent is less than 15 wt%, it is not uniformly and completely mixed with the volatile solvent and the propellant (propellant). When the volatile solvent is more than 55 wt%, the drying time is slowed, have.

On the other hand, when the present invention is used as a spray band of an aerosol formulation, since the 1,3-dioxolane and the volatile solvent are all volatilized into the air, the physical properties of the raw material may vary depending on the content of the 1,3-dioxolane and the volatile solvent, 1,3-dioxolane and the volatile solvent are all volatilized, it is considered that the 1,3-dioxolane and the volatile solvent do not greatly affect the physical properties.

When the adhesive strength improving agent is less than 1 wt%, the adhesive property is lowered and it is difficult to protect the wounds and the like in the curved portion. In particular, the adhesive strength improving agent can be easily dropped in water, and if it exceeds 5 wt%, the adhesive property becomes excessively high.

In addition, although the present invention includes mastic oil as a flavoring agent, its inherent antibacterial action and effect can also be expected.

When the propellant (propellant) is less than 15 wt%, the aerosol formulation may fail to inject uniformly after spraying. If the propellant is more than 50 wt%, the aerosol type is difficult to form due to the low concentration of the stock solution during spraying.

A method for producing a composition for a spray band of an aerosol formulation of the present invention is as follows.

First, an acrylic copolymer containing 30 to 80 wt% of ethyl acrylate (EA) and 20 to 70 wt% of methyl methacrylate (MMA) is prepared.

Dissolving the acrylic copolymer in a weight ratio of 3: 7 to 1,3-dioxolane to prepare an acrylic copolymer stock solution;

Dissolving the stock solution in ethanol; Here

Adding an adhesion-promoting agent, stirring the mixture for 30 minutes, and then adding mastic oil to prepare an aerosol-type spray stock solution; And

And filling the spraying liquid with a jetting agent (propellant).

Hereinafter, the present invention will be described concretely with reference to Examples. However, the following Examples and Experimental Examples are merely illustrative of one form of the present invention, and the scope of the present invention is not limited by the following Examples and Experimental Examples .

Reference Example  One

≪ Process for producing acrylic copolymer >

After adding 200 g of distilled water as a solvent to a three-necked polymerization reactor, 15 g of ethyl acrylate (EA) and 10 g of methyl methacrylate (MMA) were added to 30 g of distilled water, and then 0.3 g of an emulsifier, sodium lauryl sulfate . Then, 0.3 g of potassium persulfate, which is an initiator, is put into a 3% aqueous solution and reacted at 80 ° C. for 3 hours to obtain an acrylic copolymer.

Reference Example  2

<Mastic extraction>

20 g of mastic oil (Chios gum mastic) was stirred for 3 hours at 45 ° C and 50 rpm in anhydrous ethanol at a ratio of 1:10 (w / v), and then the mixture was stirred for 1 hour at room temperature Precipitate.

The supernatant of the mastic ethanol solution was filtered through a filter paper, and the filtered supernatant was concentrated under reduced pressure using a rotary vacuum evaporator at 45 ° C to obtain 18 g of a high-purity mastic extract.

Example  One

&Lt; Preparation of spray liquid for aerosol formulation >

An acrylic copolymer stock solution obtained by dissolving the acrylic copolymer obtained in Reference Example and 1,3-dioxolane at a weight ratio of about 3: 7 is used as a raw material for a spray band of an aerosol formulation. The raw material of the spray band of the aerosol formulation was dissolved in 37.7% by weight of ethanol. To the mixture was added 2.6% by weight of lubimer and the mixture was stirred for about 30 minutes. Then, 2% by weight of mastic oil was added thereto, Use as a stock solution of the band. The spray-base stock solution was placed in an aluminum can and 36 wt% of dimethyl ether was charged to prepare an aerosol-formulated composition for a spray band of the present invention.

Example  2

The composition was prepared in the same manner as in Example 1 except that an acrylic copolymer and 1,3-dioxolane were used in a weight ratio of 2: 8 to prepare a composition for an aerosol-type spray band.

Example  3

The composition was prepared in the same manner as in Example 1 except that an acrylic copolymer and 1,3-dioxolane were used in a weight ratio of 4: 6 to prepare a composition for a spray band of an aerosol formulation.

Example  4

The composition was prepared in the same manner as in Example 1 except that 20 wt% of ethanol was used and 53.7 wt% of a propellant (propellant) was used to prepare a composition for a spray band of an aerosol formulation.

Example  5

The composition was prepared in the same manner as in Example 1 except that 59.7% by weight of ethanol was used and 14% by weight of a propellant (propellant) was used for a spray band of an aerosol formulation.

Comparative Example

A medi-liquid liquid of a polyurethane component (Genewell, Korean Monsanto Co., Ltd.), which is conventionally used as a liquid band, was used instead of the spray band of the aerosol formulation of the acrylic copolymer in the solution state prepared in the above Example After purchase, maximum stress value and elongation were measured and water resistance was measured.

Experimental Example

&Lt; Evaluation of physical properties &

In order to confirm the physical properties of the composition for a spray band of the aerosol formulation prepared in the above example, a composition for a spray band of an aerosol formulation in a solution state was sprayed to a predetermined thickness (100 μm) and dried at 370 ° C. for 5 minutes A film was prepared.

1) Identification of mechanical properties of spray bands of aerosol formulation (tensile strength)

The film was subjected to a tensile test with an Instron tensile machine (ASTM D-638-03, Instron US 3360 series). The tensile test was carried out at a cross-head speed of 50 mm / min after placing a dog-bone shaped film between grips. The maximum stress ) And the elongation were obtained and are shown in Table 2. &lt; tb &gt; &lt; TABLE &gt;

2) Spray band water resistance test of aerosol formulation

As in the tensile strength test method, the spray band of the aerosol formulation was made into an acrylic copolymer film, cut into a size of 7 cm in diameter, and then taken out of 5, and left at a humidity of 65% and a temperature of 200 ° C for 2 hours or more. After that, the film and dry filter paper were fixed to the waterproof experiment device, the waterproof test device was filled with distilled water up to 500 mL, the valve was opened to put the water into the chamber, and the scale of the distilled water was not changed The change in scale and the dry filter paper wet state were observed for 5 minutes (see FIG. 1).

As a result, there was no change in the scale of the distilled water for 5 minutes, and it was confirmed that the dry filter paper was not wetted and was waterproof.

The results of the spray band water resistance test of the aerosol formulation of Example 1 are shown in Figures 2a and 2b and the filter paper is not wetted as shown in Figure 2b.

3) pH measurement

As in the tensile strength test, the spray band of the aerosol formulation was prepared as an acrylic copolymer film, and the pH of the eluted solution was measured. The eluate was prepared by adding 20 mL of saline per 4 g to the prepared film, followed by elution at 720 ° C for 24 hours. The results are shown in Table 2.

4) Moisture Vapor Transmission Rate (MVTR)

In order to measure the moisture permeability of the spray band of the aerosol formulation, an acrylic copolymer film was prepared similarly to the tensile strength test, and then a circular test piece having a diameter of 70 mm was prepared and the test specimen was prepared first. For the measurement of the moisture permeability, the moisture permeable cup was placed on a horizontal moisture permeable cup, and 20 g of calcium chloride as a moisture absorbent was placed in the moisture permeable cup in advance, and the prepared test piece was placed on the moisture permeable cup so as to be concentric. The weight of the test piece was put on the edge of the moisture permeable cup, and the paraffin solution was poured into the edge of the permeable cup to seal the edge of the test piece. After the paraffin solution was hardened, weighed cups with bonded test pieces were weighed, and then left for 24 hours at a temperature of 370 ° C and a humidity of 85%. The weight of the bonded cups was measured to determine the area and time The moisture permeability is shown in Table 2 below.

Properties
Example 1
Example 2
Example 3
Example 4
Example 5
Comparative Example
pH
7.5
7.3
7.6
7.4
7.7
6.5
Film tensile strength
(at break)
(kgf / cm ² )
360
362
363
357
360
260
Elongation (%)
610
605
590
610
600
30
Moisture permeability MVTR (g / m ^{2 ·} day)
650
660
650
650
660
470

The spray bands prepared from the acrylic copolymer raw solution of the present invention, as compared with the conventional polyurethane raw solution, show excellent test results such as film tensile strength, elongation, and moisture permeability as shown in Table 2.

1: pressure gauge 2a, 2b: gasket
3: Filter paper 4: Specimen

Claims (9)

5 to 10 wt% of an acrylic copolymer containing 30 to 80 wt% of ethyl acrylate (EA) and 20 to 70 wt% of methyl methacrylate (MMA), 10 to 25 wt% of 1,3-dioxolane, Wherein the composition comprises 15 to 55 wt% of a solvent, 1 to 5 wt% of a tackiness-improving agent, 0.5 to 3 wt% of a mastic oil, and 25 to 50 wt% of a spraying agent. delete The method according to claim 1,
Wherein the volatile solvent is at least one selected from the group consisting of ethanol, benzyl alcohol, isopropyl alcohol, ethyl acetate and acetone. The method according to claim 1,
Wherein the spray agent is at least one selected from the group consisting of dimethyl ether (DME), LPG, air, carbon dioxide nitrogen, and pouch. The method according to claim 1,
Wherein the adhesion-enhancing agent is at least one selected from the group consisting of polyvinylpyrrolidone, silicone, and lubimer 100P (Luvimer 100P, BASF). The method according to claim 1,
A perfume, a perfume, a perfume, a perfume, a perfume, a disinfectant, a perfume or a disinfectant. The method according to claim 6,
Wherein the perfume is at least one selected from the group consisting of lemon fragrance, lavender fragrance, citrus fragrance, menthol, and methyl salicylate, the humectant is at least one selected from petrolatum and glycerin, and the disinfectant is at least one selected from ethanol, isopropanol and camphor A composition for a spray band of an aerosol formulation. Preparing an acrylic copolymer comprising 30 to 80 wt% of ethyl acrylate (EA) and 20 to 70 wt% of methyl methacrylate (MMA);
Dissolving 5 to 10 wt% of the acrylic copolymer in 10 to 25 wt% of 1,3-dioxolane to prepare an acrylic copolymer stock solution;
Dissolving the acrylic copolymer raw solution in 15 to 55 wt% of a volatile solvent;
Adding 1 to 5 wt% of an adhesion promoter, stirring the mixture for 30 minutes, adding 0.5 to 3 wt% of mastic oil, which is a flavoring agent, to make an aerosol formulation; And
And filling the injector with a spraying agent. The method for manufacturing a composition for a spray band of an aerosol formulation according to claim 1, 9. The method of claim 8,
Acrylic copolymer was dissolved in 1,3-dioxolane in a weight ratio of 2: 8, 3: 7 or 4: 6, the volatile solvent was ethanol, and the adhesion promoter was polyvinylidone, silicone or lubimer 100P , Manufactured by BASF). &Lt; / RTI &gt;

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