KR101539675B1 - Hydrogel patch for wound healing and monitoring - Google Patents
Hydrogel patch for wound healing and monitoring Download PDFInfo
- Publication number
- KR101539675B1 KR101539675B1 KR1020130112983A KR20130112983A KR101539675B1 KR 101539675 B1 KR101539675 B1 KR 101539675B1 KR 1020130112983 A KR1020130112983 A KR 1020130112983A KR 20130112983 A KR20130112983 A KR 20130112983A KR 101539675 B1 KR101539675 B1 KR 101539675B1
- Authority
- KR
- South Korea
- Prior art keywords
- hydrogel
- wound
- monitoring
- patch
- present
- Prior art date
Links
- 239000000017 hydrogel Substances 0.000 title claims abstract description 39
- 238000012544 monitoring process Methods 0.000 title claims abstract description 12
- 230000029663 wound healing Effects 0.000 title description 6
- 230000000740 bleeding effect Effects 0.000 claims abstract description 10
- 208000014674 injury Diseases 0.000 claims abstract description 10
- 230000008733 trauma Effects 0.000 claims abstract description 10
- 206010052428 Wound Diseases 0.000 claims description 30
- 208000027418 Wounds and injury Diseases 0.000 claims description 30
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 claims description 24
- 239000000284 extract Substances 0.000 claims description 23
- 240000007124 Brassica oleracea Species 0.000 claims description 22
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 claims description 22
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 claims description 22
- 239000007793 ph indicator Substances 0.000 claims description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 8
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 8
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 8
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 7
- 239000000499 gel Substances 0.000 claims description 7
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 7
- 206010061218 Inflammation Diseases 0.000 claims description 6
- 230000004054 inflammatory process Effects 0.000 claims description 6
- 229920001817 Agar Polymers 0.000 claims description 5
- 239000008272 agar Substances 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 238000002169 hydrotherapy Methods 0.000 claims description 2
- 208000035143 Bacterial infection Diseases 0.000 abstract description 9
- 208000022362 bacterial infectious disease Diseases 0.000 abstract description 9
- 241000894006 Bacteria Species 0.000 abstract description 6
- 238000004519 manufacturing process Methods 0.000 description 13
- 208000032843 Hemorrhage Diseases 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 208000015181 infectious disease Diseases 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 235000010419 agar Nutrition 0.000 description 4
- 229930002877 anthocyanin Natural products 0.000 description 4
- 235000010208 anthocyanin Nutrition 0.000 description 4
- 239000004410 anthocyanin Substances 0.000 description 4
- 150000004636 anthocyanins Chemical class 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 208000034158 bleeding Diseases 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- OHVLMTFVQDZYHP-UHFFFAOYSA-N 1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-2-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound N1N=NC=2CN(CCC=21)C(CN1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)=O OHVLMTFVQDZYHP-UHFFFAOYSA-N 0.000 description 2
- 244000178937 Brassica oleracea var. capitata Species 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 230000036074 healthy skin Effects 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 230000037390 scarring Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LDXJRKWFNNFDSA-UHFFFAOYSA-N 2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]ethanone Chemical compound C1CN(CC2=NNN=C21)CC(=O)N3CCN(CC3)C4=CN=C(N=C4)NCC5=CC(=CC=C5)OC(F)(F)F LDXJRKWFNNFDSA-UHFFFAOYSA-N 0.000 description 1
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000008952 bacterial invasion Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 238000010335 hydrothermal treatment Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000002648 laminated material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00059—Accessories for dressings provided with visual effects, e.g. printed or colored
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/729—Agar; Agarose; Agaropectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Abstract
본 발명은 외상 치료 및 모니터링용 수화겔 패치에 관한 것이다. 본 발명에 따르면, 드레싱을 바꾸지 않으면서도 세균 감염 여부를 확인할 수 있고, 출혈 여부를 판단할 수 있어, 종래 상처의 감염 및 출혈 여부를 알아보기 위해 드레싱을 정기적으로 교체하는 불편함을 해소하고, 드레싱의 교체 과정에서 생길 수 있는 세균 감염의 가능성을 차단할 수 있다.The present invention relates to a hydrogel patch for trauma treatment and monitoring. According to the present invention, it is possible to confirm whether or not a bacterial infection has occurred without changing the dressing, and it is possible to judge whether or not bleeding occurs. Thus, it is possible to solve the inconvenience of periodically replacing the dressing, The possibility of a bacterial infection that may occur during the replacement of the bacteria can be prevented.
Description
본 발명은 외상 치료 및 모니터링용 수화겔 패치에 관한 것이다.
The present invention relates to a hydrogel patch for trauma treatment and monitoring.
일반적으로 상처의 치료는 수분환경을 유지하는 경우가 건조한 상태보다 치료 속도가 훨씬 빠른 것은 이미 공지의 사실인바[Rake B.A, Appl. Nurs. Res. 1998, 11, 174-182], 상처 치료를 위한 최적의 수화겔(hydrogels)을 제조하기 위한 노력이 진행되어 오고 있다.In general, it is known that the treatment of wounds is faster than the treatment of dryness in the case of maintaining the moisture environment. [Rake B.A., Appl. Nurs. Res. 1998, 11, 174-182), efforts have been made to produce optimal hydrogels for wound healing.
수화겔은 작은 상처 회복에 쓰이는 처치제로서, 상처 부위를 촉촉하게 하여 세균 침범 방지 및 흉터 방지 효과가 있고, 건식 제품 대비 습식 드레싱제의 장점이 연구결과와 업체의 메스컴 홍보로 알려지면서 제약사 간의 신제품 출시 및 마케팅 강화와 시장경쟁이 치열해진 바 있다. 특히 시장에서 가장 주목을 받고 있는 ‘하이드로콜로이드’ 소재의 습윤 드레싱제 성장세가 눈에 띄게 증가하고 있다. 습윤 드레싱제는 자연치유물질인 진물을 흡수해 상처를 빠르게 회복시키며 가피 생성을 막아 흉터 발생을 최소화시키기 때문에 미용에 대한 관심이 높은 여성 및 아이를 가진 부모들을 중심으로 사용자가 늘어나는 추세이고, 천연고분자들의 생체적합성, 생분해성, 항균력을 이용하여 의료용 소재로 이용 가능한 다양한 형태의 스펀지가 개발되고 있다.The hydrogel is a treatment used for the recovery of small wounds. It moisturizes the wound area to prevent bacterial invasion and scarring. The advantage of wet dressing compared to dry products is known as research results and the company's medical press announcement. And marketing and market competition have intensified. In particular, the growth of the "wet colloidal" wet dressing agent, which is receiving the most attention in the market, is increasing remarkably. The wet dressing agent absorbs the natural healing substance to recover the wound quickly and prevents the scarring by preventing the scar formation. Therefore, there is a tendency that the number of users is increasing mainly around parents who have a high interest in beauty, Various types of sponges which can be used as medical materials have been developed by utilizing the biocompatibility, biodegradability, and antibacterial activity of the sponges.
수화겔은 습윤 상태가 지속적으로 요구되는 화상치료 또는 피부 재생을 목적으로 사용되는 재료로서 상기 수화겔이 대개 60% 이상의 수분을 함유하여야만 상기 목적에 이용될 수 있다. 심한 화상 치료의 경우, 최종적으로는 자가이식이나 환자의 섬유아세포의 생체 내(in vivo) 배양한 조직을 이식하게 되는데, 상기의 시술을 시행하기까지는 상당한 시간을 요구하기 때문에 시술 전에 환부의 감염을 막는 것이 선행되어야 한다. 이때, 수화겔이 혈액, 체액 및 생체조직과 친화성이 있어 상처용 드레싱으로 사용될 수 있다. 이외에도 수화겔은 콘택트 렌즈 및 연골에도 사용될 수 있다.The hydrogel is a material used for the purpose of burn treatment or skin regeneration in which the wet state is constantly required, and can be used for the above purposes only when the hydrogel contains at least 60% moisture. In the case of severe burn treatment, ultimately, autologous or transplanted tissue of the patient's fibroblasts in vivo is required. Since the above procedure requires a considerable amount of time, Prevention should be preceded. At this time, the hydrogel has affinity with blood, body fluid, and biotissue, and can be used as wound dressing. In addition, hydrogels can be used for contact lenses and cartilage.
종래 미국 등록특허 제5,389,376에 방사선 가교법을 이용한 상처치료용 드레싱의 제조방법을 개시하고 있다. 상기 제조방법은 폴리비닐피롤리돈에 아가, 폴리에틸렌옥사이드를 혼합하고 이것을 방사선으로 조사하여 가교하여 이루어진다. 상기 발명은 방사선의 가교법의 특징, 즉 가교와 멸균을 동시에 추진할 수 있는 장점이 있다. 또한, 미국 등록특허 제5,480,717호에서는 점착제가 부착된 고분자 필름에 폴리비닐피롤리돈 수용액을 캐스팅하고 방사선으로 조사하여 제조된 수화겔을 개시하고 있다. 나아가, 일본 공개특허 제9-267453호 공보에서는 폴리비닐알콜을 기본 소재로 하고 여기에 다른 적층재를 첨가하여 물성을 개선하는 기술에 대하여 개시하고 있다.US Patent No. 5,389,376 discloses a method of manufacturing a wound dressing using radiation crosslinking. The above-mentioned production method is carried out by mixing polyvinyl pyrrolidone with agar and polyethylene oxide and irradiating it with crosslinking. The above-described invention has an advantage of being able to simultaneously promote the characteristics of the crosslinking method of radiation, that is, crosslinking and sterilization. In addition, U.S. Patent No. 5,480,717 discloses a hydrogel prepared by casting a polyvinylpyrrolidone aqueous solution onto a polymer film having a pressure-sensitive adhesive and irradiating it with radiation. Further, Japanese Patent Laid-Open No. 9-267453 discloses a technique for improving physical properties by using polyvinyl alcohol as a base material and adding another laminated material thereto.
한편, 인간의 방어와 회복 체계는 작은 상처를 낫게 하기 위하여 수일을 필요로 한다. 절개된 상처는 치유하는데 더 오랜 시간이 걸리며 감염도 빨리 진행된다. 드레싱 반창고는 상처를 덮어주어 균으로부터 보호하고 지혈과정을 도와 손상된 조직의 회복과 재생을 돕지만 균이 침투하여 감염이 발생할 수 있다. 또한, 상처의 출혈 여부나 감염되었는지 알아보기 위해 드레싱을 정기적으로 바꾸어 주는 행위는 아프기도 하지만, 오히려 세균이 침투할 기회를 제공함으로써 상처를 더 악화시키기도 한다. 이에, 드레싱을 바꾸지 않으면서도 출혈 여부, 세균 감염 여부 및 상처 치료의 모니터링을 위한 새로운 드레싱 소재의 개발이 요구된다.
On the other hand, human defense and recovery systems require several days to heal small wounds. The incision wound takes longer to heal and the infection progresses quickly. The dressing bandage covers the wound and protects against the bacteria, helps the hemostatic process and helps the recovery and regeneration of the damaged tissue, but the infection can occur due to the infiltration of the bacteria. Regularly changing the dressing to see if the wound is bleeding or infected is painful, but it also makes the wound worse by providing the opportunity for the bacteria to penetrate. Therefore, it is required to develop a new dressing material for monitoring bleeding, bacterial infection, and wound treatment without changing the dressing.
본 발명이 해결하고자 하는 과제는 드레싱을 바꾸지 않으면서도 세균 감염 및 출혈 여부를 확인할 수 있는 외상 치료 및 모니터링용 수화겔 패치를 제공하는 것이다.
A problem to be solved by the present invention is to provide a patch for hydrotherapy gel for trauma treatment and monitoring, which can confirm bacterial infection and bleeding without changing the dressing.
본 발명의 대표적인 일 측면에 따르면, 양배추 추출물을 상처 부위의 염증 상태에 따라 색 변화를 나타내는 pH 표시인자로 포함하는 외상 치료 및 모니터링용 수화겔 패치로서,According to a representative aspect of the present invention, there is provided a hydrogel patch for trauma treatment and monitoring, which comprises a cabbage extract as a pH-indicating factor indicative of a color change according to an inflammatory state at a wound site,
상기 수화겔은 양배추 추출물 1-10 중량%, 폴리비닐알코올 2-20 중량%, 폴리비닐피롤리돈 10-50 중량%, 글리세린 1-10 중량% 및 아가 15-35 중량%를 더 포함하는 것을 특징으로 하는 외상 치료 및 모니터링용 수화겔 패치가 개시된다.
The hydrogel further comprises 1-10% by weight of a cabbage extract, 2-20% by weight of polyvinyl alcohol, 10-50% by weight of polyvinylpyrrolidone, 1-10% by weight of glycerin and 15-35% by weight of agar A patch for hydrothermal treatment for trauma treatment and monitoring is disclosed.
본 발명에 따르면, 드레싱을 바꾸지 않으면서도 세균 감염 여부를 확인할 수 있고, 출혈 여부를 판단할 수 있어, 종래 상처의 감염 및 출혈 여부를 알아보기 위해 드레싱을 정기적으로 교체하는 불편함을 해소하고, 드레싱의 교체 과정에서 생길 수 있는 세균 감염의 가능성을 차단할 수 있다.
According to the present invention, it is possible to confirm whether or not a bacterial infection has occurred without changing the dressing, and it is possible to judge whether or not bleeding occurs. Thus, it is possible to solve the inconvenience of periodically replacing the dressing, The possibility of a bacterial infection that may occur during the replacement of the bacteria can be prevented.
도 1은 본 발명의 일 구현예에 따라 제조된 수화겔 패치를 촬영한 사진이다.
도 2는 본 발명의 일 구현예에 따라 제조된 수화겔 패치가 적용된 드레싱 제품의 모식도이다.
도 3은 본 발명의 일 구현예에 따른 양배추 추출물의 pH에 따른 색 변화를 나타내는 도면이다.1 is a photograph of a hydrogel patch prepared according to an embodiment of the present invention.
2 is a schematic view of a dressing product to which a hydrogel patch prepared according to an embodiment of the present invention is applied.
FIG. 3 is a graph showing a color change according to pH of a cabbage extract according to an embodiment of the present invention. FIG.
이하에서, 본 발명의 여러 측면 및 다양한 구현예에 대해 더욱 구체적으로 살펴보도록 한다.Hereinafter, various aspects and various embodiments of the present invention will be described in more detail.
본 발명의 일 측면에 따르면, 양배추 추출물을 pH 표시인자로 포함하는 외상 치료 및 모니터링용 수화겔 패치가 개시된다.According to one aspect of the present invention, there is provided a hydrogel patch for trauma treatment and monitoring comprising a cabbage extract as a pH indicator.
본 발명의 일 구현예에 의하면, 상기 수화겔 패치는 안토시아닌을 유효성분으로 함유하는 양배추 추출물을 포함하여 상처 부위의 치료, 출혈 및 염증 상태를 확인할 수 있는 수화겔 패치로써, 드레싱을 바꾸지 않으면서도 상처의 출혈 여부 및 세균 감염 여부를 확인할 수 있어, 종래 상처의 출혈 및 감염 여부를 알아보기 위해 드레싱을 정기적으로 교체하는 불편함을 해소하고, 드레싱의 교체 과정에서 생길 수 있는 세균 감염의 가능성을 차단할 수 있다. 또한 본 발명의 양배추 추출물 대신 pH 표시인자로써 유기 화학적으로 합성된 고가의 안토시아닌을 사용하는 경우에 비하여 경제적으로도 유리할 수 있다.
According to one embodiment of the present invention, the hydrogel patch is a patch of hydrogel which can be used to confirm the treatment, hemorrhage and inflammation of a wound site, including a cabbage extract containing anthocyanin as an active ingredient. It is possible to confirm the presence or absence of bacterial infection, thereby eliminating the inconvenience of periodically replacing the dressing to detect bleeding or infection of the wound and blocking the possibility of a bacterial infection that may occur in the process of replacing the dressing. In addition, it can be economically advantageous as compared with the case of using an expensive anthocyanin synthesized organically chemically as a pH indicator in place of the cabbage extract of the present invention.
본 발명의 다른 측면에 따르면, 양배추 추출물을 pH 표시인자로 포함하는 외상 치료 및 출혈, 감염 모니터링용 수화겔 패치로서,According to another aspect of the present invention, there is provided a hydrogel patch for trauma treatment and hemorrhage and infection monitoring comprising a cabbage extract as a pH indicator,
상기 수화겔은 양배추 추출물 1-10 중량%, 폴리비닐알코올 2-20 중량%, 폴리비닐피롤리돈 10-50 중량%, 글리세린 1-10 중량% 및 아가 15-35 중량%를 더 포함하는 것을 특징으로 하는 외상 치료 및 감염 모니터링용 수화겔 패치가 개시된다.
The hydrogel further comprises 1-10% by weight of a cabbage extract, 2-20% by weight of polyvinyl alcohol, 10-50% by weight of polyvinylpyrrolidone, 1-10% by weight of glycerin and 15-35% by weight of agar A patch of hydrogel for trauma treatment and infection monitoring is disclosed.
본 발명의 일 구현예에 의하면, 상기 수화겔 패치의 양배추 추출물은 양배추 추출물 내의 안토시아닌이 pH에 따라 민감하게 반응하여 육안으로 확인 가능한 색 변화를 나타내므로 매우 중요한 요인이다. 이에, 양배추 추출물이 수화겔 패치 전체 중량에 대하여 1 중량% 미만으로 첨가되는 경우에는 상처 pH에 따른 색 변화가 선명하지 못하여 육안 확인이 어려운 문제점이 있고, 10 중량% 초과하여 첨가되는 경우에는 더 이상의 색 변화의 차이가 나타나지 않는다.According to one embodiment of the present invention, the cabbage extract of the hydrogel patch is a very important factor because anthocyanin in the cabbage extract responds sensitively to pH and exhibits visible color change visually. Therefore, when the extract of cabbage is added in an amount of less than 1% by weight based on the total weight of the hydrogel patch, the color change is not clear according to the wound pH and it is difficult to visually confirm. On the other hand, There is no difference in change.
또한, 상기 수화겔 패치의 폴리비닐알코올, 폴리비닐피롤리돈, 글리세린 및 아가 함량은 겔형성, 흡습성 및 기포 형성여부에 따라 판단된 함량으로써, 상기 범위를 벗어나게 되는 경우에는 겔 형성이 잘 이루어지지 않거나 흡습성이 떨어지거나, 많은 양의 기포가 형성되는 문제점이 발생할 수 있으므로 수화겔 패치로 사용하기 어려운 단점이 있다.
The content of polyvinyl alcohol, polyvinylpyrrolidone, glycerin and agar in the hydrogel patch is determined by gel formation, hygroscopicity and bubble formation. If the gel content is out of the above range, There is a disadvantage that it is difficult to use as a hydrogel patch because hygroscopicity may be poor or a large amount of bubbles may be formed.
본 발명의 일 구현예에 있어서, 상기 pH 표시인자는 상처 부위의 염증 상태에 따라 색 변화를 나타내는 표시인자인 것을 특징으로 한다.In one embodiment of the present invention, the pH indicator is an indicator of color change depending on the inflammation state of the wound site.
일반적으로 피부에 물리적인 손상이 가해져서 정상적인 피부구조물의 연속성이 파괴된 경우를 상처라고 하며, 이런 불연속성을 복구하는 과정이 상처 치유(wound healing)이다. 이러한 상처 치유 과정에서 건강한 피부와 치유된 상처는 보통 pH 5 이하의 값을 나타내는데 반해, 상처나 감염 등에 의해 염증이 형성되는 경우에는 pH 값이 약 6.5-9.2로 증가하는 경향이 있다. 이에, 본 발명의 pH 표시인자가 포함되어 있는 수화겔 패치를 이용하면, 도 2에 나타낸 바와 같이, pH 변화를 육안으로 확인할 수 있을 정도의 색 변화가 나타나므로 상처의 감염여부를 판단할 수 있는 장점이 있다.In general, when the skin is damaged by physical damage and the continuity of the normal skin structure is destroyed, the wound is called a wound healing process. In these wound healing processes, healthy skin and healed wounds usually show a pH value of less than 5, whereas if inflammation is formed by a wound or infection, the pH value tends to increase to about 6.5-9.2. Thus, as shown in FIG. 2, when the pH indicator of the present invention is used, the pH change of the pH indicator can be visually confirmed. As a result, .
한편, 본 발명의 일 구현예에 따른 상기 수화겔 패치의 염증 상태에 따른 색의 변화는 필름을 통해 관찰될 수 있으며, 그 부위에서는 적어도 연한 보라색 또는 파랑색으로 변할 수 있으며, 상처가 치유됨에 따라 적색을 띌 수 있다.
Meanwhile, the color change according to the inflammation state of the hydrogel patch according to an embodiment of the present invention can be observed through the film, and at least the purple or blue color can be changed in the region, and as the wound heals, .
본 발명의 다른 구현예에 있어서, 상기 pH 표시인자는 상처 부위의 출혈 여부에 따라 색 변화를 나타내는 표시인자인 것을 특징으로 한다.In another embodiment of the present invention, the pH indicator is an indicator of color change depending on bleeding at a wound site.
체내에서 혈액의 pH는 7.35와 7.4 사이에서 정밀하게 유지되는 것으로 알려져 있고, 상처 치유 과정 중에서 상처 부위에 출혈이 발생하는 경우가 있다. 상처 부위에서 출혈이 생기면 혈액과 본 발명의 수화겔 패치의 pH 표시인자가 반응하여 적어도 연한 보라색 또는 파랑색으로 변할 수 있으며, 상처가 치유됨에 따라 적색을 띄는 등의 육안으로 확인할 수 있을 정도의 색 변화가 나타나므로 상처 부위의 출혈여부를 판단할 수 있는 장점이 있다.
The pH of the blood in the body is known to be precisely maintained between 7.35 and 7.4, and hemorrhage may occur in the wound area during the wound healing process. When hemorrhage occurs at the wound site, the pH indicator of the hydrogel patch of the present invention reacts with blood to change to at least a light purple or blue color. When the wound is healed, a color change such as visible redness And thus it is possible to judge whether or not the wound is bleeding.
이하에서 실시예 등을 통해 본 발명을 더욱 상세히 설명하고자 하며, 다만 이하에 실시예 등에 의해 본 발명의 범위와 내용이 축소되거나 제한되어 해석될 수 없다. 또한, 이하의 실시예를 포함한 본 발명의 개시 내용에 기초한다면, 구체적으로 실험 결과가 제시되지 않은 본 발명을 통상의 기술자가 용이하게 실시할 수 있음은 명백하다.
Hereinafter, the present invention will be described in more detail with reference to Examples and the like, but the scope and content of the present invention can not be construed to be limited or limited by the following Examples. In addition, it is apparent that, based on the teachings of the present invention including the following examples, those skilled in the art can easily carry out the present invention in which experimental results are not specifically shown.
제조예Manufacturing example 1 내지 4 및 1 to 4 and 참고예Reference example 1 내지 3: 1 to 3: 수화겔의Hydrated 제조 Produce
설계목적에 적절한 수화겔을 찾기 위하여 하기 표 1에 나타낸 바와 같이 수화겔 합성에 주된 성분인 폴리비닐알코올과 폴리비닐피롤리돈의 조성을 다르게 하여 다양한 겔을 합성하였다.As shown in Table 1 below, various gels were synthesized by varying the composition of polyvinyl alcohol and polyvinylpyrrolidone, which are the main components in the hydrogel synthesis, in order to find suitable hydrogels for design purposes.
증류수 100 g을 취한 뒤 하기 표 1에 나타낸 바와 같이, 조성대로 증류수에 넣고 잘 섞기 위하여 교반 시 기포가 생성된다. 혼합물을 60 ℃에서 12 시간 동안 방치하게 되면 생성된 기포가 자연스럽게 제거되면서 수화겔이 생성된다.After taking 100 g of distilled water, as shown in Table 1 below, bubbles are formed in the distilled water according to the composition and stirred to stir well. When the mixture is allowed to stand at 60 DEG C for 12 hours, the generated bubbles are naturally removed to form a hydrogel.
상기 표 1의 조성대로 제조된 수화겔의 겔형성, 흡습성, 기포형성 등에 점수를 부여하여 수화겔의 성능을 평가한 결과, 하기 표 2에 나타낸 바와 같이, 제조예 1 내지 2 경우의 수화겔이 사용 목적에 부합되는 것으로 확인되었고, 특히 제조예 1의 경우 가장 우수한 것으로 확인되었다.As a result of evaluating the performance of the hydrogels by giving scores to the gel formation, hygroscopicity and bubble formation of the hydrogels prepared according to the composition of Table 1, the hydrogels of Production Examples 1 and 2 were used for the purpose of use , And it was confirmed to be the most excellent in the case of Production Example 1 in particular.
실시예Example 1 내지 5 및 1 to 5 and 비교예Comparative Example 1 내지 3: 양배추 추출물을 포함하는 1 to 3: extracts containing cabbage extract 수화겔의Hydrated 제조 Produce
상처 치유 과정에서 건강한 피부와 치유된 상처는 보통 pH 5 이하의 값을 나타내는데 반해, 상처나 감염 등에 의해 염증이 형성되는 경우에는 pH 값이 약 6.5-9.2로 증가하는 경향이 있고, 혈액은 pH 값이 7.35와 7.4 사이에서 정밀하게 유지되는 특징이 있으므로 지시약적 특성을 가진 안토시아닌을 포함하는 양배추 추출물을 이용하여 수화겔 패치를 제조하였다.In the wound healing process, healthy skin and healed wounds usually show a pH value of less than 5, whereas if inflammation is formed by a wound or infection, the pH value tends to increase to about 6.5-9.2, Was maintained between 7.35 and 7.4. Therefore, the extract of cabbage containing anthocyanin with indicator characteristics was used to prepare a hydrogel patch.
상기 제조예 1의 수화겔의 조성(표 1 참조)에 하기 표 3에 나타낸 바와 같이, 양배추 추출물을 각각 첨가하여 양배추 추출물을 포함하는 수화겔 패치를 제조하였다.As shown in Table 3 below, the composition of the hydrogel of Preparation Example 1 (see Table 1) was supplemented with cabbage extract to prepare a hydrogel patch containing cabbage extract.
이때, 상기 에탄올 0.5ℓ에 적색 양배추 700 g을 첨가한 후, 이를 24시간 동안 방치하면 색소물질을 포함하는 양배추 성분이 에탄올 층으로 추출된다. 여과를 통하여 양배추 고형물을 제거함으로써 적색 양배추 추출물을 얻었고 70 ℃에서 감압 농축 하에 추출물의 농축액을 얻었다.At this time, 700 g of red cabbage was added to 0.5 liter of the ethanol, and the mixture was allowed to stand for 24 hours, so that the cabbage component containing the coloring matter was extracted into the ethanol layer. The red cabbage extract was obtained by removing the cabbage solids through filtration and the extract was concentrated under reduced pressure at 70 ° C.
상기 표 3의 조성으로 수화겔 패치를 제조하는 경우에는 양배추 추출물 함량이 2.5 g까지는 도 2에 나타낸 바와 같이, 색 변화가 선명해졌는데 그 이상에서는 큰 차이를 확인할 수 없었다.
In the case of preparing a hydrogel patch with the composition shown in Table 3 above, the color change became clear as shown in Fig. 2 up to 2.5 g of the cabbage extract, but no significant difference could be observed thereafter.
따라서 도 1 및 2에 나타낸 본 발명에 따른 양배추 추출물을 포함하는 수화겔을 사용하는 경우에는 드레싱을 바꾸지 않으면서도 세균 감염 여부 및 출혈 여부를 확인할 수 있어, 종래 상처의 감염 및 출혈 여부를 알아보기 위해 드레싱을 정기적으로 교체하는 불편함을 해소하고, 드레싱의 교체 과정에서 생길 수 있는 세균 감염의 가능성을 차단할 수 있다.Therefore, in the case of using the hydrogel containing the extract of cabbage according to the present invention shown in FIGS. 1 and 2, it is possible to confirm whether or not the bacteria are infected and bleeding without changing the dressing. And it is possible to prevent the possibility of a bacterial infection that may occur in the process of replacing the dressing.
Claims (4)
상기 수화겔은 양배추 추출물 1-10 중량%, 폴리비닐알코올 2-20 중량%, 폴리비닐피롤리돈 10-50 중량%, 글리세린 1-10 중량% 및 아가 15-35 중량%를 더 포함하는 것을 특징으로 하는 외상 치료 및 모니터링용 수화겔 패치.
A hydrogel patch for trauma treatment and monitoring comprising a cabbage extract as a pH indicator,
The hydrogel further comprises 1-10% by weight of a cabbage extract, 2-20% by weight of polyvinyl alcohol, 10-50% by weight of polyvinylpyrrolidone, 1-10% by weight of glycerin and 15-35% by weight of agar Patch for hydrotherapy gel for trauma treatment and monitoring.
3. The patch of claim 2, wherein the pH indicator is an indicator of color change depending on an inflammation state of the wound site.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130112983A KR101539675B1 (en) | 2013-09-24 | 2013-09-24 | Hydrogel patch for wound healing and monitoring |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020130112983A KR101539675B1 (en) | 2013-09-24 | 2013-09-24 | Hydrogel patch for wound healing and monitoring |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150033237A KR20150033237A (en) | 2015-04-01 |
| KR101539675B1 true KR101539675B1 (en) | 2015-07-27 |
Family
ID=53030619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020130112983A KR101539675B1 (en) | 2013-09-24 | 2013-09-24 | Hydrogel patch for wound healing and monitoring |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR101539675B1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102007064B1 (en) * | 2015-12-02 | 2019-08-02 | 단국대학교 산학협력단 | A wound hydrogel dressing substance with discoloring function |
| US11698344B2 (en) | 2018-09-05 | 2023-07-11 | University Of South Carolina | PH indicator swabs for biomonitoring and diagnostics |
| US11471335B2 (en) | 2018-09-05 | 2022-10-18 | University Of South Carolina | Gel-within-gel wound dressing |
| KR102180459B1 (en) * | 2018-11-30 | 2020-11-18 | 한국생산기술연구원 | Covering materials for wound capable of pH detection, and method for manufacturing the same |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010012636A1 (en) * | 1999-08-20 | 2001-08-09 | Radiancy Inc. | Chewing gum with pH indicator |
| US20120301406A1 (en) * | 2011-05-25 | 2012-11-29 | Taiwan Textile Research Institute | Skin care composition with indicating function and method of using the same |
-
2013
- 2013-09-24 KR KR1020130112983A patent/KR101539675B1/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010012636A1 (en) * | 1999-08-20 | 2001-08-09 | Radiancy Inc. | Chewing gum with pH indicator |
| US20120301406A1 (en) * | 2011-05-25 | 2012-11-29 | Taiwan Textile Research Institute | Skin care composition with indicating function and method of using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150033237A (en) | 2015-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1259269B1 (en) | Agent for the treatment of wounds | |
| KR100748348B1 (en) | Method for the preparation of hydrogels for wound dressing using radiation irradiation | |
| KR101539675B1 (en) | Hydrogel patch for wound healing and monitoring | |
| CN103159967B (en) | Preparation method of collagen-based sponge wound dressing with self-anti-inflammatory function | |
| EP3153185A1 (en) | Composition for promoting the regeneration of injured body tissue | |
| CN105797202B (en) | Liquid band-aid and preparation method thereof | |
| KR20080018360A (en) | A wound-healing dressing patch with hydrogel layer containing chitosan | |
| KR101242574B1 (en) | Hydrogels for wound dressing comprising nano-silver particle and preparation method thereof | |
| CN112546289A (en) | Composite biological hydrogel dressing and preparation method thereof | |
| CN110859989B (en) | Liquid band-aid and preparation method thereof | |
| KR102473363B1 (en) | Spray type hydrogel wound coating preparation method and Spray type hydrogel wound coating thereof | |
| US20160346335A1 (en) | Honey-based dressing for the treatment of wounds and burns | |
| CN112891615B (en) | Liquid adhesive bandage and preparation method thereof | |
| CN104225577B (en) | A kind of double course for the treatment of compound cells growth factor hydrogels and preparation method and with application | |
| CN104490760B (en) | The preparation method and applications of capsaicine collagen protein sponge | |
| WO2011100935A1 (en) | Dry material of hydrogel for wound dressing and its method of preparation | |
| KR100459494B1 (en) | Method for the preparation of hydrogels for wound dressings | |
| KR102503193B1 (en) | Hydrogel comprising Mushroom-derived Chitosan or derivatives thereof and Manufacturing Method thereof | |
| WO2022234889A1 (en) | Adhesive transparent multifunctional wound covering material and method for manufacturing same | |
| CN112957519A (en) | Composition for preparing hydrogel for promoting wound healing, hydrogel and preparation method thereof | |
| CN108992699A (en) | A kind of functional Wound dressing and preparation method thereof containing active composite material | |
| RU2674445C1 (en) | Alcohol spray for external use | |
| KR102543010B1 (en) | Composition for high-functional wound coating and manufacturing method threreof | |
| CN114522268B (en) | Skin repair material and preparation method and application thereof | |
| CN116920162A (en) | Hydrogel composition, hydrogel, preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 20180702 Year of fee payment: 4 |
|
| FPAY | Annual fee payment |
Payment date: 20190627 Year of fee payment: 5 |