KR102007064B1 - A wound hydrogel dressing substance with discoloring function - Google Patents
A wound hydrogel dressing substance with discoloring function Download PDFInfo
- Publication number
- KR102007064B1 KR102007064B1 KR1020150170723A KR20150170723A KR102007064B1 KR 102007064 B1 KR102007064 B1 KR 102007064B1 KR 1020150170723 A KR1020150170723 A KR 1020150170723A KR 20150170723 A KR20150170723 A KR 20150170723A KR 102007064 B1 KR102007064 B1 KR 102007064B1
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- KR
- South Korea
- Prior art keywords
- hydrogel
- dressing material
- wound
- discoloration
- color change
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
Abstract
The present invention relates to a discoloring hydrogel dressing material, and includes a hydrogel dyed with a discoloring agent. As the exudate of the wound is absorbed into the hydrogel, a color change occurs due to a change in pH, thereby making it easy to determine the replacement time of the dressing material.
Description
The present invention relates to a discoloring hydrogel dressing material, and more particularly, a discoloring agent that dyes the hydrogel with a discoloring agent so that the discoloration occurs when reacted with the exudate of the wound, thereby increasing the duration of the dressing material and allowing a replacement time to be known. It relates to a hydrogel dressing material comprising.
The treatment of wounds is the basis of medicine and has a long history. According to papyrus, animal oil, honey and cotton were used to treat wounds from 5000 BC. Throughout history, many changes and advances have been made in the treatment of wounds. Since 1962, a zoologist, published a research paper that suggests that keeping wounds wet helps to heal rather than drying them to crusts, the benefits of wet wound treatment Continually proven and emphasized. Wet environment Wet dressing methods that prevent the fluids secreted from the wounds from being dehydrated or dried are currently found to facilitate wound healing.
Hydrogel is a treatment used to repair small wounds. It moisturizes the wound and prevents the invasion of bacteria and prevents scars, and the merits of wet dressing materials compared to dry products are known by research results and the promotion of mescomb. Intensified marketing and market competition have intensified. In particular, the growth of the wet dressing material of the "hydrocolloid" material, which is attracting the most attention in the market, is increasing markedly. Wet dressing agent absorbs the essence of natural healing substance, recovers wounds quickly, prevents the formation of crusts and minimizes the occurrence of scars, so the number of users is increasing among women and parents who have high interest in beauty. Various types of sponges that can be used as medical materials have been developed using their biocompatibility, biodegradability, and antibacterial activity.
Hydrogel is a material used for the purpose of burn treatment or skin regeneration that requires a constant wet state, and the hydrogel can usually be used for this purpose only when the hydrogel contains at least 60% water. In the case of severe burn treatment, the result is a transplant of tissue transplanted with autograft or in vivo culture of the patient's fibroblasts, which requires considerable time before the procedure. Blocking must be preceded. In this case, the hydrogel has affinity with blood, body fluids, and biological tissues, and thus may be used as a wound dressing. In addition, hydrogels may also be used in contact lenses and cartilage.
Conventional US Patent No. 5,389,376 discloses a method for preparing a wound dressing using a radiation crosslinking method. The production method is made by mixing polyvinylpyrrolidone with agar and polyethylene oxide and irradiating it with radiation to crosslink it. The invention has the advantage of promoting the characteristics of the crosslinking method of radiation, that is, crosslinking and sterilization at the same time. In addition, US Patent No. 5,480,717 discloses a hydrogel prepared by casting polyvinylpyrrolidone aqueous solution on a polymer film with an adhesive and irradiated with radiation.
Human defense and recovery systems, on the other hand, require several days to heal small wounds. The incision takes longer to heal and the infection progresses faster. Dressing bandages cover wounds to protect them from germs and aid the hemostasis process, helping to repair and regenerate damaged tissues, but germs can penetrate and cause infection. In addition, changing dressings regularly to see if the wound is bleeding or infected can make the wound worse by providing an opportunity for bacteria to penetrate. Accordingly, there is a need to develop a new dressing material for monitoring bleeding, bacterial infection, and wound treatment without changing the dressing.
Conventional hydrogel dressing materials turn white when they absorb moisture. However, it is difficult to determine whether this water is an exudate due to inflammation of the wound, and thus there is a problem that it is difficult to grasp when the dressing material is replaced.
Accordingly, an object of the present invention is to provide a dressing material comprising a hydrogel dyed with a color change agent that can change the color of the exudate absorbed by the hydrogel to grasp the replacement time of the dressing material according to the color change.
It is also an object of the present invention to provide a discolored hydrogel dressing material in which a secondary infection that may occur when a wound site is exposed to an exudate and a color change is clearly observed.
In order to achieve the above object,
The present invention provides a discolored hydrogel dressing material including a hydrogel stained with a discolorant.
The discoloring hydrogel dressing material of the present invention can easily grasp the replacement time of the hydrogel dressing material by using the phenomenon that the color changes by contacting the hydrogel stained with the discolorant and the exudates of the wound by changing the color of the hydrogel.
In addition, the discolored hydrogel dressing material of the present invention can prevent secondary infection that may occur when the wound site is continuously exposed to exudate, thereby effectively managing the wound.
In addition, the discolored hydrogel dressing material of the present invention has a simple manufacturing process, economical and environmentally friendly effect.
1 is a photograph of a hydrogel stained with methyl orange dye.
Figure 2 is a photograph showing the color change in the acidity of the hydrogel stained with methyl orange dye.
Figure 3 is a photograph showing the color change in the basic of the hydrogel stained with methyl orange dye.
4 is a photograph of a hydrogel stained with litmus dye.
5 is a photograph showing the color change in the acidity of the hydrogel stained with litmus dye.
Figure 6 is a photograph showing the color change in the basic of the hydrogel stained with litmus dye.
7 is a cross-sectional view of the discolored hydrogel dressing material.
Hereinafter, the present invention will be described in more detail.
The present invention relates to a color change hydrogel dressing material including a hydrogel stained with a color change agent.
The discoloration hydrogel dressing material of the present invention provides a dressing material including a hydrogel dyed with a discoloring agent, whereby the exudates of wounds caused by wounds or burns and the hydrogel contact with the hydrogel, thereby causing a change in color according to pH change. This makes it possible to grasp objectively and easily the degree of contamination of the wound and the time of dressing replacement.
In addition, the color change is clearly seen, it is possible to easily determine the replacement time, thereby blocking the possibility of bacterial infection, etc. that can occur during the replacement of the dressing material. In addition, it can prevent secondary infections that can occur when the wound is continuously exposed to exudate.
In the present invention, the color change agent includes at least one selected from the group consisting of litmus dye and methyl orange, and preferably includes litmus dye.
In addition, since the color change agent is used for the human body, it is preferable to use a color change agent having a pH of 4 to 9.
The hydrogel is agarose (agarose), polyethylene glycol (PEG), alginate salt (alginate salt), polyhydroxyethyl methacrylate (polyhydroxyethyl methacrylate, p (HEMA)), polyethylene oxide (PEO) ), Polyvinyl alcohol (PVA), polyacrylamide (polyacrylamide (PAA)) and at least one selected from the group consisting of hyaluronic acid (hyaluronic acid), and preferably comprises agarose.
The hydrogel stained with the color change agent may be prepared by mixing the hydrogel and the color change solution.
More specifically, it may be prepared by mixing a hydrogel with a colorant solution containing 0.1 to 3% by weight, preferably 0.1 to 1.5% by weight, based on the total weight of water.
If the colorant in the aqueous solution of the colorant is contained less than 0.1% by weight does not become a homogenate, when contained in more than 3% by weight does not dissolve in water.
In addition, 3 to 15% by weight, preferably 5 to 7% by weight of the hydrogel is mixed with respect to the total weight of the colorant aqueous solution.
When the hydrogel is mixed at less than 3% by weight, undyed dyes remain in excessive amounts, and when mixed in excess of 15% by weight, no leveling occurs.
The hydrogel may be prepared by adding water. However, in the present invention, by using a colorant aqueous solution instead of water, the process of adding water and the dyeing process can be carried out at the same time to simplify the manufacturing process, thereby securing a price competitiveness.
The preparation of the discolored hydrogel dressing material by mixing the hydrogel and the colorant aqueous solution is made for 20 to 120 minutes, but is made at room temperature or at a temperature of 60 to 80 ℃, the temperature range is not particularly limited.
According to the present invention, by using a hydrogel dyed with a color change agent as a dressing material, the exudates of the wound are absorbed by the hydrogel, and the color change appears, so that the replacement time of the dressing material can be easily understood.
In addition, the discolored hydrogel dressing material of the present invention can be in direct contact with the skin, can be used by itself without additional components, and may include additional components.
As the additional component, the transparent waterproof film having an adhesive force may be laminated on the discolored hydrogel dressing material, and the type of transparent waterproof film is not particularly limited, and a film used in the art may be used.
By using a hydrogel stained with a color change agent that changes color in contact with the exudate as a color change dressing material, the exudate is absorbed into the hydrogel dyed with the color change agent, and the hydrogel causes color change by the pH of the exudate. Therefore, it is easy to determine whether the dressing material is replaced even without opening the inside of the dressing material.
Hereinafter, the present invention will be described in more detail by way of examples. However, the following examples are intended to further illustrate the present invention, and the scope of the present invention is not limited by the following examples.
Discoloration hydrogel dressing material manufacture
Example 1. Preparation of hydrogel dressing material dyed with methyl orange dye
Aqueous solution of methyl orange dye was prepared by adding 1% by weight of methyl orange dye to the total weight of water.
6% by weight of agarose was added to the total weight of the methyl orange dye aqueous solution. The mixture was heated to 70 ° C, mixed for 30 minutes at a temperature of 70 ° C, cooled to room temperature, and washed with distilled water. A hydrogel stained with was prepared (FIG. 1).
As a result of confirming discoloration of the hydrogel, it was confirmed that the acid turns dark red (FIG. 2) from basic to dark orange (FIG. 3).
Example 2. Preparation of hydrogel dressing material dyed with litmus dye
A hydrogel stained with litmus dye was prepared in the same manner as in Example 1, using litmus dye instead of methyl orange dye (FIG. 4).
As a result of confirming the discoloration of the hydrogel, it was confirmed that the acid is changed to red (Fig. 5), basic to indigo (Fig. 6).
In general, the exudates of wounds have a pH of 6 to 9. Therefore, when the discolored hydrogel dressing material of the present invention is used, the exudates are absorbed in the hydrogel, so that the color change according to the pH change appears, thereby facilitating the replacement of the dressing material. I can figure it out.
Therefore, it is possible to prevent the occurrence of a new disease due to the secondary infection by missing the replacement time because it does not recognize the inflammation that is a result of the immune action of the bacteria and the body infiltrated into the wound.
Claims (8)
The color change agent is litmus dye,
The hydrogel is agarose,
The hydrogel dyed with the colorant is prepared by mixing the hydrogel in a colorant solution containing 0.1 to 3% by weight of the colorant relative to the total weight of water,
Discoloration hydrogel dressing material, characterized in that for mixing the hydrogel of 3 to 15% by weight based on the total weight of the colorant aqueous solution.
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KR1020150170723A KR102007064B1 (en) | 2015-12-02 | 2015-12-02 | A wound hydrogel dressing substance with discoloring function |
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KR1020150170723A KR102007064B1 (en) | 2015-12-02 | 2015-12-02 | A wound hydrogel dressing substance with discoloring function |
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KR102007064B1 true KR102007064B1 (en) | 2019-08-02 |
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Citations (4)
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JP3009921B2 (en) * | 1989-11-28 | 2000-02-14 | イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド | Bandage with indicator |
JP2001515762A (en) | 1997-09-05 | 2001-09-25 | ティー ジー イーキン リミテッド | Wound dressing |
JP2007520694A (en) | 2003-11-22 | 2007-07-26 | エイジーティ サイエンシズ リミテッド | Polymer material containing pH indicator dye |
JP2014526314A (en) | 2011-09-08 | 2014-10-06 | インディケーター システムズ インターナショナル, インコーポレイテッド | Wound care compositions and devices activated by infection |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US5276079A (en) | 1991-11-15 | 1994-01-04 | Minnesota Mining And Manufacturing Company | Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same |
BR9305045A (en) | 1992-12-15 | 1994-07-26 | Johnson & Johnson | Laminate, composite, process to form a hydrogel laminate, bandage and method of covering a wound |
US20080145316A1 (en) * | 2006-12-14 | 2008-06-19 | Macdonald John Gavin | Skin coating with microbial indicator |
US8273306B2 (en) * | 2009-07-15 | 2012-09-25 | Kimberly-Clark Worldwide, Inc. | Color-changing materials and multiple component materials having a color-changing composition |
KR101539675B1 (en) * | 2013-09-24 | 2015-07-27 | 경상대학교산학협력단 | Hydrogel patch for wound healing and monitoring |
KR101573119B1 (en) * | 2013-12-19 | 2015-11-30 | 주식회사 원바이오젠 | A wound dressing substance with discoloring function and its manufacturing method |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3009921B2 (en) * | 1989-11-28 | 2000-02-14 | イー・アール・スクイブ・アンド・サンズ・インコーポレイテッド | Bandage with indicator |
JP2001515762A (en) | 1997-09-05 | 2001-09-25 | ティー ジー イーキン リミテッド | Wound dressing |
JP2007520694A (en) | 2003-11-22 | 2007-07-26 | エイジーティ サイエンシズ リミテッド | Polymer material containing pH indicator dye |
JP2014526314A (en) | 2011-09-08 | 2014-10-06 | インディケーター システムズ インターナショナル, インコーポレイテッド | Wound care compositions and devices activated by infection |
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