CN108728444A - 免疫调节性多核苷酸及其应用 - Google Patents

免疫调节性多核苷酸及其应用 Download PDF

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Publication number
CN108728444A
CN108728444A CN201710251198.4A CN201710251198A CN108728444A CN 108728444 A CN108728444 A CN 108728444A CN 201710251198 A CN201710251198 A CN 201710251198A CN 108728444 A CN108728444 A CN 108728444A
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cell
antibody
cancer
tumour
patient
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黄涛
邵彦
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Changchun Huapu Biotechnology Co Ltd
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Changchun Huapu Biotechnology Co Ltd
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Priority to CN201710251198.4A priority Critical patent/CN108728444A/zh
Priority to CN201880025806.2A priority patent/CN110753756B/zh
Priority to PCT/CN2018/083435 priority patent/WO2018192505A1/en
Priority to JP2019556339A priority patent/JP7251017B2/ja
Priority to US16/484,090 priority patent/US11326170B2/en
Priority to EP18787826.9A priority patent/EP3612633A4/en
Publication of CN108728444A publication Critical patent/CN108728444A/zh
Priority to US17/662,392 priority patent/US12460208B2/en
Withdrawn legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/17—Immunomodulatory nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/315—Phosphorothioates
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201710251198.4A 2017-04-18 2017-04-18 免疫调节性多核苷酸及其应用 Withdrawn CN108728444A (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201710251198.4A CN108728444A (zh) 2017-04-18 2017-04-18 免疫调节性多核苷酸及其应用
CN201880025806.2A CN110753756B (zh) 2017-04-18 2018-04-17 免疫调节性多核苷酸及其应用
PCT/CN2018/083435 WO2018192505A1 (en) 2017-04-18 2018-04-17 Immunomodulatory polynucleotides and uses thereof
JP2019556339A JP7251017B2 (ja) 2017-04-18 2018-04-17 免疫調節ポリヌクレオチド及びその使用
US16/484,090 US11326170B2 (en) 2017-04-18 2018-04-17 Immunomodulatory polynucleotides and uses thereof
EP18787826.9A EP3612633A4 (en) 2017-04-18 2018-04-17 IMMUNOMODULATORY POLYNUCLEOTIDES AND USES THEREOF
US17/662,392 US12460208B2 (en) 2017-04-18 2022-05-06 Immunomodulatory polynucleotides and uses thereof

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WO (1) WO2018192505A1 (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113058033A (zh) * 2019-12-16 2021-07-02 远大赛威信生命科学(南京)有限公司 一种用于预防和治疗乙型肝炎的药物组合物及其用途
CN113521274A (zh) * 2020-04-17 2021-10-22 北京科兴中维生物技术有限公司 一种covid-19灭活疫苗组合物及应用
CN113521267A (zh) * 2020-04-17 2021-10-22 北京科兴中维生物技术有限公司 一种covid-19重组蛋白疫苗组合物及应用
CN115252772A (zh) * 2021-04-30 2022-11-01 华普生物技术(江苏)股份有限公司 人工合成的含CpG单链脱氧寡核苷酸在疫苗中的应用
CN115368463A (zh) * 2022-07-19 2022-11-22 合肥天港免疫药物有限公司 双特异性抗体及其应用
WO2024152998A1 (zh) * 2023-01-19 2024-07-25 华普生物技术(河北)股份有限公司 CpG佐剂在制备新型冠状病毒疫苗中的应用
WO2025113554A1 (zh) * 2023-11-30 2025-06-05 华普石家庄医药有限公司 一种水痘带状疱疹疫苗组合物及其用途

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US20210122778A1 (en) * 2019-10-21 2021-04-29 Northwestern University Spherical nucleic acids with dendritic ligands
CN113521273A (zh) * 2020-04-17 2021-10-22 北京科兴中维生物技术有限公司 一种使用含有CpG寡聚脱氧核苷酸的复合佐剂的新冠COVID-19灭活疫苗
CN113521275B (zh) * 2020-04-17 2024-06-25 北京科兴中维生物技术有限公司 一种复合佐剂及使用该复合佐剂的新冠covid-19重组蛋白疫苗
WO2021249116A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Coronavirus vaccine compositions, methods, and uses thereof
IL303350A (en) 2020-12-04 2023-08-01 Macrogenics Inc Pharmaceutical compositions of a her2/neu antibody and use of the same
CN114807153A (zh) * 2022-05-13 2022-07-29 南京吉盛澳玛生物医药有限公司 多种具有免疫刺激活性的CpG寡聚脱氧核苷酸及其应用
CN119698432A (zh) * 2022-06-01 2025-03-25 希恩克罗姆恩股份有限公司 经由肿瘤细胞裂解和肿瘤内施用免疫治疗成分组合来治疗癌症的方法
CN117568339A (zh) * 2023-01-19 2024-02-20 华普生物技术(河北)股份有限公司 CpG寡核苷酸及其应用

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113058033A (zh) * 2019-12-16 2021-07-02 远大赛威信生命科学(南京)有限公司 一种用于预防和治疗乙型肝炎的药物组合物及其用途
CN113521274A (zh) * 2020-04-17 2021-10-22 北京科兴中维生物技术有限公司 一种covid-19灭活疫苗组合物及应用
CN113521267A (zh) * 2020-04-17 2021-10-22 北京科兴中维生物技术有限公司 一种covid-19重组蛋白疫苗组合物及应用
CN115252772A (zh) * 2021-04-30 2022-11-01 华普生物技术(江苏)股份有限公司 人工合成的含CpG单链脱氧寡核苷酸在疫苗中的应用
WO2022228560A1 (zh) * 2021-04-30 2022-11-03 华普生物技术(江苏)股份有限公司 人工合成的含CpG单链脱氧寡核苷酸在疫苗中的应用
CN115368463A (zh) * 2022-07-19 2022-11-22 合肥天港免疫药物有限公司 双特异性抗体及其应用
WO2024152998A1 (zh) * 2023-01-19 2024-07-25 华普生物技术(河北)股份有限公司 CpG佐剂在制备新型冠状病毒疫苗中的应用
WO2025113554A1 (zh) * 2023-11-30 2025-06-05 华普石家庄医药有限公司 一种水痘带状疱疹疫苗组合物及其用途

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EP3612633A4 (en) 2021-04-28
CN110753756A (zh) 2020-02-04
US20200002704A1 (en) 2020-01-02
JP2020516305A (ja) 2020-06-11
EP3612633A1 (en) 2020-02-26
JP7251017B2 (ja) 2023-04-04
US11326170B2 (en) 2022-05-10
CN110753756B (zh) 2023-09-01
WO2018192505A1 (en) 2018-10-25

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