CN108728314A - A kind of SOD white wine preparation methods for supporting kidney function effect with protect liver - Google Patents
A kind of SOD white wine preparation methods for supporting kidney function effect with protect liver Download PDFInfo
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Abstract
The invention discloses a kind of SOD white wine preparation methods for supporting kidney function effect with protect liver, include the following steps：Mixed extract A is extracted to obtain to agate card, oyster and semen astragali complanati high temperature and pressure；Mixed extract C is handled to obtain to pueraria lobata, okra and Cortex Eucommiae diacolation；Cordyceps militaris SOD is obtained by supersonic wave wall breaking technology and supercritical carbon dioxide extraction method；Weigh white wine and Cordyceps militaris SOD, mixed extract A and mixed extract B, ultrasonic disperse is stood, filtering to get.The mutual cooperation that the present invention passes through supersonic wave wall breaking technology and supercritical carbon dioxide extraction method, the Cordyceps militaris SOD of high activity can quickly and efficiently be extracted, avoid the waste of drug, using SOD white wine prepared by the present invention there is good protect liver to support kidney function effect, without the miscellaneous taste of strong drug, also have effects that good blood pressure lowering, antifatigue, body and mind discomfort of releiving simultaneously, has a vast market foreground.
Description
Technical field
The present invention relates to field of health care wine, specifically a kind of SOD white wine preparation methods that kidney function effect is supported with protect liver.
Background technology
Superoxide dismutase, abbreviation SOD are a kind of active materials derived from life entity, are distributed widely in various biologies
In vivo, such as animal, plant, microorganism etc., the rubbish that SOD is considered as in Life Science in the enzyme, human body of most magical magic power is clear
Doffer, it is the natural enemy of oxygen radical.It is existing it has proven convenient that the disease caused by oxygen radical is up to more than 60 kind, oxygen radical
It can cause protein denaturation and crosslinking, internal many enzymes and hormone is made to lose bioactivity, the immunocompetence of body, nerve are anti-
Penetrate the reduction of the systems vigor such as ability, locomitivity, while nucleic acid structure can also be destroyed and cause entire organism metabolism not normal etc., most
Make body that lesion occur eventually.Since SOD has special physiological activity, it can fight and block caused by oxygen radical is to cell
Damage, and repair damaged cell in time, restore caused by free radical to cell damage.Due to modern life pressure, environment
Pollution, various radiation and excess movement can all cause oxygen radical largely to be formed, therefore, the ground of SOD in biological antioxidant mechanism
Position is more and more important.
Wine is a kind of drink common in China, is wanted with the development of science and technology to wine with improvement of living standard, people
Ask higher and higher, the kind of wine is also more and more.Currently on the market, health liquor SOD combined with white wine is various in style, but
It is typically to be produced by the simple preparation methods such as filtering after directly impregnating raw material, the effective ingredient of drug is precipitated not
Completely, drug waste is caused, meanwhile, common preparation method can change the color and luster of white wine, taste, and the health liquor function of producing
It is single, different user demands cannot be met.
Invention content
It is above-mentioned to solve the purpose of the present invention is to provide a kind of SOD white wine preparation methods for supporting kidney function effect with protect liver
The problem of being proposed in background technology.
To achieve the above object, the present invention provides the following technical solutions：
A kind of SOD white wine preparation methods for supporting kidney function effect with protect liver, which is characterized in that it includes the following steps：
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 3-5 times with deionized water, dries, deionization is then added
Water 5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extracting solution is concentrated under reduced pressure, then is filtered through 1400 mesh
The mixed extract A of 1000ml is obtained afterwards；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 40-80 mesh sieve, is then placed in
Mechanical agitation is carried out in mixing machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is oozed with the pure glutinous rice wine of 10-16 times of weight
It filters processing, then the percolate of acquisition is concentrated under reduced pressure, then filtered through 1400 mesh, obtain mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 10-80 mesh, the pure glutinous rice wine that alcoholic strength is 20 ° is added, and pure
The volume ratio of glutinous rice wine and Cordyceps militaris is 4:1, it is ultrasonically treated using supersonic wave wall breaking technology, obtains mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extraction will be added in the extract F obtained in step 6)
The volume ratio of object F is 10:1, ultrasonic disperse obtains mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of 50-80 DEG C of temperature refluxing extraction 1-2 hours, add
The pure glutinous rice wine for being 25 ° with alcoholic strength isometric mixed liquor G, refluxing extraction twice, 1 hour every time, merge extracting solution three times,
By can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition is concentrated by reduced vacuum to get Cordyceps militaris SOD again；
9) the white wine 800ml that alcoholic strength is 15-45 degree is weighed, the Cordyceps militaris SOD 25- obtained in step 8) are sequentially added
It obtains obtaining mixed extract C 45-85ml in mixed extract A 20-40ml and step 3) in 450000 units, step 1), surpass
Sound disperse 20-50min, stand 2 days, 1400 mesh filtering to get.
As a further solution of the present invention：In step 1), the pressure of the high temperature and pressure extraction is 0.4-0.8MPa, when
Between be 20-30min.
As further scheme of the invention：In step 2), the churned mechanically time is 20-80min.
As further scheme of the invention：In step 3), the alcoholic strength of the pure glutinous rice wine is 10-30 °.
As further scheme of the invention：In step 4), the condition of the supersound process is ultrasonic power 80-
250W, ultrasonic time 10-50min.
As further scheme of the invention：In step 6), the pressure of the extraction is 20-30 megapascal, temperature 25-
45 DEG C, flow velocity is 15-25 ls/h.
As further scheme of the invention：In step 6), the time of the extraction is 1-6 hours.
As further scheme of the invention：In step 7), the time of the ultrasonic disperse is 20-50min.
As further scheme of the invention：In step 8), the time of the reduced vacuum concentration is 10-40min.
The SOD white wine prepared using the SOD white wine preparation methods for supporting kidney function effect with protect liver.
Compared with prior art, the beneficial effects of the invention are as follows：
(1) present invention, can be quick by the mutual cooperation of supersonic wave wall breaking technology and supercritical carbon dioxide extraction method
The Cordyceps militaris SOD for efficiently extracting high activity, avoids the waste of drug.
(2) present invention can effectively improve the clarity of SOD white wine, and it is heavy to effectively reduce the macromolecular being also easy to produce in wine
It forms sediment, the SOD white wine prepared using the present invention improves the taste of SOD white wine without the miscellaneous taste of strong drug.
(3) using SOD white wine prepared by the present invention there is good protect liver to support kidney function effect, while the activation of brain can be promoted
Property, brain tonic and intelligence development, anti-epileptic promotes sleep, beauty moisturizing to delay brain aging function, supplements human body inhibition god's grade mediator, promotees
Into kidney Fitness improvement, liver function is activated, while also having effects that good blood pressure lowering, antifatigue, body and mind discomfort of releiving, is had
Vast market prospect.
Specific implementation mode
Technical scheme of the present invention is described in more detail With reference to embodiment.
Embodiment 1
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 5 times with deionized water, dries, deionized water is then added
5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extraction pressure is 0.6MPa, time 25min, extracting solution
It is concentrated under reduced pressure, then the mixed extract A of 1000ml is obtained after the filtering of 1400 mesh；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 60 mesh sieve, then merging mixing
Mechanical agitation 40min is carried out in machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is 20 ° pure glutinous with the alcoholic strength of 13 times of weight
Rice wine carries out diacolation processing, and then the percolate of acquisition is concentrated under reduced pressure, then is filtered through 1400 mesh, obtains mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 60 mesh, the pure glutinous rice wine that alcoholic strength is 20 ° is added, and pure glutinous
The volume ratio of rice wine and Cordyceps militaris is 4:1, it is handled using supersonic wave wall breaking technology, ultrasonic power 160W, when ultrasonic
Between be 30min, obtain mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, extracting pressure 25
Megapascal, extraction temperature are 30 DEG C, and flow velocity is 18 ls/h, and extraction time is 3 hours, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extraction will be added in the extract F obtained in step 6)
The volume ratio of object F is 10:1, ultrasonic disperse 30min obtain mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of temperature 60 C refluxing extraction 1.5 hours, add and mix
The pure glutinous rice wine that the isometric alcoholic strengths of liquid G are 25 ° is closed, refluxing extraction twice, 1 hour every time, merges extracting solution three times, passes through
Can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition concentrates 25min to get Cordyceps militaris by reduced vacuum again
SOD；
9) the white wine 800ml that alcoholic strength is 25 degree is weighed, it is single to sequentially add the Cordyceps militaris SOD 250,000 obtained in step 8)
It obtains obtaining mixed extract C 45ml, ultrasonic disperse 30min in mixed extract A 20ml and step 3) in position, step 1),
Stand 2 days, 1400 mesh filtering to get.
Embodiment 2
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 5 times with deionized water, dries, deionized water is then added
5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extraction pressure is 0.6MPa, time 25min, extracting solution
It is concentrated under reduced pressure, then the mixed extract A of 1000ml is obtained after the filtering of 1400 mesh；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 60 mesh sieve, then merging mixing
Mechanical agitation 40min is carried out in machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is 20 ° pure glutinous with the alcoholic strength of 13 times of weight
Rice wine carries out diacolation processing, and then the percolate of acquisition is concentrated under reduced pressure, then is filtered through 1400 mesh, obtains mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 60 mesh, the pure glutinous rice wine that alcoholic strength is 20 ° is added, and pure glutinous
The volume ratio of rice wine and Cordyceps militaris is 4:1, it is handled using supersonic wave wall breaking technology, ultrasonic power 160W, when ultrasonic
Between be 30min, obtain mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, extracting pressure 25
Megapascal, extraction temperature are 30 DEG C, and flow velocity is 18 ls/h, and extraction time is 3 hours, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extraction will be added in the extract F obtained in step 6)
The volume ratio of object F is 10:1, ultrasonic disperse 30min obtain mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of temperature 60 C refluxing extraction 1.5 hours, add and mix
The pure glutinous rice wine that the isometric alcoholic strengths of liquid G are 25 ° is closed, refluxing extraction twice, 1 hour every time, merges extracting solution three times, passes through
Can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition concentrates 25min to get Cordyceps militaris by reduced vacuum again
SOD；
9) the white wine 800ml that alcoholic strength is 25 degree is weighed, it is single to sequentially add the Cordyceps militaris SOD 450,000 obtained in step 8)
It obtains obtaining mixed extract C 85ml, ultrasonic disperse 30min in mixed extract A 40ml and step 3) in position, step 1),
Stand 2 days, 1400 mesh filtering to get.
Embodiment 3
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 5 times with deionized water, dries, deionized water is then added
5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extraction pressure is 0.6MPa, time 25min, extracting solution
It is concentrated under reduced pressure, then the mixed extract A of 1000ml is obtained after the filtering of 1400 mesh；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 60 mesh sieve, then merging mixing
Mechanical agitation 40min is carried out in machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is 20 ° pure glutinous with the alcoholic strength of 13 times of weight
Rice wine carries out diacolation processing, and then the percolate of acquisition is concentrated under reduced pressure, then is filtered through 1400 mesh, obtains mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 60 mesh, the pure glutinous rice wine that alcoholic strength is 20 ° is added, and pure glutinous
The volume ratio of rice wine and Cordyceps militaris is 4:1, it is handled using supersonic wave wall breaking technology, ultrasonic power 160W, when ultrasonic
Between be 30min, obtain mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, extracting pressure 25
Megapascal, extraction temperature are 30 DEG C, and flow velocity is 18 ls/h, and extraction time is 3 hours, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extraction will be added in the extract F obtained in step 6)
The volume ratio of object F is 10:1, ultrasonic disperse 30min obtain mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of temperature 60 C refluxing extraction 1.5 hours, add and mix
The pure glutinous rice wine that the isometric alcoholic strengths of liquid G are 25 ° is closed, refluxing extraction twice, 1 hour every time, merges extracting solution three times, passes through
Can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition concentrates 25min to get Cordyceps militaris by reduced vacuum again
SOD；
9) the white wine 800ml that alcoholic strength is 25 degree is weighed, it is single to sequentially add the Cordyceps militaris SOD 350,000 obtained in step 8)
It obtains obtaining mixed extract C 65ml, ultrasonic disperse 30min in mixed extract A 30ml and step 3) in position, step 1),
Stand 2 days, 1400 mesh filtering to get.
Embodiment 4
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 5 times with deionized water, dries, deionized water is then added
5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extraction pressure is 0.6MPa, time 25min, extracting solution
It is concentrated under reduced pressure, then the mixed extract A of 1000ml is obtained after the filtering of 1400 mesh；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 60 mesh sieve, then merging mixing
Mechanical agitation 40min is carried out in machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is 20 ° pure glutinous with the alcoholic strength of 13 times of weight
Rice wine carries out diacolation processing, and then the percolate of acquisition is concentrated under reduced pressure, then is filtered through 1400 mesh, obtains mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 60 mesh, the pure glutinous rice wine that alcoholic strength is 20 ° is added, and pure glutinous
The volume ratio of rice wine and Cordyceps militaris is 4:1, it is handled using supersonic wave wall breaking technology, ultrasonic power 160W, when ultrasonic
Between be 10min, obtain mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, extracting pressure 25
Megapascal, extraction temperature are 30 DEG C, and flow velocity is 18 ls/h, and extraction time is 3 hours, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extraction will be added in the extract F obtained in step 6)
The volume ratio of object F is 10:1, ultrasonic disperse 30min obtain mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of temperature 60 C refluxing extraction 1.5 hours, add and mix
The pure glutinous rice wine that the isometric alcoholic strengths of liquid G are 25 ° is closed, refluxing extraction twice, 1 hour every time, merges extracting solution three times, passes through
Can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition concentrates 25min to get Cordyceps militaris by reduced vacuum again
SOD；
9) the white wine 800ml that alcoholic strength is 25 degree is weighed, it is single to sequentially add the Cordyceps militaris SOD 350,000 obtained in step 8)
It obtains obtaining mixed extract C 65ml, ultrasonic disperse 30min in mixed extract A 30ml and step 3) in position, step 1),
Stand 2 days, 1400 mesh filtering to get.
Embodiment 5
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 5 times with deionized water, dries, deionized water is then added
5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extraction pressure is 0.6MPa, time 25min, extracting solution
It is concentrated under reduced pressure, then the mixed extract A of 1000ml is obtained after the filtering of 1400 mesh；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 60 mesh sieve, then merging mixing
Mechanical agitation 40min is carried out in machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is 20 ° pure glutinous with the alcoholic strength of 13 times of weight
Rice wine carries out diacolation processing, and then the percolate of acquisition is concentrated under reduced pressure, then is filtered through 1400 mesh, obtains mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 60 mesh, the pure glutinous rice wine that alcoholic strength is 20 ° is added, and pure glutinous
The volume ratio of rice wine and Cordyceps militaris is 4:1, it is handled using supersonic wave wall breaking technology, ultrasonic power 160W, when ultrasonic
Between be 50min, obtain mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, extracting pressure 25
Megapascal, extraction temperature are 30 DEG C, and flow velocity is 18 ls/h, and extraction time is 3 hours, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extraction will be added in the extract F obtained in step 6)
The volume ratio of object F is 10:1, ultrasonic disperse 30min obtain mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of temperature 60 C refluxing extraction 1.5 hours, add and mix
The pure glutinous rice wine that the isometric alcoholic strengths of liquid G are 25 ° is closed, refluxing extraction twice, 1 hour every time, merges extracting solution three times, passes through
Can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition concentrates 25min to get Cordyceps militaris by reduced vacuum again
SOD；
9) the white wine 800ml that alcoholic strength is 25 degree is weighed, it is single to sequentially add the Cordyceps militaris SOD 350,000 obtained in step 8)
It obtains obtaining mixed extract C 65ml, ultrasonic disperse 30min in mixed extract A 30ml and step 3) in position, step 1),
Stand 2 days, 1400 mesh filtering to get.
Embodiment 6
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 5 times with deionized water, dries, deionized water is then added
5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extraction pressure is 0.6MPa, time 25min, extracting solution
It is concentrated under reduced pressure, then the mixed extract A of 1000ml is obtained after the filtering of 1400 mesh；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 60 mesh sieve, then merging mixing
Mechanical agitation 40min is carried out in machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is 20 ° pure glutinous with the alcoholic strength of 13 times of weight
Rice wine carries out diacolation processing, and then the percolate of acquisition is concentrated under reduced pressure, then is filtered through 1400 mesh, obtains mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 60 mesh, the pure glutinous rice wine that alcoholic strength is 20 ° is added, and pure glutinous
The volume ratio of rice wine and Cordyceps militaris is 4:1, it is handled using supersonic wave wall breaking technology, ultrasonic power 160W, when ultrasonic
Between be 30min, obtain mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, extracting pressure 25
Megapascal, extraction temperature are 30 DEG C, and flow velocity is 18 ls/h, and extraction time is 1 hour, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extraction will be added in the extract F obtained in step 6)
The volume ratio of object F is 10:1, ultrasonic disperse 30min obtain mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of temperature 60 C refluxing extraction 1.5 hours, add and mix
The pure glutinous rice wine that the isometric alcoholic strengths of liquid G are 25 ° is closed, refluxing extraction twice, 1 hour every time, merges extracting solution three times, passes through
Can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition concentrates 25min to get Cordyceps militaris by reduced vacuum again
SOD；
9) the white wine 800ml that alcoholic strength is 25 degree is weighed, it is single to sequentially add the Cordyceps militaris SOD 350,000 obtained in step 8)
It obtains obtaining mixed extract C 65ml, ultrasonic disperse 30min in mixed extract A 30ml and step 3) in position, step 1),
Stand 2 days, 1400 mesh filtering to get.
Embodiment 7
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 5 times with deionized water, dries, deionized water is then added
5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extraction pressure is 0.6MPa, time 25min, extracting solution
It is concentrated under reduced pressure, then the mixed extract A of 1000ml is obtained after the filtering of 1400 mesh；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 60 mesh sieve, then merging mixing
Mechanical agitation 40min is carried out in machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is 20 ° pure glutinous with the alcoholic strength of 13 times of weight
Rice wine carries out diacolation processing, and then the percolate of acquisition is concentrated under reduced pressure, then is filtered through 1400 mesh, obtains mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 60 mesh, the pure glutinous rice wine that alcoholic strength is 20 ° is added, and pure glutinous
The volume ratio of rice wine and Cordyceps militaris is 4:1, it is handled using supersonic wave wall breaking technology, ultrasonic power 160W, when ultrasonic
Between be 30min, obtain mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, extracting pressure 25
Megapascal, extraction temperature are 30 DEG C, and flow velocity is 18 ls/h, and extraction time is 6 hours, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extraction will be added in the extract F obtained in step 6)
The volume ratio of object F is 10:1, ultrasonic disperse 30min obtain mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of temperature 60 C refluxing extraction 1.5 hours, add and mix
The pure glutinous rice wine that the isometric alcoholic strengths of liquid G are 25 ° is closed, refluxing extraction twice, 1 hour every time, merges extracting solution three times, passes through
Can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition concentrates 25min to get Cordyceps militaris by reduced vacuum again
SOD；
9) the white wine 800ml that alcoholic strength is 25 degree is weighed, it is single to sequentially add the Cordyceps militaris SOD 350,000 obtained in step 8)
It obtains obtaining mixed extract C 65ml, ultrasonic disperse 30min in mixed extract A 30ml and step 3) in position, step 1),
Stand 2 days, 1400 mesh filtering to get.
Embodiment 8
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 5 times with deionized water, dries, deionized water is then added
5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extraction pressure is 0.6MPa, time 25min, extracting solution
It is concentrated under reduced pressure, then the mixed extract A of 1000ml is obtained after the filtering of 1400 mesh；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 60 mesh sieve, then merging mixing
Mechanical agitation 40min is carried out in machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is 20 ° pure glutinous with the alcoholic strength of 13 times of weight
Rice wine carries out diacolation processing, and then the percolate of acquisition is concentrated under reduced pressure, then is filtered through 1400 mesh, obtains mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 60 mesh, the pure glutinous rice wine that alcoholic strength is 20 ° is added, and pure glutinous
The volume ratio of rice wine and Cordyceps militaris is 4:1, it is handled using supersonic wave wall breaking technology, ultrasonic power 160W, when ultrasonic
Between be 30min, obtain mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, extracting pressure 25
Megapascal, extraction temperature are 30 DEG C, and flow velocity is 18 ls/h, and extraction time is 3.5 hours, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extraction will be added in the extract F obtained in step 6)
The volume ratio of object F is 10:1, ultrasonic disperse 30min obtain mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of temperature 60 C refluxing extraction 1.5 hours, add and mix
The pure glutinous rice wine that the isometric alcoholic strengths of liquid G are 25 ° is closed, refluxing extraction twice, 1 hour every time, merges extracting solution three times, passes through
Can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition concentrates 25min to get Cordyceps militaris by reduced vacuum again
SOD；
9) the white wine 800ml that alcoholic strength is 25 degree is weighed, it is single to sequentially add the Cordyceps militaris SOD 350,000 obtained in step 8)
It obtains obtaining mixed extract C 65ml, ultrasonic disperse 30min in mixed extract A 30ml and step 3) in position, step 1),
Stand 2 days, 1400 mesh filtering to get.
Comparative example 1
Compared with Example 3, be free of using supersonic wave wall breaking technology carry out ultrasound treatment step, other with embodiment 3
It is identical.
Comparative example 2
Compared with Example 3, it is free of and extraction step, other and embodiment 3 is carried out using supercritical carbon dioxide extraction method
It is identical.
Comparative example 3
Compared with Example 3, it is free of and ultrasound treatment step is carried out using supersonic wave wall breaking technology and uses overcritical dioxy
Change carbon extraction and carry out extraction step, other are same as Example 3.
Performance test
One, clarity detection experiment
Detect the clarity of the SOD white wine that kidney function effect is supported with protect liver of embodiment 3 and comparative example 1-3 preparations.Specific side
Method is that the SOD white wine for preparing embodiment 3 and comparative example 1-3 is stored 24 months, carries out clarity test respectively, takes out 30 at random
The SOD white wine that part has been stored, its light transmittance is measured with 10ml cuvettes under 752 660 nanometers of type ultraviolet specrophotometer wavelength,
Then by test, results are averaged, and specific clarity detection test result is shown in Table 1.
It is of the invention from can be seen that in the data comparison of embodiment 3 and comparative example 1 according to the clarity testing result of table 1
It is ultrasonically treated by using supersonic wave wall breaking technology, the clarity of SOD white wine can be effectively improved；From embodiment 3 with it is right
It, can be effective as can be seen that the present invention is extracted by using supercritical carbon dioxide extraction method in the data comparison of ratio 2
Improve the clarity of SOD white wine.
In addition, as can be seen that the present invention is broken by using ultrasonic wave from the data comparison of embodiment 3 and comparative example 1-3
Wall technique carries out the mutual cooperation being ultrasonically treated and supercritical carbon dioxide extraction method is extracted, and can further effectively improve
The clarity of SOD white wine shows to effectively reduce the macromolecular precipitation being also easy to produce in wine, improves the taste of SOD white wine.Table 1
Clarity testing result table
| Group | Light transmittance |
| Embodiment 3 | 99.1 |
| Comparative example 1 | 87 |
| Comparative example 2 | 85 |
| Comparative example 3 | 78 |
Two, mouse swimming exercise is tested
Test method：Healthy male mice in kunming (20 ± 2 grams of weight) 100 is taken, is randomly divided into 5 groups, every group 20,
The first 4 groups SOD white wine that kidney function effect is supported with protect liver for giving embodiment 3 and comparative example 1-3 preparations respectively, the 5th group is given physiology
Brine is as blank test, according to 0.1mL/lOg mouse weight gavage, 1 time a day, continuous 10 days, after the 11st day gavage 1 hour
Each mouse tail line fastens the small iron ring of 2 grammes per square metres, mouse is put into the bucket of depth of water 20cm, immediately timing, until mouse is completely heavy
Until entering water-bed no longer upstream, mouse swimming exercise the results are shown in Table 2.
2 mouse swimming exercise result of table
| Group | Swimming time (min) |
| Embodiment 3 | 26.2±2.5 |
| Comparative example 1 | 23.3±1.6 |
| Comparative example 2 | 22.1±1.7 |
| Comparative example 3 | 20.1±1.8 |
| Physiological saline group | 18.2±2.1 |
Sportive efforts endurance is in the whether vigorous important indicator of reaction body energy and kidney-yang deficiency and deficiency of kidney-QI
Energy is not good, fatiguability, direct performance slow in reacting etc., thus it is also kidney-yang deficiency and kidney qi to improve exercise tolerance and muscle power
The direct embodiment that deficiency is improved.It can be dramatically increased using the SOD white wine for supporting kidney function effect with protect liver prepared by the present invention
Mouse swimming time is better than physiological saline group, shows the kidney-yang deficiencies such as its, fatiguability not good to energy, slow in reacting and kidney qi not
Sufficient symptom has significant curative effect.
From the data comparison of embodiment 3 and comparative example 1 as can be seen that the present invention by using supersonic wave wall breaking technology into
Row is ultrasonically treated, and can effectively improve the precipitation effect of medicament effective component, and then kidney effect is supported in the kidney tonifying for improving SOD white wine；
As can be seen that the present invention is carried out by using supercritical carbon dioxide extraction method from data comparison of the embodiment 3 with comparative example 2
Extraction can effectively improve the precipitation effect of medicament effective component, and then kidney effect is supported in the kidney tonifying for improving SOD white wine；In addition, from
As can be seen that the present invention is carried out by using supersonic wave wall breaking technology at ultrasound in the data comparison of embodiment 3 and comparative example 1-3
The mutual cooperation that reason and supercritical carbon dioxide extraction method are extracted, can be further able to effectively improve medicament effective component
Precipitation effect, and then kidney effect is supported in the kidney tonifying for improving SOD white wine.
Three, clinical test
1. Lee, man, 38 years old, suffer from kidney deficiency and liver, blockage of main and collateral channels illness.Dizziness and tinnitus, lassitude, through curing treatment in many ways
It imitates little.Start in May, 2016 to take this wine, sb.'s illness took a favorable turn for August part, and the first half of the year in 2017 is almost recovered, clothes to present, body
In order.
2. river, female 41 years old, suffer from soreness and weakness of waist and knees, waist and knee weakness is kidney-yin deficiency through tcm diagnosis.Take this wine 7-15 days,
Constitution is obviously improved, and sleep quality significantly improves, even drink 2 months or more, illness does not occur substantially, also no anti-during stopping drink
Play symptom.
3. Chen, man, 32 years old, suffer from frequent micturition, urgent urination, insomnia and dreamful sleep takes this wine 7-15 days, and insomnia phenomenon significantly reduces,
Urine urgency-frequency is also improved, and even drinks 2-4 months, without symptom of getting up in the night to urinate, does not also rebound after stopping drink.
As can be seen that the present invention passes through supersonic wave wall breaking technology and supercritical carbon dioxide extraction method from result above
It cooperates, quickly and efficiently just can extract the Cordyceps militaris SOD of high activity in low-concentration ethanol, and then can effectively improve
The precipitation effect of medicament effective component avoids the waste of drug, while can improve the clarity of SOD white wine, without strong medicine
The miscellaneous taste of object is shown to effectively reduce the macromolecular precipitation being also easy to produce in wine, improves the taste of SOD white wine, made using the present invention
There is standby SOD white wine good protect liver to support kidney function effect, and kidney tonifying, which is made, by selected a variety of integration of drinking and medicinal herbs Chinese herbal medicines and white wine protects
Strong medicinal liquor, achievees the purpose that equilibrium between yin and yang with mending, can mild kidney tonifying, liver and kidney benefiting, replenishing vital essence and blood, to kidney deficiency and deficiency of kidney-QI symptom
Significant curative effect is played, there is good tonifying kidney and strengthening yang, the reactivity of brain, brain tonic and intelligence development, anti-epileptic is promoted to promote sleep, beauty
Moisturizing promotes brain activation, delays brain aging function, can supplement human body inhibition god's grade mediator, promotes kidney Fitness improvement, living
Change liver function, while having effects that good blood pressure lowering, antifatigue, body and mind discomfort of releiving, has a vast market foreground.
The better embodiment of the present invention is explained in detail above, but the present invention is not limited to above-mentioned embodiment party
Formula, one skilled in the relevant art within the scope of knowledge, can also be without departing from the purpose of the present invention
Various changes can be made.
Claims (10)
1. a kind of SOD white wine preparation methods for supporting kidney function effect with protect liver, which is characterized in that it includes the following steps：
1) agate card, oyster and each 800g of semen astragali complanati are weighed, is cleaned 3-5 times with deionized water, dries, deionized water is then added
5000g carries out high temperature and pressure extraction using steam pressure cooker equipment, and extracting solution is concentrated under reduced pressure, then after the filtering of 1400 mesh
Obtain the mixed extract A of 1000ml；
2) it pueraria lobata, okra and the Cortex Eucommiae of weight such as weighs, cleans, drying smashes it through 40-80 mesh sieve, then merging mixing
Mechanical agitation is carried out in machine, obtains mixture B；
3) the mixture B obtained in step 2) is put into percolator, is carried out at diacolation with the pure glutinous rice wine of 10-16 times of weight
Reason, then the percolate of acquisition is concentrated under reduced pressure, then is filtered through 1400 mesh, obtains mixed extract C；
4) it weighs Cordyceps militaris and processing is dried, be crushed to 10-80 mesh, the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice is added
The volume ratio of wine and Cordyceps militaris is 4:1, it is ultrasonically treated using supersonic wave wall breaking technology, obtains mixed liquor D；
5) the mixed liquor D obtained in step 4) is concentrated under reduced pressure, is spray-dried, obtains powder E；
6) the powder E obtained in step 5) is extracted using supercritical carbon dioxide extraction method, obtains extract F；
7) the pure glutinous rice wine that alcoholic strength is 20 °, and pure glutinous rice wine and extract F will be added in the extract F obtained in step 6)
Volume ratio be 10:1, ultrasonic disperse obtains mixed liquor G；
8) by the mixed liquor G obtained in step 7) under conditions of 50-80 DEG C of temperature refluxing extraction 1-2 hours, add and mix
The pure glutinous rice wine that the isometric alcoholic strengths of liquid G are 25 ° is closed, refluxing extraction twice, 1 hour every time, merges extracting solution three times, passes through
Can molecular cut off be 60,000 film carry out ultrafiltration, the clear liquid of acquisition is concentrated by reduced vacuum to get Cordyceps militaris SOD again；
9) the white wine 800ml that alcoholic strength is 15-45 degree is weighed, the Cordyceps militaris SOD 25-45 ten thousand obtained in step 8) are sequentially added
It obtains obtaining mixed extract C 45-85ml in mixed extract A 20-40ml and step 3) in unit, step 1), ultrasound point
Dissipate 20-50min, stand 2 days, 1400 mesh filtering to get.
2. the SOD white wine preparation methods according to claim 1 for supporting kidney function effect with protect liver, which is characterized in that step 1)
In, the pressure of the high temperature and pressure extraction is 0.4-0.8MPa, time 20-30min.
3. the SOD white wine preparation methods according to claim 1 or 2 for supporting kidney function effect with protect liver, which is characterized in that step
2) in, the churned mechanically time is 20-80min.
4. the SOD white wine preparation methods according to claim 1 for supporting kidney function effect with protect liver, which is characterized in that step 3)
In, the alcoholic strength of the pure glutinous rice wine is 10-30 °.
5. the SOD white wine preparation methods according to claim 1 for supporting kidney function effect with protect liver, which is characterized in that step 4)
In, the condition of the supersound process is ultrasonic power 80-250W, ultrasonic time 10-50min.
6. the SOD white wine preparation methods according to claim 1 for supporting kidney function effect with protect liver, which is characterized in that step 6)
In, the pressure of the extraction is 20-30 megapascal, and temperature is 25-45 DEG C, and flow velocity is 15-25 ls/h.
7. the SOD white wine preparation methods according to claim 6 for supporting kidney function effect with protect liver, which is characterized in that step 6)
In, the time of the extraction is 1-6 hours.
8. the SOD white wine preparation methods according to claim 1 for supporting kidney function effect with protect liver, which is characterized in that step 7)
In, the time of the ultrasonic disperse is 20-50min.
9. the SOD white wine preparation methods according to claim 1 for supporting kidney function effect with protect liver, which is characterized in that step 8)
In, the time of the reduced vacuum concentration is 10-40min.
10. using any SOD supported with protect liver prepared by the SOD white wine preparation methods of kidney function effect of claim 1-9
White wine.
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