CN108699006B - 3-((杂-)芳基)-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 - Google Patents

3-((杂-)芳基)-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 Download PDF

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CN108699006B
CN108699006B CN201780006506.5A CN201780006506A CN108699006B CN 108699006 B CN108699006 B CN 108699006B CN 201780006506 A CN201780006506 A CN 201780006506A CN 108699006 B CN108699006 B CN 108699006B
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cis
phenyl
diazaspiro
dimethylamino
methyl
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CN108699006A (zh
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S.屈纳特
R.M.克尼希斯
A.克莱斯
A.韦格特
I.科内齐基
P.拉特克利费
R.约施托克
T.科克
K.林茨
W.施勒德
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Gruenenthal GmbH
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    • A61K31/4164—1,3-Diazoles
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CN201780006506.5A 2016-01-13 2017-01-13 3-((杂-)芳基)-8-氨基-2-氧代-1，3-氮杂-螺-[4.5]-癸烷衍生物 Active CN108699006B (zh)

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EP16151012.8 2016-01-13
EP16151012 2016-01-13
PCT/EP2017/025005 WO2017121647A1 (en) 2016-01-13 2017-01-13 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives

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CN202111487304.1A Pending CN114149413A (zh) 2016-01-13 2017-01-13 3-((杂)芳基)-8-氨基-2-氧代-1,3-氮杂-螺-[4.5]-癸烷衍生物

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SI3402782T1 (sl) 2016-01-13 2020-11-30 Grunenthal Gmbh 8-amino-2-okso-1,3-diaza-spiro-(4,5)-dekanski derivati
CA3011176C (en) 2016-01-13 2023-09-19 Grunenthal Gmbh 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
CA3011180A1 (en) 2016-01-13 2017-07-20 Grunenthal Gmbh 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US10961242B2 (en) * 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
BR112021013557A2 (pt) 2019-01-11 2021-09-21 Grünenthal GmbH Amidas de pirrolidina substituídas iii
CN110862395B (zh) * 2019-11-13 2020-09-29 株洲千金药业股份有限公司 一种制备他达拉非重要杂质的原料化合物的制备方法
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