CN108697907A - 用于治疗恶性疾病、自身免疫疾病和炎性疾病的组合物和方法 - Google Patents

用于治疗恶性疾病、自身免疫疾病和炎性疾病的组合物和方法 Download PDF

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Publication number
CN108697907A
CN108697907A CN201780015429.XA CN201780015429A CN108697907A CN 108697907 A CN108697907 A CN 108697907A CN 201780015429 A CN201780015429 A CN 201780015429A CN 108697907 A CN108697907 A CN 108697907A
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China
Prior art keywords
cell
cells
expression
activity
disease
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CN201780015429.XA
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English (en)
Chinese (zh)
Inventor
I.沙沙尔
H.莱温斯基
L.拉多米尔
A.威纳
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Yeda Research and Development Co Ltd
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Yeda Research and Development Co Ltd
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Publication of CN108697907A publication Critical patent/CN108697907A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201780015429.XA 2016-01-06 2017-01-05 用于治疗恶性疾病、自身免疫疾病和炎性疾病的组合物和方法 Pending CN108697907A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662275378P 2016-01-06 2016-01-06
US62/275378 2016-01-06
PCT/IL2017/050019 WO2017118985A1 (en) 2016-01-06 2017-01-05 Compositions and methods for treating malignant, autoimmune and inflammatory diseases

Publications (1)

Publication Number Publication Date
CN108697907A true CN108697907A (zh) 2018-10-23

Family

ID=58016750

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780015429.XA Pending CN108697907A (zh) 2016-01-06 2017-01-05 用于治疗恶性疾病、自身免疫疾病和炎性疾病的组合物和方法

Country Status (7)

Country Link
US (3) US10828318B2 (https=)
EP (1) EP3400068A1 (https=)
JP (1) JP2019505511A (https=)
CN (1) CN108697907A (https=)
AU (1) AU2017204950A1 (https=)
CA (1) CA3009127A1 (https=)
WO (1) WO2017118985A1 (https=)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN111304316A (zh) * 2020-03-04 2020-06-19 苏州大学 基因Bmal1在制备检测治疗炎症性肠病的产品中的应用
CN115807090A (zh) * 2022-11-17 2023-03-17 中国医学科学院肿瘤医院 Slamf9在肿瘤免疫治疗中的应用
CN119857143A (zh) * 2023-10-20 2025-04-22 天津济坤医药科技有限公司 Cd84作为治疗靶点在制备防治炎症性肠病的药物中的应用

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CN106470707A (zh) 2014-05-07 2017-03-01 应用分子运输有限责任公司 用于口服递送生物活性货物的cholix毒素衍生的融合分子
EP3711488A1 (en) 2015-05-06 2020-09-23 Snipr Technologies Limited Altering microbial populations & modifying microbiota
US10828318B2 (en) 2016-01-06 2020-11-10 Yeda Research And Development Co. Ltd. Compositions and methods for treating malignant, autoimmune and inflammatory diseases
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
US10760075B2 (en) * 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
WO2020096695A1 (en) 2018-11-07 2020-05-14 Applied Molecular Transport Inc. Cholix-derived carriers for oral delivery of heterologous payload
MX2022001975A (es) 2019-08-16 2022-03-11 Applied Molecular Transport Inc Composiciones, formulaciones y produccion y purificacion de interleucinas.
JP2023516089A (ja) * 2020-03-06 2023-04-17 アレタ・バイオセラピューティクス・インコーポレイテッド がんの治療のための組成物及び方法
US20240180963A1 (en) * 2021-04-05 2024-06-06 Altheia Science S.R.L. Diagnosis and treatment of myeloid disorders and acute leukemias using novel tumor specific antigens
CN115990252A (zh) * 2021-10-18 2023-04-21 清华大学 通过阻断slam家族受体的信号来治疗肿瘤的组合物及其应用
GB202209518D0 (en) 2022-06-29 2022-08-10 Snipr Biome Aps Treating & preventing E coli infections
WO2024008659A1 (en) * 2022-07-04 2024-01-11 Institut National de la Santé et de la Recherche Médicale Use of a l-asparaginase in combination with a ferroptosis inducer for the treatment of extranodal natural killer/t-cell lymphoma
CN119857137A (zh) * 2023-10-20 2025-04-22 天津济坤医药科技有限公司 一种抗cd84抗体在制备预防和/或治疗炎症性肠病的药物中的应用

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111304316A (zh) * 2020-03-04 2020-06-19 苏州大学 基因Bmal1在制备检测治疗炎症性肠病的产品中的应用
CN115807090A (zh) * 2022-11-17 2023-03-17 中国医学科学院肿瘤医院 Slamf9在肿瘤免疫治疗中的应用
CN119857143A (zh) * 2023-10-20 2025-04-22 天津济坤医药科技有限公司 Cd84作为治疗靶点在制备防治炎症性肠病的药物中的应用

Also Published As

Publication number Publication date
US10828318B2 (en) 2020-11-10
EP3400068A1 (en) 2018-11-14
CA3009127A1 (en) 2017-07-13
AU2017204950A1 (en) 2018-08-16
US11986488B2 (en) 2024-05-21
US20190015441A1 (en) 2019-01-17
JP2019505511A (ja) 2019-02-28
WO2017118985A1 (en) 2017-07-13
US20210052626A1 (en) 2021-02-25
US20240398847A1 (en) 2024-12-05

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