CN108697769A - 用于治疗肥胖症的胰高血糖素和glp-1共激动剂 - Google Patents

用于治疗肥胖症的胰高血糖素和glp-1共激动剂 Download PDF

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Publication number
CN108697769A
CN108697769A CN201780013643.1A CN201780013643A CN108697769A CN 108697769 A CN108697769 A CN 108697769A CN 201780013643 A CN201780013643 A CN 201780013643A CN 108697769 A CN108697769 A CN 108697769A
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China
Prior art keywords
peptide
dose
less
administered
subject
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Pending
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CN201780013643.1A
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English (en)
Chinese (zh)
Inventor
M.A.贝纳雷
L.U.耶尔穆图斯
P.安贝里
M.彼得罗内
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MedImmune Ltd
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MedImmune Ltd
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Application filed by MedImmune Ltd filed Critical MedImmune Ltd
Publication of CN108697769A publication Critical patent/CN108697769A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201780013643.1A 2016-03-10 2017-03-10 用于治疗肥胖症的胰高血糖素和glp-1共激动剂 Pending CN108697769A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662306121P 2016-03-10 2016-03-10
US62/306121 2016-03-10
PCT/EP2017/055679 WO2017153575A1 (en) 2016-03-10 2017-03-10 Glucagon and glp-1 co-agonists for the treatment of obesity

Publications (1)

Publication Number Publication Date
CN108697769A true CN108697769A (zh) 2018-10-23

Family

ID=58266629

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780013643.1A Pending CN108697769A (zh) 2016-03-10 2017-03-10 用于治疗肥胖症的胰高血糖素和glp-1共激动剂

Country Status (19)

Country Link
US (3) US10676517B2 (https=)
EP (1) EP3426284B1 (https=)
JP (2) JP7237590B6 (https=)
KR (2) KR20220150416A (https=)
CN (1) CN108697769A (https=)
AR (1) AR107890A1 (https=)
AU (2) AU2017229530B2 (https=)
BR (1) BR112018067731A2 (https=)
CA (1) CA3015922A1 (https=)
EA (1) EA201891946A1 (https=)
ES (1) ES2983409T3 (https=)
IL (1) IL261528B2 (https=)
MX (1) MX2018010640A (https=)
MY (1) MY191321A (https=)
NZ (1) NZ746784A (https=)
SG (2) SG11201806342SA (https=)
TW (1) TWI793069B (https=)
WO (1) WO2017153575A1 (https=)
ZA (1) ZA201806637B (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN115975057A (zh) * 2023-03-16 2023-04-18 杭州信海医药科技有限公司 一种可妥度肽的固相合成方法

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CA3139613A1 (en) * 2019-05-21 2020-11-26 Medimmune Limited Cyclodextrin based injectable coformulations of sglt2 inhibitors and incretin peptides
EA202290107A1 (ru) 2019-07-01 2022-03-29 Медиммун Лимитед Фармацевтические композиции на основе пептидов, являющихся коагонистами глюкагона и glp-1
KR102812908B1 (ko) 2019-08-19 2025-05-28 일라이 릴리 앤드 캄파니 인크레틴 유사체의 제조 방법
JP2023505126A (ja) * 2019-12-03 2023-02-08 メディミューン，エルエルシー 肥満症の処置のためのグルカゴン及びｇｌｐ－１のコアゴニストを使用する組合せ治療
AR120714A1 (es) 2019-12-18 2022-03-09 Lilly Co Eli Análogos de incretina y sus usos
TW202140061A (zh) 2020-01-10 2021-11-01 英商梅迪繆思有限公司 用於治療２型糖尿病中的慢性腎病和糖尿病性腎病的升糖素及ｇｌｐ－１協同促效劑
CN115397455A (zh) * 2020-01-16 2022-11-25 上海仁会生物制药股份有限公司 Glp-1给药方案
CN113493503B (zh) * 2020-04-08 2022-08-05 浙江道尔生物科技有限公司 一种肠促胰岛素类似物及其制备方法和用途
KR20230005289A (ko) 2020-04-24 2023-01-09 베링거 인겔하임 인터내셔날 게엠베하 지방 간 질환 및 지방간염의 치료에서 장시간-작용성 glp-1/글루카곤 수용체 작용제로서 글루카곤 유사체
CA3201539A1 (en) * 2020-12-07 2022-06-16 Vyjayanthi Krishnan Therapeutic regimens and methods for lowering blood glucose and or body weight using glp-1r and gcgr balanced agonists
KR20230004135A (ko) * 2021-06-30 2023-01-06 한미약품 주식회사 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체를 포함하는 조합물의 치료학적 용도
KR20240043778A (ko) 2021-07-30 2024-04-03 베링거 인겔하임 인터내셔날 게엠베하 장시간-작용하는 glp1/글루카곤 수용체 작용제를 위한 용량 용법
US20230374096A1 (en) * 2022-05-19 2023-11-23 Vault Bioventures, Inc. Obesity treatment and prevention methods
KR20260022948A (ko) 2023-06-09 2026-02-20 썬 파마슈티컬 인더스트리스 리미티드 Glp-1/gip 이중 수용체 작용제, glp-1/gcg 이중 수용체 작용제, 및 glp-1/gip/gcg 삼중 수용체 작용제
KR20250067206A (ko) 2023-11-07 2025-05-15 주식회사 천농바이오푸드 대사성 질환의 예방, 개선 또는 치료 효과를 갖는 채소 추출복합물 및 이의 용도

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WO2011006497A1 (en) * 2009-07-13 2011-01-20 Zealand Pharma A/S Acylated glucagon analogues
WO2011094337A1 (en) * 2010-01-27 2011-08-04 Indiana University Research And Technology Corporation Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity
WO2012050923A2 (en) * 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Inc. Engineered polypeptides having enhanced duration of action
WO2012138941A1 (en) * 2011-04-05 2012-10-11 Longevity Biotech, Inc. Compositions comprising glucagon analogs and methods of making and using the same
CN103402536A (zh) * 2010-12-22 2013-11-20 马克迪亚生物科技公司 用gip和glp-1受体活性的基于胰高血糖素的肽来治疗代谢异常和肥胖的方法
WO2014091316A2 (en) * 2012-12-11 2014-06-19 Medimmune Limited Glucagon/glp-1 agonists for the treatment of obesity
CN104902919A (zh) * 2012-12-21 2015-09-09 赛诺菲 Glp1/gip双重激动剂或glp1/gip/胰高血糖素三重激动剂

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WO1990006952A1 (fr) 1988-12-22 1990-06-28 Kirin-Amgen, Inc. Facteur de stimulation de colonies de granulocytes modifies chimiquement
SI2173890T1 (sl) 2007-06-21 2011-06-30 Univ Muenchen Tech Biološko aktivni proteini, ki imajo povečano in vivo in/ali in vitro stabilnost
FR2932484B1 (fr) 2008-06-16 2010-06-18 Sanofi Aventis Nouveaux derives de pyrroloindole inhibiteurs d'hsp90, compositions les contenant et utilisation
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WO2011006497A1 (en) * 2009-07-13 2011-01-20 Zealand Pharma A/S Acylated glucagon analogues
WO2011094337A1 (en) * 2010-01-27 2011-08-04 Indiana University Research And Technology Corporation Glucagon antagonist - gip agonist conjugates and compositions for the treatment of metabolic disorders and obesity
WO2012050923A2 (en) * 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Inc. Engineered polypeptides having enhanced duration of action
CN103402536A (zh) * 2010-12-22 2013-11-20 马克迪亚生物科技公司 用gip和glp-1受体活性的基于胰高血糖素的肽来治疗代谢异常和肥胖的方法
WO2012138941A1 (en) * 2011-04-05 2012-10-11 Longevity Biotech, Inc. Compositions comprising glucagon analogs and methods of making and using the same
WO2014091316A2 (en) * 2012-12-11 2014-06-19 Medimmune Limited Glucagon/glp-1 agonists for the treatment of obesity
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CN104902919A (zh) * 2012-12-21 2015-09-09 赛诺菲 Glp1/gip双重激动剂或glp1/gip/胰高血糖素三重激动剂

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115975057A (zh) * 2023-03-16 2023-04-18 杭州信海医药科技有限公司 一种可妥度肽的固相合成方法
CN115975057B (zh) * 2023-03-16 2023-05-16 杭州信海医药科技有限公司 一种可妥度肽的固相合成方法

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KR20180120739A (ko) 2018-11-06
AU2020202381A1 (en) 2020-04-30
AR107890A1 (es) 2018-06-28
ZA201806637B (en) 2019-07-31
KR102460198B1 (ko) 2022-10-31
JP7237590B6 (ja) 2023-03-28
IL261528B2 (en) 2023-09-01
US10676517B2 (en) 2020-06-09
KR20220150416A (ko) 2022-11-10
EP3426284B1 (en) 2024-05-08
CA3015922A1 (en) 2017-09-14
SG11201806342SA (en) 2018-08-30
IL261528A (en) 2018-10-31
EP3426284A1 (en) 2019-01-16
WO2017153575A1 (en) 2017-09-14
NZ746784A (en) 2022-11-25
IL261528B1 (en) 2023-05-01
TW201733613A (zh) 2017-10-01
EA201891946A1 (ru) 2019-04-30
TWI793069B (zh) 2023-02-21
SG10202109721PA (en) 2021-10-28
US20220041681A1 (en) 2022-02-10
JP7237590B2 (ja) 2023-03-13
US20190185537A1 (en) 2019-06-20
ES2983409T3 (es) 2024-10-23
JP2019510014A (ja) 2019-04-11
BR112018067731A2 (pt) 2019-01-08
MY191321A (en) 2022-06-15
JP2023011864A (ja) 2023-01-24
AU2017229530B2 (en) 2020-05-07
AU2017229530A1 (en) 2018-10-25
US20200354426A1 (en) 2020-11-12
MX2018010640A (es) 2019-06-13

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