CN108693217B - Clinical eye resting potential measuring system - Google Patents
Clinical eye resting potential measuring system Download PDFInfo
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Abstract
The invention provides a clinical resting potential measuring system for eyes, belonging to the technical field of electrophysiology. The invention envisages the use of cross sampling in the electricity instead of eye movement recording, designs circuits and procedures for collecting and transmitting cross and non-cross signals, switches stably and reliably in multiple operating modes, implements the resting of the eye (non-eye movement) recording OSP instead of eye movement recording OSP, compares and evaluates the detection results in different modes. The upper computer in the system comprises software such as a control software module and a collected signal analysis module, and is used for: controlling the cross connection of the cross acquisition analog switch; controlling an AD conversion module in the singlechip to complete conversion from an analog signal to a digital signal; controlling the indicator light to be on or off and adapting to light and shade; realizing the automatic measurement of the maximum and minimum values of the detected waveform; and realizing the function of manually analyzing the detected waveform and the reference waveform; recording electrophysiological detection data and curves of the corresponding user; and recording an analysis curve of the electrophysiological detection data of the user, analysis data and the like.
Description
Technical Field
The invention relates to an eye resting potential (OSP) determination technology, belonging to the field of electrophysiology.
Background
The eyeball is known as a dipole like a battery, and a potential difference exists between the front end and the rear end. This potential difference originates in the pigmented epithelial layer of the retina of the eye, and this potential is physiologically called the resting potential of the eye (OSP). Medically, retinal function can be evaluated and fundus disease diagnosed by measuring the amount of OSP going up and down.
Closest to prior art implementations and the limitations that exist: for many years, the traditional EOG method records OSP by a pair of electrodes placed on the skin surface of inner and outer canthus of palpebral fissure in the horizontal direction and beating the eyeball, and records a pair of positive and negative potential values of the eyeball by using the same angle of the patient's eyeball rotation to control the left and right. However, the OSP recorded by this method is unstable, and the recorded result is unstable due to factors such as different eye jump angles and the degree of cooperation of the examination, and the reliability of the examination result is affected.
Disclosure of Invention
The object of the present invention is to overcome the disadvantages of the prior art and to disclose a novel ocular resting potential (OSP) measurement system for laboratory and clinical use, which aims to obtain non-ocular OSP, EOG and ocular OSP, EOG in the same subject, so that the results of the two different recording methods can be evaluated more objectively, whereby the examination item valuable in physiology and clinical medicine can be fully utilized.
The principle of the invention is that the cross sampling in electricity is assumed to replace the eye movement recording, the circuit and the program for collecting and transmitting the cross and non-cross signals are designed, the switching under a plurality of working modes is stable and reliable, the eye resting (non-eye movement) recording OSP is realized to replace the eye movement recording OSP, and the detection results under different modes are compared and evaluated.
The technical scheme required to be protected is characterized in that:
the utility model provides a clinical eye resting potential survey system, its characterized in that, this system includes inductor, alternately gathers analog switch circuit, amplifier module (in this field already belong to ripe prior art), 51 singlechips, host computer, light source, wherein:
the sensor is used for acquiring electric signals OSP of eye movement and non-eye movement;
the cross acquisition analog switch circuit comprises two CD4052 digital control analog switches and a TLP521-4 photoelectric coupling switch for isolation; the left eye electrode and the right eye electrode are respectively connected to pins (X0-X3) and pins (Y0-Y3) of the input end of each CD4052 digital control analog switch, and the two CD4052 digital control analog switches are respectively connected with the preamplifier through the pins 13 and 3; an IO pin (P20-P23) of a 51 single chip microcomputer is connected with an input pin of a TLP521-4 photoelectric coupling switch, and on/off of the TLP521-4 is controlled by an upper computer through outputting high/low level; the output pin of the TLP521-4 photoelectric coupling switch is connected with a control pin (A, B) of the CD 4052; when TLP521-4 is turned on, the control pin (A, B) of CD4052 is at low level; when off, the control pin (A, B) of CD4052 is at a high level so that the CD4052 digitally controlled analog switch can provide the eye electrode OPS signal to the amplifier in four different on modes (ground, normal, cross, off). See truth table of examples.
The amplifier module amplifies the collected electric signals;
the 51 single chip microcomputer comprises an AD (analog-to-digital) conversion unit and an IO (input/output) control module, wherein the AD conversion unit is connected with a post-amplifier of the amplifier module, converts an analog signal into digital information and provides the digital information to a computer; the IO control module is connected with the light source and used for controlling the light conditions of the light source;
the upper computer realizes the control of the cross acquisition analog switch circuit and the light source through a 51 single chip microcomputer.
The host computer includes control software module, acquisition signal analysis module, database, shows output module, wherein: the control software module: and controlling the cross connection of the cross acquisition analog switch. The method specifically comprises the following steps: the CD4052 digitally controlled analog switch is controlled 51 by controlling the high and low levels of the respective output pins of the single chip to provide the eye electrode OPS signal to the amplifier in one of four on modes (ground, normal, cross, off). See truth table of examples. Controlling 51 an AD conversion module in the singlechip to complete conversion from an analog signal to a digital signal; and controlling the indicator light to be on or off and adapting to the brightness. The acquisition signal analysis module: realizing the automatic measurement of the maximum and minimum values of the detected waveform; and the function of manual analysis of the detected waveform and the reference waveform (manual measurement of the peak value of the waveform, manual translation of the waveform, subtraction of the measured waveform and the basic waveform of the database) is realized. The database, comprising: establishing a user case, and storing and recording basic information of the user, such as name, age, gender and the like; recording electrophysiological detection data and curves of the corresponding user; and recording an analysis curve and analysis data of the electrophysiological detection data of the user. The display output module: and generating and displaying the waveform and information templated report.
Compared with the prior art, the invention has the beneficial effects that:
1. by the invention, a method for acquiring OSP without 'eye jump' can be created, so that a plurality of detection methods for acquiring OSP without eye movement and eye movement can be obtained in the same subject, and the results of different recording methods can be evaluated more objectively.
2. In addition to stability and reliability, safety and non-invasive examination of the human body is also contemplated for future clinical use.
3. The detection method for acquiring the OSP by the non-eye-jump has certain advantages, eliminates fatigue caused by the eye-jump and shortens recording time, and has application and popularization significance in laboratories and clinics.
Drawings
FIG. 1 is a schematic diagram of a system according to an embodiment of the present invention;
FIG. 2 provides a cross-acquisition analog switch circuit according to an embodiment of the present invention;
FIG. 3 illustrates a prior art amplifier circuit according to an embodiment of the present invention;
FIG. 4 is a diagram of a database structure according to an embodiment;
FIG. 5 illustrates exemplary parameter settings;
fig. 6 is a block diagram of analysis of the collected signals in the embodiment.
Detailed Description
The technical scheme of the hazardous waste safety feeding device provided by the invention is further explained by combining the specific embodiment and the attached drawings. The advantages and features of the present invention will become more apparent in conjunction with the following description.
It should be noted that the embodiments of the present invention have better practicability, and are not intended to limit the present invention in any form. The technical features or combinations of technical features described in the embodiments of the present invention should not be considered as being isolated, and they may be combined with each other to achieve a better technical effect. The scope of the preferred embodiments of the present invention may also include additional implementations, and this should be understood by those skilled in the art to which the embodiments of the present invention pertain.
Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values.
It is to be understood that the terms used in the present invention should be interpreted broadly, and the specific meanings of the above terms in the present invention can be specifically understood by those skilled in the art, unless otherwise specifically defined or limited.
The drawings of the present invention are in simplified form and are not to scale, but rather are provided for the purpose of facilitating and clearly illustrating embodiments of the present invention and are not intended to limit the scope of the invention in which the invention may be practiced. Any modification of the structure, change of the ratio or adjustment of the size of the structure should fall within the scope of the present disclosure without affecting the effect and the purpose of the present disclosure. And the same reference numbers appearing in the various drawings of the invention identify the same features or elements, which may be used in different embodiments.
The main technical principles and components of the present assay system are provided as shown in fig. 1.
The measuring system comprises:
1. inductor
For acquiring the electrical signal OSP of the non-eye movement.
This example employs a disposable silver-silver chloride electrode. Is the prior art.
2. Cross acquisition analog switch
The analog switch of fig. 2 is a circuit that collects and transmits cross and non-cross signals.
The embodiment is realized by adopting two eye electrodes, two CD4052 digital control analog switches and a TLP521-4 photoelectric coupling switch for isolation.
The left eye electrode and the right eye electrode are respectively connected to a pin X2 and a pin Y2 of the input end of the respective CD4052 digital control analog switch, and the two CD4052 digital control analog switches are respectively connected with the preamplifier through a pin 13 and a pin 3.
An IO pin (P20-P23) of a 51 single chip microcomputer is connected with an input pin of a TLP521-4 photoelectric coupling switch, and the on/off of the TLP521-4 is controlled by outputting high/low level; the output pin of the TLP521-4 photoelectric coupling switch is connected with a control pin (A, B) of the CD 4052. When TLP521-4 is turned on, the control pin (A, B) of CD4052 is at low level; when off, the control pin (A, B) of CD4052 is high.
As shown in the truth table of CD4052 in the above figure, the level of the control pin of CD4052 selects the eye electrode signal that is communicated to the amplifier module.
The circuit realizes the function of controlling cross sampling by using a 51 single chip microcomputer.
3. Amplifier module (prior art, figure 3)
The amplifier module of the system is an eye resting potential amplifier, is formed by connecting a preamplifier, an intermediate amplifier and a post amplifier in series, is used for recording electric signals with different frequencies and different potentials, protects the safety of a human body in recording, and is particularly used for collecting OSP.
The amplifier for the system is shown to have a total amplification of approximately 10000 times, in the order of 100, 8 and 12.5.
1) The preamplifier (floating portion) is composed of two stages of operational amplifiers. The first stage is low input end noise, high input impedance and high common mode rejection ratio; the second stage is a band pass filter with a low end of 0.05Hz and a high end of 10-100 Hz for supply.
2) The intermediate optical isolation amplifier adopts a linear optical coupling amplifier, can isolate 2500V voltage and is enough to protect the human safety during recording.
3) The post-stage amplifier (non-floating part) is composed of three parts: (1) the selectable 50Hz wave trap is used for limiting 50Hz interference; (2) the gain adjustment in-phase amplifier is adjustable in three steps, so that the total gain of the whole amplifier reaches 5000 times; (3) the follower is a low-impedance output for matching various displays.
4. 51 single chip microcomputer
The 51 single chip microcomputer comprises an AD (analog-to-digital) conversion unit and an IO (input/output) control module, wherein the AD conversion unit is connected with a post-amplifier of the amplifier module, converts an analog signal into digital information and provides the digital information to a computer, and the 51 single chip microcomputer transmits the converted data to the computer through a USB (universal serial bus) data line; the IO control module is connected with the light source and used for controlling the light conditions of the light source.
5. Upper computer
The upper computer controls the acquisition and light source through a 51 single chip microcomputer.
The host computer includes control software module, acquisition signal analysis module, database, shows output module, wherein:
the control software module: and controlling the cross connection of the cross acquisition analog switch. The method specifically comprises the following steps: the CD4052 digitally controlled analog switch is controlled 51 by controlling the high and low levels of the respective output pins of the single chip to provide the eye electrode OPS signal to the amplifier in one of four on modes (ground, normal, cross, off). See truth table of examples. As shown in figure 2 of the drawings, in which,
controlling 51 an AD conversion module in the singlechip to complete conversion from an analog signal to a digital signal; and controlling the indicator light to be on or off and adapting to the brightness.
The acquisition signal analysis module: realizing the automatic measurement of the maximum and minimum values of the detected waveform; and the function of manual analysis of the detected waveform and the reference waveform (manual measurement of the peak value of the waveform, manual translation of the waveform, subtraction of the measured waveform and the basic waveform of the database) is realized.
The database, comprising: establishing a user case, and storing and recording basic information of the user, such as name, age, gender and the like; recording electrophysiological detection data and curves of the corresponding user; and recording an analysis curve and analysis data of the electrophysiological detection data of the user. As shown in fig. 4, specifically, the database includes a personnel information table, an inspection item table, and an inspection parameter setting table, where the personnel information table includes personnel ID, name, age, address, and contact number; the examination item table comprises item IDs, examination items, eye states, examination time and eye movement graphs; the inspection parameter setting table includes inspection item IDs and various types of inspection parameters.
The display output module: and generating and displaying the waveform and information templated report.
When the method is applied, software sets control parameters aiming at each recording method by calling a configuration file, wherein the control parameters comprise:
(1, electrical signal switching time;
(2, sampling frequency;
(3, number of single cycles;
(4, number of single sampling points;
(5, smoothing the average;
(6, each set of cycle intervals;
(7, OSP recording mode selection (open-close, cross open-close, normal);
(8, adaptation state (light adaptation, dark adaptation);
(9, backlight status;
(10, light adaptation time;
(11, dark adaptation time, etc.;
(12, waveform Fourier data processing.
The above description is only illustrative of the preferred embodiments of the present invention and should not be taken as limiting the scope of the invention in any way. Any changes or modifications made by those skilled in the art based on the above disclosure should be considered as equivalent effective embodiments, and all the changes or modifications should fall within the protection scope of the technical solution of the present invention.
Claims (3)
1. The utility model provides a clinical eye resting potential survey system which characterized in that, this system includes inductor, alternately gathers analog switch circuit, amplifier module, 51 singlechip, host computer, light source, wherein:
the sensor is used for collecting electric signals OSP of eye movement and non-eye movement, and a left eye electrode and a right eye electrode are adopted;
the cross acquisition analog switch circuit comprises two CD4052 digital control analog switches and a TLP521-4 photoelectric coupling switch for isolation;
the CD4052 digital control analog switch comprises first input end pins 12, 14, 15 and 11, second input end pins 1, 2, 3 and 4, a first output end pin 13, a second output end pin 3 and control pins 9 and 10;
the TLP521-4 photoelectric coupling switch comprises control pins 10, 12, 14 and 16;
the amplifier module comprises a preamplifier and a post-amplifier, wherein the preamplifier comprises an amplifier channel 1 and an amplifier channel 2;
each CD4052 digital control analog switch is connected with an inductor through an input end pin thereof, and is connected with an amplifier channel in the preamplifier through an output end pin thereof;
the left eye electrode and the right eye electrode are respectively connected to pins of input ends of respective CD4052 digital control analog switches; the amplifier channel 1 is connected with a first CD4052 digital control analog switch, and the amplifier channel 2 is connected with a second CD4052 digital control analog switch; forming two parallel positive and negative electrode connecting circuits;
the CD4052 digital control analog switch is connected with the TLP521-4 photoelectric coupling switch through a control pin, and an IO pin of the 51 single chip microcomputer is connected with an input pin of the TLP521-4 photoelectric coupling switch to form a control circuit;
the 51 single chip microcomputer controls the on/off of the TLP521-4 photoelectric coupling switch by outputting high/low level; when the TLP521-4 photoelectric coupling switch is turned on, the level of a control pin of the CD4052 digital control analog switch is low; when the switch is switched off, the level of the control pin of the CD4052 digital control analog switch is high, so that the CD4052 digital control analog switch has four different switching-on modes, the four different switching-on modes are grounding, normal, cross and off, the first input terminal pins 12, 14, 15 and 11 are connected with the first output terminal pin 13 to respectively represent four switching-on selections of X0, X1, X2 and X3, the second input terminal pins 1, 2, 3 and 4 are connected with the second output terminal pin 3 to respectively represent four switching-on selections of Y0, Y1, Y2 and Y3, and the working mode is as follows: the selection of X1 and X13 is switched on, and the selection of Y1 and Y3 are switched on, so that the normal acquisition working state is realized; the selection of X2 and X13 are switched on, and the selection of Y2 and Y3 are switched on, so that the cross acquisition working state is realized;
providing an eye electrode OPS signal to an amplifier; the amplifier module amplifies the collected electric signals;
the 51 single chip microcomputer comprises an AD (analog-to-digital) conversion unit and an IO (input/output) control module, wherein the AD conversion unit is connected with a post-amplifier of the amplifier module, converts an analog signal into digital information and provides the digital information to a computer; the IO control module is connected with the light source and used for controlling the light conditions of the light source;
the host computer includes control software module, collection signal analysis module, database, shows output module, wherein:
the control software module comprises: controlling the cross connection of the cross acquisition analog switch; controlling 51 an AD conversion module in the singlechip to complete conversion from an analog signal to a digital signal; controlling the indicator light to be on or off and adapting to light and shade;
the acquisition signal analysis module: realizing the automatic measurement of the maximum and minimum values of the detected waveform; and realizing the function of manually analyzing the detected waveform and the reference waveform;
the database, comprising: establishing a user case, and storing and recording the basic information, name, age and gender of the user; recording electrophysiological detection data and curves of the corresponding user; recording an analysis curve and analysis data of electrophysiological detection data of a user;
the display output module: and generating and displaying the waveform and information templated report.
2. The system of claim 1, wherein: the reference waveform manual analysis function comprises: manually measuring the peak value of the waveform, manually translating the waveform, and subtracting the measured waveform from the basic waveform of the database.
3. The system of claim 1, wherein: the left and right eye electrodes are disposable silver-silver chloride electrodes.
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| CN201810915138.2A CN108693217B (en) | 2018-08-13 | 2018-08-13 | Clinical eye resting potential measuring system |
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| CN201810915138.2A CN108693217B (en) | 2018-08-13 | 2018-08-13 | Clinical eye resting potential measuring system |
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| CN108693217B true CN108693217B (en) | 2020-09-08 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS6118248A (en) * | 1984-07-04 | 1986-01-27 | Fujitsu Ltd | Eye pattern measuring device |
| TWM395456U (en) * | 2010-09-07 | 2011-01-01 | Holtek Semiconductor Inc | Electro-oculogram alarm apparatus |
| CN103054549B (en) * | 2012-12-29 | 2015-07-01 | 西安交通大学 | Wearable portable device and method for analyzing eye movement |
| US9084561B2 (en) * | 2013-06-17 | 2015-07-21 | Google Inc. | Symmetrically arranged sensor electrodes in an ophthalmic electrochemical sensor |
| CN103892829B (en) * | 2014-04-17 | 2016-04-27 | 安徽大学 | A kind of eye based on common space pattern moves signal recognition system and recognition methods thereof |
| CN107961008B (en) * | 2017-12-20 | 2020-09-15 | 中国科学院合肥物质科学研究院 | Auxiliary device and method for rapidly acquiring resting metabolic rate |
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