CN108852341B - Digital wireless neuroelectrophysiological signal detection single chip, system and method - Google Patents
Digital wireless neuroelectrophysiological signal detection single chip, system and method Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/369—Electroencephalography [EEG]
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/389—Electromyography [EMG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/316—Modalities, i.e. specific diagnostic methods
- A61B5/398—Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6802—Sensor mounted on worn items
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7225—Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
Abstract
The invention discloses a digital wireless neuroelectrophysiological signal detection single chip, system and method. Wherein, detect the single-chip and include: the clock reset management module is used for generating different frequency division clocks and reset signals for the detection single chip; the UART communication module is used for correspondingly configuring the working mode of the neuroelectrophysiological signal acquisition module and the functional parameters of the low-noise processing module through the working mode configuration register and the functional parameter configuration register respectively; the neuroelectricity physiological signal acquisition module is used for acquiring neuroelectricity physiological analog signals of subcutaneous tissues or skins under corresponding working modes; the low-noise processing module is used for receiving the neuro-electrophysiological analog signal, filtering and amplifying the neuro-electrophysiological analog signal, and transmitting the neuro-electrophysiological analog signal to the time-division multiplexing ADC circuit module to be converted into a neuro-electrophysiological digital signal; and the radio frequency transmitting module is used for setting the nerve electrophysiological digital signals into frames, modulating the frames into sequence carriers and radiating the sequence carriers by a radiation antenna.
Description
Technical Field
The invention belongs to the field of chip circuit design, and particularly relates to a digital wireless neuroelectrophysiological signal detection single chip, system and method.
Background
At present, due to the identification and detection requirements of various AI application scenes of various different target signals of weak small signals of a human body (such as electrocardio ECG, intracranial extracellular nerve electricity, extracranial brain electricity EEG, myoelectricity EKG and eye movement); in addition, because the voltage range of the bioelectricity signals to be identified is very weak, the small target signals to be identified are easily interfered and annihilated by the unneeded target signals, and even the small target signals to be identified are also polluted and annihilated by environmental background noise, circuit internal noise and the like, a human body biological weak small signal detection and identification chip core with a multi-neuroelectrophysiological signal detection function and suitable for general application is urgently needed to be designed.
Because in the study of hearing and optic nerve pathway, it is necessary to detect extracellular nerve electrophysiological signals of intracranial subcutaneous tissues, such as hippocampal extracellular nerve action potential spike and field potential signals, such as nerve electrical signals of auditory brainstem region; meanwhile, the neuroelectrophysiological signals outside the skin (including extracranial) such as EEG (electroencephalogram) and ECG (ECG) signals also need to be detected, so that a neuroelectric recording chip system for different subcutaneous or extracranial spatial positions is needed.
In the traditional bioelectricity recording circuit system, most of the bioelectricity recording circuit systems do not utilize a single chip system, so that the final instrument is large in volume and heavy in mass; and because traditional system does not possess multiple electrophysiological signal of human body and records the detection capability, still need utilize the commercial power to supply power, it has 50Hz power frequency interference, does not possess characteristics such as this patent is convenient for the user to carry equipment removal based on battery powered yet.
Moreover, the conventional bioelectricity detection equipment is assembled into a system based on purchasing related devices, so that interference among devices from different manufacturers is not uniformly considered and avoided and eliminated, and finally the system noise may be relatively large; meanwhile, the circuit stability and reliability of the conventional device are not well solved.
The "bio-signal measuring device" of the reuner technology company with patent application No. 201580018958.6 is based on a right leg driving circuit, and the "bio-signal measuring device" is not provided with a plurality of neuroelectrophysiological signal integrated detection functions.
The general victory signal converter of Jiangsu health online medical instrument Limited, with patent application number 201110197578.7, does not have the small and light-weight characteristics of the integrated chip of the patent, does not have the special chip circuit structure for extracellular and extracranial nerve electrical detection of the patent, and also does not have the functions of selecting a plurality of amplifier channels, specifically configuring parameters of an amplification filter and the like.
In summary, the conventional bioelectricity detection device does not provide an integrated function for performing a plurality of neuroelectrophysiological detections based on a dedicated single chip, and does not perform low power consumption design consideration, and noise reduction is not better optimized, and thus cannot meet the application requirements of future wearable systems or devices.
Disclosure of Invention
In order to solve the defects of the prior art, a first object of the present invention is to provide a single chip for detecting a digitized wireless neuroelectrophysiological signal, which is highly integrated, small in size, light in weight, and suitable for use in a wearable device.
The invention discloses a digital wireless nerve electrophysiological signal detection single chip, which comprises:
the clock reset management module is used for generating different frequency division clocks and reset signals for the detection single chip; and
the interface UART communication module is used for correspondingly configuring the working mode of the neuroelectrophysiological signal acquisition module and the functional parameters of the low-noise processing module through the working mode configuration register and the functional parameter configuration register respectively;
the neuroelectricity physiological signal acquisition module is used for acquiring neuroelectricity physiological analog signals of subcutaneous tissues or skins under corresponding working modes; the low-noise processing module is used for receiving the neuro-electrophysiological analog signal, filtering and amplifying the neuro-electrophysiological analog signal, and transmitting the neuro-electrophysiological analog signal to the time-division multiplexing ADC circuit module to be converted into a neuro-electrophysiological digital signal; and
and the radio frequency transmitting module is used for setting the nerve electrophysiological digital signals into frames, modulating the frames into sequence carriers and radiating the sequence carriers by a radiation antenna.
The digital wireless nerve electrophysiological signal detection single chip is driven by a battery to supply power, so that the problem of 50Hz power frequency interference caused by mains supply power supply is solved.
The digital wireless nerve electrophysiological signal detection single chip of the invention digitizes the acquired signal and then wirelessly radiates the packed digital frame to the receiving end by using the radio frequency emitting module, thereby avoiding the complex connection of the microchip to an upper computer and improving the speed and the accuracy of signal transmission.
Furthermore, the neuro-electrophysiological signal acquisition module comprises a multi-detection-site implanted MEMS electrophysiological signal detection probe array, which is used for acquiring a neuro-electrophysiological analog signal of subcutaneous tissue; and
an Ag/AgCl dry electrode for sensing a neuroelectrophysiological analog signal at the skin.
The neuroelectrophysiological signal acquisition module of the present invention can satisfy a variety of neuroelectrophysiological signal detection functions, such as: the detection requirements of different human body bioelectric signals such as ECG, intracranial extracellular nerve action potential, extracranial brain EEG, electromyogram EMG, eye movement and the like.
Further, the radio frequency transmitting module is further connected with a bias voltage generating module and a bias current generating module respectively, and the bias voltage generating module and the bias current generating module are used for generating bias voltage and bias current for the radio frequency transmitting module respectively.
The bias voltage generating module and the bias current generating module are used for ensuring the normal work of the radio frequency transmitting module.
Furthermore, the low-noise processing module comprises a low-noise chopper amplifier and a low-noise operational amplifier, wherein the low-noise chopper amplifier is used for amplifying uV and mV level weak signals at the skin to eliminate low-frequency flicker noise and input offset; the low-noise operational amplifier is used for amplifying the band-pass filtering tissue extracellular nerve action potential.
Furthermore, the digital wireless neuroelectrophysiological signal detection single chip further comprises a system power consumption saving management module, wherein the system power consumption saving management module is connected with the low-noise processing module and is used for closing and enabling the signal amplification and filtering processing channel so as to reduce the energy consumption of the system in different working modes.
Furthermore, the neuroelectrophysiological signal acquisition module is further connected with a multiplexer, and the multiplexer is used for providing multi-channel switching time-sharing detection for the neuroelectrophysiological analog signals acquired by the neuroelectrophysiological signal acquisition module.
The invention realizes the rapid time-sharing detection of the neuroelectrophysiological analog signal through the multiplexer.
Furthermore, a digital and radio frequency isolation loop is connected in series between the time-division multiplexing ADC circuit module and the radio frequency transmitting module, and the radio frequency isolation loop is configured to perform noise isolation on the neuroelectrophysiological digital signal and transmit the neuroelectrophysiological digital signal after noise isolation to the radio frequency transmitting module.
The invention carries out noise isolation on the nerve electrophysiological digital signal through the digital and radio frequency isolation loop, avoids generating noise interference on the radio frequency transmission module and improves the accuracy of detecting the nerve electrophysiological signal.
The second purpose of the invention is to provide a working method of the single chip for detecting the digitized wireless neuroelectrophysiological signal.
The invention discloses a working method of a digital wireless nerve electrophysiological signal detection single chip, which comprises the following steps:
the digital wireless neuroelectrophysiological signal detection single chip is powered on, and the clock reset management module generates different frequency division clocks and reset signals for the detection single chip;
the UART communication module is used for correspondingly configuring the working mode of the neuroelectrophysiological signal acquisition module and the functional parameters of the low-noise processing module through a working mode configuration register and a functional parameter configuration register respectively;
the nerve electrophysiological signal acquisition module acquires a nerve electrophysiological analog signal at subcutaneous tissue or skin under a corresponding working mode and transmits the nerve electrophysiological analog signal to the low-noise processing module for filtering and amplifying; the neural electrophysiological analog signals after filtering and amplification processing are converted into neural electrophysiological digital signals through a time division multiplexing ADC circuit module;
the radio frequency transmitting module sets the nerve electrophysiological digital signal into a frame and modulates the signal into a sequence carrier, and then the signal is radiated by a radiation antenna.
Further, the method further comprises: and a system power consumption saving management module connected with the low noise processing module is used for closing and enabling the signal amplification filtering processing channel so as to reduce the energy consumption of the system in different working modes.
Further, the method further comprises: the neuroelectrophysiological analog signals collected by the neuroelectrophysiological signal collection module are subjected to multi-channel switching time-sharing detection through a multi-channel selector.
The invention realizes the rapid time-sharing detection of the neuroelectrophysiological analog signal through the multiplexer.
Furthermore, the neuro-electrophysiological digital signal converted by the time division multiplexing ADC circuit module is subjected to noise isolation through a radio frequency isolation loop, and the neuro-electrophysiological digital signal subjected to noise isolation is transmitted to the radio frequency transmitting module.
The invention carries out noise isolation on the nerve electrophysiological digital signal through the digital and radio frequency isolation loop, avoids generating noise interference on the radio frequency transmission module and improves the accuracy of detecting the nerve electrophysiological signal.
The third purpose of the invention is to provide a digital wireless neuro-electrophysiological signal detection single system, which can focus on the detection functions of the neuro-electrophysiological signals in different areas at different positions of the human body, including the detection of the neuro-electrophysiological signals outside cells and skin (including extracranial), and has small volume and convenient carrying.
The invention discloses a digital wireless nerve electrophysiological signal detection single system, which comprises the digital wireless nerve electrophysiological signal detection single chip.
Compared with the prior art, the invention has the beneficial effects that:
(1) the neuroelectrophysiology detection chip is highly integrated, small in size, light in weight and suitable for wearable equipment.
(2) The neuroelectricity physiological detection chip can be used for detecting the neuroelectricity information of subcutaneous tissue and skin, can synchronously detect the neuroelectricity signal of the extracellular neuroelectricity of the subcutaneous tissue and the skin position (including extracranial), and can meet the detection functions of various neuroelectricity physiological signals, such as: the detection requirements of different human body bioelectric signals such as ECG, intracranial extracellular nerve action potential, extracranial brain EEG, electromyogram EMG, eye movement and the like.
(3) The neuroelectrophysiological detection chip has low power consumption management and closes the signal amplification and filtering processing channel which does not work.
(4) The neuroelectrophysiology detection chip has the configurable function of amplifying channel parameters.
(5) The neuro-electrophysiological signal detection single chip digitizes the acquired signal and then wirelessly radiates the packed digital frame to the receiving end by using the radio frequency emitting module.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the application and, together with the description, serve to explain the application and are not intended to limit the application.
FIG. 1 is a schematic diagram of a digital wireless neuroelectrophysiological signal detection single-chip embodiment of the present invention.
FIG. 2 is a flow chart of a single chip working method for detecting digitized wireless neuroelectrophysiological signals of the present invention.
Fig. 3 is a schematic diagram of a low noise chopper amplifier structure.
Fig. 4 is a schematic diagram of a low noise operational amplifier.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
As introduced in the background art, the problems that the neuroelectricity detection instrument in the prior art has overlarge volume, too heavy weight, single detection information, inconvenient movement of a wearer due to complex connection, 50Hz power frequency interference caused by mains supply and the like exist.
FIG. 1 is a schematic diagram of a digital wireless neuroelectrophysiological signal detection single-chip embodiment of the present invention.
As shown in fig. 1, a digitized wireless neuroelectrophysiological signal detection single chip of the present invention comprises:
the clock reset management module is used for generating different frequency division clocks and reset signals for the detection single chip; and
the interface UART communication module is used for correspondingly configuring the working mode of the neuroelectrophysiological signal acquisition module and the functional parameters of the low-noise processing module through the working mode configuration register and the functional parameter configuration register respectively;
the neuroelectricity physiological signal acquisition module is used for acquiring neuroelectricity physiological analog signals of subcutaneous tissues or skins under corresponding working modes; the low-noise processing module is used for receiving the neuro-electrophysiological analog signal, filtering and amplifying the neuro-electrophysiological analog signal, and transmitting the neuro-electrophysiological analog signal to the time-division multiplexing ADC circuit module to be converted into a neuro-electrophysiological digital signal; and
and the radio frequency transmitting module is used for setting the nerve electrophysiological digital signals into frames, modulating the frames into sequence carriers and radiating the sequence carriers by a radiation antenna.
The digital wireless nerve electrophysiological signal detection single chip is driven by a battery to supply power, so that the problem of 50Hz power frequency interference caused by mains supply power supply is solved.
The digital wireless nerve electrophysiological signal detection single chip of the invention digitizes the acquired signal and then wirelessly radiates the packed digital frame to the receiving end by using the radio frequency emitting module, thereby avoiding the complex connection of the microchip to an upper computer and improving the speed and the accuracy of signal transmission.
As shown in fig. 1, the neuro-electrophysiological signal acquisition module includes a multi-detection-site implanted MEMS electrophysiological signal detection probe array for acquiring a neuro-electrophysiological analog signal of a subcutaneous tissue; and
an Ag/AgCl dry electrode for sensing a neuroelectrophysiological analog signal at the skin.
The neuroelectrophysiological signal acquisition module of the present invention can satisfy a variety of neuroelectrophysiological signal detection functions, such as: the detection requirements of different human body bioelectric signals such as ECG, intracranial extracellular nerve action potential, extracranial brain EEG, electromyogram EMG, eye movement and the like.
In fig. 1, the rf transmitting module is further connected to a bias voltage generating module and a bias current generating module, respectively, and the bias voltage generating module and the bias current generating module are used for generating a bias voltage and a bias current for the rf transmitting module, respectively.
The bias voltage generating module and the bias current generating module are used for ensuring the normal work of the radio frequency transmitting module.
The circuit structures of the bias voltage generating module and the bias current generating module are the existing structures.
In fig. 1, the low-noise processing module includes a low-noise chopper amplifier and a low-noise operational amplifier, where the low-noise chopper amplifier is used to amplify uV and mV level weak signals at the skin to eliminate low-frequency flicker noise and input offset; the low-noise operational amplifier is used for amplifying the band-pass filtering tissue extracellular nerve action potential.
As shown in fig. 3, the low-noise chopper amplifier includes: the high-gain high-transconductance amplifier comprises a high-gain high-transconductance amplifier, an intermediate-frequency gain stabilizing loop and an input impedance improving loop, wherein a first chopping switch is arranged at the input end of the high-gain high-transconductance amplifier, a second chopping switch is arranged at the output end of the high-gain high-transconductance amplifier, two ends of the second chopping switch are also connected with a ripple wave suppression loop in parallel, and the ripple wave suppression loop comprises a transconductor, an integrator and a third chopping switch which are connected in series.
As shown in fig. 4, the low noise operational amplifier includes: the operational amplifier comprises two operational amplifiers connected in series, and an RC branch is connected in parallel with a positive input end and a negative output end, and a negative input end and a positive output end of each operational amplifier.
In fig. 1, the digital wireless neuroelectrophysiological signal detection single chip further includes a system power consumption saving management module, which is connected to the low noise processing module and is configured to close and enable the signal amplification and filtering processing channel to reduce energy consumption of the system in different operating modes.
The time division multiplexing ADC circuit module is an existing ADC circuit structure.
The system power consumption saving management module can be realized by adopting a circuit structure with a switching function.
The radio frequency transmitting module is of an existing radio frequency transmitting circuit structure.
In fig. 1, the neuroelectrophysiological signal acquisition module is further connected to a multiplexer, and the multiplexer is configured to provide multi-channel switching time-sharing detection for the neuroelectrophysiological analog signal acquired by the neuroelectrophysiological signal acquisition module.
The invention realizes the rapid time-sharing detection of the neuroelectrophysiological analog signal through the multiplexer.
In specific implementation, a digital and radio frequency isolation loop is further connected in series between the time-division multiplexing ADC circuit module and the radio frequency transmitting module, and the radio frequency isolation loop is configured to perform noise isolation on the neuroelectrophysiological digital signal and transmit the neuroelectrophysiological digital signal after noise isolation to the radio frequency transmitting module.
The digital and radio frequency isolation loop can be realized by adopting but not limited to an optoelectronic coupler.
The invention carries out noise isolation on the nerve electrophysiological digital signal through the digital and radio frequency isolation loop, avoids generating noise interference on the radio frequency transmission module and improves the accuracy of detecting the nerve electrophysiological signal.
The digital wireless neuroelectrophysiological signal detection single chip of the invention reads and writes the register file through the UART interface, thereby facilitating the reconfiguration and the inspection of a user; and the digital circuit in the chip is isolated, so that the digital circuit is prevented from attacking the radio frequency module.
As shown in fig. 2, the working method of a digitized wireless neuroelectrophysiological signal detection single chip of the present invention includes:
the digital wireless neuroelectrophysiological signal detection single chip is powered on, and the clock reset management module generates different frequency division clocks and reset signals for the detection single chip;
the UART communication module is used for correspondingly configuring the working mode of the neuroelectrophysiological signal acquisition module and the functional parameters of the low-noise processing module through a working mode configuration register and a functional parameter configuration register respectively;
the nerve electrophysiological signal acquisition module acquires a nerve electrophysiological analog signal at subcutaneous tissue or skin under a corresponding working mode and transmits the nerve electrophysiological analog signal to the low-noise processing module for filtering and amplifying; the neural electrophysiological analog signals after filtering and amplification processing are converted into neural electrophysiological digital signals through a time division multiplexing ADC circuit module;
the radio frequency transmitting module sets the nerve electrophysiological digital signal into a frame and modulates the signal into a sequence carrier, and then the signal is radiated by a radiation antenna.
In a specific implementation, the method further comprises: and a system power consumption saving management module connected with the low noise processing module is used for closing and enabling the signal amplification filtering processing channel so as to reduce the energy consumption of the system in different working modes.
In a specific implementation, the method further comprises: the neuroelectrophysiological analog signals collected by the neuroelectrophysiological signal collection module are subjected to multi-channel switching time-sharing detection through a multi-channel selector.
The invention realizes the rapid time-sharing detection of the neuroelectrophysiological analog signal through the multiplexer.
In specific implementation, the neuroelectrophysiological digital signal converted by the time division multiplexing ADC circuit module is subjected to noise isolation by a radio frequency isolation loop, and the neuroelectrophysiological digital signal subjected to noise isolation is transmitted to the radio frequency transmitting module.
The invention carries out noise isolation on the nerve electrophysiological digital signal through the digital and radio frequency isolation loop, avoids generating noise interference on the radio frequency transmission module and improves the accuracy of detecting the nerve electrophysiological signal.
The invention also provides a digital wireless nerve electrophysiological signal detection single system, which can concentrate the nerve electrical signal detection functions of different areas aiming at different positions of a human body, comprises the nerve electrophysiological signal detection of the extracellular part and the skin part (including the extracranial part), and has small volume and convenient carrying.
The invention discloses a digital wireless nerve electrophysiological signal detection single system, which comprises a digital wireless nerve electrophysiological signal detection single chip shown in fig. 1.
Although the embodiments of the present invention have been described with reference to the accompanying drawings, it is not intended to limit the scope of the present invention, and it should be understood by those skilled in the art that various modifications and variations can be made without inventive efforts by those skilled in the art based on the technical solution of the present invention.
Claims (6)
1. A digitized wireless neuroelectrophysiological signal detection single chip, comprising:
the clock reset management module is used for generating different frequency division clocks and reset signals for the detection single chip; and
the interface UART communication module is used for correspondingly configuring the working mode of the neuroelectrophysiological signal acquisition module and the functional parameters of the low-noise processing module through the working mode configuration register and the functional parameter configuration register respectively;
the neuroelectricity physiological signal acquisition module is used for acquiring neuroelectricity physiological analog signals of subcutaneous tissues or skins under corresponding working modes; the low-noise processing module is used for receiving the neuro-electrophysiological analog signal, filtering and amplifying the neuro-electrophysiological analog signal, and transmitting the neuro-electrophysiological analog signal to the time-division multiplexing ADC circuit module to be converted into a neuro-electrophysiological digital signal; and
the radio frequency transmitting module is used for setting the nerve electrophysiological digital signal into a frame, modulating the frame into a sequence carrier and radiating the sequence carrier by a radiation antenna;
a digital and radio frequency isolation loop is also connected in series between the time-sharing multiplexing ADC circuit module and the radio frequency sending module, and the radio frequency isolation loop is used for carrying out noise isolation on the neuroelectrophysiological digital signal and transmitting the neuroelectrophysiological digital signal after noise isolation to the radio frequency sending module;
the neuro-electrophysiological signal acquisition module comprises a multi-detection-site implanted MEMS electrophysiological signal detection probe array, and is used for acquiring neuro-electrophysiological analog signals of subcutaneous tissues; and
an Ag/AgCl dry electrode for sensing a neuroelectrophysiological analog signal at the skin;
the low-noise processing module comprises a low-noise chopper amplifier and a low-noise operational amplifier, wherein the low-noise chopper amplifier is used for amplifying uV and mV level weak signals at the skin to eliminate low-frequency flicker noise and input offset; the low-noise operational amplifier is used for amplifying the band-pass filtering tissue extracellular nerve action potential; the low-noise chopper amplifier comprises a high-gain high-transconductance amplifier, an intermediate-frequency gain stabilizing loop and an input impedance improving loop, wherein a first chopper switch is arranged at the input end of the high-gain high-transconductance amplifier, a second chopper switch is arranged at the output end of the high-gain high-transconductance amplifier, two ends of the second chopper switch are also connected in parallel with a ripple suppression loop, and the ripple suppression loop comprises a transconductor, an integrator and a third chopper switch which are connected in series; the low-noise operational amplifier comprises two operational amplifiers which are connected in series, and an RC branch is connected in parallel with the positive input end and the negative output end, and the negative input end and the positive output end of each operational amplifier;
the digital wireless neuroelectrophysiological signal detection single chip further comprises a system power consumption saving management module, wherein the system power consumption saving management module is connected with the low-noise processing module and is used for closing and enabling the signal amplification filtering processing channel so as to reduce the energy consumption of the system in different working modes.
2. The single chip for detecting digitized wireless neuroelectrophysiological signals of claim 1, wherein the rf transmitter module is further coupled to a bias voltage generator module and a bias current generator module, respectively, the bias voltage generator module and the bias current generator module being configured to generate a bias voltage and a bias current for the rf transmitter module, respectively.
3. The single-chip for detecting digitized wireless neuroelectrophysiological signals of claim 1, wherein the neuroelectrophysiological signal acquisition module is further connected to a multiplexer, and the multiplexer is configured to provide multi-channel switching time-sharing detection for the neuroelectrophysiological analog signals acquired by the neuroelectrophysiological signal acquisition module.
4. A method of operating a digitized wireless neuroelectrophysiological signal detection single chip of any of claims 1 to 3, comprising:
the digital wireless neuroelectrophysiological signal detection single chip is powered on, and the clock reset management module generates different frequency division clocks and reset signals for the detection single chip;
the UART communication module is used for correspondingly configuring the working mode of the neuroelectrophysiological signal acquisition module and the functional parameters of the low-noise processing module through a working mode configuration register and a functional parameter configuration register respectively;
the nerve electrophysiological signal acquisition module acquires a nerve electrophysiological analog signal at subcutaneous tissue or skin under a corresponding working mode and transmits the nerve electrophysiological analog signal to the low-noise processing module for filtering and amplifying; the neural electrophysiological analog signals after filtering and amplification processing are converted into neural electrophysiological digital signals through a time division multiplexing ADC circuit module;
the radio frequency transmitting module sets the nerve electrophysiological digital signal into a frame and modulates the signal into a sequence carrier, and then the signal is radiated by a radiation antenna.
5. The method for operating a digitized wireless neuroelectrophysiological signal detection single chip of claim 4, further comprising: a system power consumption saving management module connected with the low noise processing module is used for closing and enabling the signal amplification filtering processing channel so as to reduce the energy consumption of the system in different working modes;
or/and
the method further comprises the following steps: the neuroelectrophysiological analog signals collected by the neuroelectrophysiological signal collection module are subjected to multi-channel switching time-sharing detection through a multi-channel selector;
or/and
the neural electrophysiological digital signal converted by the time-division multiplexing ADC circuit module is subjected to noise isolation through a radio frequency isolation loop, and the neural electrophysiological digital signal subjected to noise isolation is transmitted to a radio frequency transmitting module.
6. A digitized wireless neuroelectrophysiological signal detection single system, comprising the digitized wireless neuroelectrophysiological signal detection single chip of any of claims 1 to 3.
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