CN108852341A - A kind of digital radio Electrophysiology signal detection single-chip, system and method - Google Patents

A kind of digital radio Electrophysiology signal detection single-chip, system and method Download PDF

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CN108852341A
CN108852341A CN201810649740.6A CN201810649740A CN108852341A CN 108852341 A CN108852341 A CN 108852341A CN 201810649740 A CN201810649740 A CN 201810649740A CN 108852341 A CN108852341 A CN 108852341A
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electrophysiology
signal
module
chip
digital
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CN108852341B (en
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孙建辉
蔡阳健
李登旺
王晶晶
赵曰峰
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Shandong Normal University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/369Electroencephalography [EEG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/389Electromyography [EMG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/398Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802Sensor mounted on worn items
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation

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Abstract

The invention discloses a kind of digital radio Electrophysiology signal detection single-chips, system and method.Wherein, detection single-chip includes:Clock-reset management module, for generating different frequency-dividing clocks and reset signal for the detection single-chip;And interface UART communication module, it is used to carry out corresponding configuration to the operating mode of Electrophysiology signal acquisition module and the functional parameter of low noise processing module by operating mode configuration register and functional parameter configuration register respectively;Electrophysiology signal acquisition module, for acquiring the Electrophysiology analog signal at subcutaneous tissue or skin under relevant work mode;Low noise processing module, for receiving Electrophysiology analog signal and being filtered enhanced processing to it, and being sent to time-sharing multiplex adc circuit module converter is Electrophysiology digital signal;And radio frequency sending module, framing and it is modulated into sequence carrier wave for Electrophysiology digital signal to be arranged, then aerial radiation is gone out via radiation.

Description

A kind of digital radio Electrophysiology signal detection single-chip, system and method
Technical field
The invention belongs to chip circuit design field more particularly to a kind of digital radio Electrophysiology signal detection lists Chip, system and method.
Background technique
Currently, due to the faint small signal of human body (such as:The extracellular neuroelectricity of electrocardio ECG, encephalic, cranium external-brain's electricity EEG, flesh Electric EKG, eye movement) various different target signals a variety of AI application scenarios recognition detection demand;And due to need to identify The voltage range of bioelectrical signals is very faint, and the small signal of the target for needing to identify is easy to be interfered by unwanted echo signal It falls into oblivion, or even the small signal of target needed can also pollute annihilation by environmental background noise and circuit inner noise etc., therefore Compel to be essential and designs the faint small signal detection of human-body biological of a pervasive application with polyneural electrophysiologicalsignal signal detection function Identification chip core.
Since in hearing, optic nerve access research, the extracellular neuroelectricity for both needing to detect encephalic subcutaneous tissue is raw Reason signal, such as the extracellular nerve action potential spike of hippocampus and field field potential signal, such as auditory brainstem region Electroneurographic signal;Simultaneously, it is also desirable to detect the Electrophysiology signal of skin outer (outside including cranium), such as EEG brain electricity, ECG Electrocardiosignal, it is therefore desirable to a neuroelectricity memorization COMS clip system for the outer different spatial of subcutaneous or skin.
In traditional bioelectricity writing circuit system, the overwhelming majority is not to utilize system-on-a-chip, therefore final instrument Body product is bigger, and quality is also than heavier;And since legacy system does not have a variety of electricity physiological signal record detection energy of human body Power, it is also necessary to utilize mains-supplied, there are 50Hz Hz noises, also do not have this patent and are based on battery power supply convenient for user The features such as Portable device is mobile.
It carries out being assembled into system moreover, traditional biological electrical detection device is based on purchase related device, therefore comes from different factories Interference between the device of family does not carry out unified consideration and avoids eliminating, therefore final system noise may be bigger;Meanwhile The circuit stability and reliability of traditional equipment are also without very good solution.
" biological signal measuring device " for the road benevolence technology company that number of patent application is 201580018958.6, but its base In driven-right-leg circuit, and " biological signal measuring device " does not have multiple Electrophysiology signals yet and integrates detection function.
" the general triumph letter for the Jiangsu HEALTH ONLINE Medical Devices Co., Ltd. that number of patent application is 201110197578.7 Number converter ", does not have the small-sized and light weight feature of this patent integrated chip, is directed to extracellularly and outside cranium without this patent The special chip circuit structure of neural electro-detection can not carry out multiple amplifier channel selections, specific amplifilter etc. The functions such as parameter configuration.
In conclusion traditional biological electrical detection device, which is not all provided, carries out multinomial Electrophysiology based on Special single-core piece The integrated functionality of detection, also without carrying out low power dissipation design consideration, noise is reduced also without preferably being optimized, is not able to satisfy The application of the following wearable system or equipment.
Summary of the invention
In order to solve the deficiencies in the prior art, the first object of the present invention is to provide a kind of digital radio Electrophysiology Signal detection single-chip, highly integrated, small in size, light weight are suitable for wearable device.
A kind of digital radio Electrophysiology signal detection single-chip of the invention, including:
Clock-reset management module is used to generate different frequency-dividing clocks and reset signal for the detection single-chip;And
Interface UART communication module is used for respectively through operating mode configuration register and functional parameter configuration register The functional parameter of operating mode and low noise processing module to Electrophysiology signal acquisition module carries out corresponding configuration;
The Electrophysiology signal acquisition module, for being acquired at subcutaneous tissue or skin under relevant work mode Electrophysiology analog signal;The low noise processing module, for receiving Electrophysiology analog signal and being filtered to it Wave enhanced processing, and being sent to time-sharing multiplex adc circuit module converter is Electrophysiology digital signal;And
Radio frequency sending module framing and is modulated into sequence carrier wave for Electrophysiology digital signal to be arranged, then through spoke Aerial radiation is penetrated to go out.
Digital radio Electrophysiology signal detection single-chip of the invention carries out driving power supply by battery, avoids city 50Hz Hz noise problem caused by electricity is powered.
Digital radio Electrophysiology signal detection single-chip of the invention is recycled after acquisition signal is digitized and is penetrated The module that takes place frequently out be packaged after digital frame wireless radiation to receiving end, avoid the microchip to host computer complicated line, Improve the speed and accuracy of signal transmission.
Further, the Electrophysiology signal acquisition module includes more detection site implantation MEMS electricity physiological signal inspections Probe array is surveyed, is used to acquire the Electrophysiology analog signal of subcutaneous tissue;And
The dry electrode of Ag/AgCl is used to perceive the Electrophysiology analog signal at skin.
Electrophysiology signal acquisition module of the invention can satisfy a variety of Electrophysiology signal testing functions, than Such as:The different human bodies biology telecommunications such as the extracellular nerve action potential of electrocardio ECG, encephalic, cranium external-brain's electricity EEG, myoelectricity EMG, eye movement Number detection demand.
Further, radio frequency sending module also bias voltage generation module and bias current generation module is respectively connected with, institute It states bias voltage generation module and bias current generation module is respectively used to generate bias voltage and biasing for radio frequency sending module Electric current.
Wherein, bias voltage generation module and bias current generation module are used to guarantee that radio frequency sending module works normally.
Further, low noise processing module includes low noise chopper amplifier and low noise operational amplifier, described low Noise chopper amplifier eliminates low-frequency flicker noise and input for amplifying to uV and mV grades of small-signal at skin Imbalance;The low noise operational amplifier, for amplifying nerve action potential outside bandpass filtering histocyte.
Further, the digital radio Electrophysiology signal detection single-chip further includes system power dissipation saving management Module, the system power dissipation save management module and are connected with low noise processing module, filter for closing with enable signal amplification Treatment channel, to reduce energy consumption when system different working modes.
Further, the Electrophysiology signal acquisition module is also connected with multiple selector, the multiple selector Switch timesharing detection for providing multichannel for Electrophysiology signal acquisition module Electrophysiology analog signal collected.
The present invention realizes that the quick timesharing to Electrophysiology analog signal is detected by multiple selector.
Further, number and radio frequency are also serially connected between the time-sharing multiplex adc circuit module and radio frequency sending module Separate loop, the radio frequency isolation loop are used to carry out Electrophysiology digital signal noise isolation, and will be after isolation noise Electrophysiology digital signal be sent to radio frequency sending module.
The present invention carries out noise isolation to Electrophysiology digital signal with radio frequency isolation loop by number, avoids to penetrating Frequency sending module generates noise jamming, improves the accuracy of Electrophysiology signal detection.
The second object of the present invention is to provide a kind of work side of digital radio Electrophysiology signal detection single-chip Method.
A kind of working method of digital radio Electrophysiology signal detection single-chip of the invention, including:
Digital radio Electrophysiology signal detection single-chip powers on, and clock-reset management module is the detection single Piece generates different frequency-dividing clocks and reset signal;
Pass through operating mode configuration register and functional parameter configuration register pair respectively using interface UART communication module The operating mode of Electrophysiology signal acquisition module and the functional parameter of low noise processing module carry out corresponding configuration;
It is raw that Electrophysiology signal acquisition module acquires the neuroelectricity at subcutaneous tissue or skin under relevant work mode It manages analog signal and is sent to low noise processing module and be filtered enhanced processing;Electrophysiology mould after filter amplifying processing Quasi- signal is Electrophysiology digital signal through time-sharing multiplex adc circuit module converter;
Electrophysiology digital signal is arranged framing and is modulated into sequence carrier wave by radio frequency sending module, then antenna via radiation It radiate.
Further, this method further includes:Management module is saved using the system power dissipation being connected with low noise processing module Amplify filtering processing channel with enable signal to close, to reduce energy consumption when system different working modes.
Further, this method further includes:Electrophysiology signal acquisition module Electrophysiology simulation letter collected Number through multiple selector carry out multichannel switching timesharing detection.
The present invention realizes that the quick timesharing to Electrophysiology analog signal is detected by multiple selector.
Further, the Electrophysiology digital signal after time-sharing multiplex adc circuit module converter is through radio frequency isolation loop Noise isolation is carried out, and the Electrophysiology digital signal after isolation noise is sent to radio frequency sending module.
The present invention carries out noise isolation to Electrophysiology digital signal with radio frequency isolation loop by number, avoids to penetrating Frequency sending module generates noise jamming, improves the accuracy of Electrophysiology signal detection.
The third object of the present invention is to provide a kind of digital radio Electrophysiology signal detection single system, being capable of needle To human body different location, different zones electroneurographic signal detection function is concentrated, including extracellularly and at skin (including outside cranium) Electrophysiology signal detection and small in size, it is easy to carry.
A kind of digital radio Electrophysiology signal detection single system of the invention, including digitlization nothing described above Line Electrophysiology signal detection single-chip.
Compared with prior art, the beneficial effects of the invention are as follows:
(1) Electrophysiology detection chip of the invention is highly integrated, small in size, light weight, is suitable for wearable device.
(2) Electrophysiology detection chip of the invention can be used for the subcutaneously neuroelectricity infomation detection with skin, and can To synchronize the electroneurographic signal of neuroelectricity and skin site (outside including cranium) outside detection subcutaneous tissue cell, can satisfy more Kind Electrophysiology signal testing function, such as:The extracellular nerve action potential of electrocardio ECG, encephalic, cranium external-brain's electricity EEG, myoelectricity The detection demand of the different human bodies bioelectrical signals such as EMG, eye movement.
(3) Electrophysiology detection chip of the invention has low-power consumption management, at the amplification filtering of idle signal Channel is managed to close.
(4) Electrophysiology detection chip of the invention has amplification channel parameter configurable functionality.
(5) recycling radio frequency after the digitlization of acquisition signal is issued mould by Electrophysiology signal detection single-chip of the invention Digital frame wireless radiation after being packaged to receiving end, Electrophysiology detection chip of the invention are had analog information after amplification by block Quantization with data frame transmit wirelessly function, have pervasive application value, avoid the microchip to host computer complicated line, Improve the speed and accuracy of signal transmission.
Detailed description of the invention
The accompanying drawings constituting a part of this application is used to provide further understanding of the present application, and the application's shows Meaning property embodiment and its explanation are not constituted an undue limitation on the present application for explaining the application.
Fig. 1 is a kind of digital radio Electrophysiology signal detection single chip embodiment structural schematic diagram of the invention.
Fig. 2 is a kind of digital radio Electrophysiology signal detection single-chip flow chart of work methods of the invention.
Fig. 3 is low noise chopper amplifier structural schematic diagram.
Fig. 4 is low noise operational amplifier structural schematic diagram.
Specific embodiment
It is noted that following detailed description is all illustrative, it is intended to provide further instruction to the application.Unless another It indicates, all technical and scientific terms used herein has usual with the application person of an ordinary skill in the technical field The identical meanings of understanding.
It should be noted that term used herein above is merely to describe specific embodiment, and be not intended to restricted root According to the illustrative embodiments of the application.As used herein, unless the context clearly indicates otherwise, otherwise singular Also it is intended to include plural form, additionally, it should be understood that, when in the present specification using term "comprising" and/or " packet Include " when, indicate existing characteristics, step, operation, device, component and/or their combination.
As background technique is introduced, exist in the prior art that neuroelectricity detecting instrument volume is excessive, and weight is too heavy, inspection The problems such as measurement information is single, and line complexity Ling Yinqi is not easy to wearer's movement, and mains-supplied causes 50Hz Hz noise, this hair It is bright to provide a kind of digital radio Electrophysiology signal detection single-chip.
Fig. 1 is a kind of digital radio Electrophysiology signal detection single chip embodiment structural schematic diagram of the invention.
As shown in Figure 1, a kind of digital radio Electrophysiology signal detection single-chip of the invention, including:
Clock-reset management module is used to generate different frequency-dividing clocks and reset signal for the detection single-chip;And
Interface UART communication module is used for respectively through operating mode configuration register and functional parameter configuration register The functional parameter of operating mode and low noise processing module to Electrophysiology signal acquisition module carries out corresponding configuration;
The Electrophysiology signal acquisition module, for being acquired at subcutaneous tissue or skin under relevant work mode Electrophysiology analog signal;The low noise processing module, for receiving Electrophysiology analog signal and being filtered to it Wave enhanced processing, and being sent to time-sharing multiplex adc circuit module converter is Electrophysiology digital signal;And
Radio frequency sending module framing and is modulated into sequence carrier wave for Electrophysiology digital signal to be arranged, then through spoke Aerial radiation is penetrated to go out.
Digital radio Electrophysiology signal detection single-chip of the invention carries out driving power supply by battery, avoids city 50Hz Hz noise problem caused by electricity is powered.
Digital radio Electrophysiology signal detection single-chip of the invention is recycled after acquisition signal is digitized and is penetrated The module that takes place frequently out be packaged after digital frame wireless radiation to receiving end, avoid the microchip to host computer complicated line, Improve the speed and accuracy of signal transmission.
As shown in Figure 1, the Electrophysiology signal acquisition module includes more detection site implantation MEMS electricity physiological signals Detection probe array is used to acquire the Electrophysiology analog signal of subcutaneous tissue;And
The dry electrode of Ag/AgCl is used to perceive the Electrophysiology analog signal at skin.
Electrophysiology signal acquisition module of the invention can satisfy a variety of Electrophysiology signal testing functions, than Such as:The different human bodies biology telecommunications such as the extracellular nerve action potential of electrocardio ECG, encephalic, cranium external-brain's electricity EEG, myoelectricity EMG, eye movement Number detection demand.
In Fig. 1, radio frequency sending module also bias voltage generation module and bias current generation module is respectively connected with, described Bias voltage generation module and bias current generation module are respectively used to generate bias voltage and biased electrical for radio frequency sending module Stream.
Wherein, bias voltage generation module and bias current generation module are used to guarantee that radio frequency sending module works normally.
The circuit structure of bias voltage generation module and bias current generation module is existing structure.
In Fig. 1, low noise processing module includes low noise chopper amplifier and low noise operational amplifier, the low noise Sound chopper amplifier eliminates low-frequency flicker noise and input for amplifying to uV and mV grades of small-signal at skin Imbalance;The low noise operational amplifier, for amplifying nerve action potential outside bandpass filtering histocyte.
As shown in figure 3, low noise chopper amplifier includes:High-gain high transconductance amplifier and intermediate-frequency gain stabilizing ring Road and input impedance improve loop, and the input terminal of high-gain high transconductance amplifier is provided with the first chopping switch, in high-gain height The output end of trsanscondutance amplifier is provided with the second chopping switch, and the both ends of the second chopping switch are also parallel with Ripple Suppression loop, The Ripple Suppression loop includes trsanscondutor, integrator and the third chopping switch being connected in series.
As shown in figure 4, low noise operational amplifier includes:The operational amplifier of two series connections, each operation amplifier The positive input terminal and negative output terminal and negative input end and positive output end of device are parallel with RC branch.
In Fig. 1, the digital radio Electrophysiology signal detection single-chip further includes system power dissipation saving management Module, the system power dissipation save management module and are connected with low noise processing module, filter for closing with enable signal amplification Treatment channel, to reduce energy consumption when system different working modes.
Wherein, time-sharing multiplex adc circuit module is existing adc circuit structure.
System power dissipation, which saves management module, can be used the circuit structure with switching function to realize.
Radio frequency sending module is existing radio frequency transmitting line structure.
In Fig. 1, the Electrophysiology signal acquisition module is also connected with multiple selector, and the multiple selector is used Switch timesharing detection in providing multichannel for Electrophysiology signal acquisition module Electrophysiology analog signal collected.
The present invention realizes that the quick timesharing to Electrophysiology analog signal is detected by multiple selector.
In specific implementation, be also serially connected between the time-sharing multiplex adc circuit module and radio frequency sending module number with Radio frequency isolation loop, the radio frequency isolation loop is used to carry out noise isolation to Electrophysiology digital signal, and isolation is made an uproar Electrophysiology digital signal after sound is sent to radio frequency sending module.
Wherein, number can be used with radio frequency isolation loop but be not limited to photoelectrical coupler to realize.
The present invention carries out noise isolation to Electrophysiology digital signal with radio frequency isolation loop by number, avoids to penetrating Frequency sending module generates noise jamming, improves the accuracy of Electrophysiology signal detection.
Digital radio Electrophysiology signal detection single-chip of the invention carries out register file text by UART interface Part read and write, reconfigures and is checked convenient for user;And the digital circuit in piece is isolated, and prevents it from attacking radio frequency mould Block.
As shown in Fig. 2, a kind of working method of digital radio Electrophysiology signal detection single-chip of the invention, packet It includes:
Digital radio Electrophysiology signal detection single-chip powers on, and clock-reset management module is the detection single Piece generates different frequency-dividing clocks and reset signal;
Pass through operating mode configuration register and functional parameter configuration register pair respectively using interface UART communication module The operating mode of Electrophysiology signal acquisition module and the functional parameter of low noise processing module carry out corresponding configuration;
It is raw that Electrophysiology signal acquisition module acquires the neuroelectricity at subcutaneous tissue or skin under relevant work mode It manages analog signal and is sent to low noise processing module and be filtered enhanced processing;Electrophysiology mould after filter amplifying processing Quasi- signal is Electrophysiology digital signal through time-sharing multiplex adc circuit module converter;
Electrophysiology digital signal is arranged framing and is modulated into sequence carrier wave by radio frequency sending module, then antenna via radiation It radiate.
In specific implementation, this method further includes:Utilize the system power dissipation saving management being connected with low noise processing module Module amplifies filtering processing channel with enable signal to close, to reduce energy consumption when system different working modes.
In specific implementation, this method further includes:Electrophysiology signal acquisition module Electrophysiology mould collected Quasi- signal carries out multichannel switching timesharing detection through multiple selector.
The present invention realizes that the quick timesharing to Electrophysiology analog signal is detected by multiple selector.
In specific implementation, the Electrophysiology digital signal after time-sharing multiplex adc circuit module converter is through radio frequency isolation Loop carries out noise isolation, and the Electrophysiology digital signal after isolation noise is sent to radio frequency sending module.
The present invention carries out noise isolation to Electrophysiology digital signal with radio frequency isolation loop by number, avoids to penetrating Frequency sending module generates noise jamming, improves the accuracy of Electrophysiology signal detection.
The present invention also provides a kind of digital radio Electrophysiology signal detection single systems, can be for human body not With position, concentrate different zones electroneurographic signal detection function, including extracellularly with the neuroelectricity at skin (outside including cranium) Bio-signal acquisition and small in size, it is easy to carry.
A kind of digital radio Electrophysiology signal detection single system of the invention, including digitlization as shown in Figure 1 Wireless Electrophysiology signal detection single-chip.
Above-mentioned, although the foregoing specific embodiments of the present invention is described with reference to the accompanying drawings, not protects model to the present invention The limitation enclosed, those skilled in the art should understand that, based on the technical solutions of the present invention, those skilled in the art are not Need to make the creative labor the various modifications or changes that can be made still within protection scope of the present invention.

Claims (10)

1. a kind of digital radio Electrophysiology signal detection single-chip, which is characterized in that including:
Clock-reset management module is used to generate different frequency-dividing clocks and reset signal for the detection single-chip;And
Interface UART communication module is used for respectively by operating mode configuration register and functional parameter configuration register to mind The functional parameter of operating mode and low noise processing module through electricity physiological signal acquisition module carries out corresponding configuration;
The Electrophysiology signal acquisition module, for acquiring the nerve at subcutaneous tissue or skin under relevant work mode Electro physiology analog signal;The low noise processing module is put for receiving Electrophysiology analog signal and being filtered to it Big processing, and being sent to time-sharing multiplex adc circuit module converter is Electrophysiology digital signal;And
Radio frequency sending module framing and is modulated into sequence carrier wave for Electrophysiology digital signal to be arranged, then day via radiation Beta radiation is gone out.
2. a kind of digital radio Electrophysiology signal detection single-chip as described in claim 1, which is characterized in that described Electrophysiology signal acquisition module includes more detection site implantation MEMS electrophysiologicalsignal signal detection probe arrays, is used to acquire The Electrophysiology analog signal of subcutaneous tissue;And
The dry electrode of Ag/AgCl is used to perceive the Electrophysiology analog signal at skin.
3. a kind of digital radio Electrophysiology signal detection single-chip as described in claim 1, which is characterized in that radio frequency Sending module also bias voltage generation module and bias current generation module is respectively connected with, the bias voltage generation module and partially Current generating module is set to be respectively used to generate bias voltage and bias current for radio frequency sending module.
4. a kind of digital radio Electrophysiology signal detection single-chip as described in claim 1, which is characterized in that low noise Sonication module includes low noise chopper amplifier and low noise operational amplifier, and the low noise chopper amplifier is used for skin UV and mV grades of small-signal at skin amplifies, and eliminates the imbalance of low-frequency flicker noise and input;The low noise operational Amplifier, for amplifying nerve action potential outside bandpass filtering histocyte.
5. a kind of digital radio Electrophysiology signal detection single-chip as described in claim 1, which is characterized in that described Digital radio Electrophysiology signal detection single-chip further includes that system power dissipation saves management module, the system power dissipation saving Management module is connected with low noise processing module, channel is filtered with enable signal amplification for closing, to reduce system not With energy consumption when operating mode.
6. a kind of digital radio Electrophysiology signal detection single-chip as described in claim 1, which is characterized in that described Electrophysiology signal acquisition module is also connected with multiple selector, and the multiple selector is used to adopt for Electrophysiology signal Collect module Electrophysiology analog signal collected and multichannel switching timesharing detection is provided.
7. a kind of digital radio Electrophysiology signal detection single-chip as described in claim 1, which is characterized in that described Number and radio frequency isolation loop, the radio frequency isolation are also serially connected between time-sharing multiplex adc circuit module and radio frequency sending module Loop is used to carry out Electrophysiology digital signal noise isolation, and the Electrophysiology digital signal after isolation noise is passed It send to radio frequency sending module.
8. a kind of work of such as digital radio Electrophysiology signal detection single-chip of any of claims 1-7 Method, which is characterized in that including:
Digital radio Electrophysiology signal detection single-chip powers on, and clock-reset management module is detection single-chip production Raw different frequency-dividing clocks and reset signal;
Pass through operating mode configuration register and functional parameter configuration register respectively to nerve using interface UART communication module The operating mode of electricity physiological signal acquisition module and the functional parameter of low noise processing module carry out corresponding configuration;
Electrophysiology signal acquisition module acquires the Electrophysiology mould at subcutaneous tissue or skin under relevant work mode Intend signal and be sent to low noise processing module to be filtered enhanced processing;Electrophysiology after filter amplifying processing simulates letter Number through time-sharing multiplex adc circuit module converter be Electrophysiology digital signal;
Electrophysiology digital signal is arranged framing and is modulated into sequence carrier wave by radio frequency sending module, then aerial radiation via radiation It goes out.
9. the working method of digital radio Electrophysiology signal detection single-chip as claimed in claim 8, feature exist In this method further includes:Management module is saved using the system power dissipation being connected with low noise processing module to close and enabled letter Number amplification filtering processing channel, to reduce energy consumption when system different working modes;
Or/and
This method further includes:Electrophysiology signal acquisition module Electrophysiology analog signal collected is through multiple selector Carry out multichannel switching timesharing detection;
Or/and
Electrophysiology digital signal after time-sharing multiplex adc circuit module converter carries out noise isolation through radio frequency isolation loop, And the Electrophysiology digital signal after isolation noise is sent to radio frequency sending module.
10. a kind of digital radio Electrophysiology signal detection single system, which is characterized in that including in such as claim 1-7 Described in any item digital radio Electrophysiology signal detection single-chips.
CN201810649740.6A 2018-06-22 2018-06-22 Digital wireless neuroelectrophysiological signal detection single chip, system and method Expired - Fee Related CN108852341B (en)

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CN205964038U (en) * 2016-05-10 2017-02-22 华南理工大学 Wearing formula multimode brain function detecting device based on NIRS EEG
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CN109567796A (en) * 2018-12-20 2019-04-05 南京畅享医疗科技有限公司 A kind of superminiature radio physiological signal collection processing system
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