CN108693217A - Clinical eye resting potential measurement system - Google Patents
Clinical eye resting potential measurement system Download PDFInfo
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- CN108693217A CN108693217A CN201810915138.2A CN201810915138A CN108693217A CN 108693217 A CN108693217 A CN 108693217A CN 201810915138 A CN201810915138 A CN 201810915138A CN 108693217 A CN108693217 A CN 108693217A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
Abstract
The present invention provides a kind of clinical eye resting potential measurement system, belongs to electrophysiological technique field.It is contemplated by the invention that the intersection in applied electricity samples to replace eye movement recording, it designs acquisition and transmission intersects and the circuit and program of non-crossing signal, the reliablely and stablely switching under multiple operating modes, realize that eye quiet (non-eye movement) records OSP to replace eye movement recording OSP, the testing result under comparison and evaluation different mode.Host computer includes the softwares such as software model, acquisition signal analysis module in system, is used for:Control intersects the interconnection of acquisition analog switch;AD conversion module completes conversion of the analog signal to digital signal in control single chip computer;Control instruction lamp on/off and light;Realize the maximin automatic measurement of detection waveform;And realize detection waveform and reference waveform manual analyzing function;The electro physiology detection data and curve of the corresponding user of record;Record analysis curve and the analysis data etc. of user's electro physiology detection data.
Description
Technical field
The present invention relates to eye resting potential (OSP) determination techniques, affiliated electro physiology fields.
Background technology
Known eyeball is a dipole as battery, and there are a potential differences for rear and front end.This potential difference rises
Derived from the pigment epithelial layer of eyes retina, this current potential is physiologically known as eye resting potential (Ocular Standing
potential,OSP).Retinal function and diagnosis retinopathy medically can be evaluated by measuring the quantitative change size of OSP.
Closest to prior art realization method and existing limitation:Conventional method for many years is by being placed on inside and outside fissura palpebrae
A pair of electrodes of corner of the eyes skin surface, with the horizontal direction dealing bounce record OSP of eyeball.The OSP recorded in this way is unstable,
Each numerical value can all be influenced to keep record result unstable by factors such as different saccade angles and inspected degree of cooperation
Confidence level that is fixed and influencing inspection result.
Invention content
It is an object of the invention to overcome the shortage of prior art, a kind of novel ocular for laboratory and clinical application is disclosed
Resting potential (OSP) measurement system, it is therefore an objective to non-eye movement OSP, EOG and eye movement OSP, EOG can be obtained in the same subject,
So as to can more objectively evaluate both different recording methods as a result, to this in physiology and clinical medicine it is valuable
Inspection item can fully be applied.
The principle of the invention:Imagine the intersection in applied electricity to sample to replace eye movement recording, designs acquisition and transmission is handed over
The circuit and program of fork and non-crossing signal, the reliablely and stablely switching under multiple operating modes realize that eye is quiet (non-eye movement)
OSP is recorded to replace eye movement recording OSP, the testing result under comparison and evaluation different mode.
The present invention needs technical solution to be protected to be characterized as:
A kind of clinic eye resting potential measurement system, which is characterized in that this system includes inductor, intersects to acquire to simulate and open
Powered-down road, amplifier module (the ripe prior art is already belonging in this field), microcontroller, host computer, light source, wherein:
The inductor is used to acquire the electric signal OSP of eye movement and non-eye movement;
The intersection acquisition analog switching circuit includes the digital control analog switches of two CD4052 and an isolation
TLP521-4 photoelectric coupling switch;Right and left eyes electrode is respectively connected to drawing for the digital control analog switch input terminals of respective CD4052
Foot (X0~X3), pin (Y0~Y3), two digital control analog switches of CD4052 respectively by pin 13, pin 3 with it is preposition
Amplifier connects;It is connected with the input pin of TLP521-4 photoelectric coupling switch using the I/O pin (P20-P23) of 51 microcontrollers, by
The control of host computer controls the on/off of TLP521-4 by exporting high/low level;The output pin of TLP521-4 photoelectric coupling switch
It is connect with the controlling switch (A, B) of CD4052;When TLP521-4 is connected, the level of the controlling switch (A, B) of CD4052 is low;It is disconnected
When opening, the level of the controlling switch (A, B) of CD4052 is height, to which the digital control analog switches of CD4052 can there are four types of different
Getting type (ground connection, normal, intersect, disconnect) eye electrode OPS signals are supplied to amplifier.See the truth table of embodiment.
The amplifier module amplifies the electric signal of acquisition;
The microcontroller includes AD AD conversion units, I/O control module, the AD AD conversion units and the amplification
The post-amplifier of device module is connected, and analog signal is changed into digital information and is supplied to computer;The I/O control module with
Light source connects the light conditions for controlling light source;
The host computer is by chip microcontroller to intersecting acquisition analog switching circuit and light source control.
Host computer includes software model, acquires signal analysis module, database, display output module, wherein:It is described
Software model:Control intersects the interconnection of acquisition analog switch.Specific implementation:Drawn by each output of control single chip computer
The low and high level of foot is to determine the digital control analog switches of CD4052 with four kinds of getting types (ground connection, disconnects normal, intersection)
One of eye electrode OPS signals are supplied to amplifier.See the truth table of embodiment.AD conversion module completes mould in control single chip computer
Conversion of the quasi- signal to digital signal;Control instruction lamp on/off and light.The acquisition signal analysis module:Realize detection
The maximin automatic measurement of waveform;And (waveform peak is manual for realization detection waveform and reference waveform manual analyzing function
Measurement, waveform manual translation, measured waveform and Basis of Database waveform subtract each other).The database, including:User's case is established,
Storage record user basic information, such as name, age, gender;The electro physiology detection data and curve of the corresponding user of record;Note
Employ the analysis curve and analysis data of family electro physiology detection data.The display output module:Generate waveform and information model
Change and reports and show.
Compared with prior art, advantageous effect of the present invention:
1, a kind of method that OSP can not be obtained by " saccade " can be createed through the invention, so same
The a variety of detection methods for obtaining OSP of non-eye movement, eye movement can be obtained in subject, more objectively to evaluate this different record side
The result of method.
2, other than with stability and reliability, it is also contemplated that safety to human body and be non-invasive inspection,
So as in the future can be in clinical application.
3, " non-saccade " obtains the detection method of OSP, has inevitable superiority, will eliminate fatigue caused by saccade
And shorten the record time, there is application and dissemination in laboratory and clinic.
Description of the drawings
Fig. 1 is system schematic provided in an embodiment of the present invention;
Fig. 2 provides intersection acquisition analog switching circuit for the embodiment of the present invention;
Fig. 3 existing amplifier circuits provided in an embodiment of the present invention;
Fig. 4 embodiment database structure figures;
Fig. 5 embodiment parameter settings;
Fig. 6 embodiments acquire signal and analyze block diagram.
Specific implementation mode
Below in conjunction with specific embodiment and its attached drawing to the technology of the safe feeding equipment of hazardous waste provided by the invention
Scheme is described further.In conjunction with following explanation, advantages and features of the invention will be apparent from.
It should be noted that the embodiment of the present invention has preferable implementation, it is not to any type of limit of the present invention
It is fixed.The combination of technical characteristic or technical characteristic described in the embodiment of the present invention is not construed as isolated, they can
To be combined with each other to reach superior technique effect.The range of the preferred embodiment for the present invention can also include other reality
It is existing, and this should be understood by person of ordinary skill in the field of the embodiment of the present invention.
Technology, method and apparatus known to person of ordinary skill in the relevant may be not discussed in detail, but suitable
In the case of, the technology, method and apparatus should be considered as authorizing part of specification.Institute that is shown here and discussing
Have in example, any occurrence should be construed as merely illustrative, not as restriction.Therefore, exemplary embodiment
Other examples can have different values.
It should be noted that unless otherwise clearly defined and limited, the term in the present invention shall be understood in a broad sense, for
For those skilled in the art, the concrete meaning of above-mentioned term in the present invention can be understood with concrete condition.
The attached drawing of the present invention is all made of very simplified form and uses non-accurate ratio, only to convenient, apparent
Ground aids in illustrating the purpose of the embodiment of the present invention, is not to limit the enforceable qualifications of the present invention.The modification of any structure,
The change of proportionate relationship or the adjustment of size, in the case where not influencing the effect of the invention that can be generated and the purpose that can reach,
It should fall in the range of disclosed technology contents can be covered.And the identical label appeared in each attached drawing of the present invention
Identical feature or component are represented, can be applied in different embodiments.
Main technical principle and component as shown in Figure 1, this measurement system are provided.
This measurement system forms:
1, inductor
Electric signal OSP for acquiring non-eye movement.
The present embodiment uses disposable silver-silver chloride electrode.For the prior art.
2, intersect acquisition analog switch
Analog switch shown in Fig. 2 acquires and transmission intersects and the circuit of non-crossing signal.
The present embodiment is using two eye electrodes and the digital control analog switches of two CD4052 and isolation
The design of TLP521-4 photoelectric coupling switch is realized.
Right and left eyes electrode is respectively connected to the pin X2 of the digital control analog switch input terminals of respective CD4052, pin Y2,
Two digital control analog switches of CD4052 are connect by pin 13, pin 3 with preamplifier respectively.
It is connected with the input pin of TLP521-4 photoelectric coupling switch using the I/O pin (P20-P23) of 51 microcontrollers, is passed through
Export the on/off of high/low level control TLP521-4;The control of the output pin and CD4052 of TLP521-4 photoelectric coupling switch is drawn
Foot (A, B) connects.When TLP521-4 is connected, the level of the controlling switch (A, B) of CD4052 is low;When disconnection, the control of CD4052
The level of pin (A, B) processed is height.
In figure as above shown in CD4050 truth tables, the level of the controlling switch of CD4052 can select to connect with amplifier module
Logical eye electrode signal.
Foregoing circuit realizes the function that ALTERNATE SAMPLING is controlled with microcontroller.
3, amplifier module (Fig. 3 is the prior art)
The amplifier module of this system is eye resting potential amplifier, is by preamplifier, intermediate amplifier and rear class
Amplifier is composed in series, the electric signal for recording different frequency, different potentials, and the human-body safety in protection record is especially used
In acquisition OSP.
The amplifier of this system is illustrated, total magnification is about 10000 times, is followed successively by 100,8 and 12.5 times.
1), pre-amplifier (floating ground part) is made of two-stage calculation amplifier.The first order is that low input terminal noise height is defeated
Enter impedance and high cmrr;The second level is bandpass filter, and passband low side is 0.05Hz, high-end to be supplied for 10--100Hz
It is selected in.
2), intermediate optically isolated amplifier uses linear optical coupling amplifier, and 2500V voltages can be isolated, it is sufficient to protection record
When human-body safety.
3), post-amplifier (non-floating ground part) is made of three parts:(1) optional 50Hz trappers, limit for needing
50Hz is used when interfering;(2) gain-adjusted in-phase amplifier divides third gear adjustable, and the overall gain of entire amplifier is made to reach 5000 times;
(3) follower exports for Low ESR, for matching kinds of displays.
4, microcontroller
Microcontroller uses 51 microcontrollers, including AD AD conversion units, I/O control module, the AD AD conversion units with
The post-amplifier of the amplifier module is connected, and analog signal is changed into digital information and is supplied to computer, microcontroller is again
Transformed data are transferred to computer by USB data line;The I/O control module is connect with light source for controlling light source
Light conditions.
5, host computer
Host computer controls acquisition and light source by microcontroller.
Host computer includes software model, acquires signal analysis module, database, display output module, wherein:
The software model:Control intersects the interconnection of acquisition analog switch.Specific implementation:By controlling monolithic
The low and high level of each output pin of machine is to determine that the digital control analog switches of CD4052 (are grounded, just with four kinds of getting types
Often, intersect, disconnect) one of eye electrode OPS signals are supplied to amplifier.See the truth table of embodiment.
AD conversion module completes conversion of the analog signal to digital signal in control single chip computer;Control instruction lamp on/off and bright
Dark adaptation.
The acquisition signal analysis module:Realize the maximin automatic measurement of detection waveform;And realize detection wave
Shape and reference waveform manual analyzing function (waveform peak manual measurement, waveform manual translation, measured waveform and Basis of Database wave
Shape is subtracted each other).
The database, including:Establish user's case, storage record user basic information, such as name, age, gender;
The electro physiology detection data and curve of the corresponding user of record;Record the analysis curve and analysis number of user's electro physiology detection data
According to.
The display output module:It generates waveform and information modelization is reported and shown.
In application, control parameter, wherein control parameter is arranged by calling configuration file, for each recording method in software
Have:
(1, electric signal switching time;
(2, sample frequency;
(3, single cycle number;
(4, unitary sampling points;
(5, smooth average;
(6, per the group repetition interval time;
(7, OSP recording modes selection (folding intersects, and intersects folding, normal);
(8, adaptive state (light adaptation, dark adaptation);
(9, background light state;
(10, the light adaptation time;
(11, dark adaptation time etc.;
(12, waveform Fourier data processing.
Foregoing description is only the description to present pre-ferred embodiments, is not any restriction to the scope of the invention.Appoint
Any change or modification what those skilled in the art makes according to the technology contents of the disclosure above should all regard
For equivalent effective embodiment, the range of technical solution of the present invention protection is belonged to.
Claims (4)
1. a kind of clinic eye resting potential measurement system, which is characterized in that this system includes inductor, intersects acquisition analog switch
Circuit, amplifier module, microcontroller, host computer, light source, wherein:
The inductor is used to acquire the electric signal OSP of eye movement and non-eye movement;
The intersection acquisition analog switching circuit includes the digital control analog switches of two CD4052 and an isolation
TLP521-4 photoelectric coupling switch;Right and left eyes electrode is respectively connected to drawing for the digital control analog switch input terminals of respective CD4052
Foot (X0~X3), pin (Y0~Y3), two digital control analog switches of CD4052 respectively by pin 13, pin 3 with it is preposition
Amplifier connects;It is connected with the input pin of TLP521-4 photoelectric coupling switch using the I/O pin (P20-P23) of 51 microcontrollers, by
The control of host computer controls the on/off of TLP521-4 by exporting high/low level;The output pin of TLP521-4 photoelectric coupling switch
It is connect with the controlling switch (A, B) of CD4052;When TLP521-4 is connected, the level of the controlling switch (A, B) of CD4052 is low;It is disconnected
When opening, the level of the controlling switch (A, B) of CD4052 is height, to which the digital control analog switches of CD4052 can there are four types of different
Getting type (ground connection, normal, intersect, disconnect) eye electrode OPS signals are supplied to amplifier;
The amplifier module amplifies the electric signal of acquisition;
The microcontroller includes AD AD conversion units, I/O control module, the AD AD conversion units and the amplifier mould
The post-amplifier of block is connected, and analog signal is changed into digital information and is supplied to computer;The I/O control module and light source
Connect the light conditions for controlling light source;
The host computer includes software model, acquires signal analysis module, database, display output module, wherein:
The software model, including:Control intersects the interconnection of acquisition analog switch;AD conversion mould in control single chip computer
Block completes conversion of the analog signal to digital signal;Control instruction lamp on/off and light;
The acquisition signal analysis module:Realize the maximin automatic measurement of detection waveform;And realize detection waveform and
Reference waveform manual analyzing function;
The database, including:Establish user's case, storage record user basic information, such as name, age, gender;Record
The electro physiology detection data and curve of corresponding user;Record the analysis curve and analysis data of user's electro physiology detection data;
The display output module:It generates waveform and information modelization is reported and shown.
2. system according to claim 1, it is characterised in that:The control intersects the interconnection of acquisition analog switch,
Specific implementation:By the low and high level of each output pin of control single chip computer to determine the digital control analog switches of CD4052 with
Eye electrode OPS signals are supplied to amplifier by one of four kinds of getting types (ground connection, disconnects normal, intersection).
3. system according to claim 1, it is characterised in that:The reference waveform manual analyzing function, including:Waveform peak
Value manual measurement, waveform manual translation, measured waveform and Basis of Database waveform subtract each other.
4. system according to claim 1, it is characterised in that:The inductor is disposable silver-silver chloride electrode.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810915138.2A CN108693217B (en) | 2018-08-13 | 2018-08-13 | Clinical eye resting potential measuring system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810915138.2A CN108693217B (en) | 2018-08-13 | 2018-08-13 | Clinical eye resting potential measuring system |
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| CN108693217A true CN108693217A (en) | 2018-10-23 |
| CN108693217B CN108693217B (en) | 2020-09-08 |
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| CN107961008A (en) * | 2017-12-20 | 2018-04-27 | 中国科学院合肥物质科学研究院 | A kind of auxiliary device and method of resting metabolic rate quick obtaining |
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2018
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| JPS6118248A (en) * | 1984-07-04 | 1986-01-27 | Fujitsu Ltd | Eye pattern measuring device |
| TWM395456U (en) * | 2010-09-07 | 2011-01-01 | Holtek Semiconductor Inc | Electro-oculogram alarm apparatus |
| CN103054549A (en) * | 2012-12-29 | 2013-04-24 | 西安交通大学 | Wearable portable device and method for analyzing eye movement |
| CN105339783A (en) * | 2013-06-17 | 2016-02-17 | 谷歌公司 | Symmetrically arranged sensor electrodes in an ophthalmic electrochemical sensor |
| CN103892829A (en) * | 2014-04-17 | 2014-07-02 | 安徽大学 | Eye movement signal identification system and method based on common spatial pattern |
| CN107961008A (en) * | 2017-12-20 | 2018-04-27 | 中国科学院合肥物质科学研究院 | A kind of auxiliary device and method of resting metabolic rate quick obtaining |
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