CN108653063A - A kind of refrigerant antipruritic skin care compositions - Google Patents
A kind of refrigerant antipruritic skin care compositions Download PDFInfo
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- CN108653063A CN108653063A CN201810740680.9A CN201810740680A CN108653063A CN 108653063 A CN108653063 A CN 108653063A CN 201810740680 A CN201810740680 A CN 201810740680A CN 108653063 A CN108653063 A CN 108653063A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9741—Pteridophyta [ferns]
- A61K8/9749—Filicopsida or Pteridopsida
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
The present invention provides a kind of skin care compositions with refrigerant itching-relieving efficacies, the raw material that the skin care compositions is matched by following weight parts is made：1~5 part of sweet mary, 0.5~5 part of giant knotweed, 0.5~5 part of Cymbidium hookerianum, 0.5~5 part of Mongolian oak fern, 0.5~5 part of shrub lespedeza, 0.5~5 part of Radix Glycyrrhizae.Raw material selection of the present invention is natural ingredient of releiving, and raw material is naturally mild, refrigerant through a variety of ways, anti-inflammatory, Shu Min, restoration and protection skin, improves cutaneous immunisation power, alleviates pruitus.It is tested and is found by red blood cell stimulation test and volunteer, can enhance the tolerance of Skin Cell, showing reduces skin sensitivity and itch phenomenon.
Description
Technical field
The present invention relates to cosmetic fields, are specifically related to a kind of refrigerant antipruritic skin care compositions.
Background technology
Pruitus is common disease, frequently-occurring disease, especially children, many reasons such as eczema, diaper rash, newborn rash, bite by mosquitos
Pruitus can all be caused, the preparation being relatively often used at present is refrigerant antipruritic tincture and refrigerant itching-relieving cream, and tincture irritation is larger,
Paste greasy feeling is strong, and gelling agent is drug and transparent or semitransparent semisolid that is uniform made of suitable auxiliary material or being suspended
Preparation, gelling agent are a kind of novel forms, good absorbing, non-greasy, other opposite dosage forms have its superiority, for this reason, we
Refrigerant Itch Stopping Gel is developed.
Invention content
The main object of the present invention is to provide a kind of skin care compositions with refrigerant itching-relieving efficacies.
Another object of the present invention is to provide a kind of refrigerant Itch Stopping Gels.
The specific technical solution of the present invention is as follows：
A kind of skin care compositions with refrigerant itching-relieving efficacies, the raw material system that the skin care compositions is matched by following weight parts
At：1~5 part of sweet mary, 0.5~5 part of giant knotweed, 0.5~5 part of Cymbidium hookerianum, 0.5~5 part of Mongolian oak fern, 0.5~5 part of shrub lespedeza, Radix Glycyrrhizae
0.5~5 part.
The raw material that the skin care compositions is matched by following weight parts in one of the embodiments, is made：Sweet mary 3
Part, 4 parts of giant knotweed, 2 parts of Cymbidium hookerianum, 2.5 parts of Mongolian oak fern, 2.5 parts of shrub lespedeza, 1 part of Radix Glycyrrhizae.
The skin care compositions is made by the following method, the specific steps are：
(1) each raw material is weighed according to said components and dosage；
(2) mixed be incorporated in water of each raw material is dipped to each raw material softness；
(3) ethyl alcohol is added；Heating extraction；Coarse filtration；Coarse filtration liquid is taken, stands, takes supernatant；
(4) supernatant is filtered by vacuum with diatomite, takes filtrate to get to the skin care compositions.
In wherein some embodiments, the mass ratio (g/ml) of raw material and water is 1: 10~20 in the step (2)；
In wherein some embodiments, the mass ratio of ethyl alcohol and water described in the step (3) is 1: 0.5~1.5；The extraction
Temperature be 70~95 DEG C, pressure be 0.2~1MPa, the time be 1~3 hour；The coarse filtration uses the filter cloth of 100~200 mesh；
The time of repose is 3~5 hours.
In wherein some embodiments, the step（3）In further include ultrasonic extraction process, the frequency of the ultrasonic wave
For 30~100KHZ, extraction time is 10~30 minutes.
In wherein some embodiments, vacuum degree is 0.05~0.1MPa in the step (4)；The diatomaceous filtering
Fineness is 500~700 mesh.
A kind of refrigerant antipruritic skin care formulation, the skin care formulation is by the above-mentioned skin care compositions with refrigerant itching-relieving efficacies
It is made with the acceptable auxiliary material of skin care field.
The skin care formulation is external preparation, and the external preparation can be gel, face cream, lotion, toner, wash one's face
Milk, spray or essence.According to using approach different, external preparation is made in the present composition, as external-use gel, face cream,
Toner, facial cleanser, spray or essence.But it is not limited to above-mentioned dosage form, it can be according to known in skin care industry field
Method, by aforementioned pharmaceutical compositions by a variety of different external preparations are made after known method degerming.
The present invention also provides a kind of refrigerant Itch Stopping Gels, include the component of following mass percentage：
Refrigerant Itch Stopping Gel of the present invention can also include preservative, and the preservative can be methyl hydroxybenzoate, oxybenzene
Propyl ester, DMDM hydantoins, iodine propilolic alcohol butyl mephenesin Carbamate, methylchloroisothiazandnone, methylisothiazolinone, benzene oxygen
Ethyl alcohol, glycerol caprylate, Sensiva SC50, benzoic acid, sodium benzoate, sorbic acid, potassium sorbate, decoyl hydroximic acid, glycerine
One or more kinds of mixing in caprylate.
In wherein some embodiments, the preservative is the mixing of decoyl hydroximic acid, glycerol caprylate, the decoyl
The additive amount of hydroximic acid is 0.1~0.5wt%, and the additive amount of the glycerol caprylate is 0.01~0.2wt%.
The preparation method of refrigerant Itch Stopping Gel of the present invention can be made according to common process.The present invention provides one kind
Preparation method includes the following steps：
(1) according to said ratio precise each component；
(2) 1,3- propylene glycol, glycerine, Sodium Hyaluronate, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers are pre-
It is first uniformly mixed, the remaining ingredient in addition to preservative is then added, stirs evenly；
(3) it is heated to 80 DEG C under stirring, opens 3000rpm homogeneous 1~5 minute；Then 40 DEG C are cooled to；
(4) it uses citric acid and/or sodium citrate to adjust pH value between 5.0~6.5, preservative is added；It stirs evenly, examines and close
Lattice can discharge, filling, packaging.
The preparation that the above method is prepared is gel, and preparation type is recommended for the present invention.
Refrigerant anti-pruritic formulation, soft made of the present invention, nonirritant peculiar smell.Its usage and dosage is as follows：
Method：After daily face cleaning, hair position applies the refrigerant anti-pruritic formulation of the present invention on skin and easily, once in the morning and once at night.
Dosage：It is appropriate to smear invention formulation according to individual demand for nursing use on ordinary days.For easily sending out portion sensitive
Position is subject to and all covers predisposing infection area.
The advantageous effect that technical solution provided in an embodiment of the present invention is brought is：
Raw material selection of the present invention is natural ingredient of releiving, and raw material is naturally mild, refrigerant through a variety of ways, anti-inflammatory, Shu Min,
Restoration and protection skin improves cutaneous immunisation power, alleviates pruitus.It is tested and is found by red blood cell stimulation test and volunteer,
It can enhance the tolerance of Skin Cell, and showing reduces skin sensitivity and itch phenomenon.
Raw material acquisition of the present invention is simple, preparation method is convenient, and cost is cheap compared with other antiallergic methods, is easy to be disappeared by vast
The person of expense receives, and has good application prospect and market prospects.
Specific implementation mode
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
Some raw materials involved in the present invention are illustrated below：
The active component of sweet mary according to the present invention is leaf, and the cosmetic standard Chinese of extract is entitled：Sweet mary
（MELISSA OFFICINALIS）Leaf extract；
The active component of giant knotweed according to the present invention is root, and the cosmetic standard Chinese of extract is entitled：Giant knotweed
（POLYGONUM CUSPIDATUM）Root extract；
The active component of Cymbidium hookerianum according to the present invention is root, and the cosmetic standard Chinese of extract is entitled：Cymbidium hookerianum
（CYMBIDIUM GRANDIFLORUM）Root extract；
The active component of Mongolian oak fern according to the present invention is rhizome, and the cosmetic standard Chinese of extract is entitled：Mongolian oak fern
（DRYNARIA FORTUNEI）Rhizome extract；
The active component of shrub lespedeza according to the present invention is bark, and the cosmetic standard Chinese of extract is entitled：Shrub lespedeza
（LESPEDEZA BICOLOR）Bark extract；
The active component of Radix Glycyrrhizae according to the present invention is root, and the cosmetic standard Chinese of extract is entitled：Radix Glycyrrhizae
（GLYCYRRHIZA URALENSIS）Root extract.
Embodiment 1
A kind of skin care compositions with refrigerant itching-relieving efficacies is prepared according to following processing step：
(1) each raw material, wherein sweet mary leaf 1kg, polygoni cuspidati,radix 5kg, Cymbidium hookerianum root 0.5kg, Drynaria fortunei(Kunze) J.Smith rhizome 5kg, shrub lespedeza are weighed
Bark 0.5kg, licorice 5kg；
(2) mixed be incorporated in water of each raw material is dipped to each raw material softness, the wherein mass ratio (g/ml) of raw material and water is 1: 10；
(3) ethyl alcohol is added, wherein the mass ratio of the ethyl alcohol and water is 1: 1.5；Heating extraction, wherein temperature are 70 DEG C, pressure
For 1MPa, the time is 1 hour；100KHZ ultrasonic extractions 10 minutes；With the filter cloth coarse filtration of 200 mesh；Coarse filtration liquid is taken, it is small to stand 3
When, take supernatant；
(4) supernatant is filtered by vacuum with diatomite, wherein vacuum degree is 0.1MPa, and the diatomaceous filtering fineness is 500
Mesh；Take filtrate to get to the skin care compositions.
Embodiment 2
A kind of skin care compositions with refrigerant itching-relieving efficacies is prepared according to following processing step：
(1) each raw material, wherein sweet mary leaf 5kg, polygoni cuspidati,radix 0.5kg, Cymbidium hookerianum root 5kg, Drynaria fortunei(Kunze) J.Smith rhizome 0.5kg, Hu Zhi are weighed
Subtree skin 5kg, licorice 0.5kg；
(2) mixed be incorporated in water of each raw material is dipped to each raw material softness, the wherein mass ratio (g/ml) of raw material and water is 1: 20；
(3) ethyl alcohol is added, wherein the mass ratio of the ethyl alcohol and water is 1: 0.5；Heating extraction, wherein temperature are 95 DEG C, pressure
For 0.2MPa, the time is 3 hours；30KHZ ultrasonic extractions 30 minutes；With the filter cloth coarse filtration of 100 mesh；Coarse filtration liquid is taken, it is small to stand 5
When, take supernatant；
(4) supernatant is filtered by vacuum with diatomite, wherein vacuum degree is 0.05MPa, and the diatomaceous filtering fineness is 700
Mesh；Take filtrate to get to the skin care compositions.
Embodiment 3
A kind of skin care compositions with refrigerant itching-relieving efficacies is prepared according to following processing step：
(1) each raw material, wherein sweet mary leaf 3kg, polygoni cuspidati,radix 4kg, Cymbidium hookerianum root 2kg, Drynaria fortunei(Kunze) J.Smith rhizome 2.5kg, shrub lespedeza are weighed
Bark 2.5kg, licorice 1kg；
(2) mixed be incorporated in water of each raw material is dipped to each raw material softness, the wherein mass ratio (g/ml) of raw material and water is 1: 15；
(3) ethyl alcohol is added, wherein the mass ratio of the ethyl alcohol and water is 1: 1；Heating extraction, wherein temperature are 80 DEG C, and pressure is
0.5MPa, time are 2 hours；50KHZ ultrasonic extractions 20 minutes；With the filter cloth coarse filtration of 200 mesh；Coarse filtration liquid is taken, it is small to stand 4
When, take supernatant；
(4) supernatant is filtered by vacuum with diatomite, wherein vacuum degree is 0.08MPa, and the diatomaceous filtering fineness is 600
Mesh；Take filtrate to get to the skin care compositions.
Comparative example 1
A kind of skin care compositions with refrigerant itching-relieving efficacies is prepared according to following processing step：
(1) sweet mary leaf 3kg is weighed；
(2) sweet mary is dipped to softness in water, the wherein mass ratio (g/ml) of raw material and water is 1: 15；
(3) ethyl alcohol is added, wherein the mass ratio of the ethyl alcohol and water is 1: 1；Heating extraction, wherein temperature are 80 DEG C, and pressure is
0.5MPa, time are 2 hours；50KHZ ultrasonic extractions 20 minutes；With the filter cloth coarse filtration of 200 mesh；Coarse filtration liquid is taken, it is small to stand 4
When, take supernatant；
(4) supernatant is filtered by vacuum with diatomite, wherein vacuum degree is 0.08MPa, and the diatomaceous filtering fineness is 600
Mesh；Take filtrate to get to the skin care compositions.
Comparative example 2
A kind of skin care compositions with refrigerant itching-relieving efficacies is prepared according to following processing step：
(1) polygoni cuspidati,radix 4kg is weighed；
(2) giant knotweed is dipped to softness in water, the wherein mass ratio (g/ml) of raw material and water is 1: 15；
(3) ethyl alcohol is added, wherein the mass ratio of the ethyl alcohol and water is 1: 1；Heating extraction, wherein temperature are 80 DEG C, and pressure is
0.5MPa, time are 2 hours；50KHZ ultrasonic extractions 20 minutes；With the filter cloth coarse filtration of 200 mesh；Coarse filtration liquid is taken, it is small to stand 4
When, take supernatant；
(4) supernatant is filtered by vacuum with diatomite, wherein vacuum degree is 0.08MPa, and the diatomaceous filtering fineness is 600
Mesh；Take filtrate to get to the skin care compositions.
Comparative example 3
A kind of skin care compositions with refrigerant itching-relieving efficacies is prepared according to following processing step：
(1) Cymbidium hookerianum root 2kg is weighed；
(2) Cymbidium hookerianum is dipped to softness in water, the wherein mass ratio (g/ml) of raw material and water is 1: 15；
(3) ethyl alcohol is added, wherein the mass ratio of the ethyl alcohol and water is 1: 1；Heating extraction, wherein temperature are 80 DEG C, and pressure is
0.5MPa, time are 2 hours；50KHZ ultrasonic extractions 20 minutes；With the filter cloth coarse filtration of 200 mesh；Coarse filtration liquid is taken, it is small to stand 4
When, take supernatant；
(4) supernatant is filtered by vacuum with diatomite, wherein vacuum degree is 0.08MPa, and the diatomaceous filtering fineness is 600
Mesh；Take filtrate to get to the skin care compositions.
Comparative example 4
A kind of skin care compositions with refrigerant itching-relieving efficacies is prepared according to following processing step：
(1) Drynaria fortunei(Kunze) J.Smith rhizome 2.5kg is weighed；
(2) Mongolian oak fern is dipped to softness in water, the wherein mass ratio (g/ml) of raw material and water is 1: 15；
(3) ethyl alcohol is added, wherein the mass ratio of the ethyl alcohol and water is 1: 1；Heating extraction, wherein temperature are 80 DEG C, and pressure is
0.5MPa, time are 2 hours；50KHZ ultrasonic extractions 20 minutes；With the filter cloth coarse filtration of 200 mesh；Coarse filtration liquid is taken, it is small to stand 4
When, take supernatant；
(4) supernatant is filtered by vacuum with diatomite, wherein vacuum degree is 0.08MPa, and the diatomaceous filtering fineness is 600
Mesh；Take filtrate to get to the skin care compositions.
Comparative example 5
A kind of skin care compositions with refrigerant itching-relieving efficacies is prepared according to following processing step：
(1) shrub lespedeza bark 2.5kg is weighed；
(2) shrub lespedeza is dipped to softness in water, the wherein mass ratio (g/ml) of raw material and water is 1: 15；
(3) ethyl alcohol is added, wherein the mass ratio of the ethyl alcohol and water is 1: 1；Heating extraction, wherein temperature are 80 DEG C, and pressure is
0.5MPa, time are 2 hours；50KHZ ultrasonic extractions 20 minutes；With the filter cloth coarse filtration of 200 mesh；Coarse filtration liquid is taken, it is small to stand 4
When, take supernatant；
(4) supernatant is filtered by vacuum with diatomite, wherein vacuum degree is 0.08MPa, and the diatomaceous filtering fineness is 600
Mesh；Take filtrate to get to the skin care compositions.
Comparative example 6
A kind of skin care compositions with refrigerant itching-relieving efficacies is prepared according to following processing step：
(1) licorice 1kg is weighed；
(2) Radix Glycyrrhizae is dipped to softness in water, the wherein mass ratio (g/ml) of raw material and water is 1: 15；
(3) ethyl alcohol is added, wherein the mass ratio of the ethyl alcohol and water is 1: 1；Heating extraction, wherein temperature are 80 DEG C, and pressure is
0.5MPa, time are 2 hours；50KHZ ultrasonic extractions 20 minutes；With the filter cloth coarse filtration of 200 mesh；Coarse filtration liquid is taken, it is small to stand 4
When, take supernatant；
(4) supernatant is filtered by vacuum with diatomite, wherein vacuum degree is 0.08MPa, and the diatomaceous filtering fineness is 600
Mesh；Take filtrate to get to the skin care compositions.
Test the experiment of 1 erythrocyte hemolysis
Experimental method is with reference to ECVAM-DB-ALM：INVITTOX protocol：Red Blood Cell Test
SystemINVITTOX n°37.Using SDS as sensibiligen, erythrocyte haemolysis is stimulated.Experiment is by measuring from erythrocyte
The degree of injury of the hemoglobin content evaluation cell membrane of middle leakage, which has directly related with the irritation of substance
Property.
Experimental principle：Hemolytic test (hemolysis test) is based on the amount for measuring the hemoglobin leaked out from red blood cell
To evaluate membrane damage.Spectrophotometry measure chemicals effect after red cell suspension absorbance, calculate hemolysis rate and
HC50 values (even if concentration value of the tested material of 50% erythrocyte hemolysis) and protein-denatured numerical value DI values.Model evaluation：Haemolysis
Experiment shows preferable correlation consistency with the Draize interpretations of result tested.Foreign countries have developed to checking research rank at present
Section, and propose the chemistry safety evaluation of programme of the replacement Draize eye irritant tests including it.As a result it calculates：
1. hemolytic test
If positive control erythrocyte hemolysis amount is 100%, different SDS concentration system RBC hemolysis rates (OD540nm/OD are calculated separately
Positive control).Curve is drawn, 50% haemolysis amount concentration (H50) on calculated curve；
2. albuminous degeneration：DI (%)=100* (R1-Ri)/(R1-R2)
Wherein：R1 is positive control OD575nm/OD540nm values；Ri is OD575nm/OD540nm values in denaturing samples experiment；R2
For the OD575nm/OD540nm values of 1mg/mLSDS；Define L/D=H50/DI；Table 2 obtains its stimulus intensity.
The L/D values of 2. different stimulated intensity of table
Skin care compositions obtained by embodiment 1-3 and comparative example 1-6 is tested, it is 1% that skin care compositions, which is diluted with water,
Prepare liquid is made in aqueous solution；Then it takes part prepare liquid that SDS is added, makes a concentration of 1mg/mL of SDS in solution；According to above-mentioned
Method carries out erythrocyte hemolysis experiment, specific experiment result such as the following table 3.
3. test result table of table
By upper table 3 it is found that the irritation unobvious relatively of the skin care compositions with refrigerant itching-relieving efficacies prepared by embodiment 1-3,
And there is effect of releiving to the red blood cell in the presence of SDS stimulants, that is to say, that the skin care compositions obtained by the present invention has
Skin cell tolerance is promoted, irritating effect of environmental stimuli object is reduced.In addition, being only added to sweet mary, tiger respectively
A kind of effect of releiving of the obtained composition of raw material in cane, Cymbidium hookerianum, Mongolian oak fern, shrub lespedeza, Radix Glycyrrhizae is limited, this also illustrates
Six kinds of raw materials share the good effects of Shi Caiyou, and unobvious are applied alone, and embody the effect for coordinating synergy.
Embodiment 4
A kind of refrigerant Itch Stopping Gel, includes the component of following mass percentage：
The preparation method of above-mentioned refrigerant Itch Stopping Gel, includes the following steps：
(1) according to said ratio precise each component；
(2) 1,3- propylene glycol, glycerine, Sodium Hyaluronate, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers are pre-
It is first uniformly mixed, the remaining ingredient in addition to preservative is then added, stirs evenly；
(3) it is heated to 80 DEG C under stirring, opens 3000rpm homogeneous 1~5 minute；Then 40 DEG C are cooled to；
(4) it uses citric acid and/or sodium citrate to adjust pH value between 5.0~6.5, preservative is added；It stirs evenly, examines and close
Lattice can discharge, filling, packaging.
Test 2 volunteers test
Clinical observation 100 is carried out using the gel C obtained by embodiment 4, skin clinical manifestation is that skin is quick before observing
Sense, itch is uncomfortable, the long-term breaking-out having.
1, method：After daily face cleaning, on skin and easily hair position smearing gel C is appropriate, once in the morning and once at night.3 days, 7 days,
1 month, statistical result.
2, judgment criteria：(1) it cures：Clinical symptoms are disappeared, are reacted again without skin sensitivity in one month；(2) effectively：It is clinical
Symptom mitigates, skin sensitivity reactive moieties subside or disappears, and reduces or reduces；(3) invalid：Clinical symptoms, skin sensitivity have no
It improves.
3, result on trial：(1) quick, 3 days, 7 days efficient reachable 90% or more, and have certain cure rate, 1 month
Cure rate be 90% or more.(2) notable to the general sensitivity treatment effect of skin.(3) there is allergy, skin in no an example reaction
Phenomena such as skin is uncomfortable.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (10)
1. a kind of skin care compositions with refrigerant itching-relieving efficacies, which is characterized in that the skin care compositions is by following weight parts
The raw material of proportioning is made：1~5 part of sweet mary, 0.5~5 part of giant knotweed, 0.5~5 part of Cymbidium hookerianum, 0.5~5 part of Mongolian oak fern, shrub lespedeza
0.5~5 part, 0.5~5 part of Radix Glycyrrhizae.
2. skin care compositions according to claim 1, which is characterized in that the skin care compositions is matched by following weight parts
The raw material of ratio is made：3 parts of sweet mary, 4 parts of giant knotweed, 2 parts of Cymbidium hookerianum, 2.5 parts of Mongolian oak fern, 2.5 parts of shrub lespedeza, 1 part of Radix Glycyrrhizae.
3. skin care compositions according to claim 1 or 2, which is characterized in that the skin care compositions is by the following method
It is made, the specific steps are：
(1) each raw material as claimed in claim 1 or 2 is weighed；
(2) mixed be incorporated in water of each raw material is dipped to each raw material softness；
(3) ethyl alcohol is added；Heating extraction；Coarse filtration；Coarse filtration liquid is taken, stands, takes supernatant；
(4) supernatant is filtered by vacuum with diatomite, takes filtrate to get to the skin care compositions.
4. skin care compositions according to claim 3, which is characterized in that the mass ratio of raw material and water in the step (2)
(g/ml) it is 1: 10~20；The mass ratio of ethyl alcohol and water described in the step (3) is 1: 0.5~1.5；The temperature of the extraction
It it is 70~95 DEG C, pressure is 0.2~1MPa, and the time is 1~3 hour；The coarse filtration uses the filter cloth of 100~200 mesh；It is described quiet
It is 3~5 hours to set the time；Vacuum degree is 0.05~0.1MPa in the step (4)；The diatomaceous filtering fineness is 500
~700 mesh.
5. skin care compositions according to claim 3, which is characterized in that the step（3）In further include ultrasonic extraction
The frequency of process, the ultrasonic wave is 30~100KHZ, and extraction time is 10~30 minutes.
6. a kind of refrigerant antipruritic skin care formulation, which is characterized in that the skin care formulation is by any one of claim 1-5 institutes
The acceptable auxiliary material of skin care compositions and skin care field stated is made.
7. a kind of refrigerant Itch Stopping Gel, which is characterized in that include the component of following mass percentage：
。
8. refrigerant Itch Stopping Gel according to claim 7, which is characterized in that the refrigerant Itch Stopping Gel further includes preventing
Rotten agent, the preservative are methyl hydroxybenzoate, Nipasol, DMDM hydantoins, iodine propilolic alcohol butyl mephenesin Carbamate, methyl
Chloroisothiazole quinoline ketone, methylisothiazolinone, Phenoxyethanol, glycerol caprylate, Sensiva SC50, benzoic acid, sodium benzoate,
One or more kinds of mixing in sorbic acid, potassium sorbate, decoyl hydroximic acid, glycerol caprylate.
9. refrigerant Itch Stopping Gel according to claim 8, which is characterized in that the preservative is decoyl hydroximic acid, sweet
The additive amount of the mixing of oily caprylate, the decoyl hydroximic acid is 0.1~0.5wt%, and the additive amount of the glycerol caprylate is
0.01~0.2wt%.
10. according to the refrigerant Itch Stopping Gel of claim 7-9 any one of them, which is characterized in that the refrigerant Itch Stopping Gel
Preparation method includes the following steps：
(1) according to said ratio precise each component；
(2) 1,3- propylene glycol, glycerine, Sodium Hyaluronate, hydroxy-ethyl acrylate/sodium acryloyldimethyl taurate copolymers are pre-
It is first uniformly mixed, the remaining ingredient in addition to preservative is then added, stirs evenly；
(3) it is heated to 80 DEG C under stirring, opens 3000rpm homogeneous 1~5 minute；Then 40 DEG C are cooled to；
(4) it uses citric acid and/or sodium citrate to adjust pH value between 5.0~6.5, preservative is added；It stirs evenly, examines and close
Lattice can discharge, filling, packaging.
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| CN201810740680.9A CN108653063A (en) | 2018-07-07 | 2018-07-07 | A kind of refrigerant antipruritic skin care compositions |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111821231A (en) * | 2020-06-19 | 2020-10-27 | 广州艾蓓生物科技有限公司 | Refreshing composition and preparation method thereof |
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2018
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111821231A (en) * | 2020-06-19 | 2020-10-27 | 广州艾蓓生物科技有限公司 | Refreshing composition and preparation method thereof |
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Application publication date: 20181016 |