CN108635265A - A kind of externally applied spray and preparation method thereof for miliaria of dispelling - Google Patents
A kind of externally applied spray and preparation method thereof for miliaria of dispelling Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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Abstract
A kind of externally applied spray for miliaria of dispelling, ingredient are made of following weight ratio：Purified water 20 50%, ethyl alcohol 20 60%, menthol 0.1 0.6%, borneol 0.01 0.6%, thyme extract 1 8%, golden yellow camomile extract 1 8%, honeysuckle flower extract 1 8%, citronella oil 1 8%, permanent flower extract 1 8%, essence 5 12%.And raw material is taken successively, after stirring and dissolving is complete, discharging can reach miliaria effect of dispelling.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of externally applied spray and preparation method thereof for miliaria of dispelling.
Background technology
Since temperature height, humidity are big in environment, excessive sweating is not easy to evaporate, and sweat makes horny layer of epidermis impregnate, and causes sweat
Gland conduit mouth narrows or blocks, and is ruptured after sweat retention because internal pressure increases in sudoriferous duct, and excessive sweat penetrates into simultaneously
It stimulates surrounding tissue and occurs papule, papulo-vesicle and phlysis at pore, to generate prickly heat.Currently, clinically generally adopting
With external application prickly-heat powder or calamine lotion, there are secondary infection person's meal with wine added with antibiotic ointment external application or oral antibiotic to be treated,
Though it has certain curative effect, it is used for a long time and easily forms drug dependence, it is palliative.Therefore, it is badly in need of one kind in the market to dispel
Miliaria effect is good, and the externally applied spray having no toxic side effect.
Invention content
Based on this, for disadvantages mentioned above, it is necessary to propose a kind of externally applied spray and preparation method thereof for miliaria of dispelling.
A kind of externally applied spray for miliaria of dispelling, ingredient are made of following weight ratio：Purified water 20-50%, ethyl alcohol 20-
60%, menthol 0.1-0.6%, borneol 0.01-0.6%, thyme extract 1-8%, golden yellow camomile extract 1-8%, honeysuckle flowers
Extract 1-8%, citronella oil 1-8%, permanent flower extract 1-8%, essence 5-12%.
Further, a kind of externally applied spray for miliaria of dispelling, ingredient are made of following weight ratio：Purified water
38.8%, ethyl alcohol 40%, menthol 0.2%, borneol 0.1%, thyme extract 4%, golden yellow camomile extract 4%, honeysuckle flowers carry
Take object 4%, citronella oil 4%, permanent flower extract 4%, essence 0.9%.
A kind of externally applied spray and preparation method thereof for miliaria of dispelling, the preparation method comprises the following steps：
（1）The preparation of citronella oil is followed the example of using supercritical CO 2 soldier：Lemon-grass is taken, is crushed after low temperature drying, crosses 20 mesh sieve, accurately
200 g lemon-grass powder are weighed in extraction kettle, are cooled down to CO2 in condenser, while extraction kettle and separating still are carried out
Heating, after system reaches 45 DEG C, pressurizes to system, adjusts CO2 flows to 30 kg/h after reaching the pressure of setting, opens
Begin to carry out cycling extraction, keep constant temperature and pressure (pressure 15MPa), after 70 minutes, lemongrass is collected from separating still 1,2 discharge ports
Oil, gained extract are citronella oil；
（2）The preparation method of permanent flower, honeysuckle flowers, thyme, golden yellow camomile extract is：Take permanent flower respectively, honeysuckle flowers,
Thyme, golden yellow chamomile removal impurity and non-medicinal effects, then it is heated to 80- after adding purified water to impregnate 15-20 hours respectively
100 DEG C persistently decoct 1-3 times, decoct every time 1-2 hour, filtration, room temperature to be cooled to, and add ethyl alcohol that alcohol content is made to be 50-70%,
It stirs evenly, refrigerates 24-72 hours, take supernatant, filter, filtrate recycling ethanol is concentrated into 45-60 DEG C, and gained concentrate is respectively
Permanent flower extract, honeysuckle flower extract, thyme extract, golden yellow camomile extract；
（3）It takes the purified water of formula ratio into agitated kettle, is heated to 80 DEG C, keeps the temperature 20 minutes, cooling and stirring pot, pot temperature to be mixed
30 DEG C are down to, the ethyl alcohol of formula ratio is added；
（4）Continue cooling and stirring pot, etc. temperature be down to 25 DEG C or room temperature, be added the menthol of formula ratio, borneol, permanent flower extraction
Object, honeysuckle flower extract, thyme extract, golden yellow camomile extract stirring and dissolving is complete, and mixing speed is 30 revs/min
Clock stirs 20 minutes；
（5）It is 22 DEG C or room temperature to continue cooling and stirring pot to temperature, and the essence of formula ratio, citronella oil stirring, mixing speed is added
It it is 25 revs/min, mixing time 30 minutes takes semi-finished product inspection, discharges after the assay was approved after stirring and dissolving is complete.
Specific implementation method：
In a kind of embodiment, a kind of externally applied spray for miliaria of dispelling, ingredient is made of following weight ratio：Purified water 20-50%,
Ethyl alcohol 20-60%, menthol 0.1-0.6%, borneol 0.01-0.6%, thyme extract 1-8%, golden yellow camomile extract 1-
8%, honeysuckle flower extract 1-8%, citronella oil 1-8%, permanent flower extract 1-8%, essence 5-12%.
Further, a kind of externally applied spray for miliaria of dispelling, ingredient are made of following weight ratio：Purified water 38.8%, second
Alcohol 40%, menthol 0.2%, borneol 0.1%, thyme extract 4%, golden yellow camomile extract 4%, honeysuckle flower extract 4% are fragrant
Thatch oil 4%, permanent flower extract 4%, essence 0.9%.
Ethyl alcohol：It is a kind of organic matter, is commonly called as alcohol, chemical formula is CH3CH2OH (C2H6O or C2H5OH) or EtOH, is band
There are one the saturated monohydroxy alcohols of hydroxyl, are a kind of inflammable, volatile colourless transparent liquids under room temperature, normal pressure, it water-soluble
Liquid has the smell of aroma, and slightly stimulates.There are smells of wine and the pungent flavour of stimulation, micro-sweet.
Menthol：A kind of chemical agent, menthol in the leaf and stem of peppermint by being extracted, white crystal, molecular formula
C10H20O is the main component in peppermint and lavender essential oil.In the world, India is main natural peppermint producing country.It is thin
Lotus brain and Racementhol can be employed as toothpaste；Perfume；The odorant of beverage and candy etc..It is used as excitants in medicine, makees
For skin or mucous membrane, there is refrigerant itching-relieving action；It is for oral administration to can be used as carminative, for headache and nose；Pharynx；Laryngitis etc..Its ester
For fragrance and drug.
Borneol：Borneol, kapur, brain, borneol, piece brain, borneol brain, plum blossom brain, natural borneol, old Borneolum, Borneolum.It is main
Want ingredient：This product is the crystallization obtained from the resin and volatile oil of kapur, is intimate pure d-Bomeol.Kapur
Containing there are many ter penoids in resin and volatile oil.Borneol is the processed goods of Spore density kapur, and ingredient contains dextrorotation
Borneol humulene, beta-elemene, carypohyllene etc..This product acrid flavour, it is cold in nature, there are logical all keys, dissipate stagnated fire, the effects that going screen of subsiding a swelling.
Heat-clearing and fire-dispersing is made with it in beauty side, wards off the turbid product of dirtyization, for because of blood-head, it is swollen that interior heat pents up caused halitosis, body gas, sore
The treatment of the diseases such as furuncle.
Thyme：With antibacterial, the effects that expelling parasite, eliminating the phlegm reduces serium inorganic phosphorus, increases blood glucose.
Golden yellow chamomile：Chamomile is feverfew, originates in Europe.The nickname of chamomile is called Rome chamomile, Germany
Chamomile.All there are many common features for they：About 30 centimeters of height, center are yellow, and petal is white, and blade slightly feels young pilose antler
It is fine and soft.It is also popular health protection and pharmaceutical preparation by the chamomile essential oil that chamomile extract.Because chamomile can be helped
Sleep is helped, inflammation and the pain symptom of patient are alleviated, alleviates the effect of having a sleepless night caused by neurotic skin itch.
Honeysuckle flowers：Improve scytitis, resist bacterium, promotes pore convergence, keep skin more moist.
Citronella oil：Citronella oil is extract from lemon-grass, and there is softening skin, the effect for tranquilizing the mind of releiving also to answer for it
For mosquito repellent.
Permanent flower：Permanent flower has the antibacterial of strength, anti-inflammatory, outstanding beauty work(that is antiviral, promoting cytothesis ability
Effect.Ancient Chinese medical book be once recorded " permanent flower, it is expensive and real, it is savory and warm-natured and, the work(refreshed oneself of tool detoxicating ".
In a kind of embodiment, a kind of externally applied spray and preparation method thereof for miliaria of dispelling comprising external application described above
Spray ingredient, the preparation method comprises the following steps：
（1）The preparation of citronella oil is followed the example of using supercritical CO 2 soldier：Lemon-grass is taken, is crushed after low temperature drying, crosses 20 mesh sieve, accurately
200 g lemon-grass powder are weighed in extraction kettle, are cooled down to CO2 in condenser, while extraction kettle and separating still are carried out
Heating, after system reaches 45 DEG C, pressurizes to system, adjusts CO2 flows to 30 kg/h after reaching the pressure of setting, opens
Begin to carry out cycling extraction, keep constant temperature and pressure (pressure 15MPa), after 70 minutes, lemongrass is collected from separating still 1,2 discharge ports
Oil, gained extract are citronella oil；
（2）The preparation method of permanent flower, honeysuckle flowers, thyme, golden yellow camomile extract is：Take permanent flower respectively, honeysuckle flowers,
Thyme, golden yellow chamomile removal impurity and non-medicinal effects, then it is heated to 80- after adding purified water to impregnate 15-20 hours respectively
100 DEG C persistently decoct 1-3 times, decoct every time 1-2 hour, filtration, room temperature to be cooled to, and add ethyl alcohol that alcohol content is made to be 50-70%,
It stirs evenly, refrigerates 24-72 hours, take supernatant, filter, filtrate recycling ethanol is concentrated into 45-60 DEG C, and gained concentrate is respectively
Permanent flower extract, honeysuckle flower extract, thyme extract, golden yellow camomile extract；
（3）It takes the purified water of formula ratio into agitated kettle, is heated to 80 DEG C, keeps the temperature 20 minutes, cooling and stirring pot, pot temperature to be mixed
30 DEG C are down to, the ethyl alcohol of formula ratio is added；
（4）Continue cooling and stirring pot, etc. temperature be down to 25 DEG C or room temperature, be added the menthol of formula ratio, borneol, permanent flower extraction
Object, honeysuckle flower extract, thyme extract, golden yellow camomile extract stirring and dissolving is complete, and mixing speed is 30 revs/min
Clock stirs 20 minutes；
（5）It is 22 DEG C or room temperature to continue cooling and stirring pot to temperature, and the essence of formula ratio, citronella oil stirring, mixing speed is added
It it is 25 revs/min, mixing time 30 minutes takes semi-finished product inspection, discharges after the assay was approved after stirring and dissolving is complete.
Beneficial effects of the present invention are：
（1）The extraction efficiency of the citronella oil is good, and the Chemical Composition of The Essential Oil of extraction is stablized；
（2）For each ingredient used in the present invention by scientific and reasonable formula, prescription is rigorous, has and absorbs comparatively fast, and curative effect is rapid, apparent,
Easy to use, no skin irritation when use, safety has no toxic side effect；
（3）Preparation method is simple in the present invention, substantially increases the dissolubility of each ingredient, avoids leading to shadow because mixing is uneven
The volatilization of pharmacological property is rung, it is at low cost.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (3)
1. a kind of externally applied spray for miliaria of dispelling, which is characterized in that its ingredient is made of following weight ratio：Purified water 20-50%,
Ethyl alcohol 20-60%, menthol 0.1-0.6%, borneol 0.01-0.6%, thyme extract 1-8%, golden yellow camomile extract 1-
8%, honeysuckle flower extract 1-8%, citronella oil 1-8%, permanent flower extract 1-8%, essence 5-12%.
2. composition according to claim 1, which is characterized in that its ingredient is made of following weight ratio：Purified water
38.8%, ethyl alcohol 40%, menthol 0.2%, borneol 0.1%, thyme extract 4%, golden yellow camomile extract 4%, honeysuckle flowers carry
Take object 4%, citronella oil 4%, permanent flower extract 4%, essence 0.9%.
3. the preparation method of composition according to claim 2, which is characterized in that the preparation method is by following steps
It is made：
（1）The preparation of citronella oil is followed the example of using supercritical CO 2 soldier：Lemon-grass is taken, is crushed after low temperature drying, crosses 20 mesh sieve, accurately
200 g lemon-grass powder are weighed in extraction kettle, are cooled down to CO2 in condenser, while extraction kettle and separating still are carried out
Heating, after system reaches 45 DEG C, pressurizes to system, adjusts CO2 flows to 30 kg/h after reaching the pressure of setting, opens
Begin to carry out cycling extraction, keep constant temperature and pressure (pressure 15MPa), after 70 minutes, lemongrass is collected from separating still 1,2 discharge ports
Oil, gained extract are citronella oil；
（2）The preparation method of permanent flower, honeysuckle flowers, thyme, golden yellow camomile extract is：Take permanent flower respectively, honeysuckle flowers,
Thyme, golden yellow chamomile removal impurity and non-medicinal effects, then it is heated to 80- after adding purified water to impregnate 15-20 hours respectively
100 DEG C persistently decoct 1-3 times, decoct every time 1-2 hour, filtration, room temperature to be cooled to, and add ethyl alcohol that alcohol content is made to be 50-70%,
It stirs evenly, refrigerates 24-72 hours, take supernatant, filter, filtrate recycling ethanol is concentrated into 45-60 DEG C, and gained concentrate is respectively
Permanent flower extract, honeysuckle flower extract, thyme extract, golden yellow camomile extract；
（3）It takes the purified water of formula ratio into agitated kettle, is heated to 80 DEG C, keeps the temperature 20 minutes, cooling and stirring pot, pot temperature to be mixed
30 DEG C are down to, the ethyl alcohol of formula ratio is added；
（4）Continue cooling and stirring pot, etc. temperature be down to 25 DEG C or room temperature, be added the menthol of formula ratio, borneol, permanent flower extraction
Object, honeysuckle flower extract, thyme extract, golden yellow camomile extract stirring and dissolving is complete, and mixing speed is 30 revs/min
Clock stirs 20 minutes；
（5）It is 22 DEG C or room temperature to continue cooling and stirring pot to temperature, and the essence of formula ratio, citronella oil stirring, mixing speed is added
It it is 25 revs/min, mixing time 30 minutes takes semi-finished product inspection, discharges after the assay was approved after stirring and dissolving is complete.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1869183A (en) * | 2006-06-23 | 2006-11-29 | 合肥工业大学 | Method of extracting fresh pomelo flower fragrant substance |
| CN103194311A (en) * | 2013-04-22 | 2013-07-10 | 湖南康瑞琦生物科技有限公司 | Process method for extracting litsea cubeba oil by using supercritical CO2 |
| CN103333745A (en) * | 2013-07-12 | 2013-10-02 | 徐州华元罐头食品有限公司 | Method of extracting lemongrass essential oil based on supercritical CO2 extraction technology |
| CN105395788A (en) * | 2015-12-11 | 2016-03-16 | 鞠进英 | Nanometer nursing composition for preventing bedsores, eliminating miliaria and relieving itching and preparation method thereof |
-
2018
- 2018-06-25 CN CN201810642123.3A patent/CN108635265A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1869183A (en) * | 2006-06-23 | 2006-11-29 | 合肥工业大学 | Method of extracting fresh pomelo flower fragrant substance |
| CN103194311A (en) * | 2013-04-22 | 2013-07-10 | 湖南康瑞琦生物科技有限公司 | Process method for extracting litsea cubeba oil by using supercritical CO2 |
| CN103333745A (en) * | 2013-07-12 | 2013-10-02 | 徐州华元罐头食品有限公司 | Method of extracting lemongrass essential oil based on supercritical CO2 extraction technology |
| CN105395788A (en) * | 2015-12-11 | 2016-03-16 | 鞠进英 | Nanometer nursing composition for preventing bedsores, eliminating miliaria and relieving itching and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 广东名辰堂健康产业股份有限公司: "泰蛇麝香草儿童热痱水", 《国产非特殊用途化妆品备案服务平台》 * |
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Application publication date: 20181012 |