CN108619377A - 一种具有改善睡眠作用的组合物 - Google Patents
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Abstract
本发明公开了一种具有改善睡眠作用的组合物，包括三七茎叶提取物、百合提取物、谷维素、茶氨酸、γ‑氨基丁酸，所述的组合物各成分重量配比为三七茎叶提取物0.01‑0.3克、百合提取物0‑1.5克、谷维素0.01‑0.1克、茶氨酸0‑0.4克、γ‑氨基丁酸0‑0.4克、维生素B60‑8毫克。该组合物能够提高人们的睡眠质量，从而使人体更加健康强壮。
Description
技术领域
本发明属于食品技术领域，具体涉及一种具有改善睡眠作用的组合物。
背景技术
健康的体魄来自睡眠，长期睡眠不足，将导致大脑疲劳，学习和工作效率大大下降，还 会损坏记忆力、决策力及思想集中的能力。我国古代医学家称睡眠是“养生之要务”，莎士比 亚把睡眠比做是“生命筵席上的滋补品”。
随着人们社会压力的不断增加，越来越多的人受到睡眠不足甚至失眠的困扰。失眠又称 入睡和维持睡眠障碍，为各种原因引起入睡困难、睡眠深度或频度过短、早醒及睡眠时间不 足或质量差等，失眠是一种常见、多发、对健康危害重大的疾病。据世界卫生组织调查资料 显示，全球至少有27％以上的人有睡眠问题，1/3以上有不同程度的失眠症状，其中美国失眠 发生率为32％～35％，英国为10％～14％，日本为20％。在我国，估计患病率至少大于10％， 即1.3亿人以上。
目前，市面的很多改善睡眠的产品达不到预期的效果，所以发明一种具有改善睡眠的功 能食品具有重大意义。
发明内容
本发明的目的在于提供一种具有改善睡眠作用的组合物，该组合物中的各种成分合理组 方、配合共用，通过多种途径、多层次达到改善睡眠的保健作用。
本发明提供的具有改善睡眠作用的组合物中各成分重量配比为：三七茎叶提取物0.01-0.3 克、百合提取物0-1.5克、谷维素0.01-0.1克、茶氨酸0-0.4克、γ-氨基丁酸0-0.4克、维生 素B6 0-8毫克。
制备本发明组合物中各组分的优选重量配比为：三七茎叶提取物0.015-0.2克、百合提取 物0.01-1克、谷维素0.02-0.05克、茶氨酸0.02-0.3克、γ-氨基丁酸0-0.4克、维生素B6 0-4 毫克。
制备本发明组合物中各组分的最佳重量配比为：三七茎叶提取物0.015克、百合提取物 0.5克、谷维素0.04克、茶氨酸0.3克。
上述具有改善睡眠作用的组合物可制成片剂、口服液、颗粒剂、药膏以及压片糖果、饼 干、饮料类食品。
上述组分中三七茎叶提取物具有活血祛瘀，通脉活络的功效，具有抑制血小板聚集和增 加心脑血流量的作用，可应用于心脑血管疾病。百合是名贵传统中药材，现在药理研究表明 百合总皂苷能显著减少小鼠自主活动，增加戊巴比妥钠阈下剂量引起小鼠入睡个数，延长戊 巴比妥钠引起小鼠睡眠时间，并随着剂量增加，其镇静催眠作用增强。谷维素主要作用于间 脑的植物神经系统与分泌中枢，从而改善和调节植物神经功能失调、内分泌平衡障碍及精神 失调等症状。茶氨酸具有促进吸收与代谢、调节脑内神经传达物质的变化、提高学习能力和 记忆力、镇静、改善经期综合症等作用。
附图说明
图1为固体饮料试吃前后对睡眠改善情况统计分析图，是根据本发明具体实施例4所提 供的配比，通过常规工艺所制得的固体饮料进行功效验证试验的统计结果。
具体实施方式
下面通过具体的实施例对本发明作进一步说明,以下实施方式只以举例的方式描述本发 明。但本发明的保护范围并不局限于此。
实施例1：
一种具有改善睡眠作用的组合物，由以下原料制成：三七茎叶提取物0.1克、百合提取 物0.5克、谷维素0.03克、茶氨酸0.2克、γ-氨基丁酸0.1克、维生素B6 3毫克。
实施例2：
一种具有改善睡眠作用的组合物，由以下原料制成：：三七茎叶提取物0.02克、百合提 取物0.1克、谷维素0.02克、茶氨酸0.1克、γ-氨基丁酸0.05克。
实施例3：
一种具有改善睡眠作用的组合物，由以下原料制成：三七茎叶提取物0.04克、百合提取 物0.2克、谷维素0.02克、茶氨酸0.1克、维生素B6 1毫克。
实施例4：
一种具有改善睡眠作用的组合物，由以下原料制成：本发明组合物中各组分的重量配比 为：三七茎叶提取物0.015克、百合提取物0.5克、谷维素0.04克、茶氨酸0.3克。
以上实施例中，各组分可通过常规工艺可制成片剂、口服液、颗粒剂、药膏以及压片糖 果、饼干、饮料类食品。
实施例5：人体试食
申请人使用按上述实施例4所提供的配比，通过常规工艺所制得的固体饮料进行了功效 验证试验，试验结果如下：
1、根据保健品人体试食功能评价原则以及本次评价要达到的目的，特制定以下试食前后睡眠 状况自评量表表格。
运用睡眠状况自评量表(SRSS)进行自评，了解受试者试验前后的变化(量表详见附件)。 此表包括试食前后的入睡时间、睡眠时间、睡眠质量、和睡眠觉醒程度及觉醒后的精神状态 等指标。
睡眠状况自评量表(Self-Rating Scale of Sleep,SRSS)
为了解您近一个月内睡眠情况，请根据自身的实际情况对每一个评测项目进行打分。
注明：以上测评表得分越低说明睡眠质量越好，反之睡眠质量越差。
试食后睡眠状况自评量表(Self-Rating Scale of Sleep,SRSS)
为了解您近一个月内睡眠情况，请根据自身的实际情况对每一个评测项目进行打分。
注明：以上测评表得分越低说明睡眠质量越好，反之睡眠质量越差。
2、受试者纳入标准
(1)有睡眠质量不佳或不同程度失眠，持续在一个月以上的人群；
(2)睡眠状况自评量表(SRSS)超过20分者，由医生根据主诉打分或病人自填表；
(3)年龄18～65岁；
(4)能回答或看懂睡眠状况自评量表；
(5)获知情同意，能配合随访者。
3、排除受试者标准
(1)有器质性(身体的某些器官所引起的)和外界环境干扰因素引起睡眠障碍者；
(2)合并有心、脑血管、肝、肾、消化道、造血系统等严重原发性疾病，精神病患者；
(3)过敏体质或对受试物过敏者；
(4)短期内服用与受试功能有关的物品，如近期服用抗抑郁药者，影响到对结果的判断 者；
(5)未按标准服用受试样品、资料不全影响功效或安全性判断者；
(6)年龄在18岁以下或65岁以上者，孕期或哺乳期妇女。
4、试食评价结果
9位受试者在服用半个月后睡眠状况得到改善，从说明书附图1中可以清晰地看到服用 半个月后每位受试者的测评分数都有一定幅度的降低，说明该组方对睡眠有一定的改善效果。
Claims (4)
1.一种具有改善睡眠作用的组合物，其特征在于：所述的组合物各成分重量配比为三七茎叶提取物0.01-0.3克、百合提取物0 -1.5克、谷维素0.01 -0.1克、茶氨酸0-0.4克、γ-氨基丁酸0-0.4克、维生素B6 0-8毫克。
2.根据权利要求1 所述的一种具有改善睡眠作用的组合物，其特征在于：所述的组合物中各成分重量配比为三七茎叶提取物0.015-0.2克、百合提取物0.01 -1克、谷维素0.02-0.05克、茶氨酸0.02-0.3克、γ-氨基丁酸0-0.4克、维生素B6 0-4毫克。
3.根据权利要求1 所述的一种具有改善睡眠作用的组合物，其特征在于：所述的组合物可制成片剂、口服液、颗粒剂、药膏等剂型的保健食品。
4.根据权利要求1 所述的一种具有改善睡眠作用的组合物，其特征在于：所述的组合物可开发成压片糖果、饼干、饮料等形式的功能食品。
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