CN108619075A - Anti-apolexis composition, cosmetics and preparation method thereof - Google Patents
Anti-apolexis composition, cosmetics and preparation method thereof Download PDFInfo
- Publication number
- CN108619075A CN108619075A CN201810549319.8A CN201810549319A CN108619075A CN 108619075 A CN108619075 A CN 108619075A CN 201810549319 A CN201810549319 A CN 201810549319A CN 108619075 A CN108619075 A CN 108619075A
- Authority
- CN
- China
- Prior art keywords
- stem cell
- apolexis composition
- cosmetics
- apolexis
- peony extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a kind of anti-apolexis compositions, which is characterized in that it counts in parts by weight, including：15 parts of peony extract；0.5 10 parts of stem cell medium.Said components rationally coordinate in specific proportions, obtain a kind of anti-apolexis composition, linoleic acid wherein in peony extract is changed into arachidonic acid in human body, it cooperates with the oligopeptides contained in stem cell medium, form normal eucaryotic cell structure, it maintains and adjusts cell physiological function and metabolic activity, so that Skin Cell maintains vigour, promote Skin Cell regeneration, to play the role of effective anti-aging, in addition coordinate with antioxidant composition contained in peony extract and nutrient, it adjusts cell metabolism, promote Skin Cell regeneration, it is anti-oxidant, the unification of nutrition composition quadruple effect is provided, greatly improve anti-aging effects.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of anti-apolexis composition, cosmetics and preparation method thereof.
Background technology
Anti-aging is the wonderful dream that people pursue always from ancient times to the present, but with advancing age, the cell meeting of people
Aging, skin, which can follow the string, generates wrinkle.Aging can seriously affect personal image, and puzzlement is brought to social activity.Currently, common
Anti-aging cosmetics contain more additive and effect is not obvious.Therefore, the significant composition of anti-aging effects is found
Anti-aging cosmetics are prepared, are a problem to be solved.
Invention content
Based on this, in view of the above-mentioned problems, the purpose of the present invention is to provide a kind of clear efficacy, anti-agings with obvious effects
Cosmetic composition.
To achieve the above object, the present invention provides following technical solutions：
A kind of anti-apolexis composition, is counted in parts by weight, including：
1-5 parts of peony extract；
0.5-10 parts of stem cell medium.
In wherein some embodiments, the culture solution of stem cell medium behaviour source mescenchymal stem cell.
It is thin after stem cell medium behaviour source mescenchymal stem cell culture 1~4 week in wherein some embodiments
Born of the same parents' culture solution, wherein containing epithelical cell growth factor, fibroblast growth factor, keratinocyte growth factor, stem cell
Growth factor.
In wherein some embodiments, the anti-apolexis composition further includes：0.1-2 parts of inositol.
In wherein some embodiments, the peony extract, the stem cell medium and the inositol mass ratio
It is 1：(1~2)：(0.02~0.2).
The present invention also aims to provide a kind of preparation method of anti-apolexis composition, specific technical solution is as follows：
The preparation method of above-mentioned anti-apolexis composition, includes the following steps：
The supernatant of stem cell culture is collected, filtering takes filtrate, obtains stem cell medium；
By the stem cell medium, peony extract mixing；Or by the stem cell medium, peony extract and flesh
Alcohol mixing to get.
It is another object of the present invention to provide a kind of application of anti-apolexis composition, specific technical solution is as follows：
Application of the above-mentioned anti-apolexis composition in preparing anti-aging cosmetics.
It is another object of the present invention to provide a kind of anti-aging cosmetics, specific technical solution is as follows：
A kind of anti-aging cosmetics are prepared by acceptable auxiliary agent in above-mentioned anti-apolexis composition and cosmetics.
In wherein some embodiments, by mass percentage, the anti-apolexis composition is 1.5%~15%, described
Acceptable auxiliary agent includes in cosmetics：
In wherein some embodiments, the emulsifier is selected from PEG-100 stearates, methyl sesquialter stearic acid
Ester, PEG-20 methyls sesquistearate, lanolin alcohol polyethers -25, Phosphoric acid monohexadecyl ester potassium, tribehenin essence PEG-20 esters
In it is one or more；And/or
The thickener is selected from hydroxyethyl cellulose, carbomer, xanthan gum, sodium acrylate/acryloyldimethyl taurine
It is one or more in sodium copolymer；And/or
The emollient be selected from cetostearyl alcohol, isopropyl palmitate, ethylhexyl palmitate, dimethyl silicone polymer,
Ring five dimethyl silicone polymer, caprylic/capric triglyceride, jojoba seed oil, dormant oil, Butyrospermum parkii fruit fatty oil, grape seed oil,
It is one or more in wheat-germ oil, safflower seed oil, isopropyl myristate, Seabuckthorn Oil, saualane；And/or
The moisturizer is selected from glycerine, butanediol, glycine betaine, erythrite, methyl propanediol, Sodium Hyaluronate, panthenol, sea
It is one or more in algae sugar；And/or
The skin conditioning agent is selected from bisabolol, tocopherol acetate, glucan, niacinamide, 3-o- ethyl Vitamin Cs
It is one or more in acid, Gotu Kola P.E；And/or
The pH adjusting agent is one or more in triethanolamine, potassium hydroxide, arginine, sodium hydroxide；And/or
The preservative is selected from one kind of methyl hydroxybenzoate, Nipasol, Chlorphenesin, Phenoxyethanol, Sensiva SC50
Or it is a variety of；And/or
The solvent is water.
In wherein some embodiments, by mass percentage, including following component：
Peony extract 1.0-5.0%, stem cell medium 0.5-10.0%, inositol 0.1-1.8%, tribehenin essence PEG-
20 esters 1.0-3.0%, methyl sesquistearate 0.6-1.2%, lanolin alcohol polyethers -250.8-1.5%, nutmeg
Isopropyl propionate 1.0-3.0%, ethylhexyl palmitate 1.0-3.0%, dimethyl silicone polymer 0.5-1.5%, five poly- diformazan of ring
Radical siloxane 1.0-5.0%, Butyrospermum parkii fruit fatty oil 0.5-2.0%, Seabuckthorn Oil 1.0-3.0%, cetostearyl alcohol 1.0-
2.0%, dormant oil 1.0-6.0%, saualane 0.1-3.0%, bisabolol 0.05-0.25%, wheat-germ oil 0.1-1.0%,
Methyl hydroxybenzoate 0.01-0.2%, Nipasol 0.01-0.1%, glycerine 1.0-6.0%, methyl propanediol 1.0-6.0%, propylene
Sour sodium/sodium acryloyldimethyl taurate copolymers 0.1-0.3%, Sodium Hyaluronate 0.01-0.05%, niacinamide 1.0-
4.0%, panthenol 0.01-0.5%, erythrite 1.0-4.0%, glucan 0.1-3.0%, Phenoxyethanol 0.3-0.9%, ethyl hexyl
Base glycerol 0.01-0.1%, surplus are water.
In anti-apolexis composition of the present invention, stem cell medium, peony extract and inositol have the characteristics that：
Peony extract has skin care, reinforcing and the self-protection of active skin, promotes cytothesis, skin is made to protect
The effect of young vigor and elasticity is held, contains multiple efficacies ingredient in peony, wherein flavonoids, polyphenol compound is tree peony
Main active constituent is spent, and anthocyanin has stronger antioxidant activity, peony also to contain K, Ca, Mg, P, Se, VB1, VB2
Equal mineral matter elements and vitamins nutritional ingredient.Also contain in peony extract there are many important higher fatty acids, mainly with
Palmitic acid (C16：0), linoleic acid (C18：And leukotrienes (C18 2)：3) based on.Unsaturated fatty acid such as linoleic acid is needed by human
Aliphatic acid can be changed into arachidonic acid in human body, for synthetic phospholipid, form eucaryotic cell structure, all is maintained to organize
Normal function is all necessary.
Containing oligopeptides -1, oligopeptides -3, oligopeptides -5, oligopeptides -6 in stem cell medium, to various kinds of cell physiological function and generation
The activity of thanking plays physiological regulatory action, while being also rich in various kinds of cell production factor：EGF (epithelical cell growth factor), b-FGF
(fibroblast growth factor), KGF (keratinocyte growth factor), SCF (stem cell factor), these four cell growths
Combinations of factors, which is got up, can activate multi-signal albumen in Skin Cell, promote the proliferation of Skin Cell, repair and be damaged skin.
Inositol is naturally occurring in skin, can be protected cells from osmotic stress and is dehydrated, in conjunction with transport moisture, well
Moisture-keeping function.It can also participate in permeating, promote the osmotic absorption of other functional components.
Based on the above-mentioned technical proposal, the invention has the advantages that：
The present invention is rationally coordinated in specific proportions by stem cell medium, peony extract and inositol, is obtained a kind of anti-
Anti-aging composition is applied in cosmetics, and wherein the linoleic acid in peony extract is changed into arachidonic acid in human body, is done
Cell growth culture solution is prepared by the mescenchymal stem cell culture of people source, containing tetra- kinds of EGF, b-FGF, KGF and SCF growth because
Son, a combination thereof is got up, and it is good with the compatibility of application on human skin, and four kinds of growth factors coordinate with peony extract, human activin skin,
With significant anti-aging effects；Contain oligopeptides in SCF, with arachidonic acid coordinate, advantageously form normal eucaryotic cell structure,
Cell physiological function and metabolic activity are maintained and adjust, so that Skin Cell maintains vigour, Skin Cell is promoted to regenerate, to carry
The effect of high anti-aging.
Moreover, can also include inositol in anti-apolexis composition provided by the invention, on the one hand inositol can protect cell to exempt from
Be dehydrated by osmotic stress, in conjunction with transport moisture, on the other hand promote stem cell factor, polypeptide and male in stem cell medium
The Transdermal absorption of red extract, for three when acting on skin, compounding collaboration greatly improves anti-aging effects.
Anti-apolexis composition of the present invention can be applied in the product form of a variety of anti-aging cosmetics, have system
Preparation Method is simple, the characteristics of being widely used, can adapt to the market demand.
Specific implementation mode
The present invention provides a kind of anti-aging cosmetics compositions and the preparation method and application thereof.For the ease of understanding this hair
Bright, below with reference to embodiment to invention is more fully described, following present presently preferred embodiments of the present invention.But
It is that the present invention can realize in many different forms, however it is not limited to embodiment described herein.These embodiments are provided
Purpose be to make the disclosure of the present invention more thorough and comprehensive.All kinds of raw materials used in embodiment, unless
It is otherwise noted, is common commercial product.
Unless otherwise defined, all of technologies and scientific terms used here by the article and belong to the technical field of the present invention
The normally understood meaning of technical staff is identical.Used term is intended merely to describe specific reality in the description of the invention
Apply the purpose of example, it is not intended that in the limitation present invention.Term as used herein "and/or" includes one or more relevant institutes
Any and all combinations of list of items.
Wherein, the peony extract in the present invention is tree peony (PAEONIA SUFFRUTICOSA) extract, Butyrospermum parkii
Fruit grease is Butyrospermum parkii (BUTYROSPERMUM PARKII) fruit fatty oil, Seabuckthorn Oil is sea-buckthorn (HIPPOPHAE
RHAMNOIDES) oil, wheat-germ oil are wheat (TRITICUM VULGARE) embryo oil, are bought from Huzhou company of Jiamei.
Embodiment 1-4, comparative example 1-3
Embodiment 1-4, comparative example 1-3 provide a kind of anti-aging cream, count in parts by weight, raw material components are as shown in table 1：
Table 1
Wherein in upper table, the culture solution of stem cell, preparation method described in embodiment 1-4 and comparative example 1 are specific as follows：
People source mescenchymal stem cell is chosen, at 37 DEG C, 5%CO2Culture 1~4 week in constant temperature and humidity incubator, collects cell
Then the supernatant is placed on 2000 revs/min of centrifuge and centrifuges 10 minutes by culture supernatant, then with 0.22 μm of filter membrane into
Row filtering, takes filtrate, you can obtain stem cell medium.In the stem cell medium of people source mescenchymal stem cell, contain oligopeptides-
1, oligopeptides -3, oligopeptides -5, oligopeptides -6 are also rich in various kinds of cell production factor：EGF (epithelical cell growth factor), b-FGF (at
Fibroblast growth factor), KGF (keratinocyte growth factor), SCF (stem cell factor).Wherein, embodiment 1 is dry
Cell culture fluid is cell culture supernatant to be collected after cultivating 1 week, and embodiment 2-4 is the cell culture collected after cultivating 3 weeks
Supernatant.
Preparation method is as follows：
(1) various raw materials in precise formula are held with vessel that are clean and disinfecting；
(2) by A phases raw material (water, glycerine, methyl propanediol, sodium acrylate/sodium acryloyldimethyl taurate copolymers,
Sodium Hyaluronate, niacinamide, panthenol, erythrite) it is added in vacuum emulsification pot, after stirring is warming up to 80~85 DEG C, it is sufficiently stirred
Uniformly, it keeps the temperature spare；
(3) by B phases raw material (tribehenin essence PEG-20 esters, methyl sesquistearate, lanolin alcohol polyethers -25,
Isopropyl myristate, ethylhexyl palmitate, dimethyl silicone polymer, ring five dimethyl silicone polymer, Butyrospermum parkii
(BUTYROSPERMUM PARKII) fruit fatty oil, sea-buckthorn (HIPPOPHAE RHAMNOIDES) oil, cetostearyl alcohol, dormant oil, angle
Shark alkane, bisabolol, wheat (TRITICUM VULGARE) embryo oil, methyl hydroxybenzoate, Nipasol) it is added in oil cauldron, stirring
80~85 DEG C are warming up to, is stirred, heat preservation is spare；
(4) B phase raw materials are pumped into vacuum emulsification pot, after being mixed evenly, after emulsifying 5-8 minutes, are fully stirred
It mixes uniformly, constant temperature stirring defoaming cools down after ten minutes；
(5) hereinafter, C phases raw material (glucan, stem cell medium, tree peony (PAEONIA is added when being cooled to 45 DEG C
SUFFRUTICOSA) extract), it stirs evenly and continues to cool down；
(6) it hereinafter, D phases raw material (Phenoxyethanol and Sensiva SC50) is added when being cooled to 40 DEG C, stirs
It discharges, stand afterwards；
(7) after the assay was approved, filling, packaging, coding；
(8) after the assay was approved, it is put in storage.
According to QB/T1857 (O/W types), physical and chemical index test is carried out to the above-mentioned anti-aging cream being prepared.As a result such as
Under：
1, appearance：White lotion.
2, pH value：5.5-6.8.
3, heat-resistant stability is investigated：(40 ± 1) DEG C are kept for 24 hours, qualified without water-oil separating phenomenon after recovery room temperature.
4, resist cold study on the stability：(﹣ 8 ± 2) DEG C is kept for 24 hours, qualified without water-oil separating phenomenon after recovery room temperature.
Efficacy test, including the test of dermatoglyph degree and skin wrinkle resisting reality are carried out to the above-mentioned anti-aging cream being prepared
It tests, concrete scheme is as follows：
One, dermatoglyph degree is tested
(1) Example 1-4 and comparative example 1-3 anti-aging creams.
(2) at selection subject's face left and right cheekbone, nose and pupil intersection or so at cheek, temple and corners of the mouth intersection
Left and right sides is as test area.
(3) skin image analysis system (Skin Visiometer SV600) determination experiment is used by technical staff first
The dermatoglyph degree before embodiment and comparative example cosmetics is smeared at position, and every is surveyed five times, is averaged.
(4) subject uses skin image analysis system after continuous use embodiment or comparative example cosmetics four weeks
(Skin Visiometer SV600) tests dermatoglyph degree.
(5) numerical value that statistics subject position measures every time, analyzes its dermatoglyph changing rule, so that it is determined that real
Apply example and the effect of comparative example cosmetics improve dermatoglyph.(every subject per is that the same technical staff carries out
It measures.)
Two, the crease-resistant experiment of human skin
The crease-resistant experiment of human skin is test anti-wrinkle effect most straightforward approach.
Under the guidance of technical staff, embodiment and comparative example cosmetics are used by tested crowd, then use skin bullet
Property tester (Cutometer dual MPA580) measure smear position elastic numerical value change situation.(every subject per
All it is that the same technical staff measures.)
(1) Example and comparative example cosmetics.
(2) at selection subject's face left and right cheekbone, nose and pupil intersection or so at cheek, temple and corners of the mouth intersection
Left and right sides is as test area.
(3) it smears sooner or later daily twice, the photo before smearing is control.During experiment, subject cannot smear it is any its
Its cosmetics.
(4) for subject after embodiment and comparative example cosmetics four weeks is used continuously, statistics uses front and back skin elasticity number
Value.
(5) numerical value that statistics subject position measures every time, analyzes its skin elasticity changing rule, to evaluate its skin
Skin Flexible change situation.
Test population：The person 140 that has wrinkle that average age is 35-45 Sui.Wherein, male 40, female 80, skin are strong
Health is not damaged.Each 20 subjects of each embodiment and comparative example.
After the said goods surrounding (28 days), the case where data statistics such as table 2 and table 3.
Table 2
Table 3
From the above results, because without one or more groups in anti-apolexis composition in the cosmetics of comparative example 1-3
Point, mating reaction can not be played, for subject after using 4 weeks, the elasticity and texture improvement of skin are general, and use real
After using 4 weeks, skin elasticity and texture improve obviously the subject for applying a 1-4, illustrate that the anti-aging effects of product obviously carry
It rises.And in embodiment 4, because being free of inositol component, although containing peony extract and stem cell medium, not no three
Synergistic effect, effect is close with embodiment 1-2, on the weak side compared with Example 3.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to following reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
Cannot the limitation to the scope of the claims of the present invention therefore be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of anti-apolexis composition, which is characterized in that it counts in parts by weight, including：
1-5 parts of peony extract；
0.5-10 parts of stem cell medium.
2. anti-apolexis composition according to claim 1, which is characterized in that stem cell medium behaviour source mesenchyma
The culture solution of stem cell.
3. anti-apolexis composition according to claim 2, which is characterized in that stem cell medium behaviour source mesenchyma
Stem cell cultivate 1~4 week after cell culture fluid.
4. anti-apolexis composition according to claim 3, which is characterized in that stem cell medium behaviour source mesenchyma
Stem cell cultivate 2~3 weeks after cell culture fluid.
5. according to claim 1-4 any one of them anti-apolexis compositions, which is characterized in that the anti-apolexis composition also wraps
It includes：Inositol 0.1-2 parts by weight.
6. anti-apolexis composition according to claim 5, which is characterized in that the peony extract, stem cell training
Nutrient solution and the weight ratio of the inositol are 1：(1~2)：(0.02~0.2).
7. a kind of preparation method of anti-apolexis composition, which is characterized in that include the following steps：
The supernatant of stem cell culture is collected, filtering takes filtrate, obtains stem cell medium；
By the stem cell medium, peony extract mixing；Or the stem cell medium, peony extract and inositol are mixed
It is even to get.
8. application of the claim 1-6 any one of them anti-apolexis composition in preparing the cosmetics for anti-aging.
9. a kind of anti-aging cosmetics, which is characterized in that by claim 1-6 any one of them anti-apolexis composition and makeup
Acceptable auxiliary agent is prepared in product.
10. anti-aging cosmetics according to claim 7, which is characterized in that the cosmetics are face cream, by quality percentage
Than meter, the anti-apolexis composition is 1.5%~15%, and acceptable auxiliary agent includes in the cosmetics：
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810549319.8A CN108619075A (en) | 2018-05-31 | 2018-05-31 | Anti-apolexis composition, cosmetics and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810549319.8A CN108619075A (en) | 2018-05-31 | 2018-05-31 | Anti-apolexis composition, cosmetics and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108619075A true CN108619075A (en) | 2018-10-09 |
Family
ID=63690820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810549319.8A Pending CN108619075A (en) | 2018-05-31 | 2018-05-31 | Anti-apolexis composition, cosmetics and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108619075A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113893183A (en) * | 2021-03-03 | 2022-01-07 | 陕西医赛尔生物科技有限公司 | Composition for promoting transdermal absorption of polypeptide and application of composition in skin care product |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120009183A (en) * | 2010-07-23 | 2012-02-01 | (주)아모레퍼시픽 | Composition for promoting the differentiation of human mesenchymal stem cell |
| CN105769740A (en) * | 2016-05-11 | 2016-07-20 | 紫程瑞生会(北京)生物技术发展有限公司 | Method for preparing human stem cell sourcing biobeauty raw material and product thereof |
| CN107661286A (en) * | 2017-11-01 | 2018-02-06 | 广州赛莱拉干细胞科技股份有限公司 | A kind of anti-aging skin care product containing Chinese herbaceous peony stem cell extract |
-
2018
- 2018-05-31 CN CN201810549319.8A patent/CN108619075A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120009183A (en) * | 2010-07-23 | 2012-02-01 | (주)아모레퍼시픽 | Composition for promoting the differentiation of human mesenchymal stem cell |
| CN105769740A (en) * | 2016-05-11 | 2016-07-20 | 紫程瑞生会(北京)生物技术发展有限公司 | Method for preparing human stem cell sourcing biobeauty raw material and product thereof |
| CN107661286A (en) * | 2017-11-01 | 2018-02-06 | 广州赛莱拉干细胞科技股份有限公司 | A kind of anti-aging skin care product containing Chinese herbaceous peony stem cell extract |
Non-Patent Citations (1)
| Title |
|---|
| 李凯等: "牡丹花、牡丹籽成分与功能研究进展", 《食品研究与开发》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113893183A (en) * | 2021-03-03 | 2022-01-07 | 陕西医赛尔生物科技有限公司 | Composition for promoting transdermal absorption of polypeptide and application of composition in skin care product |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106726769B (en) | A kind of peony seed oil anti-apolexis composition and preparation method thereof | |
| EP2260829B1 (en) | Use of an extract from snow algae in cosmetic or dermatological formulations | |
| CN110731923B (en) | Enhanced moisturizing cosmetic compositions | |
| JP2021020887A (en) | Enhanced anti-aging cosmetic composition | |
| CN106265371B (en) | Antioxidant cosmetic composition and preparation method thereof | |
| TW200812638A (en) | Compositions comprising kakadu plum extract or acai berry extract | |
| CN106727027A (en) | Anti- blue light, anti-oxidant, the free based composition and use thereof in packaging of removing, skin care item and preparation method | |
| CN108553405A (en) | It releives the composition of maintenance skin, cosmetics and preparation method thereof | |
| CN109381356A (en) | A kind of sleep late frost and preparation method thereof | |
| US9603881B2 (en) | Bioactive fractions from stress-induced photosynthetic organisms and methods of their manufacture and use | |
| CN102228419A (en) | Emulsified sunscreen cosmetic | |
| CN109310598A (en) | Educate a mao agent | |
| CN111803422B (en) | Oil control composition and application thereof | |
| US8629180B2 (en) | Antiseptic agent composition | |
| CN113384507B (en) | Anti-aging composition and preparation method and application thereof | |
| CN103349623A (en) | Mild long-lasting moisturizing night cream | |
| CN109330954B (en) | Whitening skin brightening lotion, preparation method thereof and tyrosinase inhibitor | |
| US20130302385A1 (en) | Compositions containing a water-based gel and a water-in-oil emulsion | |
| CN112315845A (en) | Whitening and freckle removing cream and preparation method thereof | |
| US20220023196A1 (en) | Cosmetic composition for skin improvement comprising green barley extract | |
| CN109316368A (en) | Anti-aging skin care product and preparation method thereof | |
| CN108836901A (en) | A kind of facial mask essence of the Product filtrate containing saccharomycetes to make fermentation and preparation method thereof | |
| CN113509400A (en) | Skin composition and application thereof, whitening and brightening cosmetic composition and preparation method thereof | |
| KR20120056594A (en) | Cosmetic composition containing SARGASSUM FULVELLUM extract, CODIUM FRAGILE extract and UNDARIA PINNATIFIDA extract | |
| FR3029417A1 (en) | ACTIVE COMPLEX FOR A COSMETIC PRODUCT AGAINST SKIN AGING |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181009 |
|
| RJ01 | Rejection of invention patent application after publication |