CN108618148A - A kind of health food to alcoholic liver injury with defencive function - Google Patents
A kind of health food to alcoholic liver injury with defencive function Download PDFInfo
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- CN108618148A CN108618148A CN201710169040.2A CN201710169040A CN108618148A CN 108618148 A CN108618148 A CN 108618148A CN 201710169040 A CN201710169040 A CN 201710169040A CN 108618148 A CN108618148 A CN 108618148A
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- spirulina
- health food
- schisandra
- polysaccharide
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- 206010067125 Liver injury Diseases 0.000 title claims abstract description 15
- 235000016425 Arthrospira platensis Nutrition 0.000 claims abstract description 41
- 240000002900 Arthrospira platensis Species 0.000 claims abstract description 41
- 229940082787 spirulina Drugs 0.000 claims abstract description 41
- 150000004676 glycans Chemical class 0.000 claims abstract description 37
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 37
- 239000005017 polysaccharide Substances 0.000 claims abstract description 37
- 235000008422 Schisandra chinensis Nutrition 0.000 claims abstract description 34
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of health foods to alcoholic liver injury with defencive function, it belongs to technical field of health care food.The health food includes following mass fraction ingredient：Spirulina polysaccharide 60% 80% and Schisandra chinens P.E 20% 40%, wherein the spirulina polysaccharide is the polysaccharide extracted from seawater or freshwater aquiculture spirulina, wherein the Schisandra chinens P.E is that Schisandra chinensis puies forward obtained material through water, the present invention by with various active spirulina polysaccharide and have the Schisandra chinens P.E compatibility of significant curative effect to hepatic lesion, can effectively improve the hepatic injury caused by largely intake alcohol.The present invention is pure natural plant extract simultaneously, is a kind of safe and reliable health food.
Description
Technical field
The present invention relates to a kind of health foods to alcoholic liver injury with defencive function, belong to health food technology neck
Domain.
Background technology
It is well known that the serious damage liver function of excessive drinking.Excessive consumption of alcohol can aggravate burden of liver, make the impaired denaturation of liver cell,
Cirrhosis is eventually led to, is medically referred to as " alcoholic liver ".In American-European countries, alcoholic cirrhosis accounts for the 50- of whole hepatic sclerosis
90%.Chronic alcoholism person has an effect on fat metabolism, can cause fatty liver.Alcohol can be such that degeneration of liver cells, necrosis, fibr tissue increases
It gives birth to and causes hepatic sclerosis.
Alcoholic liver is due to long-term heavy drinking（It is addicted to drink）Caused hepar damnification disease.Nearly ten years, with the people
The consumption figure of the expansion of improvement of living standard and social circle, global drinks surges.Meanwhile the case of alcoholic liver also significantly increases
Add.The incidence of alcoholic liver is caused also to be in apparent ascendant trend due to drinking in China, it has also become the implicit type killer that can not be ignored.
Liver cans be compared to human body chemical plant, and the Synthesis of the various nutriments of human body is all completed by liver, various
Toxin will also be decomposed by liver.It drinks on a small quantity, after liver detoxification is metabolized, the substance for becoming nontoxic excretes；If
The metabolite acetaldehyde of long-term heavy drinking, alcohol is just very big to the toxic effect of liver cell.So being damaged for alcoholic liver
The Protection significance of wound is great.
Invention content
In view of the above-mentioned problems, the technical problem to be solved in the present invention is to provide a kind of safe and reliable to alcoholic liver injury tool
There is the health food of defencive function.
The a kind of of the present invention there is the health food of defencive function to include following mass fraction ingredient alcoholic liver injury：
Spirulina polysaccharide 60%-80% and Schisandra chinens P.E 20%-40%, wherein the spirulina polysaccharide is supported from seawater or fresh water
The polysaccharide extracted in spirulina is grown, specific extraction step is：Spirulina is after freeze thawing, and centrifugation removal supernatant, what is obtained consolidates
10 times of amount water of algal gel dry weight are added in body substance, the solid after ethyl alcohol Soxhlet extraction, in 0.5-5% neutral proteinases, pH=7.0,
Stirring extraction 2-5h under the conditions of 35-45 DEG C, then carries out centrifugation extraction, and centrifugal condition is the centrifugal treating at 4000rpm
The supernatant of centrifugation gained is concentrated under reduced pressure into and is added 2-5 times after 1/6 volume and measures 95% ethyl alcohol, placed at 3-5 DEG C by 15min
4-12h is filtered, and after filtering, filter cake is washed 1-3 times with absolute ethyl alcohol, is dried to get spirulina polysaccharide, wherein the five tastes
Seed extract is that Schisandra chinensis puies forward obtained material through water, and specific extraction process is by Schisandra chinensis with 1:10 ratio is mixed with water,
It is extracted 5 hours at 65-70 DEG C, Fructus Schisandrae Chinensis extractive solution is obtained after removal precipitation, Fructus Schisandrae Chinensis extractive solution is obtained to Schisandra chinensis after drying and is carried
Take object solid.
Further preferably, the health food includes following mass fraction ingredient：Spirulina polysaccharide 60% and Schisandra chinensis
Extract 40%.
Preferably, the health food with defencive function can be made into tablet, pill, capsule or aqueous solvent,
The health food preparation process of wherein tablet, pill and capsule is：Spirulina polysaccharide, Schisandra chinens P.E and excipient are passed through
Tablet is obtained using mixed pressuring plate mechanism after crushing, pill is made of granulator, capsule is made by powder pulverized powder is encapsulated,
Or aqueous solvent is made through the processes such as water-soluble, filling, gland, sterilizing.
Spirulina polysaccharide in the present invention is the polysaccharide extracted from unicellular alga protozoa-spirulina, and spirulina is rich in
The nutriments such as protein, amino acid, multivitamin, polysaccharide, chlorophyll needed by human, some researches show that 1 gram of spirulinas
It is equivalent to the summation of 1 kilogram of various vegetables and fruit part nutrition, is a kind of balanced nutraceutical comprehensively.Spirulina polysaccharide
It is to be extracted from spirulina using modernization Measurement for Biochemistry and technique, it is higher pure natural containing a variety of and bioactivity
Biological products.It is the careful studying through the several years in US Experts first, is developed in middle nineteen nineties, spirulina polysaccharide
Now it is widely used for makeup, health care, medicine and other fields.Spirulina polysaccharide is reduced by inhibiting free-radical oxidation in body to react
Lipid peroxidation can be effectively protected detrimental effect of the alcohol to liver.
Schisandra chinens P.E：Schisandra chinensis, ancient medical book Cheng Ta Chinese magnoliavines, Chinese magnoliavine, meeting and, be listed in Sheng Nong's herbal classic top grade earliest,
Herbal function is that the power of strengthening by means of tonics, medical value are high.Schisandra fruit implementation Chinese medicine function nourishing generate fluid, nourshing kidney of astringing the lung,
Antidiarrheal, it is puckery essence, calm the nerves, chronic cough and dyspnea of deficiency type can be controlled, dry lack in Tianjin, seminal emission chronic diarrhea, it is forgetful have a sleepless night etc. diseases.Pharmacological testing proof can be adjusted
The excitement of central nervous system and process of inhibition promote body metabolism, adjust gastric juice and bile secretion, turn ammonia to hepatitis convalescence
Enzyme raising person has reduction effect.Studies have shown that Schisandra chinensis can promote the detoxification processes of liver, protect liver from poisoning, and energy
Effectively restore the liver organization impaired because of abuse of alcohol, drug or hepatitis.Schisandra chinensis can also be effectively reduced constantly raised
Transaminase-alanine aminotransferase and Alpha fetoprotein are horizontal.
The present invention by with various active spirulina polysaccharide and there is the Schisandra chinens P.E of significant curative effect to match hepatic lesion
5, it can effectively improve the hepatic injury caused by largely intake alcohol.The present invention is pure natural plant extract simultaneously, is a kind of
Safe and reliable health food.
Specific implementation mode
Present embodiment uses following technical scheme：The health food includes following mass fraction ingredient：Spiral shell
Polysaccharides 60%-80% and Schisandra chinens P.E 20%-40% is revolved, wherein the spirulina polysaccharide is from seawater or freshwater aquiculture
The polysaccharide extracted in spirulina, specific extraction step are：Spirulina is after freeze thawing, centrifugation removal supernatant, obtained solid
10 times of amount water of algal gel dry weight are added in substance, the solid after ethyl alcohol Soxhlet extraction, in 0.5-5% neutral proteinases, pH=7.0,
Stirring extraction 2-5h under the conditions of 35-45 DEG C, then carries out centrifugation extraction, and centrifugal condition is the centrifugal treating at 4000rpm
The supernatant of centrifugation gained is concentrated under reduced pressure into and is added 2-5 times after 1/6 volume and measures 95% ethyl alcohol, placed at 3-5 DEG C by 15min
4-12h is filtered, and after filtering, filter cake is washed 1-3 times with absolute ethyl alcohol, is dried to get spirulina polysaccharide, wherein the five tastes
Seed extract is that Schisandra chinensis puies forward obtained material through water, and specific extraction process is by Schisandra chinensis with 1:10 ratio is mixed with water,
It is extracted 5 hours at 65-70 DEG C, Fructus Schisandrae Chinensis extractive solution is obtained after removal precipitation, Fructus Schisandrae Chinensis extractive solution is obtained to Schisandra chinensis after drying and is carried
Take object solid.
Further preferably, the health food includes following mass fraction ingredient：Spirulina polysaccharide 60% and Schisandra chinensis
Extract 40%.
Preferably, the health food with defencive function can be made into tablet, pill, capsule or aqueous solvent,
The health food preparation process of wherein tablet, pill and capsule is：Spirulina polysaccharide, Schisandra chinens P.E and excipient are passed through
Tablet is obtained using mixed pressuring plate mechanism after crushing, pill is made of granulator, capsule is made by powder pulverized powder is encapsulated,
Or aqueous solvent is made through the processes such as water-soluble, filling, gland, sterilizing.
Embodiment：
Embodiment 1. weighs spirulina polysaccharide 80g, Schisandra chinens P.E 20g, routinely manufactures tablet, pill, capsule or water
Solution.
Embodiment 2. weighs spirulina polysaccharide 60g, Schisandra chinens P.E 40g, routinely manufactures tablet, pill, capsule
Or aqueous solution.
Embodiment 3. verifies protective effect of the spirulina polysaccharide to acute liver, chooses mouse 50, random to divide
It it is five groups, respectively：Blank group, model group, spirulina polysaccharide high dose group, spirulina polysaccharide middle dose group, spirulina polysaccharide
Low dose group, (spirulina polysaccharide senior middle school low dose group standard be 400,200,100mg/kgbw), by each group mouse continuous gavage
30d, blank group and model group are pressed after normal saline gavage the 31st day, and 50% ethyl alcohol (12mL/kg) is given, and establish animal urgency
Property liver injury model.The dead mouse of removal after putting to death mouse living after gavage 12h, takes mouse liver to measure every anti-oxidant
Index, and mouse liver injury degree is analyzed using paraffin section.Analysis retrieval display is compared with model group, each dose of spirulina polysaccharide
Amount group can reduce liver MDA content, improve liver SOD activity, CAT activity, GSH-Px activity and GSH contents, liver denaturation
It is substantially reduced with the pathological changes such as necrosis, it is preferred especially with high dose group.Conclusion:Spirulina polysaccharide has Alcoholic Hepatic Injury
There is obvious protective function.
Embodiment 4. verifies protective effect of the Schisandra chinens P.E to alcoholic liver injury.Mouse 50 is chosen, it is random to divide
It it is five groups, respectively：Blank group, model group, Fructus Schisandrae Chinensis extractive solution high dose group, Fructus Schisandrae Chinensis extractive solution middle dose group, Schisandra chinensis
Extracting solution low dose group, by each group mouse continuous gavage 30d, blank group and model group are by the after normal saline gavage the 31st
It, gives 50% ethyl alcohol (12mL/kg), first mice serum is taken to be detected in gavage 12h, so puts to death mouse living, takes Mouse Liver
The every Antioxidant Indexes of dirty measurement, and mouse liver injury degree is analyzed using paraffin section.Analysis testing result can obtain Schisandra chinensis
Each dosage group of extracting solution can reduce serum alt, AST, TG, VLDL activity or content, increase liver organization SOD activity, drop
Low MDA contents, with the significant (P of liver injury model group comparing difference<0.05 or 0.01)；Liver histopathology changes to be damaged compared with liver
Wound model group significantly mitigates (P<0.05).Conclusion Fructus Schisandrae Chinensis extractive solution has protection to make acute alcohol-induced hepatic injury mouse liver
With.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technical staff of the industry
It should be appreciated that the present invention is not limited to the above embodiments, the above embodiments and description only describe the present invention
Principle, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these variation and
Improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention is by appended claims and its equivalent
Object defines.
Claims (3)
1. a kind of health food to alcoholic liver injury with defencive function, it is characterised in that：The health food includes
Following mass fraction ingredient：Spirulina polysaccharide 60%-80% and Schisandra chinens P.E 20%-40%, wherein the spirulina polysaccharide
It is the polysaccharide extracted from seawater or freshwater aquiculture spirulina, specific extraction step is：Spirulina is after freeze thawing, centrifugation removal
10 times of amount water of algal gel dry weight are added, in 0.5-5% in supernatant, obtained solid matter, the solid after ethyl alcohol Soxhlet extraction
Property protease, pH=7.0, stirring extraction 2-5h under the conditions of 35-45 DEG C then carry out centrifugation extraction, centrifugal condition be
The supernatant of centrifugation gained is concentrated under reduced pressure into and is added 2-5 times after 1/6 volume and measures 95% second by centrifugal treating 15min under 4000rpm
Alcohol, placement 4-12h is filtered at 3-5 DEG C, and after filtering, filter cake is washed 1-3 times with absolute ethyl alcohol, and drying is more to get spirulina
Sugar, wherein the Schisandra chinens P.E is Schisandra chinensis puies forward obtained material through water, specific extraction process is by Schisandra chinensis with 1:10
Ratio mixed with water, extracted 5 hours at 65-70 DEG C, removal precipitation after Fructus Schisandrae Chinensis extractive solution, Fructus Schisandrae Chinensis extractive solution is passed through
Schisandra chinens P.E solid is obtained after drying.
2. a kind of health food to alcoholic liver injury with defencive function described in accordance with the claim 1, it is characterised in that：
The health food includes following mass fraction ingredient：Spirulina polysaccharide 60% and Schisandra chinens P.E 40%.
3. a kind of health food to alcoholic liver injury with defencive function described in accordance with the claim 1, it is characterised in that：
The health food with defencive function can be made into tablet, pill, capsule or aqueous solvent, wherein tablet, pill and glue
The health food preparation process of wafer is：By spirulina polysaccharide, Schisandra chinens P.E and excipient after crushed using mixing pressure
Piece mechanism obtained tablet, pill is made of granulator, capsule is made by powder pulverized powder is encapsulated, or through water-soluble, filling, pressure
Aqueous solvent is made in the processes such as lid, sterilizing.
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| CN201710169040.2A CN108618148A (en) | 2017-03-21 | 2017-03-21 | A kind of health food to alcoholic liver injury with defencive function |
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| CN101606709A (en) * | 2009-07-03 | 2009-12-23 | 威海格瑞安生物工程有限公司 | A kind of health food that alcoholic liver injury is had defencive function |
| CN101961367A (en) * | 2010-11-10 | 2011-02-02 | 江苏省奥康生物科技有限公司 | Chinese medicinal composition for preventing alcoholic liver injury |
| CN104815060A (en) * | 2015-04-09 | 2015-08-05 | 江苏省中医药研究院 | Traditional Chinese medicine composition for treating acute alcoholic liver injury |
| CN106135891A (en) * | 2015-04-15 | 2016-11-23 | 吉林省中医药科学院 | A kind of health food to alcoholic liver injury with defencive function |
| CN105106386A (en) * | 2015-09-17 | 2015-12-02 | 漳州片仔癀药业股份有限公司 | Chinese herbal medicine composition capable of preventing and curing alcoholic liver injury |
| CN105901720A (en) * | 2016-05-17 | 2016-08-31 | 吉林昆阆医药科技有限公司 | Health care food capable of lowering alcoholic liver injury harm and preparation method thereof |
| CN106038733A (en) * | 2016-08-06 | 2016-10-26 | 甘肃鑫晟源生物科技开发有限责任公司 | Chewing tablet with effect of preventing alcohol-caused liver damage and preparation method thereof |
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