CN101606709A - A kind of health food that alcoholic liver injury is had defencive function - Google Patents
A kind of health food that alcoholic liver injury is had defencive function Download PDFInfo
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- CN101606709A CN101606709A CNA2009100166843A CN200910016684A CN101606709A CN 101606709 A CN101606709 A CN 101606709A CN A2009100166843 A CNA2009100166843 A CN A2009100166843A CN 200910016684 A CN200910016684 A CN 200910016684A CN 101606709 A CN101606709 A CN 101606709A
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- spirulina
- spirulina polysaccharide
- health food
- schisandra chinens
- alcoholic liver
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Abstract
The invention discloses and a kind of alcoholic liver injury is had the health food of defencive function, comprise spirulina polysaccharide and Schisandra chinens P.E, wherein the shared weight ratio of spirulina polysaccharide is 60%～80%, and surplus is a Schisandra chinens P.E.The present invention will have the spirulina polysaccharide of various active and hepatic lesion will be had the Schisandra chinens P.E compatibility of significant curative effect, can effectively improve because of a large amount of and take in the hepatic injury that alcohol cause.The present invention simultaneously is a pure natural plant extract, is a kind of safe and reliable health food.
Description
Technical field
The present invention relates to a kind of health food that alcoholic liver injury is had defencive function.
Background technology
As everyone knows, excessive drinking grievous injury liver function.Excessive consumption of alcohol can increase the weight of burden of liver, makes the impaired sex change of liver cell, finally causes cirrhosis, medically is referred to as " alcoholic liver ".In American-European countries, alcoholic cirrhosis accounts for the 50-90% of whole cirrhosis.Long-term great drinker also influences fat metabolism, can cause fatty liver.Alcohol can make degeneration of liver cells, necrosis, proliferation of fibrous tissue and cause cirrhosis.
Alcoholic liver is because the hepar damnification disease due to the long-term heavy drinking (being addicted to drink).Over past ten years, along with the raising of living standards of the people and the expansion of social circle, the surge of the consumption figure of global drinks.Simultaneously, the case of alcoholic liver also significantly increases.Because the incidence that causes alcoholic liver of drinking also is obvious ascendant trend, become the latent type killer who can not be ignored in China.
Liver cans be compared to the human body chemical plant, and the conversion of the various nutriments of human body is synthetic all to be finished by liver, and various toxin also will decompose through liver.Drink on a small quantity, after the liver detoxification metabolism, become nontoxic material and excrete; If long-term heavy drinking, the metabolite acetaldehyde of alcohol is just very big to hepatocellular toxic action.So, significant for the protection of alcoholic liver injury; By edible health food protection liver is a kind of simple, effective, commonly used and low method of cost.
Summary of the invention
At above-mentioned prior art, the invention provides a kind of health food that alcoholic liver injury is had defencive function.
The present invention is achieved by the following technical solutions:
A kind of have the health food of defencive function to alcoholic liver injury, comprises spirulina polysaccharide and Schisandra chinens P.E, and wherein the shared weight ratio of spirulina polysaccharide is 60%～80%, and surplus is a Schisandra chinens P.E.
Described spirulina polysaccharide obtains through following method separation and Extraction from seawater or fresh water spirulina:
1) gets fresh spirulina, weigh, centrifuge washing 1～3 time, the algae mud of weighing, in supernatant, add the water of 0.5～4 times of algae mud weight, stir, twice of freeze thawing, for the second time after the dissolving, the water that adds 2～8 times of weight of algae mud is again placed 2～8h, and is centrifugal, to precipitate through the cable-styled extraction of ethanol, collecting precipitation is used for the extraction of spirulina polysaccharide;
2) water of 10 times of amounts of adding algae mud dry weight in precipitation, neutral proteinase with 0.5～5% is enzymolysis 2～5h under 35～45 ℃ of stirrings, the centrifugal 15min of 4000rpm, supernatant is evaporated to 1/6 volume, adds 95% ethanol of 2～5 times of amounts, place 4～12h for 4 ℃, filter, filter cake is washed 1～3 time with absolute ethyl alcohol, and oven dry promptly gets spirulina polysaccharide.
Described Schisandra chinens P.E separation and Extraction and obtaining by the following method from the fruit of Chinese magnoliavine:
1) gets dry magnolia vine fruit kernel and be ground into meal, extract with alcohol reflux;
2) filter extract, the recovered under reduced pressure solvent is concentrated into proportion and is 1.38～1.40 thick paste, promptly gets Schisandra chinens P.E.
When edible, can be made into formulation arbitrarily such as tablet, pill, capsule, aqueous solvent.
Spirulina is a kind of unicellular alga protist, is rich in the nutriment such as protein, amino acid, multivitamin, polysaccharide, chlorophyll of needed by human.There are some researches show that 1 gram spirulina is equivalent to the summation of 1 kilogram of various vegetables and the nutrition of fruit part, is a kind of comprehensive and balanced nutraceutical.The used spirulina polysaccharide of the present invention is to adopt modern biochemical isolation technics and technology, extracts from spirulina and obtains, and this spirulina polysaccharide contains the large biological molecule of multiple high bioactivity, is a kind of biological products of pure natural.Spirulina polysaccharide now is widely used in cosmetic, health care, medicine and other fields, and it reduces lipid peroxidation by suppressing free-radical oxidation reaction in the body, can effectively protect the detrimental effect of alcohol to liver.
The fruit of Chinese magnoliavine, ancient medical book Cheng Ta Chi Zhu, profound and, can and, it is top grade to list in Sheng Nong's herbal classic the earliest, herbal function is the power of strengthening by means of tonics, medical value is high.Schisandra fruit is made Chinese medicine function nourishing generate fluid, the nourshing kidney of astringing the lung, antidiarrheal, puckery essence, is calmed the nerves, and can control diseases such as chronic cough void is breathed heavily, dry is lacked in Tianjin, seminal emission is rushed down for a long time, forgetful insomnia.The pharmacological testing proof can be regulated the excitement and the process of inhibition of central nervous system, promotes body metabolism, regulates the secretion of gastric juice and bile, and rising person has the reduction effect to hepatitis convalescence transaminase.Studies show that the fruit of Chinese magnoliavine can promote the detoxification processes of liver, protection liver to avoid poisoning, and efficient recovery can be arranged because of the impaired liver organization of abuse of alcohol, medicine or hepatitis.The fruit of Chinese magnoliavine also can reduce the transaminase-alanine aminotransferase and the first type fetoprotein level of continuous rising effectively.
The present invention will have the spirulina polysaccharide of various active and hepatic lesion will be had the Schisandra chinens P.E compatibility of significant curative effect, can effectively improve because of a large amount of and take in the hepatic injury that alcohol cause.The present invention simultaneously is a pure natural plant extract, is a kind of safe and reliable health food.
The specific embodiment
The present invention is further illustrated with experiment below in conjunction with embodiment:
Embodiment 1: taking by weighing spirulina polysaccharide 80g, Schisandra chinens P.E 20g is raw material, makes tablet according to a conventional method.
Embodiment 2: taking by weighing spirulina polysaccharide 75g, Schisandra chinens P.E 25g is raw material, makes pill according to a conventional method.
Embodiment 3: taking by weighing spirulina polysaccharide 70g, Schisandra chinens P.E 30g is raw material, makes capsule according to a conventional method.
Embodiment 4: taking by weighing spirulina polysaccharide 65g, Schisandra chinens P.E 35g is raw material, makes the aqueous solution according to a conventional method.
Embodiment 5: taking by weighing spirulina polysaccharide 60g, Schisandra chinens P.E 40g is raw material, makes tablet routinely.
Experimental example 1: the checking spirulina polysaccharide is to the protective effect of alcoholic liver injury: 50 of mouse, be divided into five groups at random, and be respectively: blank group, model group, spirulina polysaccharide, height, middle low dose group.Give to give the alcohol modeling behind the spirulina polysaccharide 30d, detect the liver tissue injury situation.Because of the hepatic tissue MDA (MDA) in the liver organization, reductive glutathione (GSH) have important effect aspect the liver function protecting.Under alcohol infringement, MDA content raises, and GSH content reduces, and then causes liver dysfunction, and can not effectively carry out the eubolism of substance in vivo, is subjected to remarkable influence as the metabolism meeting of triglycerides (TG).So the content of the MDA in the mensuration hepatic tissue, GSH and TG can well be estimated the hepatic injury situation.MDA, the GSH that measures by the standard reagent box, and the TG content results shown in table 1, table 2, table 3, data show in the table, spirulina polysaccharide can effectively reduce the hepatic injury that alcohol causes.
The variation of table 1 MDA content
The variation of table 2 GSH content
The variation of table 3 TG content
Experimental example 2: the authentication Schisandra chinens P.E is to the protective effect of alcoholic liver injury: 50 of mouse, be divided into five groups at random, and be respectively: blank group, model group, spirulina polysaccharide, height, middle low dose group.Give to give the alcohol modeling behind the Schisandra chinens P.E 30d, detect the liver tissue injury situation.The content of MDA, GSH and TG in the mensuration hepatic tissue, the result is shown in table 4, table 5, table 6, and data show in the table, and Schisandra chinens P.E can effectively reduce the hepatic injury that alcohol causes.
The variation of table 4 MDA content
The variation of table 5 GSH content
The variation of table 6 TG content
Spirulina polysaccharide among the present invention and Schisandra chinens P.E all are the food of medicine-food two-purpose, they are mixed associate with, and have obtained and have complemented one another, the health-care effect of the alcoholic liver injury that brings out the best in each other.Provide a kind of health food effective aspect the alcoholic liver injury protecting for the adult.
Claims (3)
1. one kind has the health food of defencive function to alcoholic liver injury, and it is characterized in that: comprise spirulina polysaccharide and Schisandra chinens P.E, wherein the shared weight ratio of spirulina polysaccharide is 60%～80%, and surplus is a Schisandra chinens P.E.
2. according to claim 1 a kind ofly have the health food of defencive function to alcoholic liver injury, and it is characterized in that: described spirulina polysaccharide obtains through following method separation and Extraction from seawater or fresh water spirulina:
1) gets fresh spirulina, weigh, centrifuge washing 1～3 time, the algae mud of weighing, in supernatant, add the water of 0.5～4 times of algae mud weight, stir, twice of freeze thawing, for the second time after the dissolving, the water that adds 2～8 times of weight of algae mud is again placed 2～8h, and is centrifugal, to precipitate through the cable-styled extraction of ethanol, collecting precipitation is used for the extraction of spirulina polysaccharide;
2) water of 10 times of amounts of adding algae mud dry weight in precipitation, neutral proteinase with 0.5～5% is enzymolysis 2～5h under 35～45 ℃ of stirrings, the centrifugal 15min of 4000rpm, supernatant is evaporated to 1/6 volume, adds 95% ethanol of 2～5 times of amounts, place 4～12h for 4 ℃, filter, filter cake is washed 1～3 time with absolute ethyl alcohol, and oven dry promptly gets spirulina polysaccharide.
3. according to claim 1 a kind ofly have the health food of defencive function to alcoholic liver injury, it is characterized in that: described Schisandra chinens P.E separation and Extraction and obtaining by the following method from the fruit of Chinese magnoliavine:
1) gets dry magnolia vine fruit kernel and be ground into meal, extract with alcohol reflux;
2) filter extract, the recovered under reduced pressure solvent is concentrated into proportion and is 1.38～1.40 thick paste, promptly gets Schisandra chinens P.E.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100166843A CN101606709A (en) | 2009-07-03 | 2009-07-03 | A kind of health food that alcoholic liver injury is had defencive function |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100166843A CN101606709A (en) | 2009-07-03 | 2009-07-03 | A kind of health food that alcoholic liver injury is had defencive function |
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| CN101606709A true CN101606709A (en) | 2009-12-23 |
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| Application Number | Title | Priority Date | Filing Date |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579477A (en) * | 2012-04-01 | 2012-07-18 | 新乡医学院 | Application of spirulina phatensis polysaccharide in preparing medicament for preventing and treating embryotoxicity caused by organophosphorus pesticide |
| CN108618148A (en) * | 2017-03-21 | 2018-10-09 | 江苏海睿生物科技有限公司 | A kind of health food to alcoholic liver injury with defencive function |
-
2009
- 2009-07-03 CN CNA2009100166843A patent/CN101606709A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102579477A (en) * | 2012-04-01 | 2012-07-18 | 新乡医学院 | Application of spirulina phatensis polysaccharide in preparing medicament for preventing and treating embryotoxicity caused by organophosphorus pesticide |
| CN102579477B (en) * | 2012-04-01 | 2013-04-03 | 新乡医学院 | Application of spirulina phatensis polysaccharide in preparing medicament for preventing and treating embryotoxicity caused by organophosphorus pesticide |
| CN108618148A (en) * | 2017-03-21 | 2018-10-09 | 江苏海睿生物科技有限公司 | A kind of health food to alcoholic liver injury with defencive function |
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Application publication date: 20091223 |