CN108605999A - A kind of medical bactericidal liquid and preparation method thereof - Google Patents
A kind of medical bactericidal liquid and preparation method thereof Download PDFInfo
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- CN108605999A CN108605999A CN201810657686.XA CN201810657686A CN108605999A CN 108605999 A CN108605999 A CN 108605999A CN 201810657686 A CN201810657686 A CN 201810657686A CN 108605999 A CN108605999 A CN 108605999A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/28—Myrtaceae [Myrtle family], e.g. teatree or clove
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Abstract
The invention discloses a kind of medical bactericidal liquids for belonging to medical disinfection technology field and preparation method thereof.Include the raw material of following weight fraction：5 10 parts of peppermint leaf extract, 5 10 parts of eucalyptus leaf essential oil, 58 parts of lilac extract, 13 parts of essence, 13 parts of borneol, 100 150 parts of ethyl alcohol, 80 100 parts of water.Medical bactericidal liquid prepared by the present invention can be used as spray, it is suitble to the daily disinfection of medical occasion, select peppermint leaf extract, eucalyptus leaf essential oil and lilac extract substitute hydrogen peroxide as Fungicidal active substance, it is good with smell, it has no toxic and side effect to human body, the advantages that useful life longevity is strong, and bactericidal effect is good.
Description
Technical field
The invention belongs to medical disinfection technology fields, and in particular to a kind of medical bactericidal liquid and preparation method thereof.
Background technology
Currently, generally hydrogen peroxide is used to carry out air sterillization in hospital, hydrogen peroxide can kill pathogenic entero becteria, suppurative ball
Bacterium, pathogenic yeast bacterium, is generally used for surface disinfection.Hydrogen peroxide have oxidation, but medical hydrogen peroxide concentration be equal to or
Less than 3%, wipe wound face, have burning sensation, surface be oxidized to white and effervescent, cleaned with clear water
, spend 3-5 minutes and just restore the original colour of skin.Hydrogen peroxide has cheap, easy preparation as medical environment disinfectant, extensively
Many advantages, such as composing antibacterial, still, hydrogen peroxide is Strong oxdiative substance, and side effect can be generated long to human body by using, and smell compares
Unpleasant, high concentration has irritation, has higher side effect to the staff for matching producing hydrogen peroxide for a long time.And hydrogen peroxide is unstable
It is fixed, there is the danger for generating and exploding in amount transport.It is badly in need of research and substitutes the thimerosal that hydrogen peroxide carries out the daily disinfection of medical treatment.
Patent 201710952979.6 discloses a kind of graphene bactericidal liquid and preparation method.By anion surface active
Agent, nonionic surfactant, antiredeposition group, thickener, emulsifier, a concentration of 30%-75% ethyl alcohol, Graphene powder, Pu
Radix Herba Taraxaci powder, mulberry leaf powder, coptis powder, pigment, fragrance and deionized water.Preparation method includes preliminary mixing and secondary mixing
Totally two steps.The bactericidal liquid has effects that broad-spectrum sterilization, and still, volatility is poor, is only applicable to wash one's hands, instrument cleaning
Disinfection is used, and environment sterilization is not suitable for.
Patent 201310423693.0 discloses a kind of air disinfection liquid.It is prepared by raw material by following ingredients,
Component is：Lemon ammonium leaf 15g-20g, juniper leaf 15g-25g, cacumen biotae 5g-15g, lacebark pine leaf 5g-10g, Pinus massoniana 2g-
5g, cedar leaf 15g-25g, Chinese pine leaf 12g-15g, fir leaf 10g-15g, basyleaves 5g-15g, Lignum seu Ramulus Cunninghamiae Lanceolatae leaf 15g-25g, cryptomeria
Leaf 5g-15g, black walnut leaf 2g-5g, five-leaved pine leaf 5g-10g, common crapemyrtle leaf 12g-15g, Pistacia Chinensis Leaf 2g-5g, yellow cinnamon leaf 5g-
10g, plane tree leaf 10g-15g, jasmine petal 50g-60g.The bactericidal liquid complicated component, manufacturing cost is high, and bactericidal effect ratio
It is poor.
Invention content
The purpose of the present invention is to provide a kind of medical bactericidal liquids and preparation method thereof, are killed suitable for everyday air disinfection
Bacterium.
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：5-10 parts of peppermint leaf extract, eucalyptus leaf essential oil
5-10 parts, 5-8 parts of lilac extract, 1-3 parts of essence, 1-3 parts of borneol, 100-150 parts of ethyl alcohol, 80-100 parts of water.
The essence is flavoring rose essence, lily essence, cream jasmin france, magnolia compound, lilac compound, Narcissus compound, sunflower
Essence, gardenia compound, hyacinth essence, yulan extrait, lavender oil, locust tree extrait, fragrant bamboo stone essence, fragrance of osmanthus
Essence, violet compound, the one or more in chrysanthemum essence.
The extracting method of the peppermint leaf extract is：Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 5-10 times of weight is added
Twice, each 18h merges extracting solution, and filtering is concentrated under reduced pressure to obtain thick medicinal extract, water is added to be suspended, and using petroleum ether extraction, returns for extraction
Petroleum ether layer extract is received up to peppermint leaf extract.
The extracting method of the eucalyptus leaf essential oil is：Eucalyptus leaves are taken, by leaf shredder, the leaf of chopping is placed in volatile oil
It is 1 by solid-liquid ratio in extractor:Water is added in (8-12), and after soaking at room temperature 8h, heating and refluxing extraction 20-40 minutes obtains eucalyptus leaves
Essential oil.
The extracting method of the lilac extract is：Lilac root is taken, is shredded, is made the section of length 1-3cm, add
75% alcohol reflux of 8-10 times of weight extracts 3 times, extracts 1-3 hours, merges extracting solution, and extracting solution recycles ethyl alcohol to no alcohol
Taste filters, and concentration obtains lilac medicinal extract.
The medical bactericidal liquid further includes thick 3-8 parts of leaf U.S. flowers and plants extract.
The extracting method of described thickness leaf U.S. flowers and plants extract is：Thick leaf U.S. flowers and plants are taken, shreds, is placed in volatile oil extractor
In, it is 1 by solid-liquid ratio:Water is added in (6-10), and after soaking at room temperature 6h, heating and refluxing extraction 20-40 minutes obtains thick leaf U.S. flowers and plants and carries
Take object.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, 100-150 parts of ethyl alcohol is taken, is heated to 45-55 DEG C, 1-3 parts of borneol is added, stirs 10-
20min fully dissolves, is cooled to room temperature；
(2) according to parts by weight, 5-10 parts of peppermint leaf extract, 5-10 parts of eucalyptus leaf essential oil, lilac extract 5-8 are taken
Part, 80-100 parts of water is added in 1-3 parts of essence, stirs 10-20min, fully dissolves；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 10-20min, system
At.
Thick 3-8 parts of leaf U.S. flowers and plants extract is additionally added in step (2).
Beneficial effects of the present invention：Medical bactericidal liquid prepared by the present invention can be used as spray, be suitble to medical occasion
Daily disinfection selects peppermint leaf extract, eucalyptus leaf essential oil and lilac extract to be substituted as Fungicidal active substance double
The advantages that oxygen water has smell good, has no toxic and side effect to human body, and useful life longevity is strong, and bactericidal effect is good.
Specific implementation mode
With reference to specific embodiment, the present invention will be further described.
Embodiment 1
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：Peppermint leaf extract 8g, eucalyptus leaf essential oil 8g,
Lilac extract 6g, flavoring rose essence 2g, borneol 2g, ethyl alcohol 120g, water 90g.
The extracting method of the peppermint leaf extract is：Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 8 times of weight is added to carry
It takes twice, each 18h, merges extracting solution, filtering is concentrated under reduced pressure to obtain thick medicinal extract, water is added to be suspended, using petroleum ether extraction, recycling
Petroleum ether layer extract is up to peppermint leaf extract.
The extracting method of the eucalyptus leaf essential oil is：Eucalyptus leaves are taken, by leaf shredder, the leaf of chopping is placed in volatile oil
It is 1 by solid-liquid ratio in extractor:10 are added water, and after soaking at room temperature 8h, heating and refluxing extraction 30 minutes obtains eucalyptus leaf essential oil.
The extracting method of the lilac extract is：Lilac root is taken, is shredded, is made the section of length 2cm, add 9
75% alcohol reflux of times weight extracts 3 times, extracts 2 hours, merges extracting solution, and extracting solution recycles ethyl alcohol to no alcohol taste, filters,
Concentration, obtains lilac medicinal extract.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, ethyl alcohol 120g is taken, is heated to 50 DEG C, borneol 2g is added, 15min is stirred, fully dissolves,
It is cooled to room temperature；
(2) according to parts by weight, peppermint leaf extract 8g, eucalyptus leaf essential oil 8g, lilac extract 6g, flavoring rose essence
Water 90g is added in 2g, stirs 15min, fully dissolves；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 15min, is made.
Embodiment 2
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：Peppermint leaf extract 5g, eucalyptus leaf essential oil 5g,
Lilac extract 5g, cream jasmin france 1g, borneol 1g, ethyl alcohol 100g, water 80g.
The extracting method of the peppermint leaf extract is：Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 5 times of weight is added to carry
It takes twice, each 18h, merges extracting solution, filtering is concentrated under reduced pressure to obtain thick medicinal extract, water is added to be suspended, using petroleum ether extraction, recycling
Petroleum ether layer extract is up to peppermint leaf extract.
The extracting method of the eucalyptus leaf essential oil is：Eucalyptus leaves are taken, by leaf shredder, the leaf of chopping is placed in volatile oil
It is 1 by solid-liquid ratio in extractor:8 are added water, and after soaking at room temperature 8h, heating and refluxing extraction 20 minutes obtains eucalyptus leaf essential oil.
The extracting method of the lilac extract is：Lilac root is taken, is shredded, is made the section of length 1cm, add 8
75% alcohol reflux of times weight extracts 3 times, extracts 1 hour, merges extracting solution, and extracting solution recycles ethyl alcohol to no alcohol taste, filters,
Concentration, obtains lilac medicinal extract.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, ethyl alcohol 100g is taken, is heated to 45 DEG C, borneol 1g is added, 10min is stirred, fully dissolves,
It is cooled to room temperature；
(2) according to parts by weight, peppermint leaf extract 5g, eucalyptus leaf essential oil 5g, lilac extract 5g, cream jasmin france are taken
Water 80g is added in 1g, stirs 10min, fully dissolves；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 10min, is made.
Embodiment 3
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：Peppermint leaf extract 10g, eucalyptus leaf essential oil
10g, lilac extract 8g, lavender oil 3g, borneol 3g, ethyl alcohol 150g, water 100g.
The extracting method of the peppermint leaf extract is：Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 10 times of weight is added to carry
It takes twice, each 18h, merges extracting solution, filtering is concentrated under reduced pressure to obtain thick medicinal extract, water is added to be suspended, using petroleum ether extraction, recycling
Petroleum ether layer extract is up to peppermint leaf extract.
The extracting method of the eucalyptus leaf essential oil is：Eucalyptus leaves are taken, by leaf shredder, the leaf of chopping is placed in volatile oil
It is 1 by solid-liquid ratio in extractor:12 are added water, and after soaking at room temperature 8h, heating and refluxing extraction 40 minutes obtains eucalyptus leaf essential oil.
The extracting method of the lilac extract is：Lilac root is taken, is shredded, is made the section of length 3cm, add 10
75% alcohol reflux of times weight extracts 3 times, extracts 3 hours, merges extracting solution, and extracting solution recycles ethyl alcohol to no alcohol taste, filters,
Concentration, obtains lilac medicinal extract.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, ethyl alcohol 150g is taken, is heated to 55 DEG C, borneol 3g is added, 20min is stirred, fully dissolves,
It is cooled to room temperature；
(2) according to parts by weight, peppermint leaf extract 10g, eucalyptus leaf essential oil 10g, lilac extract 8g, essence are taken
Water 100g is added in 3g, stirs 20min, fully dissolves；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 20min, is made.
Embodiment 4
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：Peppermint leaf extract 8g, eucalyptus leaf essential oil 8g,
Lilac extract 6g, thick leaf U.S. flowers and plants extract 6g, flavoring rose essence 2g, borneol 2g, ethyl alcohol 120g, water 90g.
The extracting method of described thickness leaf U.S. flowers and plants extract is：Take thick leaf U.S. flowers and plants (Callianthemum
Alatavicum Freyn), chopping is placed in volatile oil extractor, is 1 by solid-liquid ratio:8 are added water, after soaking at room temperature 6h, add
Circumfluence distillation 30 minutes obtains thick leaf U.S. flowers and plants extract.
The extracting method of the peppermint leaf extract is：Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 8 times of weight is added to carry
It takes twice, each 18h, merges extracting solution, filtering is concentrated under reduced pressure to obtain thick medicinal extract, water is added to be suspended, using petroleum ether extraction, recycling
Petroleum ether layer extract is up to peppermint leaf extract.
The extracting method of the eucalyptus leaf essential oil is：Eucalyptus leaves are taken, by leaf shredder, the leaf of chopping is placed in volatile oil
It is 1 by solid-liquid ratio in extractor:10 are added water, and after soaking at room temperature 8h, heating and refluxing extraction 30 minutes obtains eucalyptus leaf essential oil.
The extracting method of the lilac extract is：Lilac root is taken, is shredded, is made the section of length 2cm, add 9
75% alcohol reflux of times weight extracts 3 times, extracts 2 hours, merges extracting solution, and extracting solution recycles ethyl alcohol to no alcohol taste, filters,
Concentration, obtains lilac medicinal extract.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, ethyl alcohol 120g is taken, is heated to 50 DEG C, borneol 2g is added, 15min is stirred, fully dissolves,
It is cooled to room temperature；
(2) according to parts by weight, peppermint leaf extract 8g, eucalyptus leaf essential oil 8g, lilac extract 6g, thick leaf U.S. flowers and plants
Water 90g is added in extract 6g, flavoring rose essence 2g, stirs 15min, fully dissolves；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 15min, is made.
Embodiment 5
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：Peppermint leaf extract 8g, eucalyptus leaf essential oil 8g,
Lilac extract 6g, slender lobule U.S. flowers and plants extract 6g, flavoring rose essence 2g, borneol 2g, ethyl alcohol 120g, water 90g.
The extracting method of described thickness leaf U.S. flowers and plants extract is：Take slender lobule U.S. flowers and plants (Callianthemum
Angustifolium Witasek), chopping is placed in volatile oil extractor, is 1 by solid-liquid ratio:8 are added water, soaking at room temperature 6h
Afterwards, heating and refluxing extraction 30 minutes obtain slender lobule U.S. flowers and plants extract.
The extracting method of the peppermint leaf extract is：Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 8 times of weight is added to carry
It takes twice, each 18h, merges extracting solution, filtering is concentrated under reduced pressure to obtain thick medicinal extract, water is added to be suspended, using petroleum ether extraction, recycling
Petroleum ether layer extract is up to peppermint leaf extract.
The extracting method of the eucalyptus leaf essential oil is：Eucalyptus leaves are taken, by leaf shredder, the leaf of chopping is placed in volatile oil
It is 1 by solid-liquid ratio in extractor:10 are added water, and after soaking at room temperature 8h, heating and refluxing extraction 30 minutes obtains eucalyptus leaf essential oil.
The extracting method of the lilac extract is：Lilac root is taken, is shredded, is made the section of length 2cm, add 9
75% alcohol reflux of times weight extracts 3 times, extracts 2 hours, merges extracting solution, and extracting solution recycles ethyl alcohol to no alcohol taste, filters,
Concentration, obtains lilac medicinal extract.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, ethyl alcohol 120g is taken, is heated to 50 DEG C, borneol 2g is added, 15min is stirred, fully dissolves,
It is cooled to room temperature；
(2) according to parts by weight, peppermint leaf extract 8g, eucalyptus leaf essential oil 8g, lilac extract 6g, slender lobule U.S. flowers and plants
Water 90g is added in extract 6g, flavoring rose essence 2g, stirs 15min, fully dissolves；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 15min, is made.
Embodiment 6
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：Peppermint leaf extract 8g, eucalyptus leaf essential oil 8g,
Lilac extract 6g spends more Resina garciniae extract 6g, flavoring rose essence 2g, borneol 2g, ethyl alcohol 120g, water 90g.
The extracting method for spending more Resina garciniae extract is：It takes and spends more gamboge (Garcinia polyantha Oliver)
Blade, chopping, is placed in volatile oil extractor, is 1 by solid-liquid ratio:8 are added water, after soaking at room temperature 6h, heating and refluxing extraction 30
Minute, Resina garciniae extract must be spent more.
The extracting method of the peppermint leaf extract is：Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 8 times of weight is added to carry
It takes twice, each 18h, merges extracting solution, filtering is concentrated under reduced pressure to obtain thick medicinal extract, water is added to be suspended, using petroleum ether extraction, recycling
Petroleum ether layer extract is up to peppermint leaf extract.
The extracting method of the eucalyptus leaf essential oil is：Eucalyptus leaves are taken, by leaf shredder, the leaf of chopping is placed in volatile oil
It is 1 by solid-liquid ratio in extractor:10 are added water, and after soaking at room temperature 8h, heating and refluxing extraction 30 minutes obtains eucalyptus leaf essential oil.
The extracting method of the lilac extract is：Lilac root is taken, is shredded, is made the section of length 2cm, add 9
75% alcohol reflux of times weight extracts 3 times, extracts 2 hours, merges extracting solution, and extracting solution recycles ethyl alcohol to no alcohol taste, filters,
Concentration, obtains lilac medicinal extract.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, ethyl alcohol 120g is taken, is heated to 50 DEG C, borneol 2g is added, 15min is stirred, fully dissolves,
It is cooled to room temperature；
(2) according to parts by weight, peppermint leaf extract 8g, eucalyptus leaf essential oil 8g, lilac extract 6g spend more gamboge and carry
Object 6g, flavoring rose essence 2g are taken, water 90g is added, 15min is stirred, fully dissolves；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 15min, is made.
Comparative example 1
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：Eucalyptus leaf essential oil 8g, lilac extract 6g,
Flavoring rose essence 2g, borneol 2g, ethyl alcohol 120g, water 90g.
The extracting method of the eucalyptus leaf essential oil is：Eucalyptus leaves are taken, by leaf shredder, the leaf of chopping is placed in volatile oil
It is 1 by solid-liquid ratio in extractor:10 are added water, and after soaking at room temperature 8h, heating and refluxing extraction 30 minutes obtains eucalyptus leaf essential oil.
The extracting method of the lilac extract is：Lilac root is taken, is shredded, is made the section of length 2cm, add 9
75% alcohol reflux of times weight extracts 3 times, extracts 2 hours, merges extracting solution, and extracting solution recycles ethyl alcohol to no alcohol taste, filters,
Concentration, obtains lilac medicinal extract.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, ethyl alcohol 120g is taken, is heated to 50 DEG C, borneol 2g is added, 15min is stirred, fully dissolves,
It is cooled to room temperature；
(2) according to parts by weight, eucalyptus leaf essential oil 8g, lilac extract 6g, flavoring rose essence 2g are taken, water 90g is added, stirs
15min is mixed, is fully dissolved；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 15min, is made.
Comparative example 2
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：Peppermint leaf extract 8g, lilac extract
6g, flavoring rose essence 2g, borneol 2g, ethyl alcohol 120g, water 90g.
The extracting method of the peppermint leaf extract is：Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 8 times of weight is added to carry
It takes twice, each 18h, merges extracting solution, filtering is concentrated under reduced pressure to obtain thick medicinal extract, water is added to be suspended, using petroleum ether extraction, recycling
Petroleum ether layer extract is up to peppermint leaf extract.
The extracting method of the lilac extract is：Lilac root is taken, is shredded, is made the section of length 2cm, add 9
75% alcohol reflux of times weight extracts 3 times, extracts 2 hours, merges extracting solution, and extracting solution recycles ethyl alcohol to no alcohol taste, filters,
Concentration, obtains lilac medicinal extract.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, ethyl alcohol 120g is taken, is heated to 50 DEG C, borneol 2g is added, 15min is stirred, fully dissolves,
It is cooled to room temperature；
(2) according to parts by weight, peppermint leaf extract 8g, lilac extract 6g, flavoring rose essence 2g are added water 90g, stir
15min is mixed, is fully dissolved；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 15min, is made.
Comparative example 3
A kind of medical bactericidal liquid, includes the raw material of following weight fraction：Peppermint leaf extract 8g, eucalyptus leaf essential oil 8g,
Flavoring rose essence 2g, borneol 2g, ethyl alcohol 120g, water 90g.
The extracting method of the peppermint leaf extract is：Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 8 times of weight is added to carry
It takes twice, each 18h, merges extracting solution, filtering is concentrated under reduced pressure to obtain thick medicinal extract, water is added to be suspended, using petroleum ether extraction, recycling
Petroleum ether layer extract is up to peppermint leaf extract.
The extracting method of the eucalyptus leaf essential oil is：Eucalyptus leaves are taken, by leaf shredder, the leaf of chopping is placed in volatile oil
It is 1 by solid-liquid ratio in extractor:10 are added water, and after soaking at room temperature 8h, heating and refluxing extraction 30 minutes obtains eucalyptus leaf essential oil.
The preparation method of above-mentioned medical bactericidal liquid, includes the following steps：
(1) according to parts by weight, ethyl alcohol 120g is taken, is heated to 50 DEG C, borneol 2g is added, 15min is stirred, fully dissolves,
It is cooled to room temperature；
(2) according to parts by weight, water 90g, stirring is added in peppermint leaf extract 8g, eucalyptus leaf essential oil 8g, flavoring rose essence 2g
15min fully dissolves；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 15min, is made.
Experimental example：
Each 10mL of bactericidal liquid prepared by Example 1-6 and comparative example 1-3 is sprayed onto 10m3In space, with reference to GB/
Clump count in the method for T18204.1-2000 and the air for requiring survey sprinkling front and back, each group are done 3 experiments and are averaged, and survey
Test result is shown in Table 1.
Clump count in the front and back detection plate of 1 each experimental group of table sprinkling
Note：* the P compared with 1 group of embodiment is represented<0.05；**P<0.01.
As can be seen from Table 1, the sterilizing rate of embodiment 1-3, embodiment 5, comparative example 1 are not much different, poor without conspicuousness
Different, the sterilizing rate of embodiment 4 is noticeably greater than embodiment 1, and the sterilizing rate pole of embodiment 6 is significantly higher than embodiment 1, and comparative example 2-
3 sterilizing rate pole is substantially less than embodiment 1.
Claims (9)
1. a kind of medical bactericidal liquid, which is characterized in that include the raw material of following weight fraction：5-10 parts of peppermint leaf extract,
5-10 parts of eucalyptus leaf essential oil, 5-8 parts of lilac extract, 1-3 parts of essence, 1-3 parts of borneol, 100-150 parts of ethyl alcohol, water 80-100
Part.
2. medical bactericidal liquid according to claim 1, which is characterized in that the essence is flavoring rose essence, lily essence, jasmine
Jasmine essence, magnolia compound, lilac compound, Narcissus compound, heliotrope essence, gardenia compound, hyacinth essence, yulan extrait smoke
Clothing hay-scented essence, locust tree extrait, fragrant bamboo stone essence, osmanthus flower fragrance, violet compound, one kind in chrysanthemum essence or it is a kind of with
On.
3. medical bactericidal liquid according to claim 1, which is characterized in that the extracting method of the peppermint leaf extract is：
Dried peppermint leaf is taken, is smashed to pieces, 75% ethyl alcohol cold soaking of 5-10 times of weight is added to extract twice, each 18h merges extracting solution, filters, decompression
It is concentrated to give thick medicinal extract, water is added to be suspended, using petroleum ether extraction, recycling petroleum ether layer extract is up to peppermint leaf extract.
4. medical bactericidal liquid according to claim 1, which is characterized in that the extracting method of the eucalyptus leaf essential oil is：It takes
Leaf shredder is placed in the leaf of chopping in volatile oil extractor by eucalyptus leaves, is 1 by solid-liquid ratio:Water, room is added in (8-12)
After temperature impregnates 8h, heating and refluxing extraction 20-40 minutes obtains eucalyptus leaf essential oil.
5. medical bactericidal liquid according to claim 1, which is characterized in that the extracting method of the lilac extract is：
Lilac root is taken, shreds, makes the section of length 1-3cm, adds 75% alcohol reflux of 8-10 times of weight to extract 3 times, extraction
1-3 hours, merge extracting solution, extracting solution recycles ethyl alcohol to no alcohol taste, filters, and concentration obtains lilac medicinal extract.
6. medical bactericidal liquid according to claim 1, which is characterized in that the medical bactericidal liquid further includes that thick leaf U.S.A spends
Careless extract 3-8 parts.
7. medical bactericidal liquid according to claim 1, which is characterized in that the extracting method of described thickness leaf U.S. flowers and plants extract
For：Thick leaf U.S. flowers and plants are taken, shreds, is placed in volatile oil extractor, are 1 by solid-liquid ratio:Water, soaking at room temperature 6h is added in (6-10)
Afterwards, heating and refluxing extraction 20-40 minutes, thick leaf U.S. flowers and plants extract is obtained.
8. the preparation method of medical bactericidal liquid described in claim 1, which is characterized in that include the following steps：
(1) according to parts by weight, 100-150 parts of ethyl alcohol is taken, is heated to 45-55 DEG C, 1-3 parts of borneol is added, stirs 10-20min,
Fully dissolving, is cooled to room temperature；
(2) according to parts by weight, 5-10 parts of peppermint leaf extract is taken, 5-10 parts of eucalyptus leaf essential oil, 5-8 parts of lilac extract,
80-100 parts of water is added in 1-3 parts of essence, stirs 10-20min, fully dissolves；
(3) aqueous solution prepared by the ethanol solution and step (2) prepared step (1) mixes, and stirs 10-20min, is made.
9. the preparation method of medical bactericidal liquid according to claim 1, which is characterized in that step is additionally added thick leaf in (2)
3-8 parts of U.S. flowers and plants extract.
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| WO2021217324A1 (en) * | 2020-04-27 | 2021-11-04 | 陕西高源体外诊断试剂有限公司 | Disinfectant composition, preparation method therefor, and use thereof |
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