CN108586611A - 重组全人源抗破伤风毒素单克隆抗体 - Google Patents
重组全人源抗破伤风毒素单克隆抗体 Download PDFInfo
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- CN108586611A CN108586611A CN201810401688.2A CN201810401688A CN108586611A CN 108586611 A CN108586611 A CN 108586611A CN 201810401688 A CN201810401688 A CN 201810401688A CN 108586611 A CN108586611 A CN 108586611A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
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- General Health & Medical Sciences (AREA)
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- Biotechnology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
Abstract
Description
抗体名称 | ka(1/Ms) | kd(1/s) | KD(M) |
TRN1014 | 5.51E+04 | 6.07E-05 | 1.10E-0.9 |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810401688.2A CN108586611B (zh) | 2018-04-28 | 2018-04-28 | 重组全人源抗破伤风毒素单克隆抗体 |
Applications Claiming Priority (1)
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CN201810401688.2A CN108586611B (zh) | 2018-04-28 | 2018-04-28 | 重组全人源抗破伤风毒素单克隆抗体 |
Publications (2)
Publication Number | Publication Date |
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CN108586611A true CN108586611A (zh) | 2018-09-28 |
CN108586611B CN108586611B (zh) | 2021-01-26 |
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CN201810401688.2A Active CN108586611B (zh) | 2018-04-28 | 2018-04-28 | 重组全人源抗破伤风毒素单克隆抗体 |
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CN (1) | CN108586611B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109477084A (zh) * | 2016-07-19 | 2019-03-15 | 国立研究开发法人农业·食品产业技术综合研究机构 | 使用等离子体在植物细胞内导入物质的方法 |
CN114702580A (zh) * | 2021-11-07 | 2022-07-05 | 吉林大学重庆研究院 | 特异性结合人血清白蛋白单克隆抗体及其应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101220096A (zh) * | 2003-12-30 | 2008-07-16 | 龚小迪 | 人源抗破伤风毒素单克隆抗体的制备和应用 |
CN102206275A (zh) * | 2011-04-27 | 2011-10-05 | 上海生物制品研究所 | 抗破伤风毒素单克隆中和抗体,其组合物及其用途 |
US20140193402A1 (en) * | 2013-01-09 | 2014-07-10 | Regeneron Pharmaceuticals, Inc. | ANTI-PDGFR-beta ANTIBODIES AND USES THEREOF |
CN105153305A (zh) * | 2015-06-26 | 2015-12-16 | 安泰吉(北京)生物技术有限公司 | 一种全人源抗破伤风毒素单克隆抗体及其衍生物制备方法和应用 |
CN106589127A (zh) * | 2015-10-16 | 2017-04-26 | 钜川生物医药 | 一种pcsk9抗体及其制备方法和应用 |
-
2018
- 2018-04-28 CN CN201810401688.2A patent/CN108586611B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101220096A (zh) * | 2003-12-30 | 2008-07-16 | 龚小迪 | 人源抗破伤风毒素单克隆抗体的制备和应用 |
CN102206275A (zh) * | 2011-04-27 | 2011-10-05 | 上海生物制品研究所 | 抗破伤风毒素单克隆中和抗体,其组合物及其用途 |
US20140193402A1 (en) * | 2013-01-09 | 2014-07-10 | Regeneron Pharmaceuticals, Inc. | ANTI-PDGFR-beta ANTIBODIES AND USES THEREOF |
CN105153305A (zh) * | 2015-06-26 | 2015-12-16 | 安泰吉(北京)生物技术有限公司 | 一种全人源抗破伤风毒素单克隆抗体及其衍生物制备方法和应用 |
CN106589127A (zh) * | 2015-10-16 | 2017-04-26 | 钜川生物医药 | 一种pcsk9抗体及其制备方法和应用 |
Non-Patent Citations (5)
Title |
---|
BOWERS,E. 等: ""immunoglobulin G heavy chain variable region, partial [Homo sapiens]"", 《GENBANK》 * |
BOWERS,E.等: ""immunoglobulin A heavy chain variable region, partial [Homo sapiens]"", 《GENBANK DATABASE》 * |
王晗 等: ""人破伤风免疫噬菌体单链抗体库的构建及体外亲和筛选"", 《军事医学》 * |
程洁 等: ""抗破伤风毒素人源单克隆抗体中和效力的研究"", 《微生物学免疫学进展》 * |
赵红 等: ""人源抗破伤风毒素单克隆抗体的中和活性和预防治疗作用"", 《中国生物制品学杂志》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109477084A (zh) * | 2016-07-19 | 2019-03-15 | 国立研究开发法人农业·食品产业技术综合研究机构 | 使用等离子体在植物细胞内导入物质的方法 |
CN114702580A (zh) * | 2021-11-07 | 2022-07-05 | 吉林大学重庆研究院 | 特异性结合人血清白蛋白单克隆抗体及其应用 |
CN114702580B (zh) * | 2021-11-07 | 2023-06-27 | 吉林大学重庆研究院 | 特异性结合人血清白蛋白单克隆抗体及其应用 |
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CN108586611B (zh) | 2021-01-26 |
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Address after: 510632 No. 601, Whampoa Avenue, Tianhe District, Guangdong, Guangzhou Patentee after: Jinan University Patentee after: Zhuhai Tainuo Maibo Pharmaceutical Co.,Ltd. Patentee after: GUANGZHOU TAINUODI BIOTECHNOLOGY Co.,Ltd. Address before: 510632 No. 601, Whampoa Avenue, Tianhe District, Guangdong, Guangzhou Patentee before: Jinan University Patentee before: ZHUHAI TRINOMAB BIOTECHNOLOGY Co.,Ltd. Patentee before: GUANGZHOU TAINUODI BIOTECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20230824 Address after: 510632 No. 601, Whampoa Avenue, Tianhe District, Guangdong, Guangzhou Patentee after: Jinan University Patentee after: Zhuhai Tainuo Maibo Pharmaceutical Co.,Ltd. Address before: 510632 No. 601, Whampoa Avenue, Tianhe District, Guangdong, Guangzhou Patentee before: Jinan University Patentee before: Zhuhai Tainuo Maibo Pharmaceutical Co.,Ltd. Patentee before: GUANGZHOU TAINUODI BIOTECHNOLOGY Co.,Ltd. |