CN108578554A - 一种口腔溃疡喷剂及其制备方法 - Google Patents
一种口腔溃疡喷剂及其制备方法 Download PDFInfo
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- CN108578554A CN108578554A CN201810628076.7A CN201810628076A CN108578554A CN 108578554 A CN108578554 A CN 108578554A CN 201810628076 A CN201810628076 A CN 201810628076A CN 108578554 A CN108578554 A CN 108578554A
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Abstract
本发明公开了一种口腔溃疡喷剂,其原料按重量份数如下:三黄中药10‑20份,甘草2‑3份、草楮实子1‑3份、茺蔚子1‑3份、芜菁子1‑3份、苘麻子1‑3份、大黄3‑5份,甜菊素0.5‑0.8份、枸橼酸0.1‑0.2份,食用盐3‑5份,大蒜膜5‑7份,冰糖3‑5份,蜂胶10‑13份,芦荟6‑8份,金银花5‑10份,薄荷6‑8份,海带5‑10份,冰硼散7‑9份,西红柿9‑11份,全脂奶粉5‑10份和水150‑200份。本发明通过三黄中药、甘草均为清热解读的中药原料,采用的冰硼散具有清热消肿、敛疮生肌的功效,冰糖和蜂胶润肤生肌,消炎止痛,促进细胞再生的功效,而且采用大蒜膜含有挥发油和大蒜素,可杀菌,采用的口腔溃疡喷剂均为凉性原料,对口腔溃疡治疗有很好的疗效,而且均为无毒害制剂原料,易于人体吸收,适合广泛推广。
Description
技术领域
本发明涉及口腔溃疡技术领域,具体为一种口腔溃疡喷剂,同时本发明还涉及一种口腔溃疡喷剂的制备方法。
背景技术
口腔溃疡俗称“口疮”,是一种常见的发生于口腔黏膜的溃疡性损伤病症,多见于唇内侧、舌头、舌腹、颊黏膜、前庭沟、软腭等部位,这些部位的黏膜缺乏角质化层或角化较差。舌头溃疡指发生于舌头、舌腹部位的口腔溃疡。口腔溃疡发作时疼痛剧烈,局部灼痛明显,严重者还会影响饮食、说话,对日常生活造成极大不便;可并发口臭、慢性咽炎、便秘、头痛、头晕、恶心、乏力、烦躁、发热、淋巴结肿大等全身症状。
在口腔溃疡治疗过程中,现有的口腔溃疡喷剂治疗效果单一,疗效较慢,而且不易人体吸收,采用的多数西药中,副作用较高,而且容易复发。
发明内容
本发明的目的在于提供一种口腔溃疡喷剂及其制备方法,采用的口腔溃疡喷剂均为凉性原料,对口腔溃疡治疗有很好的疗效,而且均为无毒害制剂原料,易于人体吸收,见效快,不易复发,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:一种口腔溃疡喷剂,其原料按重量份数如下:三黄中药10-20份,甘草2-3份、草楮实子1-3份、茺蔚子1-3份、芜菁子1-3份、苘麻子1-3份、大黄3-5份,甜菊素0.5-0.8份、枸橼酸0.1-0.2份,食用盐3-5份,大蒜膜5-7份,冰糖3-5份,蜂胶10-13份,芦荟6-8份,金银花5-10份,薄荷6-8份,海带5-10份,冰硼散7-9份,西红柿9-11份,全脂奶粉5-10份和水150-200份。
优选的,所述三黄中药黄芩、黄连和黄柏的混合物,混合比例为1:1:1。
优选的,所述冰硼散为冰片和玄明粉的混合物,混合比例为3:1。
优选的,所述全脂奶粉中蛋白质不低于24%,脂肪不低于26%,乳糖不低于37%。
本发明还提供一种口腔溃疡喷剂的制备方法,包括如下步骤:
S1:S1:取料,将三黄中药、甘草、草楮实子、茺蔚子、芜菁子、苘麻子、大黄、甜菊素、枸橼酸、食用盐、大蒜膜、冰糖、蜂胶、芦荟、金银花、薄荷、海带、冰硼散、西红柿、全脂奶粉和水按重量份数称取,备用;
S2:炒料,将草楮实子、茺蔚子、芜菁子、苘麻子置入温度为70-80℃的旋转炒锅内恒温炒制15-20min,降温至55-65℃后,继续恒温炒制20-25min,取出,粉碎备用;
S3:烤料,将金银花和海带进行烘干干燥处理,烘干温度为50-100℃,干燥时间20-30min,使得金银花和海带的含水率低于3%,将获得的干燥金银花和海带研磨成粉,粉料粒度为80-100目;
S4:研磨粉碎,将三黄中药、甘草、大黄、大蒜膜、冰糖、芦荟、薄荷、冰硼散和西红柿均放入研磨机中研磨成粉,获得粉末混合物,研磨颗粒大小控制在80-100目之间,备用;
S5:发酵,将S2中炒制粉碎的原料,S3中烤制的粉碎的原料,S4中研磨成粉的原料和和二分之一的水均倒入发酵罐中进行先进行恒温发酵,发酵时间2-3h,再进行升温发酵,发酵时间1-2h,最后进行降温发酵,发酵时间1-2h;
S6:熬煮,将S5发酵完成的物料和剩余二分之一的水倒入煮锅中进行熬煮,并将甜菊素、枸橼酸和全脂奶粉倒入继续进行熬煮,边熬煮边搅拌,熬煮时间为70-80min,熬煮温度80-90℃;
S7:过滤,将S6中熬煮完成后的混合物料通过80-100目的滤布进行过滤,收集滤液,并自然冷却,即获得口腔溃疡喷剂原液;
S8:真空包装,将冷却完成后的口腔溃疡喷剂原液进行真空无菌灌装,灌装完成后置于阴凉处封存。
优选的,所述步骤S2、S3和S4中的研磨粉碎采用的是WF系列万能粉碎机,主轴转速在3000-4000r/min。
优选的,所述步骤S3中烘干方式采用的是CT-C型系列热风循环烘箱,进风温度50-100℃。
优选的,所述步骤S5中发酵中恒温发酵温度在30-40℃,升温发酵温度上升幅度为5-10℃,降温发酵的降温幅度为5-10℃。
与现有技术相比,本发明的有益效果是:本发明严格控制该口腔溃疡喷剂及其制备方法,通过严格控制口腔溃疡喷剂的各组份的占比以及制备工艺参数,通过三黄中药、甘草均为清热解读的中药原料,采用的冰硼散具有清热消肿、敛疮生肌的功效,冰糖和蜂胶润肤生肌,消炎止痛,促进细胞再生的功效,而且采用大蒜膜含有挥发油和大蒜素,可杀菌,能预防溃疡面感染,全脂奶粉中维生素B含量高,而且西红柿中含有大量B、C族维生素、胡萝卜素,以及钙、铁、锌、碘等微量元素,采用的口腔溃疡喷剂均为凉性原料,采用中药和食物相结合方式,对口腔溃疡治疗有很好的疗效,而且均为无毒害制剂原料,易于人体吸收,见效快,不易复发,适合广泛推广。
具体实施方式
为了使本发明的目的、技术方案及优点更加清楚明白,以下结合具体实施例,对本发明进行进一步详细说明。应当理解,此处所描述的具体实施例仅仅用以解释本发明,并不用于限定本发明。
实施例1
一种口腔溃疡喷剂,其原料按重量份数如下:三黄中药10份,甘草2份、草楮实子1份、茺蔚子1份、芜菁子1份、苘麻子1份、大黄3份,甜菊素0.5份、枸橼酸0.1份,食用盐3份,大蒜膜5份,冰糖3份,蜂胶10份,芦荟6份,金银花5份,薄荷6份,海带5份,冰硼散7份,西红柿9份,全脂奶粉5份和水150份,所述三黄中药黄芩、黄连和黄柏的混合物,混合比例为1:1:1,所述冰硼散为冰片和玄明粉的混合物,混合比例为3:1,所述全脂奶粉中蛋白质不低于24%,脂肪不低于26%,乳糖不低于37%。
本发明还提供一种口腔溃疡喷剂的制备方法,包括如下步骤:
S1:取料,将三黄中药、甘草、草楮实子、茺蔚子、芜菁子、苘麻子、大黄、甜菊素、枸橼酸、食用盐、大蒜膜、冰糖、蜂胶、芦荟、金银花、薄荷、海带、冰硼散、西红柿、全脂奶粉和水按重量份数称取,备用;
S2:炒料,将草楮实子、茺蔚子、芜菁子、苘麻子置入温度为70℃的旋转炒锅内恒温炒制15min,降温至55℃后,继续恒温炒制20min,取出,粉碎备用;
S3:烤料,将金银花和海带进行烘干干燥处理,烘干温度为50℃,干燥时间20min,使得金银花和海带的含水率低于3%,将获得的干燥金银花和海带研磨成粉,粉料粒度为80目;
S4:研磨粉碎,将三黄中药、甘草、大黄、大蒜膜、冰糖、芦荟、薄荷、冰硼散和西红柿均放入研磨机中研磨成粉,获得粉末混合物,研磨颗粒大小控制在80目,备用;
S5:发酵,将S2中炒制粉碎的原料,S3中烤制的粉碎的原料,S4中研磨成粉的原料和和二分之一的水均倒入发酵罐中进行先进行恒温发酵,发酵时间2h,再进行升温发酵,发酵时间1h,最后进行降温发酵,发酵时间1h;
S6:熬煮,将S5发酵完成的物料和剩余二分之一的水倒入煮锅中进行熬煮,并将甜菊素、枸橼酸和全脂奶粉倒入继续进行熬煮,边熬煮边搅拌,熬煮时间为70min,熬煮温度80℃;
S7:过滤,将S6中熬煮完成后的混合物料通过80目的滤布进行过滤,收集滤液,并自然冷却,即获得口腔溃疡喷剂原液;
S8:真空包装,将冷却完成后的口腔溃疡喷剂原液进行真空无菌灌装,灌装完成后置于阴凉处封存。
所述步骤S2、S3和S4中的研磨粉碎采用的是WF系列万能粉碎机,主轴转速在3000r/min,所述步骤S3中烘干方式采用的是CT-C型系列热风循环烘箱,进风温度50℃,所述步骤S5中发酵中恒温发酵温度在30℃,升温发酵温度上升幅度为5℃,降温发酵的降温幅度为5℃。
实施例2
一种口腔溃疡喷剂,其原料按重量份数如下:三黄中药15份,甘草2.5份、草楮实子2份、茺蔚子2份、芜菁子2份、苘麻子2份、大黄4份,甜菊素0.65份、枸橼酸0.15份,食用盐4份,大蒜膜6份,冰糖4份,蜂胶11.5份,芦荟7份,金银7.5份,薄荷7份,海带7.5份,冰硼散8份,西红柿10份,全脂奶粉7.5份和水175份,所述三黄中药黄芩、黄连和黄柏的混合物,混合比例为1:1:1,所述冰硼散为冰片和玄明粉的混合物,混合比例为3:1,所述全脂奶粉中蛋白质不低于24%,脂肪不低于26%,乳糖不低于37%。
本发明还提供一种口腔溃疡喷剂的制备方法,包括如下步骤:
S1:取料,将三黄中药、甘草、草楮实子、茺蔚子、芜菁子、苘麻子、大黄、甜菊素、枸橼酸、食用盐、大蒜膜、冰糖、蜂胶、芦荟、金银花、薄荷、海带、冰硼散、西红柿、全脂奶粉和水按重量份数称取,备用;
S2:炒料,将草楮实子、茺蔚子、芜菁子、苘麻子置入温度为75℃的旋转炒锅内恒温炒制17.5min,降温至60℃后,继续恒温炒制22.5min,取出,粉碎备用;
S3:烤料,将金银花和海带进行烘干干燥处理,烘干温度为75℃,干燥时间25min,使得金银花和海带的含水率低于3%,将获得的干燥金银花和海带研磨成粉,粉料粒度为90目;
S4:研磨粉碎,将三黄中药、甘草、大黄、大蒜膜、冰糖、芦荟、薄荷、冰硼散和西红柿均放入研磨机中研磨成粉,获得粉末混合物,研磨颗粒大小控制在90目,备用;
S5:发酵,将S2中炒制粉碎的原料,S3中烤制的粉碎的原料,S4中研磨成粉的原料和和二分之一的水均倒入发酵罐中进行先进行恒温发酵,发酵时间2.5h,再进行升温发酵,发酵时间1.5h,最后进行降温发酵,发酵时间1.5h;
S6:熬煮,将S5发酵完成的物料和剩余二分之一的水倒入煮锅中进行熬煮,并将甜菊素、枸橼酸和全脂奶粉倒入继续进行熬煮,边熬煮边搅拌,熬煮时间为75min,熬煮温度85℃;
S7:过滤,将S6中熬煮完成后的混合物料通过90目的滤布进行过滤,收集滤液,并自然冷却,即获得口腔溃疡喷剂原液;
S8:真空包装,将冷却完成后的口腔溃疡喷剂原液进行真空无菌灌装,灌装完成后置于阴凉处封存。
所述步骤S2、S3和S4中的研磨粉碎采用的是WF系列万能粉碎机,主轴转速在3500r/min,所述步骤S3中烘干方式采用的是CT-C型系列热风循环烘箱,进风温度75℃,所述步骤S5中发酵中恒温发酵温度在35℃,升温发酵温度上升幅度为7.5℃,降温发酵的降温幅度为7.5℃。
实施例3
一种口腔溃疡喷剂,其原料按重量份数如下:三黄中药20份,甘草3份、草楮实子3份、茺蔚子3份、芜菁子3份、苘麻子3份、大黄5份,甜菊素0.8份、枸橼酸0.2份,食用盐5份,大蒜膜7份,冰糖5份,蜂胶13份,芦荟8份,金银花10份,薄荷8份,海带10份,冰硼散9份,西红柿11份,全脂奶粉10份和水200份,所述三黄中药黄芩、黄连和黄柏的混合物,混合比例为1:1:1,所述冰硼散为冰片和玄明粉的混合物,混合比例为3:1,所述全脂奶粉中蛋白质不低于24%,脂肪不低于26%,乳糖不低于37%。
本发明还提供一种口腔溃疡喷剂的制备方法,包括如下步骤:
S1:取料,将三黄中药、甘草、草楮实子、茺蔚子、芜菁子、苘麻子、大黄、甜菊素、枸橼酸、食用盐、大蒜膜、冰糖、蜂胶、芦荟、金银花、薄荷、海带、冰硼散、西红柿、全脂奶粉和水按重量份数称取,备用;
S2:炒料,将草楮实子、茺蔚子、芜菁子、苘麻子置入温度为80℃的旋转炒锅内恒温炒制20min,降温至65℃后,继续恒温炒制25min,取出,粉碎备用;
S3:烤料,将金银花和海带进行烘干干燥处理,烘干温度为100℃,干燥时间30min,使得金银花和海带的含水率低于3%,将获得的干燥金银花和海带研磨成粉,粉料粒度为100目;
S4:研磨粉碎,将三黄中药、甘草、大黄、大蒜膜、冰糖、芦荟、薄荷、冰硼散和西红柿均放入研磨机中研磨成粉,获得粉末混合物,研磨颗粒大小控制在100目,备用;
S5:发酵,将S2中炒制粉碎的原料,S3中烤制的粉碎的原料,S4中研磨成粉的原料和和二分之一的水均倒入发酵罐中进行先进行恒温发酵,发酵时间3h,再进行升温发酵,发酵时间2h,最后进行降温发酵,发酵时间2h;
S6:熬煮,将S5发酵完成的物料和剩余二分之一的水倒入煮锅中进行熬煮,并将甜菊素、枸橼酸和全脂奶粉倒入继续进行熬煮,边熬煮边搅拌,熬煮时间为80min,熬煮温度90℃;
S7:过滤,将S6中熬煮完成后的混合物料通过100目的滤布进行过滤,收集滤液,并自然冷却,即获得口腔溃疡喷剂原液;
S8:真空包装,将冷却完成后的口腔溃疡喷剂原液进行真空无菌灌装,灌装完成后置于阴凉处封存。
所述步骤S2、S3和S4中的研磨粉碎采用的是WF系列万能粉碎机,主轴转速在4000r/min,所述步骤S3中烘干方式采用的是CT-C型系列热风循环烘箱,进风温度100℃,所述步骤S5中发酵中恒温发酵温度在40℃,升温发酵温度上升幅度为10℃,降温发酵的降温幅度为10℃。
本发明严格控制该口腔溃疡喷剂及其制备方法,通过严格控制口腔溃疡喷剂的各组份的占比以及制备工艺参数,通过三黄中药、甘草均为清热解读的中药原料,采用的冰硼散具有清热消肿、敛疮生肌的功效,冰糖和蜂胶润肤生肌,消炎止痛,促进细胞再生的功效,而且采用大蒜膜含有挥发油和大蒜素,可杀菌,能预防溃疡面感染,全脂奶粉中维生素B含量高,而且西红柿中含有大量B、C族维生素、胡萝卜素,以及钙、铁、锌、碘等微量元素,采用的口腔溃疡喷剂均为凉性原料,采用中药和食物相结合方式,对口腔溃疡治疗有很好的疗效,而且均为无毒害制剂原料,易于人体吸收,见效快,不易复发,适合广泛推广。
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。
Claims (8)
1.一种口腔溃疡喷剂,其特征在于:其原料按重量份数如下:三黄中药10-20份,甘草2-3份、草楮实子1-3份、茺蔚子1-3份、芜菁子1-3份、苘麻子1-3份、大黄3-5份,甜菊素0.5-0.8份、枸橼酸0.1-0.2份,食用盐3-5份,大蒜膜5-7份,冰糖3-5份,蜂胶10-13份,芦荟6-8份,金银花5-10份,薄荷6-8份,海带5-10份,冰硼散7-9份,西红柿9-11份,全脂奶粉5-10份和水150-200份。
2.根据权利要求1所述的一种口腔溃疡喷剂,其特征在于:所述三黄中药黄芩、黄连和黄柏的混合物,混合比例为1:1:1。
3.根据权利要求1所述的一种口腔溃疡喷剂,其特征在于:所述冰硼散为冰片和玄明粉的混合物,混合比例为3:1。
4.根据权利要求1所述的一种口腔溃疡喷剂,其特征在于:所述全脂奶粉中蛋白质不低于24%,脂肪不低于26%,乳糖不低于37%。
5.一种根据权利要求1所述的口腔溃疡喷剂的制备方法,其特征在于:包括如下步骤:
S1:取料,将三黄中药、甘草、草楮实子、茺蔚子、芜菁子、苘麻子、大黄、甜菊素、枸橼酸、食用盐、大蒜膜、冰糖、蜂胶、芦荟、金银花、薄荷、海带、冰硼散、西红柿、全脂奶粉和水按重量份数称取,备用;
S2:炒料,将草楮实子、茺蔚子、芜菁子、苘麻子置入温度为70-80℃的旋转炒锅内恒温炒制15-20min,降温至55-65℃后,继续恒温炒制20-25min,取出,粉碎备用;
S3:烤料,将金银花和海带进行烘干干燥处理,烘干温度为50-100℃,干燥时间20-30min,使得金银花和海带的含水率低于3%,将获得的干燥金银花和海带研磨成粉,粉料粒度为80-100目;
S4:研磨粉碎,将三黄中药、甘草、大黄、大蒜膜、冰糖、芦荟、薄荷、冰硼散和西红柿均放入研磨机中研磨成粉,获得粉末混合物,研磨颗粒大小控制在80-100目之间,备用;
S5:发酵,将S2中炒制粉碎的原料,S3中烤制的粉碎的原料,S4中研磨成粉的原料和和二分之一的水均倒入发酵罐中进行先进行恒温发酵,发酵时间2-3h,再进行升温发酵,发酵时间1-2h,最后进行降温发酵,发酵时间1-2h;
S6:熬煮,将S5发酵完成的物料和剩余二分之一的水倒入煮锅中进行熬煮,并将甜菊素、枸橼酸和全脂奶粉倒入继续进行熬煮,边熬煮边搅拌,熬煮时间为70-80min,熬煮温度80-90℃;
S7:过滤,将S6中熬煮完成后的混合物料通过80-100目的滤布进行过滤,收集滤液,并自然冷却,即获得口腔溃疡喷剂原液;
S8:真空包装,将冷却完成后的口腔溃疡喷剂原液进行真空无菌灌装,灌装完成后置于阴凉处封存。
6.根据权利要求5所述的一种口腔溃疡喷剂的制备方法,其特征在于:所述步骤S2、S3和S4中的研磨粉碎采用的是WF系列万能粉碎机,主轴转速在3000-4000r/min。
7.根据权利要求5所述的一种口腔溃疡喷剂的制备方法,其特征在于:所述步骤S3中烘干方式采用的是CT-C型系列热风循环烘箱,进风温度50-100℃。
8.根据权利要求5所述的一种口腔溃疡喷剂的制备方法,其特征在于:所述步骤S5中发酵中恒温发酵温度在30-40℃,升温发酵温度上升幅度为5-10℃,降温发酵的降温幅度为5-10℃。
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