CN108567944A - A kind of preparation method of the plant extract Chinese medicine composition of external curing eczema - Google Patents
A kind of preparation method of the plant extract Chinese medicine composition of external curing eczema Download PDFInfo
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses a kind of preparation method of the plant extract Chinese medicine composition of external curing eczema, raw material is by including：Glycerine, camellia seed oil, dormant oil, caprylic/capric triglyceride, two polysiloxanes, tocopherol acetate, cetostearyl alcohol, cuttle bone, fucose, cetearyl glucoside, moutan bark, bisabolol, pectin, Asian puccoon, alum, Radix stemonae japonicae, cloves bud, purslane, centella, sorrel root, menthol, methyl hydroxybenzoate, hexylene glycol, Chlorphenesin, Phenoxyethanol；Preparation method includes the following steps：Phase object mixing extraction, aqueous-phase material mixing extraction, oil phase mixing, water phase mixing, mixing and emulsifying, addition preservative, natural cooling obtain product.Small side effects and easy to use, using effect is more preferable.
Description
Technical field
The present invention relates to tcm fields, and in particular to a kind of system of the plant extract Chinese medicine composition of external curing eczema
Preparation Method.
Background technology
Eczema, i.e. atopic dermatitis (atopic dermatitis, AD), also known as atopic dermatitis, atopy skin
Inflammation is chronic one kind, recurrent, inflammatory dermatoses.It falls ill, and delays to children and adulthood more than infant period.With
Eczema sample fash, with violent itch, recurrent exerbation is clinical characters, often there is apparent " idiocrasy " in sufferer or family,
Seriously affect quality of life.Child with eczema originally rubefaction, occur fash, followed by skin send out rough, furfur, stroke child
The skin of son is as touching on sand paper.Heat, chance are wet can all to make eczema performance notable.
Prior art treatment eczema mostly uses greatly following two methods：
A, oneself buys Chinese medicine, decocts washout after Chinese medicine.This method can only be effective to slight eczema, the dose control of decocting herb,
The bad grasps such as duration and degree of heating control, and use will decoct once every time, it is fairly cumbersome.
B, it is smeared and is treated using hormone ointment.It is more convenient to smear hormone ointment, but frequent or a large amount of or prolonged application contains
The drug of cortin has the side effect of whole body and local skin, and the local skin side effect containing corticosteroid drug is relatively prominent
What is gone out is drug-dependent dermatitis and rebound dermatitis, may cause steroid dependent dermatitis, atrophoderma, relaxation, because of capillary
Blood vessel dilatation causes cheek to redden, pigmentation, skin susceptible, and crinosity or even generation system influence, and inhibits growth hair
It educates and the side effects such as immunity degradation.
Using the pan-fried external washout with traditional Chinese herbs of the prior art or the method for painting hormone ointment it is of course possible to use, or but decoct make
Though with inconvenient or convenient but frequently or a large amount of or drug of the prolonged application containing cortin, whole body and local skin are had
Side effect, the local skin side effect containing corticosteroid drug it is more prominent be drug-dependent dermatitis and rebound dermatitis, can
It can cause steroid dependent dermatitis, atrophoderma, relaxation, because telangiectasis causes cheek to redden, pigmentation, skin is easy
Infected, crinosity or even generation system influence, and inhibit the side effects such as growth and development and immunity degradation.
The drug of the treatment eczema of the prior art is either inconvenient for use or side effect is big, and using effect is ideal not enough.
Invention content
In order to overcome the deficiencies of the prior art, the present invention provides a kind of one kind without hormone constituted using pure natural components
The preparation method of the plant extract Chinese medicine composition of external curing eczema, Small side effects and easy to use, using effect is more preferable.
The present invention is technical solution used by reaching above-mentioned technical purpose：A kind of plant extract of external curing eczema
The preparation method of Chinese medicine composition, raw material include by weight：14-16 parts of glycerine, 7-9 parts of camellia seed oil, dormant oil 0.8-1.2
Part, 1.5-2.5 parts of caprylic/capric triglyceride, 1.5-2.5 parts of two polysiloxanes, 1.5-2.5 parts of tocopherol acetate, spermaceti
1.5-2.5 parts of stearyl alcohol, 2.5-3.5 parts of cuttle bone, 0.8-1.2 parts of fucose, 1-2 parts of cetearyl glucoside, moutan bark
0.5-1.5 parts, 0.2-0.5 parts of bisabolol, 0.1-0.3 parts of pectin, 8-9 parts of Asian puccoon, 8-9 parts of alum, 8-9 parts of Radix stemonae japonicae,
8-9 parts of cloves bud, 8-9 parts of purslane, 8-9 parts of centella, 8-9 parts of sorrel root, 0.08-0.12 parts of menthol, oxybenzene
0.15-0.25 parts of methyl esters, 0.1-0.15 parts of hexylene glycol, 0.1-0.15 parts of Chlorphenesin, 0.1-0.15 parts of Phenoxyethanol；It is prepared
Method includes the following steps：
Step A, oil phase thing mixing extraction：By the Asian puccoon of corresponding parts by weight, cloves bud, moutan bark, camellia seed oil, sweet
Oil, dormant oil are placed in container after mixing impregnates 24-30 hours, the liquid object in mixture are separated by filtration spare：
Step B, aqueous-phase material mixing extraction：By the cuttle bone of corresponding parts by weight, alum, centella, sorrel root, dent
Amaranth, Radix stemonae japonicae are placed in container, and the water of 20-30 parts by weight is added, and 40-50 DEG C of water temperature will mix after impregnating 36-48 hours
Liquid object in object is separated by filtration spare；
Step C, oil phase mixes：The liquid object filtered to isolate in above-mentioned steps A is added to octanoic acid/last of the ten Heavenly stems of corresponding parts by weight
It is heated to 75-85 DEG C after acid glycerol three ester, tocopherol acetate, cetostearyl alcohol, cetearyl glucoside mixing, when heating
Between 30-45 minutes, the oil mixture being uniformly mixing to obtain is spare；
Step D, water phase mixes：The liquid object filtered to isolate in above-mentioned steps B is added to the dimerization silicon of corresponding parts by weight
75-85 DEG C is heated to after oxygen alkane, fucose, bisabolol, pectin, menthol mixing, heating time 30-45 minute, stirring is equal
Even obtained aqueous mixture is spare；
Step E, mixing and emulsifying：The oil mixture obtained in above-mentioned steps C is mixed with the water phase obtained in above-mentioned steps D
Close object mixing and emulsifying obtain mixing and emulsifying object, by mixing and emulsifying object be cooled to 45-55 DEG C it is spare；
Step F, preservative is added：Corresponding weight will be added in the mixing and emulsifying object after cooling obtained in above-mentioned E steps
The methyl hydroxybenzoate, hexylene glycol, Chlorphenesin, Phenoxyethanol of part are mixed evenly rear natural cooling and obtain product.
The beneficial effects of the invention are as follows：Since the technology of the present invention can prepare the Chinese medicine group for providing and being made of pure natural components
Object is closed, and is the paste emulsion object without hormone.Therefore the present invention has the advantages that Small side effects and easy to use, using effect
More preferably.
Specific implementation mode
With reference to embodiment, the invention will be further described：
Embodiment 1, a kind of preparation method of the plant extract Chinese medicine composition of external curing eczema, raw material is by weight
Including：14 parts of glycerine, 7 parts of camellia seed oil, 0.8 part of dormant oil, 1.5 parts of caprylic/capric triglyceride, 1.5 parts of two polysiloxanes, life
Educate 1.5 parts of phenol acetic acid esters, 1.5 parts of cetostearyl alcohol, 2.5 parts of cuttle bone, 0.8 part of fucose, 1 part of cetearyl glucoside,
0.5 part of moutan bark, 0.2 part of bisabolol, 0.1 part of pectin, 8 parts of Asian puccoon, 8 parts of alum, 8 parts of Radix stemonae japonicae, 8 parts of cloves bud,
8 parts of purslane, 8 parts of centella, 8 parts of sorrel root, 0.08 part of menthol, 0.15 part of methyl hydroxybenzoate, 0.1 part of hexylene glycol, chlorine
0.1 part of the sweet ether of benzene, 0.1 part of Phenoxyethanol；Preparation method includes the following steps：
Step A, oil phase thing mixing extraction：By the Asian puccoon of corresponding parts by weight, cloves bud, moutan bark, camellia seed oil, sweet
Oil, dormant oil are placed in container after mixing impregnates 24 hours, the liquid object in mixture are separated by filtration spare；
Step B, aqueous-phase material mixing extraction：By the cuttle bone of corresponding parts by weight, alum, centella, sorrel root, dent
Amaranth, Radix stemonae japonicae are placed in container, and the water of 20 parts by weight, 40 DEG C of water temperature, after impregnating 36 hours, by the liquid in mixture is added
Object is separated by filtration spare；
Step C, oil phase mixes：The liquid object filtered to isolate in above-mentioned steps A is added to octanoic acid/last of the ten Heavenly stems of corresponding parts by weight
75 DEG C are heated to after acid glycerol three ester, tocopherol acetate, cetostearyl alcohol, cetearyl glucoside mixing, heating time
30 minutes, the oil mixture being uniformly mixing to obtain was spare；
Step D, water phase mixes：The liquid object filtered to isolate in above-mentioned steps B is added to the dimerization silicon of corresponding parts by weight
75 DEG C are heated to after oxygen alkane, fucose, bisabolol, pectin, menthol mixing, 30 minutes heating times, is uniformly mixing to obtain
Aqueous mixture it is spare；
Step E, mixing and emulsifying：The oil mixture obtained in above-mentioned steps C is mixed with the water phase obtained in above-mentioned steps D
Close object mixing and emulsifying obtain mixing and emulsifying object, by mixing and emulsifying object be cooled to 45 DEG C it is spare；
Step F, preservative is added：Corresponding weight will be added in the mixing and emulsifying object after cooling obtained in above-mentioned E steps
The methyl hydroxybenzoate, hexylene glycol, Chlorphenesin, Phenoxyethanol of part are mixed evenly rear natural cooling and obtain product.
Embodiment 2, a kind of preparation method of the plant extract Chinese medicine composition of external curing eczema, raw material is by weight
Including：16 parts of glycerine, 9 parts of camellia seed oil, 1.2 parts of dormant oil, 2.5 parts of caprylic/capric triglyceride, 2.5 parts of two polysiloxanes, life
Educate 2.5 parts of phenol acetic acid esters, 2.5 parts of cetostearyl alcohol, 3.5 parts of cuttle bone, 1.2 parts of fucose, 2 parts of cetearyl glucoside,
1.5 parts of moutan bark, 0.5 part of bisabolol, 0.3 part of pectin, 9 parts of Asian puccoon, 9 parts of alum, 9 parts of Radix stemonae japonicae, 9 parts of cloves bud,
9 parts of purslane, 9 parts of centella, 9 parts of sorrel root, 0.12 part of menthol, 0.25 part of methyl hydroxybenzoate, 0.15 part of hexylene glycol, chlorine
0.15 part of the sweet ether of benzene, 0.15 part of Phenoxyethanol；Preparation method includes the following steps：
Step A, oil phase thing mixing extraction：By the Asian puccoon of corresponding parts by weight, cloves bud, moutan bark, camellia seed oil, sweet
Oil, dormant oil are placed in container after mixing impregnates 30 hours, the liquid object in mixture are separated by filtration spare；
Step B, aqueous-phase material mixing extraction：By the cuttle bone of corresponding parts by weight, alum, centella, sorrel root, dent
Amaranth, Radix stemonae japonicae are placed in container, and the water of 30 parts by weight, 50 DEG C of water temperature, after impregnating 48 hours, by the liquid in mixture is added
Object is separated by filtration spare；
Step C, oil phase mixes：The liquid object filtered to isolate in above-mentioned steps A is added to octanoic acid/last of the ten Heavenly stems of corresponding parts by weight
85 DEG C are heated to after acid glycerol three ester, tocopherol acetate, cetostearyl alcohol, cetearyl glucoside mixing, heating time
45 minutes, the oil mixture being uniformly mixing to obtain was spare；
Step D, water phase mixes：The liquid object filtered to isolate in above-mentioned steps B is added to the dimerization silicon of corresponding parts by weight
85 DEG C are heated to after oxygen alkane, fucose, bisabolol, pectin, menthol mixing, 45 minutes heating times, is uniformly mixing to obtain
Aqueous mixture it is spare；
Step E, mixing and emulsifying：The oil mixture obtained in above-mentioned steps C is mixed with the water phase obtained in above-mentioned steps D
Close object mixing and emulsifying obtain mixing and emulsifying object, by mixing and emulsifying object be cooled to 55 DEG C it is spare；
Step F, preservative is added：Corresponding weight will be added in the mixing and emulsifying object after cooling obtained in above-mentioned E steps
The methyl hydroxybenzoate, hexylene glycol, Chlorphenesin, Phenoxyethanol of part are mixed evenly rear natural cooling and obtain product.
Embodiment 3, a kind of preparation method of the plant extract Chinese medicine composition of external curing eczema, raw material is by weight
Including：15 parts of glycerine, 8 parts of camellia seed oil, 1 part of dormant oil, 2 parts of caprylic/capric triglyceride, 2 parts of two polysiloxanes, tocopherol second
It is 2 parts of acid esters, 2 parts of cetostearyl alcohol, 3 parts of cuttle bone, 1 part of fucose, 1.5 parts of cetearyl glucoside, 1 part of moutan bark, red
0.35 part of bisabol, 0.2 part of pectin, 8.5 parts of Asian puccoon, 8.5 parts of alum, 8.5 parts of Radix stemonae japonicae, 8.5 parts of cloves bud, purslane
8.5 parts, 8.5 parts of centella, 8.5 parts of sorrel root, 0.1 part of menthol, 0.2 part of methyl hydroxybenzoate, 0.12 part of hexylene glycol, chlorobenzene
0.13 part of sweet ether, 0.12 part of Phenoxyethanol；Preparation method includes the following steps：
Step A, oil phase thing mixing extraction：By the Asian puccoon of corresponding parts by weight, cloves bud, moutan bark, camellia seed oil, sweet
Oil, dormant oil are placed in container after mixing impregnates 27 hours, the liquid object in mixture are separated by filtration spare；
Step B, aqueous-phase material mixing extraction：By the cuttle bone of corresponding parts by weight, alum, centella, sorrel root, dent
Amaranth, Radix stemonae japonicae are placed in container, and the water of 25 parts by weight, 45 DEG C of water temperature, after impregnating 42 hours, by the liquid in mixture is added
Object is separated by filtration spare；
Step C, oil phase mixes：The liquid object filtered to isolate in above-mentioned steps A is added to octanoic acid/last of the ten Heavenly stems of corresponding parts by weight
80 DEG C are heated to after acid glycerol three ester, tocopherol acetate, cetostearyl alcohol, cetearyl glucoside mixing, heating time
38 minutes, the oil mixture being uniformly mixing to obtain was spare；
Step D, water phase mixes：The liquid object filtered to isolate in above-mentioned steps B is added to the dimerization silicon of corresponding parts by weight
80 DEG C are heated to after oxygen alkane, fucose, bisabolol, pectin, menthol mixing, 37 minutes heating times, is uniformly mixing to obtain
Aqueous mixture it is spare；
Step E, mixing and emulsifying：The oil mixture obtained in above-mentioned steps C is mixed with the water phase obtained in above-mentioned steps D
Close object mixing and emulsifying obtain mixing and emulsifying object, by mixing and emulsifying object be cooled to 50 DEG C it is spare；
Step F, preservative is added：Corresponding weight will be added in the mixing and emulsifying object after cooling obtained in above-mentioned E steps
The methyl hydroxybenzoate, hexylene glycol, Chlorphenesin, Phenoxyethanol of part are mixed evenly rear natural cooling and obtain product.
To further description of the present invention：Product of the present invention is all made of food grade materials, using plurality of Chinese
The problems such as extract component, mild safe good effect, there is no toxic side effect and product dependences.Camellia oil in formula is using wound
New process extracts, and remains the active ingredient to skin in camellia oil to greatest extent；Traditional Chinese medicine ingredients in formula, according to this formula
In required drug effect, different modes extraction is respectively adopted, with the maximum active ingredient retained in Chinese medicine.Asian puccoon, cloves, moutan bark are adopted
With camellia oil extraction, traditional water or solvent extraction are abandoned, can both extract wherein oily molten part has eczema
Ingredient-Acetylshikonin, beta-hydroxyisovalerylshiderivative, alkannin, the β of effect, beta-dimethyl acryloyl alkannin, eugenol,
Aceteugenol, paeonol, paeonoside, paeonol original glycosides etc. in turn avoid bringing into its in other dissolvent residuals and formula
His impurity；Alum, cuttle bone, Radix stemonae japonicae, purslane, centella, sorrel etc. use low-pressure low-temperature aqueous extraction method, avoid
High temperature active ingredient therein.Inventive formulation is formulated using oil-in-water (O/W), camellia oil and Asian puccoon, cloves, moutan bark
Extract, which has skin, moistens heat preservation and film-formation result, and moist protective film is formed in skin surface, is conducive to that eczema skin is isolated
Eczema skin is acted on the contact of environmental stimuli ingredient, conducive to effective component of chinese medicine；Water phase in formula all using alum,
The water extraction component of cuttle bone, Radix stemonae japonicae, purslane, centella, sorrel etc. ensure that the Chinese medicine being entirely formulated contains
Amount.
For the cause of childhood eczema, by the effect of camellia oil and Chinese medical extract, isolation eczema skin is pierced with extraneous
Swash the invasion of environment, anti-inflammation and sterilization, soothe the skin itch, decline red swelling of the skin, calms down pachylosis, improves the desquamation of skin；It is wet
The pH value of rash skin is disorderly, pectin can balance skin pH value, so that skin is maintained healthy normal ph range.To reach removal
Eczema, smooth skin, safeguard the effect of skin health.
Oil-soluble, water-soluble effective component of chinese medicine are fused together to form a cream by emulsifying technology.
Claims (1)
1. a kind of preparation method of the plant extract Chinese medicine composition of external curing eczema, which is characterized in that its raw material is by weight
Part include：14-16 parts of glycerine, 7-9 parts of camellia seed oil, 0.8-1.2 parts of dormant oil, 1.5-2.5 parts of caprylic/capric triglyceride, two
1.5-2.5 parts of polysiloxanes, 1.5-2.5 parts of tocopherol acetate, 1.5-2.5 parts of cetostearyl alcohol, 2.5-3.5 parts of cuttle bone,
0.8-1.2 parts of fucose, 1-2 parts of cetearyl glucoside, 0.5-1.5 parts of moutan bark, 0.2-0.5 parts of bisabolol, pectin
0.1-0.3 parts, 8-9 parts of Asian puccoon, 8-9 parts of alum, 8-9 parts of Radix stemonae japonicae, 8-9 parts of cloves bud, 8-9 parts of purslane, centella
8-9 parts, 8-9 parts of sorrel root, 0.08-0.12 parts of menthol, 0.15-0.25 parts of methyl hydroxybenzoate, 0.1-0.15 parts of hexylene glycol,
0.1-0.15 parts of Chlorphenesin, 0.1-0.15 parts of Phenoxyethanol；Preparation method includes the following steps：
Step A, oil phase thing mixing extraction：By the Asian puccoon of corresponding parts by weight, cloves bud, moutan bark, camellia seed oil, glycerine, mine
Oil is placed in container after mixing impregnates 24-30 hours, the liquid object in mixture is separated by filtration spare；
Step B, aqueous-phase material mixing extraction：By the cuttle bone of corresponding parts by weight, alum, centella, sorrel root, purslane,
Radix stemonae japonicae is placed in container, and the water of 20-30 parts by weight is added, and 40-50 DEG C of water temperature will be in mixture after impregnating 36-48 hours
Liquid object be separated by filtration it is spare；
Step C, oil phase mixes：The caprylic/capric that the liquid object filtered to isolate in above-mentioned steps A is added to corresponding parts by weight is sweet
It is heated to 75-85 DEG C after oily three esters, tocopherol acetate, cetostearyl alcohol, cetearyl glucoside mixing, heating time
30-45 minutes, the oil mixture being uniformly mixing to obtain was spare；
Step D, water phase mixes：By the liquid object filtered to isolate in above-mentioned steps B be added corresponding parts by weight two polysiloxanes,
It is heated to 75-85 DEG C after fucose, bisabolol, pectin, menthol mixing, heating time 30-45 minute, is uniformly mixing to obtain
Aqueous mixture it is spare；
Step E, mixing and emulsifying：The aqueous mixture that will be obtained in the oil mixture obtained in above-mentioned steps C and above-mentioned steps D
Mixing and emulsifying obtains mixing and emulsifying object, by mixing and emulsifying object be cooled to 45-55 DEG C it is spare；
Step F, preservative is added：Corresponding parts by weight will be added in the mixing and emulsifying object after cooling obtained in above-mentioned E steps
Methyl hydroxybenzoate, hexylene glycol, Chlorphenesin, Phenoxyethanol are mixed evenly rear natural cooling and obtain product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114129479A (en) * | 2021-12-03 | 2022-03-04 | 沃淄(上海)生物科技有限公司 | Composition for effectively and rapidly relieving infant dry eczema and preparation method and application thereof |
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|---|---|---|---|---|
| CN1299652A (en) * | 2000-04-28 | 2001-06-20 | 四川省亿晖贸易发展有限公司 | External-use lotion and its preparation |
| CN105640793A (en) * | 2016-01-21 | 2016-06-08 | 北京斯利安药业有限公司 | Composition for preparing skin cream, skin cream prepared from composition and preparing method of skin cream |
| CN107951771A (en) * | 2017-12-14 | 2018-04-24 | 广东添乐化妆品有限公司 | A kind of baby child releives moisturizing skin care creams and preparation method thereof |
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2018
- 2018-07-13 CN CN201810769258.6A patent/CN108567944A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299652A (en) * | 2000-04-28 | 2001-06-20 | 四川省亿晖贸易发展有限公司 | External-use lotion and its preparation |
| CN105640793A (en) * | 2016-01-21 | 2016-06-08 | 北京斯利安药业有限公司 | Composition for preparing skin cream, skin cream prepared from composition and preparing method of skin cream |
| CN107951771A (en) * | 2017-12-14 | 2018-04-24 | 广东添乐化妆品有限公司 | A kind of baby child releives moisturizing skin care creams and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114129479A (en) * | 2021-12-03 | 2022-03-04 | 沃淄(上海)生物科技有限公司 | Composition for effectively and rapidly relieving infant dry eczema and preparation method and application thereof |
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