CN105535261A - Folium artemisiae argyi health-care essential oil and preparation method thereof - Google Patents
Folium artemisiae argyi health-care essential oil and preparation method thereof Download PDFInfo
- Publication number
- CN105535261A CN105535261A CN201511007932.XA CN201511007932A CN105535261A CN 105535261 A CN105535261 A CN 105535261A CN 201511007932 A CN201511007932 A CN 201511007932A CN 105535261 A CN105535261 A CN 105535261A
- Authority
- CN
- China
- Prior art keywords
- folium artemisiae
- artemisiae argyi
- oil
- essential oil
- cymene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
Abstract
The invention belongs to the technical field of essential oil and particularly discloses folium artemisiae argyi health-care essential oil and a preparation method thereof. The folium artemisiae argyi health-care essential oil comprises the following raw materials in parts by weight: 0.5-2 parts of folium artemisiae argyi essential oil, 54-60 parts of camellia oil, 30-36 parts of jojoba oil, 10-18 parts of avocado oil and 1-3 parts of vitamin E. The folium artemisiae argyi health-care essential oil has the effects of eliminating swelling and stopping pain, can be directly smeared at the affected part to achieve the purposes of diminishing inflammation and eliminating swelling, can also relieve intractable pain, toothache, muscular strain and the like, and is simple in formula and preparation method, stable in system and long in shelf life.
Description
Technical field
The invention belongs to quintessence oil technical field, be specifically related to a kind of Folium Artemisiae Argyi health care essential oil and preparation method thereof.
Background technology
Quintessence oil is from the flower of plant, leaf, stem, root or fruit, is refined the volatile flavor of extraction, primarily of chemical molecular compositions such as terpenes, aldehydes, esters, alcohols by steam distillation, squeezing and pressing method, cold-maceration or solvent extraction method.Quintessence oil has lipotropy, be easy to be dissolved in oils and fats, because the strand of quintessence oil is usually shorter, this makes them very easily permeate in skin, and enters in body by blood capillary abundant under subcutaneous fat, and acts on health and participate in the object that blood circulation to whole body reaches treatment health preserving, the fragrance energy endocrine regulation organ of quintessence oil simultaneously, promote hormone secretion etc., function in balanced body, plays the effect of beauty and skin care.The chemical constitution that has each plants essential oil decides the mode of its fragrance, color, mobility and it and System Operation, also makes each plants essential oil respectively have a set of special function speciality.
Quintessence oil divides folk prescription quintessence oil and compound essential Oil.Folk prescription quintessence oil is from the whole strain of a kind of plant or some positions purification by liquid extraction and the essential ingredient obtained, generally there is this comparatively strong plant scent, and there is specific effect and characteristics of personality, but folk prescription quintessence oil very high purity, just can be used on skin after needing fully dilution.Folk prescription quintessence oil of more than two kinds and base oil proportionally mix to reach specific therapeutical by compound oil exactly, are mutually to coordinate between quintessence oil and quintessence oil, and some also has the effect of complementing each other, heightening the effect of a treatment each other.
Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort ArtemisiaargyiLevl.etVant..The effects such as modern experimental research proves, Folium Artemisiae Argyi has antibacterial, antiviral, relievings asthma, antitussive and eliminating the phlegm, hemostasis and anticoagulation, calm and antiallergic.There is face cream gland in Folium Artemisiae Argyi, can P-Cymene be refined.Chinese patent CN103540404B discloses a kind of Compound Chinese mugwort essential oil, it contains Artemisia argyi Levl. et Van. var. argyi cv. Qiai quintessence oil, cinnamon essential oil, clove oil and Archangelica officinalis Hoffmann quintessence oil, and the base oil to be made up of Semen pruni armeniacae oil, Semen Tritici aestivi germ oil, Oleum Vitis viniferae, Rosehips oil, Fructus Pruni peach kernel oil and olive oil, it effectively nurses one's health health, improves immunity, play and prevent disease, the effect of health of body, but its formula is complicated, and cost is high, system is unstable, is unfavorable for applying.Therefore, be necessary to research and develop a kind of cost low, have the health-care effects such as good antiinflammatory, detumescence, fatigue alleviating and stable system, the Folium Artemisiae Argyi health care essential oil of long shelf-life.
Summary of the invention
In order to overcome the deficiencies in the prior art, the invention discloses a kind of Folium Artemisiae Argyi health care essential oil, it has the effect of detumescence, pain relieving, directly can be applied in the object that affected part can reach anti-inflammation detumescence, pain relieving, also intractable pain can be alleviated, the pain such as toothache, muscular strain, and its formula is simple, stable system, long shelf-life.
To achieve these goals, technical scheme of the present invention is as follows:
A kind of Folium Artemisiae Argyi health care essential oil, comprises the raw material of following weight portion: P-Cymene 0.5 ~ 2 part, Camellia oil 54 ~ 60 parts, Jojoba oil 30 ~ 36 parts, Avocado Oil 10 ~ 18 parts and vitamin e1 ~ 3 part.
Preferably, described Folium Artemisiae Argyi health care essential oil comprises the raw material of following weight portion: P-Cymene 1 part, Camellia oil 58 parts, Jojoba oil 34 parts, Avocado Oil 12 parts and vitamin E2 part.
Further, in order to improve effect and the stability of Folium Artemisiae Argyi health care essential oil system of the present invention, described Folium Artemisiae Argyi health care essential oil also comprises magnolol 0.05 ~ 0.2 weight portion.
As the preferred embodiment of the present invention, described Folium Artemisiae Argyi health care essential oil is made up of the raw material of following weight portion: P-Cymene 1 part, Camellia oil 58 parts, Jojoba oil 34 parts, Avocado Oil 12 parts, vitamin E2 part honokiol 0.1 part.
Wherein, P-Cymene of the present invention is obtained by following methods:
The preparation of A1, Folium Artemisiae Argyi extractum: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 20 ~ 25MPa, pressing down is 22 ~ 27MPa, temperature is 45 ~ 52 DEG C, and the pressure of setting extraction-container is 4 ~ 6MPa, and temperature is 55 ~ 65 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2 ~ 3%, obtain Folium Artemisiae Argyi extractum;
The preparation of A2, P-Cymene: setting jacket temperature is 65 ~ 75 DEG C, charging rate is 125 ~ 135ML/H, evaporation layer temperature is 65 ~ 75 DEG C, condensate layer temperature is 35 ~ 45 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 65 ~ 75 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene.
In addition, present invention also offers the preparation method of described Folium Artemisiae Argyi health care essential oil, specifically comprise the following steps:
S1, supercritical carbon dioxide extraction technology extract Folium Artemisiae Argyi extractum from Folium Artemisiae Argyi: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 20 ~ 25MPa, pressing down is 22 ~ 27MPa, temperature is 45 ~ 52 DEG C, and the pressure of setting extraction-container is 4 ~ 6MPa, and temperature is 55 ~ 65 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2 ~ 3%, obtain Folium Artemisiae Argyi extractum;
S2, molecularly distilled extract P-Cymene from Folium Artemisiae Argyi extractum: setting jacket temperature is 65 ~ 75 DEG C, charging rate is 125 ~ 135ML/H, evaporation layer temperature is 65 ~ 75 DEG C, condensate layer temperature is 35 ~ 45 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 65 ~ 75 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene;
S3, described P-Cymene to be mixed homogeneously with Camellia oil, Jojoba oil and Avocado Oil, then add vitamin E, stir and obtain Folium Artemisiae Argyi health care essential oil.
Wherein, adding of magnolol is also comprised in step S3; More specifically, while adding vitamin E, magnolol is added.
In Folium Artemisiae Argyi health care essential oil of the present invention, described P-Cymene is refined by supercritical carbon dioxide extraction technology and molecularly distilled and obtains from Folium Artemisiae Argyi, mix with the base oil formed with a certain proportion of Camellia oil, Jojoba oil and Avocado Oil, mutual coordination, having each other complements each other reaches the effect of detumescence, pain relieving; But the composition of composite essential oil is various and complicated, time composite, easily occur the phenomenon such as layering, precipitation, but each component of Folium Artemisiae Argyi health care essential oil of the present invention is coordinated, and does not occur the phenomenon such as layering, precipitation; Add vitamin E simultaneously, not only further improve the action effect of quintessence oil, also play antioxidative effect, make quintessence oil system more stable, not perishable; Combine the magnolol (No. CAS: 528-43-8) of trace again, work in coordination with vitamin E, P-Cymene, play the effect of antiseptic, extend the quintessence oil shelf-life.
Therefore, compared with prior art, advantage of the present invention is:
(1) the invention provides a kind of new Folium Artemisiae Argyi health care essential oil, its fragrant odour is charming, not only have pleasure, the effect of pressure of releiving, also there is the health-care effect of detumescence, pain relieving, directly can be applied in the object that affected part can reach anti-inflammation detumescence, pain relieving, also by massaging to alleviate intractable pain after painting quintessence oil of the present invention, as cervical spondylosis, rheumatism etc., can also there is certain effect of releiving to toothache, muscular strain simultaneously.
(2) the natural safety of Folium Artemisiae Argyi health care essential oil of the present invention, not containing antiseptic, each component is worked in coordination with, stable system, long shelf-life;
(3) Folium Artemisiae Argyi health care essential oil formula of the present invention is simple, and cost of manufacture is low, and preparation method is simple and easy, and condition is controlled, can suitability for industrialized production, has good application prospect.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, Folium Artemisiae Argyi health care essential oil of the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
Embodiment 1, Folium Artemisiae Argyi health care essential oil of the present invention and preparation thereof
Formula: P-Cymene 1kg, Camellia oil 58kg, Jojoba oil 34kg, Avocado Oil 12kg and vitamin E2 kg.
Wherein, described P-Cymene is obtained by following methods:
The preparation of A1, Folium Artemisiae Argyi extractum: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 25MPa, press down as 27MPa, temperature is 48 DEG C, and the pressure of setting extraction-container is 5MPa, and temperature is 60 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2.5%, obtain Folium Artemisiae Argyi extractum;
The preparation of A2, P-Cymene: setting jacket temperature is 70 DEG C, charging rate is 130ML/H, evaporation layer temperature is 70 DEG C, condensate layer temperature is 40 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 70 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene.
Preparation method:
S1, supercritical carbon dioxide extraction technology extract Folium Artemisiae Argyi extractum from Folium Artemisiae Argyi: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 25MPa, press down as 27MPa, temperature is 48 DEG C, and the pressure of setting extraction-container is 5MPa, and temperature is 60 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2.5%, obtain Folium Artemisiae Argyi extractum;
S2, molecularly distilled extract P-Cymene from Folium Artemisiae Argyi extractum: setting jacket temperature is 70 DEG C, charging rate is 130ML/H, evaporation layer temperature is 70 DEG C, condensate layer temperature is 40 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 70 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene;
S3, described P-Cymene to be mixed homogeneously with Camellia oil, Jojoba oil and Avocado Oil, then add vitamin E, stir and obtain Folium Artemisiae Argyi health care essential oil.
Embodiment 2, Folium Artemisiae Argyi health care essential oil of the present invention and preparation thereof
Formula: P-Cymene 0.5kg, Camellia oil 54kg, Jojoba oil 30kg, Avocado Oil 10kg and vitamin e1 kg.
Wherein, described P-Cymene is obtained by following methods:
The preparation of A1, Folium Artemisiae Argyi extractum: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 20MPa, press down as 22MPa, temperature is 52 DEG C, and the pressure of setting extraction-container is 6MPa, and temperature is 65 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2%, obtain Folium Artemisiae Argyi extractum;
The preparation of A2, P-Cymene: setting jacket temperature is 65 DEG C, charging rate is 125ML/H, evaporation layer temperature is 65 DEG C, condensate layer temperature is 35 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 65 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene.
Preparation method:
S1, supercritical carbon dioxide extraction technology extract Folium Artemisiae Argyi extractum from Folium Artemisiae Argyi: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 20MPa, press down as 22MPa, temperature is 52 DEG C, and the pressure of setting extraction-container is 6MPa, and temperature is 65 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2%, obtain Folium Artemisiae Argyi extractum;
S2, molecularly distilled extract P-Cymene from Folium Artemisiae Argyi extractum: setting jacket temperature is 65 DEG C, charging rate is 125ML/H, evaporation layer temperature is 65 DEG C, condensate layer temperature is 35 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 65 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene;
S3, described P-Cymene to be mixed homogeneously with Camellia oil, Jojoba oil and Avocado Oil, then add vitamin E, stir and obtain Folium Artemisiae Argyi health care essential oil.
Embodiment 3, Folium Artemisiae Argyi health care essential oil of the present invention and preparation thereof
Formula: P-Cymene 2kg, Camellia oil 60kg, Jojoba oil 36kg, Avocado Oil 18kg and vitamin E 3kg.
Wherein, described P-Cymene is obtained by following methods:
The preparation of A1, Folium Artemisiae Argyi extractum: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 25MPa, press down as 27MPa, temperature is 45 DEG C, and the pressure of setting extraction-container is 4MPa, and temperature is 55 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 3%, obtain Folium Artemisiae Argyi extractum;
The preparation of A2, P-Cymene: setting jacket temperature is 75 DEG C, charging rate is 135ML/H, evaporation layer temperature is 75 DEG C, condensate layer temperature is 45 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 75 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene.
Preparation method:
S1, supercritical carbon dioxide extraction technology extract Folium Artemisiae Argyi extractum from Folium Artemisiae Argyi: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 25MPa, press down as 27MPa, temperature is 45 DEG C, and the pressure of setting extraction-container is 4MPa, and temperature is 55 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 3%, obtain Folium Artemisiae Argyi extractum;
S2, molecularly distilled extract P-Cymene from Folium Artemisiae Argyi extractum: setting jacket temperature is 75 DEG C, charging rate is 135ML/H, evaporation layer temperature is 75 DEG C, condensate layer temperature is 45 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 75 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene;
S3, described P-Cymene to be mixed homogeneously with Camellia oil, Jojoba oil and Avocado Oil, then add vitamin E, stir and obtain Folium Artemisiae Argyi health care essential oil.
Embodiment 4, Folium Artemisiae Argyi health care essential oil of the present invention and preparation thereof
Formula: P-Cymene 1kg, Camellia oil 58kg, Jojoba oil 34kg, Avocado Oil 12kg, vitamin E2 kg honokiol 0.1kg.
Wherein, described P-Cymene is obtained by following methods:
The preparation of A1, Folium Artemisiae Argyi extractum: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 25MPa, press down as 27MPa, temperature is 48 DEG C, and the pressure of setting extraction-container is 5MPa, and temperature is 60 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2.5%, obtain Folium Artemisiae Argyi extractum;
The preparation of A2, P-Cymene: setting jacket temperature is 70 DEG C, charging rate is 130ML/H, evaporation layer temperature is 70 DEG C, condensate layer temperature is 40 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 70 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene.
Preparation method:
S1, supercritical carbon dioxide extraction technology extract Folium Artemisiae Argyi extractum from Folium Artemisiae Argyi: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 25MPa, press down as 27MPa, temperature is 48 DEG C, and the pressure of setting extraction-container is 5MPa, and temperature is 60 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2.5%, obtain Folium Artemisiae Argyi extractum;
S2, molecularly distilled extract P-Cymene from Folium Artemisiae Argyi extractum: setting jacket temperature is 70 DEG C, charging rate is 130ML/H, evaporation layer temperature is 70 DEG C, condensate layer temperature is 40 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 70 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene;
S3, described P-Cymene to be mixed homogeneously with Camellia oil, Jojoba oil and Avocado Oil, then add vitamin E honokiol, stir and obtain Folium Artemisiae Argyi health care essential oil.
Embodiment 5, Folium Artemisiae Argyi health care essential oil of the present invention and preparation thereof
Formula: P-Cymene 1kg, Camellia oil 58kg, Jojoba oil 34kg, Avocado Oil 12kg, vitamin E2 kg honokiol 0.05kg.
The preparation method of described P-Cymene and the present embodiment Folium Artemisiae Argyi health care essential oil is with embodiment 4.
Embodiment 6, Folium Artemisiae Argyi health care essential oil of the present invention and preparation thereof
Formula: P-Cymene 1kg, Camellia oil 58kg, Jojoba oil 34kg, Avocado Oil 12kg, vitamin E2 kg honokiol 0.2kg.
The preparation method of described P-Cymene and the present embodiment Folium Artemisiae Argyi health care essential oil is with embodiment 4.
Comparative example 1 ~ 4
Comparative example 1 P-Cymene is obtained by following methods:
The preparation of A1, Folium Artemisiae Argyi extractum: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 18MPa, press down as 20MPa, temperature is 56 DEG C, and the pressure of setting extraction-container is 5MPa, and temperature is 65 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2.5%, obtain Folium Artemisiae Argyi extractum;
The preparation of A2, P-Cymene: setting jacket temperature is 60 DEG C, charging rate is 130ML/H, evaporation layer temperature is 60 DEG C, condensate layer temperature is 30 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 60 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene.
Comparative example 1 preparation method:
S1, supercritical carbon dioxide extraction technology extract Folium Artemisiae Argyi extractum from Folium Artemisiae Argyi: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 18MPa, press down as 20MPa, temperature is 56 DEG C, and the pressure of setting extraction-container is 5MPa, and temperature is 65 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2.5%, obtain Folium Artemisiae Argyi extractum;
S2, molecularly distilled extract P-Cymene from Folium Artemisiae Argyi extractum: setting jacket temperature is 60 DEG C, charging rate is 130ML/H, evaporation layer temperature is 60 DEG C, condensate layer temperature is 30 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 60 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene;
S3, described P-Cymene to be mixed homogeneously with Camellia oil, Jojoba oil and Avocado Oil, then add vitamin E honokiol, stir and obtain Folium Artemisiae Argyi health care essential oil.
The preparation method reference example 4 of comparative example 2 ~ 4 P-Cymene and Folium Artemisiae Argyi health care essential oil.
The detumescence effect of test example one, Folium Artemisiae Argyi health care essential oil of the present invention
One, materials and methods
1, animal: SD healthy rat 54, body weight 150 ± 30g, male and female half and half.
2, tested material: the quintessence oil made according to formula and the method for the embodiment of the present invention 1 ~ 4, comparative example 1 ~ 4.
3, animal grouping: animal is divided into 9 groups at random, often organize 6:
Matched group: normal saline 0.05ml/ only;
Quintessence oil 1 group: the quintessence oil 0.05ml/ that embodiment 1 obtains only;
Quintessence oil 2 groups: the quintessence oil 0.05ml/ that embodiment 2 obtains only;
Quintessence oil 3 groups: the quintessence oil 0.05ml/ that embodiment 3 obtains only;
Quintessence oil 4 groups: the quintessence oil 0.05ml/ that embodiment 4 obtains only;
Contrast 1 group: the quintessence oil 0.05ml/ that comparative example 1 obtains only;
Contrast 2 groups: the quintessence oil 0.05ml/ that comparative example 2 obtains only;
Contrast 3 groups: the quintessence oil 0.05ml/ that comparative example 3 obtains only;
Contrast 4 groups: the quintessence oil 0.05ml/ that comparative example 4 obtains only.
4, experimental technique: each Mus marking pen performs labelling at right ankle joint, and measure the Zhou Jing in right ankle joint with special tape measure.Then often organize rat and be coated with above-mentioned quintessence oil 3 times respectively, interval 30min by table 1 in the right sufficient sole of the foot of each Mus.30min after last coating, with Fresh 10% Ovum Gallus domesticus album physiological salt liquid 0.1ml/ only, to be injected to ankle joint surrounding subcutaneous by right back ball portion and cause inflammation, cause scorching after 0.5,1,2,3h measures right ankle and foot Zhou Jing respectively, each survey finish after, repaste quintessence oil once.Calculate swelling.The results are shown in Table 1.
Two, result
The each quintessence oil of table 1 causes the impact (X ± SD) of foot swelling to rat Ovum Gallus domesticus album
Compared with matched group, * P < 0.05, * * P < 0.01.
From upper table 1:
(1) Folium Artemisiae Argyi health care essential oil of the present invention causes rat paw edema to Ovum Gallus domesticus album, after causing inflammation, 0.5h, 1h, 2h, 3h have certain inhibitory action, compared with matched group, quintessence oil 1 ~ 4 group all has significant difference (P < 0.05 or P < 0.01), wherein the fastest with the onset of embodiment 1 and embodiment 4 quintessence oil, detumescence effect is the most obvious.
(2) compared with embodiment 1 ~ 4, the detumescence effect of comparative example 1 ~ 4 quintessence oil is poor, illustrates that the change of P-Cymene preparation method and the change of Folium Artemisiae Argyi health care essential oil formula of the present invention all can have an impact to effect of quintessence oil.
The analgesic effect of test example two, Folium Artemisiae Argyi health care essential oil of the present invention
One, materials and methods
1, animal: ICR mice 62, female, 6 ~ 7 week age, body weight 25 ~ 30g.
2, tested material: the quintessence oil made according to formula and the method for the embodiment of the present invention 1 ~ 4, comparative example 1 ~ 4.
3, experimental apparatus: GJ-8402 type hot plate dolorimeter
4, experimental technique: use hot plate dolorimeter, constant temperature 55 DEG C ± 0.5 DEG C, first choose qualified animal (put into hot plate to occurring licking metapedes with mice, the time of appearance is this Mus pain threshold values) mice 54 of pain threshold values in 5 ~ 30s before experiment and be divided into 9 groups at random, as follows.As pain threshold values before administration after medicine before measurement twice pain threshold values is average.Each group of mice two metapedes is coated with corresponding quintessence oil once, records t inspection between pain threshold values group with different time.
Matched group: normal saline 0.05ml/ only;
Quintessence oil 1 group: the quintessence oil 0.05ml/ often foot that embodiment 1 is obtained;
Quintessence oil 2 groups: the quintessence oil 0.05ml/ often foot that embodiment 2 is obtained;
Quintessence oil 3 groups: the quintessence oil 0.05ml/ often foot that embodiment 3 is obtained;
Quintessence oil 4 groups: the quintessence oil 0.05ml/ often foot that embodiment 4 is obtained;
Contrast 1 group: the quintessence oil 0.05ml/ often foot that comparative example 1 is obtained;
Contrast 2 groups: the quintessence oil 0.05ml/ often foot that comparative example 2 is obtained;
Contrast 3 groups: the quintessence oil 0.05ml/ often foot that comparative example 3 is obtained;
Contrast 4 groups: the quintessence oil 0.05ml/ often foot that comparative example 4 is obtained.
Two, result
The results are shown in following table 2.
The each quintessence oil of table 2 is on the impact (X ± SD) of mice pain threshold values
Compared with matched group, * P < 0.05, * * P < 0.01.
From upper table 2,
(1) Folium Artemisiae Argyi health care essential oil of the present invention is smearing 15min i.e. effective raising mice pain threshold values, and it acts on sustainable more than 30min, compared with matched group, after smearing quintessence oil 15min, quintessence oil 1 and quintessence oil 4 groups have significant difference (P < 0.05).
(2) compared with embodiment 1 ~ 4, the analgesic effect of comparative example 1 ~ 4 quintessence oil is poor, illustrates that the change of P-Cymene preparation method and the change of Folium Artemisiae Argyi health care essential oil formula of the present invention all can have an impact to effect of quintessence oil.
Compbined test example one and test example two, Folium Artemisiae Argyi health care essential oil of the present invention has good reducing swelling and alleviating pain effect, directly can be applied in the object that affected part can reach anti-inflammation detumescence, pain relieving, simultaneously also can by massaging to alleviate intractable pain after painting quintessence oil of the present invention, as cervical spondylosis, rheumatism etc., also there is certain effect of releiving to toothache, muscular strain.
The estimation of stability of test example three, Folium Artemisiae Argyi health care essential oil of the present invention
Respectively by the Folium Artemisiae Argyi health care essential oil of embodiment 1 and 4, comparative example 1 ~ 4, carry out fill with dark brown vial, open wide bottle cap, be placed in 35 DEG C, under relative humidity 85% environment, continuous observation, concrete outcome sees the following form 3.
Table 3 each Folium Artemisiae Argyi health care essential oil stability result table
Note: "+" represents normal; "-" represents becomes sour.
From upper table 3, under uncovered, hot and humid condition, the long shelf-life of the Folium Artemisiae Argyi health care essential oil (embodiment 4 ~ 6) containing magnolol is in the Folium Artemisiae Argyi health care essential oil (embodiment 1) not containing magnolol, illustrate that magnolol has certain antisepsis in this system, and its antisepsis is subject to the impact (embodiment 4 ~ 6) of itself and vitamin E proportioning, also can be subject to the impact (comparative example 1) of P-Cymene composition; If but not containing vitamin E, only containing magnolol (comparative example 2), its antiseptic effect is but than only poor containing vitamin E (embodiment 1), illustrate that vitamin E and magnolol exist synergism, and the synergism of vitamin E and magnolol also can be subject to the impact (comparative example 3 ~ 4) of system component.
Another test, the fill of the embodiment of the present invention 4 Folium Artemisiae Argyi health care essential oil, in dark brown vial, is preserved at room temperature (18-25 DEG C) environment lower seal, phenomenon of not becoming sour in 3 years.
Principle of the present invention and effect thereof are described, but not for limiting the present invention.Any person skilled in the art scholar all without prejudice under spirit of the present invention and category, can modify above-described embodiment or changes.Therefore, such as have in art usually know the knowledgeable do not depart from complete under disclosed spirit and technological thought all equivalence modify or change, must be contained by claim of the present invention.
Claims (6)
1. a Folium Artemisiae Argyi health care essential oil, is characterized in that, comprises the raw material of following weight portion: P-Cymene 0.5 ~ 2 part, Camellia oil 54 ~ 60 parts, Jojoba oil 30 ~ 36 parts, Avocado Oil 10 ~ 18 parts and vitamin e1 ~ 3 part.
2. Folium Artemisiae Argyi health care essential oil as claimed in claim 1, is characterized in that, comprise the raw material of following weight portion: P-Cymene 1 part, Camellia oil 58 parts, Jojoba oil 34 parts, Avocado Oil 12 parts and vitamin E2 part.
3. Folium Artemisiae Argyi health care essential oil as claimed in claim 1 or 2, it is characterized in that, described Folium Artemisiae Argyi health care essential oil also comprises magnolol 0.05 ~ 0.2 weight portion.
4. Folium Artemisiae Argyi health care essential oil as claimed in claim 1 or 2, it is characterized in that, described P-Cymene is obtained by following methods:
The preparation of A1, Folium Artemisiae Argyi extractum: fill extraction kettle after being pulverized by dry Folium Artemisiae Argyi, the upper pressure of setting extraction kettle is 20 ~ 25MPa, pressing down is 22 ~ 27MPa, temperature is 45 ~ 52 DEG C, and the pressure of setting extraction-container is 4 ~ 6MPa, and temperature is 55 ~ 65 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2 ~ 3%, obtain Folium Artemisiae Argyi extractum;
The preparation of A2, P-Cymene: setting jacket temperature is 65 ~ 75 DEG C, charging rate is 125 ~ 135ML/H, evaporation layer temperature is 65 ~ 75 DEG C, condensate layer temperature is 35 ~ 45 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 65 ~ 75 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene.
5. prepare a method for Folium Artemisiae Argyi health care essential oil as claimed in claim 1, it is characterized in that, comprise the following steps:
S1, dry Folium Artemisiae Argyi is pulverized after fill extraction kettle, the upper pressure of setting extraction kettle is 20 ~ 25MPa, pressing down is 22 ~ 27MPa, temperature is 45 ~ 52 DEG C, and the pressure of setting extraction-container is 4 ~ 6MPa, and temperature is 55 ~ 65 DEG C, then CO 2 fluid extraction is passed into, collect extractum at extraction-container, stop when output reaches 2 ~ 3%, obtain Folium Artemisiae Argyi extractum;
S2, setting jacket temperature are 65 ~ 75 DEG C, charging rate is 125 ~ 135ML/H, evaporation layer temperature is 65 ~ 75 DEG C, condensate layer temperature is 35 ~ 45 DEG C, pressure is less than 0.1Pa, and pours liquid nitrogen in cold well, is then in a liquid state 65 ~ 75 DEG C of water-baths by described Folium Artemisiae Argyi extractum, pour feed well charging into, the oil content that light component bottle is collected is P-Cymene;
S3, described P-Cymene to be mixed homogeneously with Camellia oil, Jojoba oil and Avocado Oil, then add vitamin E, stir and obtain Folium Artemisiae Argyi health care essential oil.
6. the preparation method of Folium Artemisiae Argyi health care essential oil as claimed in claim 5, is characterized in that, also comprise adding of magnolol in described step S3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511007932.XA CN105535261A (en) | 2015-12-30 | 2015-12-30 | Folium artemisiae argyi health-care essential oil and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511007932.XA CN105535261A (en) | 2015-12-30 | 2015-12-30 | Folium artemisiae argyi health-care essential oil and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105535261A true CN105535261A (en) | 2016-05-04 |
Family
ID=55815172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201511007932.XA Pending CN105535261A (en) | 2015-12-30 | 2015-12-30 | Folium artemisiae argyi health-care essential oil and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105535261A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389162A (en) * | 2016-09-29 | 2017-02-15 | 广州暨南生物医药研究开发基地有限公司 | Massage oil emulsion containing argy wormwood leaf essential oil and preparation method of massage oil emulsion |
| CN108888646A (en) * | 2018-09-04 | 2018-11-27 | 广州暨南生物医药研究开发基地有限公司 | A kind of wormwood cream and preparation method thereof |
| CN111419947A (en) * | 2020-03-12 | 2020-07-17 | 广东暨晴生物医药科技有限公司 | Folium artemisiae argyi compound essential oil capable of relieving throat pain and preparation method thereof |
| CN112121109A (en) * | 2020-09-30 | 2020-12-25 | 李泰颖 | Essential oil composition and application thereof in preparation of Du-dredging essential oil |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1611289A (en) * | 2003-10-30 | 2005-05-04 | 华中科技大学同济医学院附属同济医院 | Supercritical carbon dioxide mugwort active substance extracting method |
| CN102836351A (en) * | 2012-09-03 | 2012-12-26 | 皖南医学院 | Skin care essential balm for relieving itching and diminishing swelling and preparation method thereof |
| CN102908268A (en) * | 2012-10-19 | 2013-02-06 | 伊国群 | Camellia type skin care solution |
| CN103446247A (en) * | 2013-09-13 | 2013-12-18 | 湖北李时珍生物科技股份有限公司 | High-seepage-force compound essential oil for preventing skins from being aged |
-
2015
- 2015-12-30 CN CN201511007932.XA patent/CN105535261A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1611289A (en) * | 2003-10-30 | 2005-05-04 | 华中科技大学同济医学院附属同济医院 | Supercritical carbon dioxide mugwort active substance extracting method |
| CN102836351A (en) * | 2012-09-03 | 2012-12-26 | 皖南医学院 | Skin care essential balm for relieving itching and diminishing swelling and preparation method thereof |
| CN102908268A (en) * | 2012-10-19 | 2013-02-06 | 伊国群 | Camellia type skin care solution |
| CN103446247A (en) * | 2013-09-13 | 2013-12-18 | 湖北李时珍生物科技股份有限公司 | High-seepage-force compound essential oil for preventing skins from being aged |
Non-Patent Citations (1)
| Title |
|---|
| 侯彩霞等: ""挥发油的超临界流体萃取与分离进展"", 《化工进展》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389162A (en) * | 2016-09-29 | 2017-02-15 | 广州暨南生物医药研究开发基地有限公司 | Massage oil emulsion containing argy wormwood leaf essential oil and preparation method of massage oil emulsion |
| CN108888646A (en) * | 2018-09-04 | 2018-11-27 | 广州暨南生物医药研究开发基地有限公司 | A kind of wormwood cream and preparation method thereof |
| CN108888646B (en) * | 2018-09-04 | 2021-09-24 | 广州暨南生物医药研究开发基地有限公司 | Wormwood paste and preparation method thereof |
| CN111419947A (en) * | 2020-03-12 | 2020-07-17 | 广东暨晴生物医药科技有限公司 | Folium artemisiae argyi compound essential oil capable of relieving throat pain and preparation method thereof |
| WO2021179567A1 (en) * | 2020-03-12 | 2021-09-16 | 广东暨晴生物医药科技有限公司 | Chinese mugwort leaf composite essential oil for relieving sore throat and preparation method therefor |
| CN112121109A (en) * | 2020-09-30 | 2020-12-25 | 李泰颖 | Essential oil composition and application thereof in preparation of Du-dredging essential oil |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105456064B (en) | A kind of anti-aging folium artemisiae argyi composite essential oil and preparation method thereof | |
| CN102397182B (en) | Compound essential oil for improving skin properties | |
| CN103479775B (en) | Scraping liniment and preparation method thereof | |
| JP2005501851A (en) | Composition for removing toxins | |
| CN105535261A (en) | Folium artemisiae argyi health-care essential oil and preparation method thereof | |
| CN104027399A (en) | Essential oil composition and preparation method thereof | |
| CN107519046A (en) | A kind of anticreep strengthen the hair hair growth composition, preparation method and applications | |
| CN105062726A (en) | Medicated soap for conditioning skin and weakening melanin | |
| CN104815026A (en) | Hypnotic essential oil composition | |
| CN107184483A (en) | High penetration camellia massage essential oil promoting blood circulation and removing obstruction in channels and preparation method thereof | |
| CN104644537A (en) | Hair and body wash | |
| CN102872240B (en) | Compound essential oil for relaxing and activating collaterals | |
| CN104644535A (en) | Hair and body wash powder | |
| CN104027439B (en) | Compositions and preparation method thereof | |
| CN102743506A (en) | Camellia japonica oil acne lotion and preparation method thereof | |
| CN107854681A (en) | A kind of anti-inflammatory composition and preparation method thereof | |
| CN104688661A (en) | Aloe mask | |
| CN100459971C (en) | Anti-frozen skin-care cream and preparation method | |
| CN107157961A (en) | Nurse one's health mammary gland disease and have newborn film of moulding beautification function and preparation method thereof to female breast | |
| CN106728166A (en) | Treat the Chinese medicine composition of eczema | |
| CN104800137A (en) | Application of camellia nitidissima Chi flower extract, moisturizing and skin caring composition and preparation method thereof | |
| KR20210012144A (en) | Diy kit for manufacturing natural cosmetic | |
| CN111686016A (en) | Water-oil two-layer scalp care plant essential oil | |
| CN103919881A (en) | Preparation method of Chinese herbal ointment | |
| CN106798669A (en) | Anti-ageing BB frosts of the antiallergic anti-inflammatory moisturizing of a kind of not silicate-containing oil and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160504 |
|
| RJ01 | Rejection of invention patent application after publication |