CN108567644A - A kind of long-acting moisturizing sun care preparations and preparation method - Google Patents

A kind of long-acting moisturizing sun care preparations and preparation method Download PDF

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CN108567644A
CN108567644A CN201810783875.1A CN201810783875A CN108567644A CN 108567644 A CN108567644 A CN 108567644A CN 201810783875 A CN201810783875 A CN 201810783875A CN 108567644 A CN108567644 A CN 108567644A
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chitosan
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care preparations
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CN108567644B (en
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赵宏伟
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Zhejiang iseqi Pharmaceutical Technology Co.,Ltd.
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赵宏伟
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/29—Titanium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

Abstract

The invention belongs to the technical field of cosmetics, a kind of long-acting moisturizing sun care preparations and preparation method are provided.This method to chitosan by carrying out hydrophilic and oleophilic modification, and the chitosan aeroge for carrying tannin, general flavone and nano-titanium dioxide is made, again with hyaluronic acid, 1,3 butanediols, collagen, SIMMONDSIA CHINENSIS SEED OIL, refined jasmine oil, deionized water mix homogeneous, moisturizing sun care preparations are made.Compared with conventional method, cosmetics prepared by the present invention when being applied to skin surface, easily form chitosan aeroge sunscreen film, and prevent moisture loss, therefore can have good long-acting moisturizing and sun-proof result simultaneously in coating surface.

Description

A kind of long-acting moisturizing sun care preparations and preparation method
Technical field
The invention belongs to the technical field of cosmetics, a kind of long-acting moisturizing sun care preparations and preparation method are provided.
Background technology
As being constantly progressive for social economy is abundant with material life, skin protection cosmetics has come into ordinary citizen house as the popular vehicles, And play the role of to the spirit of people, image enhancing great.Skin care item type is various, and feature is different, mainly have moisturizing, Whitening, moisturizing, oil-control, anti-aging, sensitive skin, pore refining, blackhead of dispelling, nti-freckle, the special skin care item of the fat that disappears.Wherein moisturizing is protected Wet is basis and important skin care content the most, and in addition the injury of ultraviolet light is for the very harmful of skin, thus it is sun-proof also at It is important one of skin protection cosmetics.
The skin of health should be smooth moist flexible, this is largely attributed to the fact that the moisture in skin! And these appearance marks are related with the function of skin moisture-keeping system itself.The function of moisture-keeping system, which is that, maintains the skin certain Water content is resisted by internal and external factor to the evaporation drying caused by skin, the even damages such as embrittlement.What skin protection cosmetics should have Most basic performance is performance of keeping humidity.Skin protection cosmetics can increase the flexibility and flatness of skin, and extend this effect It is heard when continuing, skin is made not influenced as possible by extraneous adverse circumstances.
In addition, daily life, work, tourism all be unable to do without outdoor activities, and no matter weather is cloudy, fine, skin, hair Will be by ultraviolet irradiation, ultraviolet light strong for a long time irradiation can be such that rubefaction, the hot small red bubble of life is produced when serious Add lustre to spot, makes skin aging.Effective sun care preparations safe to use can mitigate injury of the ultraviolet light to skin.Sun-proof skin care Containing appropriate safely and effectively sun-screening agent in product, it can substantially be divided into two classes：It is physical ultraviolet light screener, chemically synthesized Ultra-violet absorber, the development of sun care preparations are mainly the research and development of sun-screening agent.
Chinese invention patent application number 201710335725.X discloses a kind of cosmetic composition and its application, main To include plantain blueweed seed oil, sunflower seed oil unsaponifiable matter, cardiospermum halicacabum flower/leaf/boisiana extract etc., effectively sun-proof is same When, also skin-nourishing, inhibition aging keeps skin more water profit smooth.But there are the bad defects of replenishing water and preserving moisture performance.
Chinese invention patent application number 201610768736.2 discloses a kind of sun-proof, moisturizing, the amino acidification of anti-aging Cosmetic, including amino acid composition and cosmetic base, amino acid composition accounts for the 18 ~ 25% of cosmetics gross mass, according to amino The weight meter of acid composition, amino acid composition include 2.0 ~ 3.0 parts of lysines, 0.5 ~ 1.1 part of histidine, 6 ~ 7 parts of arginine, 5 ~ 6 parts of aspartic acids, 7 ~ 8 parts of threonines, 12 ~ 13 parts of serines, 12 ~ 13 parts of glutamic acid, 8 ~ 9 parts of proline, 5 ~ 6 parts of sweet ammonia Acid, 4 ~ 5 parts of alanine, 5 ~ 6 parts of valines, 0.5 ~ 1.1 part of methionine, 2 ~ 3 parts of isoleucines, 6 ~ 7 parts of leucines, 2 ~ 3 portions of junket Propylhomoserin, 1 ~ 2 part of phenylalanine, 15 ~ 16 parts of cysteines.But it is undesirable with moistening effect that there are sun-proof, and persistence difference etc. lacks Point.
In conclusion in currently used cosmetics, the moisture of replenishing water and preserving moisture cosmetics is easy to lose, is unable to reach long-acting guarantor Wet purpose, and sun-proof result is poor, and the moisture retention of sun care preparations is poor, it is difficult to sun-proof and replenishing water and preserving moisture effect is had both, because This, which is developed, a kind of having both moisturizing moisturizing and the cosmetics of sun-proof result and has great significance.
Invention content
As it can be seen that in the skin protection cosmetics of prior art preparation, the moisture of moisturizing cosmetics is easy to lose, cannot long-acting moisturizing, Sun-proof result is poor, and the moisture retention of sunscreen product is poor, it is difficult to have both moisturizing and sun-proof dual property.For such case, we It proposes a kind of long-acting moisturizing sun care preparations and preparation method, can effectively realize getting both for long-acting replenishing water and preserving moisture and sun-screening function, It has broad application prospects.
To achieve the above object, specific technical solution of the present invention is as follows：
A kind of preparation method of long-acting moisturizing sun care preparations, specific steps prepared by the long-acting moisturizing sun care preparations are such as Under：
（1）Fresh witch hazel branch is taken, is crushed in plant pulverizer, then in supercritical CO2In extracted, obtain To tannin crude extract, crude extract is added to the water, the feed liquid that mass fraction is 16 ~ 20% is made into, then passes through hollow sulfonation Polysulfone fibre film carries out UF membrane, and purifying hamameli tannin is made；
（2）Chitosan is dissolved in the acetum that mass concentration is 2%, addition glue acid anhydrides powder, adjusting pH value to 7.5 ~ 8.5, 6 ~ 7h is reacted, precipitation, filtering, dry, obtained hydrophilic modifying chitosan are then soluble in water by hydrophilic modifying chitosan, are added Methyl fatty acyl chlorides adjusts pH value to 8 ~ 9, reacts 5 ~ 6h, hydrophilic and oleophilic modification of chitosan is made in precipitation, filtering, drying；
（3）Hydrophilic and oleophilic modification of chitosan is added to the water, purifying hamameli tannin, total seabuckthorn flavone, nanometer two is then added Titanium oxide, it is 30 ~ 40% that heating, which is concentrated into moisture content, then is freeze-dried, and is made and carries tannin, general flavone and nano-titanium dioxide Chitosan aeroge；
（4）By step（3）Chitosan aeroge obtained and hyaluronic acid, 1,3 butylene glycol, collagen, SIMMONDSIA CHINENSIS SEED OIL, jasmine Jasmine essential oil, deionized water mix homogeneous, and long-acting moisturizing sun care preparations is made.
Preferably, step（1）The pressure of the supercritical extract is 28 ~ 32MPa, and temperature is 40 ~ 45 DEG C, supercritical CO2 Flow velocity be 8 ~ 12mL/min, extraction time be 60 ~ 80min.
Preferably, step（1）The transmembrane pressure of the UF membrane is 0.1 ~ 0.15MPa, and temperature is 36 ~ 42 DEG C, and feed liquid exists The flow velocity of film surface is 2.2 ~ 2.5m/s.
Preferably, step（2）The parts by weight of each reactant are 40 ~ 60 parts by weight of chitosan, 10 ~ 20 weight of glue acid anhydrides Measure part, 30 ~ 40 parts by weight of Methyl fatty acyl chlorides.
Preferably, step（3）The temperature of the freeze-drying is -60 ~ -30 DEG C, and the time is 30 ~ 50min.
Preferably, step（3）In the chitosan aeroge, 22 ~ 25 parts by weight of hamameli tannin, total seabuckthorn flavone 25 ~ 28 parts by weight, 15 ~ 20 parts by weight of nano-titanium dioxide, 27 ~ 38 parts by weight of hydrophilic and oleophilic modification of chitosan.
Preferably, step（4）In the cosmetics, 20 ~ 30 parts by weight of chitosan aeroge, 0.2 ~ 0.5 weight of hyaluronic acid Measure part, 5 ~ 10 parts by weight of 1,3 butylene glycol, 5 ~ 8 parts by weight of collagen, 5.5 ~ 9 parts by weight of SIMMONDSIA CHINENSIS SEED OIL, refined jasmine oil 0.3 ~ 0.5 parts by weight, 42 ~ 64 parts by weight of deionized water.
Preferably, step（4）The speed of the homogeneous is 1500 ~ 2000r/min, and the time is 3 ~ 10min.
The present invention has been grafted fatty long-chain so that cosmetic applying by carrying out parents' modification to chitosan on molecule When skin surface, carry tannin, general flavone and nano-titanium dioxide chitosan aeroge easily formed in coating surface it is sun-proof Film.Tannin, general flavone and nano-titanium dioxide, which play, cooperates with sun-proof effect.Wherein, between tannin and flavones with hydrophobic bond and Hydrogen bond forms molecular complex, and on the one hand chromatic effect altogether occurs for copigment each other, improves absorbance, on the other hand improves water-soluble Property, be conducive to the performance of synergistic effect.
Especially, after coating surface forms chitosan aerogel film, moisture loss can be prevented, promotes hyaluronic acid, 1, The water lock effect of 3- butanediols, collagen is played long-acting moistening effect, and is promoted in the infiltration of SIMMONDSIA CHINENSIS SEED OIL and refined jasmine oil Under, realize the deep water supplement to skin.
The present invention also provides the long-acting moisturizing sun care preparations that a kind of above-mentioned preparation method is prepared.The long-acting guarantor Wet sun care preparations is by carrying out hydrophilic and oleophilic modification to chitosan, and being made and carry tannin, general flavone and nanometer titanium dioxide The chitosan aeroge of titanium, then with hyaluronic acid, 1,3-BDO, collagen, SIMMONDSIA CHINENSIS SEED OIL, refined jasmine oil, deionized water It mixes homogeneous and is made.
It is compared with prior art, outstanding the present invention provides a kind of long-acting moisturizing sun care preparations and preparation method Feature and excellent effect are：
1. after smearing, it is anti-easily to form aeroge by being modified to chitosan in coating surface for cosmetics prepared by the present invention Film is shone, tannin, general flavone and the nano-titanium dioxide carried in aeroge plays the sun-proof effect that cooperates with, therefore with good Sun-proof result.
2. cosmetics prepared by the present invention are conducive to prevent moisture loss, reach due to foring chitosan film layer after smearing To long-acting moisturizing, and it can realize deep water supplement.
3. the preparation method of the present invention, raw material are easy to get, process is easy to control, it can be achieved that large-scale production.
Specific implementation mode
In the following, the present invention will be further described in detail by way of specific embodiments, but this should not be interpreted as to the present invention Range be only limitted to example below.Without departing from the idea of the above method of the present invention, according to ordinary skill The various replacements or change that knowledge and customary means are made, should be included in the scope of the present invention.
Embodiment 1
（1）Fresh witch hazel branch is taken, is crushed in plant pulverizer, then in supercritical CO2In extracted, obtain To tannin crude extract, crude extract is added to the water, is made into the feed liquid that mass fraction is 17%, it is then poly- by hollow sulfonation Sulfone tunica fibrosa carries out UF membrane, and purifying hamameli tannin is made；The pressure of supercritical extract is 29MPa, and temperature is 43 DEG C, super to face Boundary CO2Flow velocity be 11mL/min, extraction time 72min；The transmembrane pressure of UF membrane is 0.13MPa, and temperature is 38 DEG C, material Liquid is 2.3m/s in the flow velocity of film surface；
（2）Chitosan is dissolved in the acetum that mass concentration is 2%, glue acid anhydrides powder is added, adjusted pH value to 8, react 6.5h, precipitation, filtering, dry, obtained hydrophilic modifying chitosan are then soluble in water by hydrophilic modifying chitosan, and methyl is added Fat acyl chloride adjusts pH value to 8.5, reacts 5.5h, hydrophilic and oleophilic modification of chitosan is made in precipitation, filtering, drying；Each reaction The parts by weight of object are 48 parts by weight of chitosan, 16 parts by weight of glue acid anhydrides, 36 parts by weight of Methyl fatty acyl chlorides；
（3）Hydrophilic and oleophilic modification of chitosan is added to the water, purifying hamameli tannin, total seabuckthorn flavone, nanometer two is then added Titanium oxide, it is 36% that heating, which is concentrated into moisture content, then is freeze-dried, and the shell for carrying tannin, general flavone and nano-titanium dioxide is made Glycan aeroge；The temperature of freeze-drying is -50 DEG C, time 42min；In chitosan aeroge, 23 weight of hamameli tannin Part, 27 parts by weight of total seabuckthorn flavone, 17 parts by weight of nano-titanium dioxide, 33 parts by weight of hydrophilic and oleophilic modification of chitosan；
（4）By step（3）Chitosan aeroge obtained and hyaluronic acid, 1,3 butylene glycol, collagen, SIMMONDSIA CHINENSIS SEED OIL, jasmine Jasmine essential oil, deionized water mix homogeneous, and long-acting moisturizing sun care preparations is made；The speed of homogeneous is 1700r/min, and the time is 7min；In cosmetics, 26 parts by weight of chitosan aeroge, 0.3 parts by weight of hyaluronic acid, 7 parts by weight of 1,3-BDO, collagen egg White 7 parts by weight, 7 parts by weight of SIMMONDSIA CHINENSIS SEED OIL, 0.4 parts by weight of refined jasmine oil, 52.3 parts by weight of deionized water.
Test method is：
（1）Sun protection factor：It is anti-to be tested using international human efficiency's test evaluation method and external machine survey method, referenceization Cosmetic technical specification of security 2015 editions, instrument are the SPF-290AS sun protection factor measuring systems of Solar Light companies；Selection 40 18 ~ 60 years old healthy volunteers test, and are tested, are continuously generated as light source using solar simulator xenon arc lamp Wavelength is the ultraviolet light of 290 ~ 400nm, irradiates back, lean forward position or prone position can be taken, by cosmetics sample produced by the present invention Product are coated on back, and area is not less than 30cm2, by 2mg/cm2Dosage weigh sample, sample is uniformly applied using latex finger cot It is distributed in the trial zone of back, takes 5 points of ultraviolet lights with various dose to irradiate, exposure dose or time amplification are incremented by successively, and 24 is small When after observe as a result, with skin occur the minimum exposure dose of erythema or most short irradiation time be subject's normal skin most Small erythema dose (ED) MED, according to formula sun protection factor（SPF）The skin MED/ of=smearing cosmetics does not smear the skin MED meters of cosmetics It calculates；
（2）Skin moisture content（MMV）：Using the moisture of capacitance measurement human skin keratinocyte's layer, test environment temperature It it is 22 DEG C, relative humidity 50% selects 40 people of healthy volunteer, and the age, test position selected forearm between 16 years old ~ 65 years old Blank district of the same area is selected in the regions 3cm × 3cm at random as trial zone, does not use within 2 ~ 3 days before recipient site and appoints What cosmetics, measures initial skin moisture, then according to 2mg using Corneometer825 skin moisture content testers /cm2Dosage weigh cosmetic sample produced by the present invention, even application in trial zone, measure respectively 2h, 6h, 12h and The moisture of trial zone and blank district when for 24 hours；
The data obtained is as shown in table 1.
Embodiment 2
（1）Fresh witch hazel branch is taken, is crushed in plant pulverizer, then in supercritical CO2In extracted, obtain To tannin crude extract, crude extract is added to the water, is made into the feed liquid that mass fraction is 16%, it is then poly- by hollow sulfonation Sulfone tunica fibrosa carries out UF membrane, and purifying hamameli tannin is made；The pressure of supercritical extract is 28MPa, and temperature is 40 DEG C, super to face Boundary CO2Flow velocity be 8mL/min, extraction time 80min；The transmembrane pressure of UF membrane is 0.1MPa, and temperature is 36 DEG C, feed liquid It is 2.2m/s in the flow velocity of film surface；
（2）Chitosan is dissolved in the acetum that mass concentration is 2%, glue acid anhydrides powder is added, adjusted pH value to 7.5, react 6h, precipitation, filtering, dry, obtained hydrophilic modifying chitosan are then soluble in water by hydrophilic modifying chitosan, and methyl fat is added Fat acyl chlorides adjusts pH value to 8, reacts 5h, hydrophilic and oleophilic modification of chitosan is made in precipitation, filtering, drying；The weight of each reactant It is 60 parts by weight of chitosan, 10 parts by weight of glue acid anhydrides, 30 parts by weight of Methyl fatty acyl chlorides to measure part；
（3）Hydrophilic and oleophilic modification of chitosan is added to the water, purifying hamameli tannin, total seabuckthorn flavone, nanometer two is then added Titanium oxide, it is 30% that heating, which is concentrated into moisture content, then is freeze-dried, and the shell for carrying tannin, general flavone and nano-titanium dioxide is made Glycan aeroge；The temperature of freeze-drying is -60 DEG C, time 30min；In chitosan aeroge, 22 weight of hamameli tannin Part, 25 parts by weight of total seabuckthorn flavone, 15 parts by weight of nano-titanium dioxide, 38 parts by weight of hydrophilic and oleophilic modification of chitosan；
（4）By step（3）Chitosan aeroge obtained and hyaluronic acid, 1,3 butylene glycol, collagen, SIMMONDSIA CHINENSIS SEED OIL, jasmine Jasmine essential oil, deionized water mix homogeneous, and long-acting moisturizing sun care preparations is made；The speed of homogeneous is 1500r/min, and the time is 10min；In cosmetics, 20 parts by weight of chitosan aeroge, 0.2 parts by weight of hyaluronic acid, 5 parts by weight of 1,3-BDO, collagen 5 parts by weight of albumen, 5.5 parts by weight of SIMMONDSIA CHINENSIS SEED OIL, 0.3 parts by weight of refined jasmine oil, 64 parts by weight of deionized water.
Test method is consistent with embodiment 1, and the data obtained is as shown in table 1.
Embodiment 3
（1）Fresh witch hazel branch is taken, is crushed in plant pulverizer, then in supercritical CO2In extracted, obtain To tannin crude extract, crude extract is added to the water, is made into the feed liquid that mass fraction is 20%, it is then poly- by hollow sulfonation Sulfone tunica fibrosa carries out UF membrane, and purifying hamameli tannin is made；The pressure of supercritical extract is 32MPa, and temperature is 45 DEG C, super to face Boundary CO2Flow velocity be 12mL/min, extraction time 60min；The transmembrane pressure of UF membrane is 0.15MPa, and temperature is 42 DEG C, material Liquid is 2.5m/s in the flow velocity of film surface；
（2）Chitosan is dissolved in the acetum that mass concentration is 2%, glue acid anhydrides powder is added, adjusted pH value to 8.5, react 7h, precipitation, filtering, dry, obtained hydrophilic modifying chitosan are then soluble in water by hydrophilic modifying chitosan, and methyl fat is added Fat acyl chlorides adjusts pH value to 9, reacts 6h, hydrophilic and oleophilic modification of chitosan is made in precipitation, filtering, drying；The weight of each reactant It is 40 parts by weight of chitosan, 20 parts by weight of glue acid anhydrides, 40 parts by weight of Methyl fatty acyl chlorides to measure part；
（3）Hydrophilic and oleophilic modification of chitosan is added to the water, purifying hamameli tannin, total seabuckthorn flavone, nanometer two is then added Titanium oxide, it is 40% that heating, which is concentrated into moisture content, then is freeze-dried, and the shell for carrying tannin, general flavone and nano-titanium dioxide is made Glycan aeroge；The temperature of freeze-drying is -30 DEG C, time 50min；In chitosan aeroge, 25 weight of hamameli tannin Part, 28 parts by weight of total seabuckthorn flavone, 20 parts by weight of nano-titanium dioxide, 27 parts by weight of hydrophilic and oleophilic modification of chitosan；
（4）By step（3）Chitosan aeroge obtained and hyaluronic acid, 1,3 butylene glycol, collagen, SIMMONDSIA CHINENSIS SEED OIL, jasmine Jasmine essential oil, deionized water mix homogeneous, and long-acting moisturizing sun care preparations is made；The speed of homogeneous is 2000r/min, and the time is 3min；In cosmetics, 30 parts by weight of chitosan aeroge, 0.5 parts by weight of hyaluronic acid, 10 parts by weight of 1,3-BDO, collagen 8 parts by weight of albumen, 9 parts by weight of SIMMONDSIA CHINENSIS SEED OIL, 0.5 parts by weight of refined jasmine oil, 42 parts by weight of deionized water.
Test method is consistent with embodiment 1, and the data obtained is as shown in table 1.
Embodiment 4
（1）Fresh witch hazel branch is taken, is crushed in plant pulverizer, then in supercritical CO2In extracted, obtain To tannin crude extract, crude extract is added to the water, is made into the feed liquid that mass fraction is 17%, it is then poly- by hollow sulfonation Sulfone tunica fibrosa carries out UF membrane, and purifying hamameli tannin is made；The pressure of supercritical extract is 29MPa, and temperature is 41 DEG C, super to face Boundary CO2Flow velocity be 9mL/min, extraction time 75min；The transmembrane pressure of UF membrane is 0.11MPa, and temperature is 38 DEG C, material Liquid is 2.3m/s in the flow velocity of film surface；
（2）Chitosan is dissolved in the acetum that mass concentration is 2%, glue acid anhydrides powder is added, adjusted pH value to 7.5, react 7h, precipitation, filtering, dry, obtained hydrophilic modifying chitosan are then soluble in water by hydrophilic modifying chitosan, and methyl fat is added Fat acyl chlorides adjusts pH value to 8, reacts 6h, hydrophilic and oleophilic modification of chitosan is made in precipitation, filtering, drying；The weight of each reactant It is 55 parts by weight of chitosan, 12 parts by weight of glue acid anhydrides, 33 parts by weight of Methyl fatty acyl chlorides to measure part；
（3）Hydrophilic and oleophilic modification of chitosan is added to the water, purifying hamameli tannin, total seabuckthorn flavone, nanometer two is then added Titanium oxide, it is 32% that heating, which is concentrated into moisture content, then is freeze-dried, and the shell for carrying tannin, general flavone and nano-titanium dioxide is made Glycan aeroge；The temperature of freeze-drying is -50 DEG C, time 45min；In chitosan aeroge, 23 weight of hamameli tannin Part, 26 parts by weight of total seabuckthorn flavone, 16 parts by weight of nano-titanium dioxide, 35 parts by weight of hydrophilic and oleophilic modification of chitosan；
（4）By step（3）Chitosan aeroge obtained and hyaluronic acid, 1,3 butylene glycol, collagen, SIMMONDSIA CHINENSIS SEED OIL, jasmine Jasmine essential oil, deionized water mix homogeneous, and long-acting moisturizing sun care preparations is made；The speed of homogeneous is 1600r/min, and the time is 4min；In cosmetics, 22 parts by weight of chitosan aeroge, 0.3 parts by weight of hyaluronic acid, 6 parts by weight of 1,3-BDO, collagen egg White 6 parts by weight, 6 parts by weight of SIMMONDSIA CHINENSIS SEED OIL, 0.3 parts by weight of refined jasmine oil, 59.4 parts by weight of deionized water.
Test method is consistent with embodiment 1, and the data obtained is as shown in table 1.
Embodiment 5
（1）Fresh witch hazel branch is taken, is crushed in plant pulverizer, then in supercritical CO2In extracted, obtain To tannin crude extract, crude extract is added to the water, is made into the feed liquid that mass fraction is 19%, it is then poly- by hollow sulfonation Sulfone tunica fibrosa carries out UF membrane, and purifying hamameli tannin is made；The pressure of supercritical extract is 31MPa, and temperature is 44 DEG C, super to face Boundary CO2Flow velocity be 11mL/min, extraction time 65min；The transmembrane pressure of UF membrane is 0.14MPa, and temperature is 40 DEG C, material Liquid is 2.4m/s in the flow velocity of film surface；
（2）Chitosan is dissolved in the acetum that mass concentration is 2%, glue acid anhydrides powder is added, adjusted pH value to 8.5, react 6h, precipitation, filtering, dry, obtained hydrophilic modifying chitosan are then soluble in water by hydrophilic modifying chitosan, and methyl fat is added Fat acyl chlorides adjusts pH value to 9, reacts 5h, hydrophilic and oleophilic modification of chitosan is made in precipitation, filtering, drying；The weight of each reactant It is 44 parts by weight of chitosan, 18 parts by weight of glue acid anhydrides, 38 parts by weight of Methyl fatty acyl chlorides to measure part；
（3）Hydrophilic and oleophilic modification of chitosan is added to the water, purifying hamameli tannin, total seabuckthorn flavone, nanometer two is then added Titanium oxide, it is 38% that heating, which is concentrated into moisture content, then is freeze-dried, and the shell for carrying tannin, general flavone and nano-titanium dioxide is made Glycan aeroge；The temperature of freeze-drying is -40 DEG C, time 35min；In chitosan aeroge, 24 weight of hamameli tannin Part, 27 parts by weight of total seabuckthorn flavone, 18 parts by weight of nano-titanium dioxide, 31 parts by weight of hydrophilic and oleophilic modification of chitosan；
（4）By step（3）Chitosan aeroge obtained and hyaluronic acid, 1,3 butylene glycol, collagen, SIMMONDSIA CHINENSIS SEED OIL, jasmine Jasmine essential oil, deionized water mix homogeneous, and long-acting moisturizing sun care preparations is made；The speed of homogeneous is 1900r/min, and the time is 5min；In cosmetics, 27 parts by weight of chitosan aeroge, 0.4 parts by weight of hyaluronic acid, 9 parts by weight of 1,3-BDO, collagen egg White 7 parts by weight, 8 parts by weight of SIMMONDSIA CHINENSIS SEED OIL, 0.5 parts by weight of refined jasmine oil, 48.1 parts by weight of deionized water.
Test method is consistent with embodiment 1, and the data obtained is as shown in table 1.
Embodiment 6
（1）Fresh witch hazel branch is taken, is crushed in plant pulverizer, then in supercritical CO2In extracted, obtain To tannin crude extract, crude extract is added to the water, is made into the feed liquid that mass fraction is 18%, it is then poly- by hollow sulfonation Sulfone tunica fibrosa carries out UF membrane, and purifying hamameli tannin is made；The pressure of supercritical extract is 30MPa, and temperature is 42 DEG C, super to face Boundary CO2Flow velocity be 10mL/min, extraction time 70min；The transmembrane pressure of UF membrane is 0.12MPa, and temperature is 39 DEG C, material Liquid is 2.4m/s in the flow velocity of film surface；
（2）Chitosan is dissolved in the acetum that mass concentration is 2%, glue acid anhydrides powder is added, adjusted pH value to 8, react 6.5h, precipitation, filtering, dry, obtained hydrophilic modifying chitosan are then soluble in water by hydrophilic modifying chitosan, and methyl is added Fat acyl chloride adjusts pH value to 8.5, reacts 5.5h, hydrophilic and oleophilic modification of chitosan is made in precipitation, filtering, drying；Each reaction The parts by weight of object are 50 parts by weight of chitosan, 15 parts by weight of glue acid anhydrides, 35 parts by weight of Methyl fatty acyl chlorides；
（3）Hydrophilic and oleophilic modification of chitosan is added to the water, purifying hamameli tannin, total seabuckthorn flavone, nanometer two is then added Titanium oxide, it is 35% that heating, which is concentrated into moisture content, then is freeze-dried, and the shell for carrying tannin, general flavone and nano-titanium dioxide is made Glycan aeroge；The temperature of freeze-drying is -45 DEG C, time 40min；In chitosan aeroge, 24 weight of hamameli tannin Part, 26 parts by weight of total seabuckthorn flavone, 18 parts by weight of nano-titanium dioxide, 32 parts by weight of hydrophilic and oleophilic modification of chitosan；
（4）By step（3）Chitosan aeroge obtained and hyaluronic acid, 1,3 butylene glycol, collagen, SIMMONDSIA CHINENSIS SEED OIL, jasmine Jasmine essential oil, deionized water mix homogeneous, and long-acting moisturizing sun care preparations is made；The speed of homogeneous is 1800r/min, and the time is 8min；In cosmetics, 25 parts by weight of chitosan aeroge, 0.4 parts by weight of hyaluronic acid, 8 parts by weight of 1,3-BDO, collagen egg White 6 parts by weight, 7 parts by weight of SIMMONDSIA CHINENSIS SEED OIL, 0.4 parts by weight of refined jasmine oil, 53.2 parts by weight of deionized water.
Test method is consistent with embodiment 1, and the data obtained is as shown in table 1.
Comparative example 1
In preparation process, hydrophilic and oleophilic modification is not carried out to chitosan, does not form aeroge, all the components directly carry out mixing Matter, other preparation conditions and formula are consistent with embodiment 6.
Test method is consistent with embodiment 1, and the data obtained is as shown in table 1.
Table 1：

Claims (9)

1. a kind of preparation method of long-acting moisturizing sun care preparations, which is characterized in that prepared by the long-acting moisturizing sun care preparations It is as follows：
（1）Fresh witch hazel branch is taken, is crushed in plant pulverizer, then in supercritical CO2In extracted, obtain To tannin crude extract, crude extract is added to the water, the feed liquid that mass fraction is 16 ~ 20% is made into, then passes through hollow sulfonation Polysulfone fibre film carries out UF membrane, and purifying hamameli tannin is made；
（2）Chitosan is dissolved in the acetum that mass concentration is 2%, addition glue acid anhydrides powder, adjusting pH value to 7.5 ~ 8.5, 6 ~ 7h is reacted, precipitation, filtering, dry, obtained hydrophilic modifying chitosan are then soluble in water by hydrophilic modifying chitosan, are added Methyl fatty acyl chlorides adjusts pH value to 8 ~ 9, reacts 5 ~ 6h, hydrophilic and oleophilic modification of chitosan is made in precipitation, filtering, drying；
（3）Hydrophilic and oleophilic modification of chitosan is added to the water, purifying hamameli tannin, total seabuckthorn flavone, nanometer two is then added Titanium oxide, it is 30 ~ 40% that heating, which is concentrated into moisture content, then is freeze-dried, and is made and carries tannin, general flavone and nano-titanium dioxide Chitosan aeroge；
（4）By step（3）Chitosan aeroge obtained and hyaluronic acid, 1,3 butylene glycol, collagen, SIMMONDSIA CHINENSIS SEED OIL, jasmine Jasmine essential oil, deionized water mix homogeneous, and long-acting moisturizing sun care preparations is made.
2. a kind of preparation method of long-acting moisturizing sun care preparations according to claim 1, it is characterised in that：Step（1）Institute The pressure for stating supercritical extract is 28 ~ 32MPa, and temperature is 40 ~ 45 DEG C, supercritical CO2Flow velocity be 8 ~ 12mL/min, when extraction Between be 60 ~ 80min.
3. a kind of preparation method of long-acting moisturizing sun care preparations according to claim 1, it is characterised in that：Step（1）Institute The transmembrane pressure for stating UF membrane is 0.1 ~ 0.15MPa, and temperature is 36 ~ 42 DEG C, and feed liquid is 2.2 ~ 2.5m/s in the flow velocity of film surface.
4. a kind of preparation method of long-acting moisturizing sun care preparations according to claim 1, it is characterised in that：Step（2）Institute The parts by weight for stating each reactant are 40 ~ 60 parts by weight of chitosan, 10 ~ 20 parts by weight of glue acid anhydrides, 30 ~ 40 weight of Methyl fatty acyl chlorides Measure part.
5. a kind of preparation method of long-acting moisturizing sun care preparations according to claim 1, it is characterised in that：Step（3）Institute The temperature for stating freeze-drying is -60 ~ -30 DEG C, and the time is 30 ~ 50min.
6. a kind of preparation method of long-acting moisturizing sun care preparations according to claim 1, it is characterised in that：Step（3）Institute It states in chitosan aeroge, 22 ~ 25 parts by weight of hamameli tannin, 25 ~ 28 parts by weight of total seabuckthorn flavone, nano-titanium dioxide 15 ~ 20 parts by weight, 27 ~ 38 parts by weight of hydrophilic and oleophilic modification of chitosan.
7. a kind of preparation method of long-acting moisturizing sun care preparations according to claim 1, it is characterised in that：Step（4）Institute It states in cosmetics, 20 ~ 30 parts by weight of chitosan aeroge, 0.2 ~ 0.5 parts by weight of hyaluronic acid, 5 ~ 10 weight of 1,3-BDO Part, 5 ~ 8 parts by weight of collagen, 5.5 ~ 9 parts by weight of SIMMONDSIA CHINENSIS SEED OIL, 0.3 ~ 0.5 parts by weight of refined jasmine oil, deionized water 42 ~ 64 Parts by weight.
8. a kind of preparation method of long-acting moisturizing sun care preparations according to claim 1, it is characterised in that：Step（4）Institute The speed for stating homogeneous is 1500 ~ 2000r/min, and the time is 3 ~ 10min.
9. a kind of long-acting moisturizing sun care preparations that any one of claim 1 ~ 8 preparation method is prepared.
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