CN108542820A - Skin penetration enhancer, skin matrix and its preparation method and application - Google Patents
Skin penetration enhancer, skin matrix and its preparation method and application Download PDFInfo
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- CN108542820A CN108542820A CN201810523186.7A CN201810523186A CN108542820A CN 108542820 A CN108542820 A CN 108542820A CN 201810523186 A CN201810523186 A CN 201810523186A CN 108542820 A CN108542820 A CN 108542820A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The present invention relates to a kind of skin penetration enhancers, skin matrix and its preparation method and application.The skin penetration enhancer is made of natural transdermal enhancer and chemical transdermal enhancer, and the mass percent of the natural transdermal enhancer and chemical transdermal enhancer is 65%~85%：15%~35%；The natural transdermal enhancer is selected from least one of camellia seed oil, angelica extract, Salvia root P.E and cinnamomum cassia extract；The chemistry transdermal enhancer is selected from least one of sodium lauroyl sarcosine, cetyl sulfobetaines and dodecyl benzyl dimethyl ammonium chloride.The skin penetration enhancer of the present invention can be effectively improved the Transdermal absorption of functional component in cosmetics or skin care item.The Transdermal absorption excellent effect of the skin matrix of the present invention has antiallergic maintenance, moisturizing and other effects.
Description
Technical field
The present invention relates to skin care or cosmetic technical fields, more particularly to a kind of skin penetration enhancer, skin care base
Matter and its preparation method and application.
Background technology
Cosmetics or skin care item publicity in the market have moisturizing, whitening and anti-aging, maintenance and other effects, but such as it
The correlative study what carries out transdermal delivery effect is also to be hoisted.As fruit cosmetic or skin care item stay in always skin table
Face will result in nutritional ingredient surplus, skin oxidative, while also result in the growth and breeding of parasitic bacteria so as to cause skin sense
Dye.Therefore, the Transdermal absorption of active ingredient is most important to the performance of its effect in cosmetics or skin care item.
Transdermal absorption in cosmetics or skin care item refers to that the functional components in cosmetics are made by the validity of product
For skin surface or enter epidermis or corium, and the process gathered and played a role at the position.Such as, the UV in sunscreen product
Absorbent should be trapped in skin surface, play a part of to absorb and reflect ultraviolet light；Whitening agent in whitening product often acts on table
Basal layer in skin plays a part of that melanin is blocked to generate；And the effect of anti-aging product ingredient then often acts on skin corium
Fibrocyte makes skin high resilience.
With cause the factor of skin irritatin more and more in the environment such as air pollution and people to beautiful pursuit and into
The U.S. Minimally Invasive Surgery practised medicine causes skin to become more and more sensitive, or even the situations such as inflammation, rubescent, allergy occurs.Daily list
Pure preserving moisture and protecting skin has been unable to the above-mentioned skin problem of maintenance, skin be stimulated after cannot timely maintenance, the state of skin
Increasingly worse, this to have the cosmetics for repairing antiallergic function or skin care item are more and more favored by consumers.
The skin care item of maintenance antiallergic after being stimulated on the market for above-mentioned skin at present, often not because of its functional component
Can effectively Transdermal absorption and cause effect not notable.Therefore, it improves antiallergic based on the Transdermal absorption for improving functional component and repaiies
The cosmetics of shield effect will necessarily have huge market potential.
Invention content
Based on this, the present invention provides a kind of skin penetration enhancers, can be effectively improved in cosmetics or skin care item
The Transdermal absorption of functional component.
Specific technical solution is as follows：
A kind of skin penetration enhancer is made of, the natural transdermal enhancer and chemistry natural transdermal enhancer and chemical transdermal enhancer
The mass percent of transdermal enhancer is 65%~85%：15%~35%；The natural transdermal enhancer is selected from camellia seed oil, Radix Angelicae Sinensis extracts
At least one of object, Salvia root P.E and cinnamomum cassia extract；The chemistry transdermal enhancer is selected from sodium lauroyl sarcosine, hexadecane
At least one of base sulfobetaines and dodecyl benzyl dimethyl ammonium chloride.
In wherein some embodiments, the mass percent of the natural transdermal enhancer and chemical transdermal enhancer is 65%~
75%：25%~35%.
In wherein some embodiments, the skin penetration enhancer is 1 by mass ratio：0.5~1:0.5~1 camellia
Seed oil, angelica extract and cetyl sulfobetaines composition.
In wherein some embodiments, the skin penetration enhancer is 1 by mass ratio：0.7~0.8:0.7~0.8
Camellia seed oil, angelica extract and cetyl sulfobetaines composition.
The present invention also provides a kind of skin matrixes.The Transdermal absorption excellent effect of the skin matrix, have antiallergic maintenance,
Moisturizing and other effects.
Specific technical solution is as follows：
A kind of skin matrix, the raw material for preparing the skin matrix include above-mentioned skin penetration enhancer.
In wherein some embodiments, additive amount of the skin penetration enhancer in the skin matrix be 0.01~
0.5%.
In wherein some embodiments, additive amount of the skin penetration enhancer in the skin care item matrix is 0.2
~0.5%.
In wherein some embodiments, the raw material for preparing the skin matrix further includes skin care compositions, the skin care group
Close the component that object includes following parts by weight：
In wherein some embodiments, the skin care compositions includes the component of following parts by weight：
In wherein some embodiments, the skin care compositions further includes the component of following parts by weight：
0.01~1 part of Pelargonium roseum extract, and/or
0.01~1 part of kuh-seng root extract, and/or
0.01~1 part of oligopeptides -1.
In wherein some embodiments, the skin care compositions further includes the component of following parts by weight：
0.1~0.5 part of Pelargonium roseum extract, and/or
0.1~0.5 part of kuh-seng root extract, and/or
0.3~0.5 part of oligopeptides -1.
In wherein some embodiments, additive amount of the skin care compositions in the skin matrix is 0.2~15%.
In wherein some embodiments, additive amount of the skin care compositions in the skin matrix is 3~5%.
In wherein some embodiments, the raw material for preparing the skin matrix includes following components in percentage by weight：
In wherein some embodiments, the raw material for preparing the skin matrix includes following components in percentage by weight：
In wherein some embodiments, the preservative is selected from long and thin hot pepper extract, Radix Pulsatillae extract and palpus sunglo extraction
At least one of object.
The present invention also provides a kind of skin care item or cosmetics.
Specific technical solution is as follows：
A kind of skin care item raw material that either cosmetics prepare the cosmetics or skin care item includes above-mentioned skin care base
Other acceptable auxiliary materials in matter and cosmetics or skin care item.Above-mentioned skin matrix has effects that antiallergic reparation, matrix
The effect of ingredient be easily absorbed transdermally, provide nutrition for skin；The matrix can be further by adding cosmetics or skin care item
In Related Component or auxiliary material, be made the cosmetics or skin care item of a variety of dosage forms, including but not limited to aqua, facial mask, lotion,
Lotion, frost, cream, gel.
The present invention also provides the preparation methods of above-mentioned skin matrix.
Specific technical solution is as follows：
Skin penetration enhancer is uniformly dissolved with mixed solvent, obtains the mixed solution of skin penetration enhancer, it is described mixed
Bonding solvent is that mass ratio is 4~6:2~3:1 water, absolute ethyl alcohol and glycerine, the gross mass of the skin penetration enhancer and institute
The mass ratio for stating mixed solvent is 1:0.8~1.2；
The remainder of the remainder of the water, 1,3-PD and the glycerine is added in agitated kettle, 80~
It is uniformly mixed at a temperature of 90 DEG C, adds the mixed solution of the skin penetration enhancer, be uniformly mixed, obtain A
Mix liquid；
It waits for that the A mixes the temperature of liquid and is cooled to 60~70 DEG C, B phase substances is added, stirs evenly, obtains A/B and mix
Liquid；The B phases substance is the rutin sophorin and American aloe stem extraction；
Wait for that the temperature of the A/B mixed liquors is cooled to 35~45 DEG C, C phase substances be added, stir evenly to get；The C phases
Substance is the component in addition to rutin sophorin and American aloe stem extraction in preservative and the skin care compositions.
The skin penetration enhancer of the present invention, skin matrix and its preparation method and application have the following advantages and beneficial to effects
Fruit：
The specific natural transdermal enhancer of present invention selection is compounded to obtain a kind of compound Transdermal absorption rush with chemical transdermal enhancer
Into agent, the saturating effect of rush of transdermal enhancer can be significantly improved, is used it in skin matrix cosmetics or skin care item, it can be with
The Transdermal absorption for significantly improving skin-care effect ingredient, to improve the skin effect of cosmetics or skin care item, this is compound transdermal
Sorbefacient has dosage few, and no hysteresis quality promotees the advantages that effect is good.
Camellia seed oil, Radix Angelicae Sinensis and the cetyl of the further preferred special ratios of compound skin penetration enhancer of the present invention
Sulfobetaines is compounded, and further improves skin penetration enhancer to the saturating effect of the rush of skin-care effect ingredient.Camellia seed
The main component of oil is oleic acid (85%-88%), linoleic acid, while being rich in vitamin A, B, E, D, carrotene and other antioxygens
Agent.Oleic acid i.e. 18 carbon monoenoic acids, it is quite similar with fatty acid structure in human skin, Stratum corneum lipids structure can be influenced,
Change is brought it about, increases lipid fluidity, to promote the infiltration of effect substance.Linoleic acid is diene unsaturated acids, on mountain
Relatively stablize in tea-seed oil, is not easy to be aoxidized, while having the function of vitamin E sample.Camellia seed oil coordinates Radix Angelicae Sinensis and cetyl
Sulfobetaines is used together, and has the function of synergy, can significantly improve the saturating effect of rush of compound penetration enhancer.
In the skin matrix of the present invention, specific skin care compositions is further selected, each component is assisted in the skin care compositions
Same-action has the function of apparent antiallergic maintenance, moisturizing, coordinates the good transdermal enhancing effect of skin penetration enhancer, carries significantly
The high Transdermal absorption effect of skin care compositions, makes the skin matrix of the present invention have the effect of significant antiallergic maintenance, moisturizing,
And it is safe and non-stimulating.
Specific implementation mode
Below in conjunction with specific embodiment, the present invention will be further described in detail.
Agents useful for same and raw material are commercially available general reagent and raw material unless otherwise specified in following embodiment.
Wherein, cosmetics-stage camellia seed oil is purchased from the Nanning bio tech ltd Run Shengtang；
Angelica extract is purchased from the bio tech ltd Beijing Orient Miao Senshen；
American aloe stem extraction is purchased from Beijing Nai Que biochemical technologies research institute；
Pelargonium roseum extract is purchased from Guangzhou Xing Mei Chemical Co., Ltd.s；
Golden yellow camomile extract is purchased from Zhuhai Ke Laiming Chemical Co., Ltd.s；
Kuh-seng root extract is purchased from the Guangzhou bio tech ltd Qi Yuan；
Purslane extract is purchased from Shenzhen Luo Jia new materials Science and Technology Ltd.；
Long and thin hot pepper extract is purchased from the Guangzhou bio tech ltd Pin Yan；
Radix Pulsatillae extract is purchased from the Guangzhou bio tech ltd Pin Yan；
Palpus extractive of usnea is purchased from the Guangzhou bio tech ltd Pin Yan.
Embodiment 1
The present embodiment provides a kind of skin matrix with antiallergic maintenance, preparation method is as follows：
(1) stirring is opened, the water of 84.28 parts by weight, the 1,3-PD of 4 parts by weight, 6 parts by weight are added into agitated kettle
Glycerine, after 85 DEG C, mixing speed 400rpm, mixing time 30min of temperature, the compound Transdermal absorption that 0.01 parts by weight are added promotees
Into agent (consisting of 40% cosmetics-stage camellia seed oil, 30% angelica extract, 30% cetyl sulfobetaines；It is added
Preceding to be first uniformly dissolved with mixed solvent, mixed solvent is that weight ratio is 10:5:2 water, absolute ethyl alcohol and glycerine, cosmetics-stage mountain
The mass ratio of tea-seed oil, the gross mass of angelica extract and cetyl sulfobetaines and mixed solvent is 1:1) it, stirs
30min obtains A and mixes liquid to being uniformly mixed, cooling for use.
(2) it is mixed to the A for being cooled to 65 DEG C and the rutin sophorin of 2 parts by weight and the American aloe stem of 1 parts by weight is added in liquid
Extract, 65 DEG C of constant temperature, 400rpm stir 30min, are uniformly mixed, and obtain A/B and mix liquid, cooling for use.
(3) the Pelargonium roseum extract that 0.2 parts by weight are added in liquid, 0.4 weight are mixed to the A/B for being cooled to 40 DEG C
30min is mixed in the golden yellow camomile extract of part, the purslane extract of 0.1 parts by weight, 500rpm；It is subsequently added into 1 weight
Long and thin hot pepper extract, the 1 parts by weight Radix Pulsatillae extract for measuring part, due to the volatilization of moisture in heating stirring manufacturing process, then into one
It is 100 parts to walk moisturizing to total amount, and 30min is mixed, and discharging obtains antiallergic maintenance skin matrix.
Embodiment 2
The present embodiment provides a kind of skin matrix with antiallergic maintenance, preparation method is as follows：
(1) stirring is opened, the water of 83.7 parts by weight, the 1,3-PD of 4 parts by weight, 6 parts by weight are added into agitated kettle
Glycerine, after 85 DEG C, mixing speed 400rpm, mixing time 30min of temperature, the compound Transdermal absorption that 0.2 parts by weight are added promotees
Into agent (consisting of 40% cosmetics-stage camellia seed oil, 30% angelica extract, 30% cetyl sulfobetaines；It is added
Preceding to be first uniformly dissolved with mixed solvent, mixed solvent is that weight ratio is 10:5:2 water, absolute ethyl alcohol and glycerine, cosmetics-stage mountain
The mass ratio of tea-seed oil, the gross mass of angelica extract and cetyl sulfobetaines and mixed solvent is 1:1) it, stirs
30min obtains A and mixes liquid to being uniformly mixed, cooling for use.
(2) it is mixed to the A for being cooled to 65 DEG C and the rutin sophorin of 2 parts by weight and the American aloe stem of 1 parts by weight is added in liquid
Extract, 65 DEG C of constant temperature, 400rpm stir 30min, are uniformly mixed, and obtain A/B and mix liquid, cooling for use.
(3) oligopeptides -1 that 0.5 parts by weight are added in liquid, the golden yellow ocean of 0.2 parts by weight are mixed to the A/B for being cooled to 40 DEG C
30min is mixed in the purslane extract of Flos Chrysanthemi extract, 0.2 parts by weight, 500rpm；It is subsequently added into the long and thin hot pepper of 1 parts by weight
Extract, 1 parts by weight Radix Pulsatillae extract, due to the volatilization of moisture in heating stirring manufacturing process, further moisturizing is to total
Amount is 100 parts, and 30min is mixed, and discharging obtains antiallergic maintenance skin matrix.
Embodiment 3
The present embodiment provides a kind of skin matrix with antiallergic maintenance, preparation method is as follows：
(1) stirring is opened, the water of 83.1 parts by weight, the 1,3-PD of 4 parts by weight, 6 parts by weight are added into agitated kettle
Glycerine, after 85 DEG C, mixing speed 400rpm, mixing time 30min of temperature, the compound Transdermal absorption that 0.5 parts by weight are added promotees
Into agent (consisting of 40% cosmetics-stage camellia seed oil, 30% angelica extract, 30% cetyl sulfobetaines；It is added
Preceding to be first uniformly dissolved with mixed solvent, mixed solvent is that weight ratio is 10:5:2 water, absolute ethyl alcohol and glycerine, cosmetics-stage mountain
The mass ratio of tea-seed oil, the gross mass of angelica extract and cetyl sulfobetaines and mixed solvent is 1:1) it, stirs
30min obtains A and mixes liquid to being uniformly mixed, cooling for use.
(2) it is mixed to the A for being cooled to 65 DEG C and the rutin sophorin of 2 parts by weight and the American aloe stem of 1 parts by weight is added in liquid
Extract, 65 DEG C of constant temperature, 400rpm stir 30min, are uniformly mixed, and obtain A/B and mix liquid, cooling for use.
(3) oligopeptides -1 that 0.5 parts by weight are added in liquid, the golden yellow ocean of 0.2 parts by weight are mixed to the A/B for being cooled to 40 DEG C
30min is mixed in the purslane extract of Flos Chrysanthemi extract, 0.2 parts by weight, 500rpm；It is subsequently added into the long and thin hot pepper of 1 parts by weight
Extract, 1 parts by weight Radix Pulsatillae extract, due to the volatilization of moisture in heating stirring manufacturing process, further moisturizing is to total
Amount is 100 parts, and 30min is mixed, and discharging obtains antiallergic maintenance skin matrix.
Comparative example 1
This comparative example provides a kind of skin matrix with antiallergic maintenance, and preparation method is as follows：
(1) stirring is opened, the water of 83.7 parts by weight, the 1,3-PD of 4 parts by weight, 6 parts by weight are added into agitated kettle
Glycerine, after 85 DEG C, mixing speed 400rpm, mixing time 30min of temperature, natural transdermal enhancer (its group of 0.2 parts by weight is added
As angelica extract, first it is uniformly dissolved with mixed solvent before being added, mixed solvent is that weight ratio is 10:5:2 water, anhydrous second
Alcohol and glycerine, the quality of angelica extract and the mass ratio of mixed solvent are 1:1), stirring 30min obtains A phases and mixes to being uniformly mixed
Liquid is closed, it is cooling for use.
(2) it is mixed to the A for being cooled to 65 DEG C and the rutin sophorin of 2 parts by weight and the American aloe stem of 1 parts by weight is added in liquid
Extract, 65 DEG C of constant temperature, 400rpm stir 30min, are uniformly mixed, and obtain A/B and mix liquid, cooling for use.
(3) oligopeptides -1 that 0.5 parts by weight are added in liquid, the golden yellow ocean of 0.2 parts by weight are mixed to the A/B for being cooled to 40 DEG C
30min is mixed in the purslane extract of Flos Chrysanthemi extract, 0.2 parts by weight, 500rpm；It is subsequently added into the long and thin hot pepper of 1 parts by weight
Extract, 1 parts by weight Radix Pulsatillae extract, due to the volatilization of moisture in heating stirring manufacturing process, further moisturizing is to total
Amount is 100 parts, and 30min is mixed, and discharging obtains antiallergic maintenance skin matrix.
Comparative example 2
This comparative example provides a kind of skin matrix with antiallergic maintenance, and preparation method is as follows：
(1) stirring is opened, the water of 83.7 parts by weight, the 1,3-PD of 4 parts by weight, 5 parts by weight are added into agitated kettle
Glycerine, after 85 DEG C, mixing speed 400rpm, mixing time 30min of temperature, chemical transdermal enhancer (its group of 0.2 parts by weight is added
As cetyl sulfobetaines, first it is uniformly dissolved with mixed solvent before being added, mixed solvent is that weight ratio is 10:5:2
Water, absolute ethyl alcohol and glycerine, the quality of cetyl sulfobetaines and the mass ratio of mixed solvent are 1:1) 30min, is stirred
To being uniformly mixed, obtains A and mix liquid, it is cooling for use.
(2) it is mixed to the A for being cooled to 65 DEG C and the rutin sophorin of 2 parts by weight and the American aloe stem of 1 parts by weight is added in liquid
Extract, 65 DEG C of constant temperature, 400rpm stir 30min, are uniformly mixed, and obtain A/B and mix liquid, cooling for use.
(3) oligopeptides -1 that 0.5 parts by weight are added in liquid, the golden yellow ocean of 0.2 parts by weight are mixed to the A/B for being cooled to 40 DEG C
30min is mixed in the purslane extract of Flos Chrysanthemi extract, 0.2 parts by weight, 500rpm；It is subsequently added into the long and thin hot pepper of 1 parts by weight
Extract, 1 parts by weight Radix Pulsatillae extract, due to the volatilization of moisture in heating stirring manufacturing process, further moisturizing is to total
Amount is 100 parts, and 30min is mixed, and discharging obtains antiallergic maintenance skin matrix.
Comparative example 3
This comparative example provides a kind of skin matrix with antiallergic maintenance, and preparation method is as follows：
(1) stirring is opened, the water of 83.7 parts by weight, the 1,3-PD of 4 parts by weight, 6 parts by weight are added into agitated kettle
Glycerine, after 85 DEG C, mixing speed 400rpm, mixing time 30min of temperature, natural transdermal enhancer (its group of 0.2 parts by weight is added
As cosmetics-stage camellia seed oil, first it is uniformly dissolved with mixed solvent before being added, mixed solvent is that weight ratio is 10:5:2 water,
Absolute ethyl alcohol and glycerine, the quality of cosmetics-stage camellia seed oil and the mass ratio of mixed solvent are 1:1), stirring 30min is extremely mixed
Uniformly, it obtains A and mixes liquid, it is cooling for use.
(2) it is mixed to the A for being cooled to 65 DEG C and the rutin sophorin of 2 parts by weight and the American aloe stem of 1 parts by weight is added in liquid
Extract, 65 DEG C of constant temperature, 400rpm stir 30min, are uniformly mixed, and obtain A/B and mix liquid, cooling for use.
(3) oligopeptides -1 that 0.5 parts by weight are added in liquid, the golden yellow ocean of 0.2 parts by weight are mixed to the A/B for being cooled to 40 DEG C
30min is mixed in the purslane extract of Flos Chrysanthemi extract, 0.2 parts by weight, 500rpm；It is subsequently added into the long and thin hot pepper of 1 parts by weight
Extract, 1 parts by weight Radix Pulsatillae extract, due to the volatilization of moisture in heating stirring manufacturing process, further moisturizing is to total
Amount is 100 parts, and 30min is mixed, and discharging obtains antiallergic maintenance skin matrix.
Comparative example 4
This comparative example provides a kind of skin matrix with antiallergic maintenance, and preparation method is as follows：
(1) stirring is opened, the water of 84.1 parts by weight, the 1,3-PD of 4 parts by weight, 6 parts by weight are added into agitated kettle
Glycerine, after 85 DEG C, mixing speed 400rpm, mixing time 30min of temperature, be not added with any transdermal enhancer, obtain A and mix liquid, it is cold
For use.
(2) it is mixed to the A for being cooled to 65 DEG C and the rutin sophorin of 2 parts by weight and the American aloe stem of 1 parts by weight is added in liquid
Extract, 65 DEG C of constant temperature, 400rpm stir 30min, are uniformly mixed, and obtain A/B and mix liquid, cooling for use.
(3) oligopeptides -1 that 0.5 parts by weight are added in liquid, the golden yellow ocean of 0.2 parts by weight are mixed to the A/B for being cooled to 40 DEG C
30min is mixed in the purslane extract of Flos Chrysanthemi extract, 0.2 parts by weight, 500rpm；It is subsequently added into the long and thin hot pepper of 1 parts by weight
Extract, 1 parts by weight Radix Pulsatillae extract, due to the volatilization of moisture in heating stirring manufacturing process, further moisturizing is to total
Amount is 100 parts, and 30min is mixed, and discharging obtains antiallergic maintenance skin matrix.
4 efficacy assessments of embodiment
1, allergy sexual stimulus is tested：Totally 140 subjects, age level is 20-50 one full year of life, wherein 70 subjects
Skin be rubescent sensitive skin or had the U.S. operation of doctor wait for maintenance skin or do not repair complete skin (do not occur new allergy,
Red and swollen, spot), the skin of another 70 subjects is without apparent ill symptoms.7 groups are divided into, wherein every group there are 10 at random
Subject for rubefaction sensitivity skin and 10 subjects of the skin without apparent ill symptoms, every group is tried out embodiment respectively
Skin matrix prepared by 1-3 and comparative example 1-4.Embodiment 1-3 and comparative example the 1-4 skin matrix prepared are uniformly smeared
In the face, the back of the hand and abdomen of subject, see whether the adverse reactions such as redness, spot occur.It is repeatedly tested by a large amount of,
It is bad or uncomfortable not occur anaphylaxis redness, spot etc. in the skin matrix subject of embodiment 1-3 and comparative example 1-4
Reaction illustrates that the skin matrix of the present invention is safe.
2, the barrier properties of skin pass through keratoderma water content and transepidermal water loss (Transepidermal water
loss,TEWL,g/(cm2* it h)) characterizes, water content of stratum corneum is higher, TEWL is smaller, the barrier function of skin is better.Using
German non-invasive skin test instrument test keratoderma water content, through epidermis dehydration, be unified in without sunlight direct projection, it is calm,
25 DEG C of room temperature, indoor carry out subjects skin's cleaning of humidity 50-60% are tested after the 15min that sits quietly, and measure select every time
With the same position of face, measures three times, be averaged altogether.Correlation computations formula is as follows：
Subject method：80 sensitive skin subjects, random to be grouped, every group of 10 people, 1-7 groups are on probation real in face respectively
Skin matrix prepared by example 1~3 and comparative example 1~4 is applied, each smearing is primary sooner or later daily；8th group is blank control group, is not made
With any matrix the average transepidermal water loss rate of every group of subject is investigated after trying out 28 days.
Test result is as follows for it shown in table：
| Given the test agent | Transepidermal water loss is reduced than (%) | Keratoderma water content increases than (%) |
| The skin matrix of embodiment 1 | 0.223421 | 0.378943 |
| The skin matrix of embodiment 2 | 0.208342 | 0.386674 |
| The skin matrix of embodiment 3 | 0.207963 | 0.387896 |
| The skin matrix of comparative example 1 | 0.243964 | 0.358324 |
| The skin matrix of comparative example 2 | 0.241832 | 0.367566 |
| The skin matrix of comparative example 3 | 0.239675 | 0.371643 |
| The skin matrix of comparative example 4 | 0.246873 | 0.352562 |
| Blank control group | 0.261702 | 0 |
Skin matrix prepared by embodiment 1-3, can be preferable compared with the skin matrix prepared by comparative example 1-4
Increase moisture content of skin and reduce transepidermal water loss rate, illustrates that the skin matrix prepared by embodiment 1-3 is compound due to being added to
Skin sorbefacient, energy Enough preferably improves the Transdermal absorption of maintenance functional component, to improve skin matrix to skin barrier
The maintenance effect of function improves the barrier kinetic energy of skin, the effect of to reach better maintenance skin.Comparative example 1-3 only adds
A kind of saturating ingredient of rush is added, comparative example 4, which lacks, promotees saturating ingredient, maintenance performance of the skin matrix prepared to skin barrier function
It is poor.
3, maintenance therapeutic evaluation
Totally 160 subjects, age level are 20-50 one full year of life, and the skin of all subjects is rubescent sensitive flesh
Skin and there are the performances such as redness, spot, impaired, is randomly divided into 8 groups, every group has 20 people, every group of 1-7 to try out embodiment 1- respectively
Skin matrix prepared by 3 and comparative example 1-4, the 8th group is blank control group, does not use any matrix.Respectively to subject's
Skin of face is tested.Embodiment 1-3 and comparative example the 1-4 skin matrix prepared are applied to subject's face, sooner or later
Each 1 time, 28 days are a cycle, count the using effect in two periods, evaluate subjects skin.Meanwhile it using
Period, user avoid excessive pungent stimulation food, wine for giving off smoking from paying attention to avoiding abuse cosmetics on diet.
Criterion of therapeutical effect：
Recovery from illness：The performances such as red swelling of the skin completely disappear, and skin lesion area maintenance improves 100%；
It is effective：The performance such as red swelling of the skin, impaired be improved significantly, skin lesion area maintenance improves >=75%；
Effectively：The performances such as red swelling of the skin, impaired make moderate progress, and skin lesion area maintenance improves >=50%；
In vain：The above clinical symptoms person is not met；
Total effective rate=cure rate+obvious effective rate.
Test result is as follows for it shown in table：
| Given the test agent | It fully recovers (people) | Effective (people) | Effectively (people) | (people) in vain | Total effective rate |
| The skin matrix of embodiment 1 | 15 | 3 | 2 | 0 | 90% |
| The skin matrix of embodiment 2 | 18 | 1 | 1 | 0 | 95% |
| The skin matrix of embodiment 3 | 18 | 1 | 1 | 0 | 95% |
| The skin matrix of comparative example 1 | 10 | 5 | 5 | 0 | 75% |
| The skin matrix of comparative example 2 | 11 | 5 | 4 | 0 | 80% |
| The skin matrix of comparative example 3 | 12 | 5 | 3 | 0 | 85% |
| The skin matrix of comparative example 4 | 5 | 6 | 7 | 2 | 55% |
| Blank control group | 1 | 2 | 4 | 13 | 15% |
Skin matrix prepared by embodiment 1-3 is compared with the skin matrix prepared by comparative example 1-4, to sensitive skin
With better maintenance curative effect, the compound skin penetration enhancer of the present invention is added in skin matrix, energy Enough preferably improves
The Transdermal absorption of maintenance functional component, the effect of so as to significantly improve skin matrix.In addition, after two periods, it is all tested
Person does not occur obvious adverse reaction.
Each technical characteristic of embodiment described above can be combined arbitrarily, to keep description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Several embodiments of the invention above described embodiment only expresses, the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of skin penetration enhancer, which is characterized in that be made of natural transdermal enhancer and chemical transdermal enhancer, the natural rush is saturating
The mass percent of agent and chemical transdermal enhancer is 65%~85%：15%~35%；The natural transdermal enhancer be selected from camellia seed oil,
At least one of angelica extract, Salvia root P.E and cinnamomum cassia extract；The chemistry transdermal enhancer is selected from Hamposyl L
At least one of sodium, cetyl sulfobetaines and dodecyl benzyl dimethyl ammonium chloride.
2. skin penetration enhancer according to claim 1, which is characterized in that by mass ratio be 1：0.5~1:0.5~1
Camellia seed oil, angelica extract and cetyl sulfobetaines composition.
3. a kind of skin matrix, which is characterized in that the raw material for preparing the skin matrix includes as claimed in claim 1 or 2
Skin penetration enhancer.
4. skin matrix according to claim 3, which is characterized in that the skin penetration enhancer is in the skin matrix
In additive amount be 0.01~0.5%.
5. skin matrix according to claim 3, which is characterized in that the raw material for preparing the skin matrix further includes skin care
Composition, the skin care compositions include the component of following parts by weight：
6. skin matrix according to claim 5, which is characterized in that the skin care compositions further includes following parts by weight
Component：
0.01~1 part of Pelargonium roseum extract, and/or
0.01~1 part of kuh-seng root extract, and/or
0.01~1 part of oligopeptides -1.
7. skin matrix according to claim 5 or 6, which is characterized in that the skin care compositions is in the skin matrix
In additive amount be 0.2-15%.
8. skin matrix according to claim 5 or 6, which is characterized in that the raw material for preparing the skin matrix include with
The component of lower weight percent：
9. a kind of skin care item or cosmetics, which is characterized in that the raw material for preparing the skin care item or cosmetics includes having the right
Profit requires other acceptable auxiliary materials in 3-8 any one of them skin matrix and cosmetics or skin care item.
10. a kind of preparation method of skin matrix according to any one of claims 8, which is characterized in that include the following steps：
Skin penetration enhancer is uniformly dissolved with mixed solvent, obtains the mixed solution of skin penetration enhancer, the mixing is molten
Agent is that mass ratio is 4~6:2~3:1 water, absolute ethyl alcohol and glycerine, the gross mass of the skin penetration enhancer are mixed with described
The mass ratio of bonding solvent is 1:0.8~1.2；
The remainder of the remainder of the water, 1,3-PD and the glycerine is added in agitated kettle, at 80~90 DEG C
At a temperature of be uniformly mixed, add the mixed solution of the skin penetration enhancer, be uniformly mixed, obtain A phases and mix
Close liquid；
It waits for that the A mixes the temperature of liquid and is cooled to 60~70 DEG C, B phase substances is added, stirs evenly, obtains A/B and mix liquid；Institute
It is the rutin sophorin and American aloe stem extraction to state B phase substances；
Wait for that the temperature of the A/B mixed liquors is cooled to 35~45 DEG C, C phase substances be added, stir evenly to get；The C phases substance
For the component in preservative and the skin care compositions in addition to rutin sophorin and American aloe stem extraction.
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| CN112120970A (en) * | 2020-09-29 | 2020-12-25 | 上海相宜本草化妆品股份有限公司 | Essential oil composition, preparation method and application thereof |
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