CN108541711A - A kind of bactericidal composition of containing chlorine fluorine ether bacterium azoles and fluxapyroxad - Google Patents
A kind of bactericidal composition of containing chlorine fluorine ether bacterium azoles and fluxapyroxad Download PDFInfo
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- CN108541711A CN108541711A CN201810679187.0A CN201810679187A CN108541711A CN 108541711 A CN108541711 A CN 108541711A CN 201810679187 A CN201810679187 A CN 201810679187A CN 108541711 A CN108541711 A CN 108541711A
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- fluxapyroxad
- bacterium azoles
- ether bacterium
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Abstract
The invention discloses a kind of bactericidal compositions of containing chlorine fluorine ether bacterium azoles and fluxapyroxad, which is characterized in that the quality parts ratio of the bacterium azoles of fluorine chlorine ether containing effective active composition and fluxapyroxad, the effective active composition fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:50~50:1, further preferably than being 1:30~30:1, it is further preferential than being 1:20~20:1, further preferably than being 1:10~10:1, further preferably than being 1:1、1:2、1:3、1:5、2:3、5:7、2:1、3:8, both the effective active composition fluorine chlorine ether bacterium azoles and fluxapyroxad account for the mass percentage 1~80% of composition, and fluorine chlorine ether bacterium azoles is compounded with fluxapyroxad with certain proportion, have higher control effect to graw mold of tomato and rice sheath blight disease.
Description
Technical field
The invention belongs to technical field of pesticide, and in particular to a kind of Bactericidal composite of containing chlorine fluorine ether bacterium azoles and fluxapyroxad
Application of the object in crop disease.
Background technology
Fluorine chlorine ether bacterium azoles (mefentrifluconazole) be a kind of wide spectrum, efficiently, interior suction, have and root out and protect work
Fungicide shows excellent biological property, is expected to become the important tool of efficiently control disease, and will be used for slowing down
The resistance development of fungicide.Studies have shown that fluorine chlorine ether bacterium azoles has outstanding bioactivity to many refractory fungal diseases, fits
For many field crops and special crop in world wide, such as corn, cereal, soybean and industrial crops.It is reported that fluorine chlorine ether
Bacterium azoles is more preferable than prothioconazoles and epoxiconazole preventive effect.
The chemical constitution of fluorine chlorine ether bacterium azoles is as follows：
Fluxapyroxad (fluxapyroxad) chemical name：3- (difluoro) -1- methyl-N- (3', 4', 5'- trifluoro [1,
1'- biphenyl] -2- bases) -1-H- pyrazoles -4- amides, molecular formula：C18H12F5N3O belongs to pyrazole amide series bactericidal agent, for preventing
Broad spectrum fungus disease, the mode of action are that the succinate dehydrogenase in the Complex II to mitochondrial respiratory chain plays inhibiting effect,
To the spore-germination of suppression target fungi, germ tube elongation, mycelia growth and sporogenesis.
In recent years, the difficulty of prevention and cure of phytopathogen is increasing, when due to the change of pattern of farming, cultivated area by
Step expands, and disease occurrence degree, generation quantity is caused to increase；Furthermore the resistance of pathogen selects pressure in lasting medicament
Rise year by year under power, the control effect of single dose is had a greatly reduced quality, and the active ingredient of different role mechanism is compounded, and is to delay disease
The harmful common method that develops immunity to drugs, complex role are significantly formulated, can significantly improve preventive effect, substantially reduce the use of pesticide
Dose can also expand fungicidal spectrum, improve germicidal efficiency and there are no at present about the compounding of fluorine chlorine ether bacterium azoles and fluxapyroxad
Report
Invention content
In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide it is a kind of it is applied widely, at low cost, effect is good,
The fluorine chlorine ether bacterium azoles of plant disease resistance problem and the antimicrobial combination of fluxapyroxad can be solved, active ingredient is fluorine chlorine ether
Bacterium azoles and fluxapyroxad.
In order to solve the above technical problems, the present invention uses following technical scheme：
A kind of bactericidal composition of containing chlorine fluorine ether bacterium azoles and fluxapyroxad, the fluorine chlorine ether bacterium azoles and fluxapyroxad
Quality parts ratio is 1:50~50:1, further preferably than being 1:30~30:1, it is further preferential than being 1:20~20:1,
Further preferably than being 1:10~10:1, further preferably than being 1:1、1:2、1:3、1:5、2:3、5:7.
Further, the quality parts ratio of fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:30~30:1.
Further, the quality parts ratio of fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:20~20:1.
Further, the quality parts ratio of fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:10~10:1.
Further, the quality parts ratio of fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:1、1:2、1:3、1:5、2:3、5:7、
2:1、3:8。
In the present invention, both the fluorine chlorine ether bacterium azoles and fluxapyroxad account for composition mass percentage be 1~
80%, further preferably 3~50%.Wherein effective ingredient is present in composition with enhancing effective amount in bactericidal composition
In, " % " of the present invention is mass percentage.
The bactericidal composition, it is multiple as principle active component and known auxiliary agent using fluorine chlorine ether bacterium azoles and fluxapyroxad
It is made into any dosage form allowed on pesticide, preferred dosage form has suspending agent, microcapsule suspending agent, water dispersible granules, wettable
Pulvis, wet seed dressing, missible oil, suspension seed-coating agent, aqueous emulsion or microemulsion.
The auxiliary agent includes surfactant, solvent, emulsifier, wetting agent, dispersant, antifreezing agent, thickener, bonding
Agent, antifoaming agent, stabilizer, filler etc. are all to commonly use in pesticidal preparations or allow the ingredient used, are not particularly limited, specifically
Ingredient and dosage are according to the recipe requirements determined by the test etc..
The surfactant be selected from calcium dodecyl benzene sulfonate, alkyl phenol polyoxyethylene ether, Ben-zylphenol Polyoxyethyl Ether,
Phenethyl phenol polyethenoxy ether, fatty alcohol polyoxyethylene ether and its similar products, aliphatic amine polyoxyethylene ether, aliphatic acid epoxy second
Alkane addition product, polyoxyethylene polyoxy propylene block compound, castor oil polyoxyethylene ether, neopelex, dodecane
Base sulfate, TWEEN Series, fatty alcohol polyoxyethylene ether, polyethylene glycol series, Sulfonates, carboxylate, sulfate, phosphoric acid
The mixing of one or more of salt, phosphite, lignosulfonates, phenol formaldehyde condensate, ammonium salt, quaternary etc.
Object.
The solvent is selected from acetone, butanone, cyclohexanone, toluene, dimethylbenzene, trimethylbenzene, durene, methyl naphthalene, oleic acid first
Ester, ethyl acetate, fatty acid methyl ester, loose base oil, soybean oil, rapeseed oil, biodiesel, ethyl alcohol, normal propyl alcohol, isopropanol, the third two
Alcohol, glycerine, n-butanol, isooctanol, sec-Butyl Acetate, dimethyl carbonate, diesel oil, white oil, machine oil, disalt base ester, N- methyl
The mixture of one or more of pyrrolidones, DMAC N,N' dimethyl acetamide, deionized water etc..
The emulsifier be selected from agriculture breast 400, agriculture breast 500, agriculture breast 600, Nongru-700, NP series, 0201B, 0203B,
2201, peaceful breast 31, peaceful breast 33, peaceful breast 37,0202,0202C, APES sulfosuccinate, castor-oil plant
Oily polyoxyethylene ether, aliphatic acid polyethenoxy ether, polyoxyethylene aliphatic alcohol ether, ethoxy castor oil, polymethyl acrylate, fat
The mixture of one or more of acid polyethylene glycol ester, trilaurin polyoxyethylene ether etc..
The wetting agent be selected from naphthalene sulfonate, lauryl sodium sulfate, Teepol, fatty alcohol polyoxyethylene ether,
The mixture of one or more of nonylphenol polyoxyethylene ether, alkylsulfonate etc..
The dispersant be selected from sodium lignin sulfonate, calcium lignosulfonate, Sodium Polyacrylate, di-2-ethylhexylphosphine oxide naphthalene sulfonate,
Alkyl benzene sulfonate calcium salt, alkylbenzenesulfonate amine salt, sodium methylene bis-naphthalene sulfonate formaldehyde condensation products, carboxymethyl cellulose, polyethylene
The mixture of one or more of alcohol, polyvinylpyrrolidone, sodium tripolyphosphate, alkylnaphthalene sulfonate condensation polymer etc..
The antifreezing agent is in ethylene glycol, propylene glycol, glycerine, polyethylene glycol, sorbierite, urea, inorganic salts etc.
One or more kinds of mixtures.
The thickener is selected from selected from xanthans, organobentonite, aluminium-magnesium silicate and white carbon, gelatin, Arabic gum, gathers
The mixture of one or more of vinyl alcohol etc..
The binder is selected from glucose, sucrose, hydroxyethyl cellulose, soluble starch, polyethylene glycol, Methyl cellulose
Element, polycarboxylic acid and water-soluble high-molecular compound sodium carboxymethylcellulose, polyvinyl alcohol, paraffin, gypsum, hydroxypropyl methyl are fine
Tie up the mixture of one or more of element, polyacrylamide etc..
The antifoaming agent is selected from silicone oil, silicone compound, C10-20Saturated fat acids compound, C8-10Aliphatic alcohols,
The mixture of one or more of hexanol, butanol, octanol etc..
The stabilizer is selected from sodium citrate, resorcinol, epoxidized soybean oil, epoxychloropropane, epoxidized linseed oil, season penta
The mixture of one or more of tetrol, xylitol, butylated hydroxy anisole etc..
The filler be mainly kaolin, cornstarch, ammonium sulfate, fine particle calcium carbonate, selected from white carbon, kaolin, bentonite,
One kind in precipitated calcium carbonate, gypsum, attapulgite, urea, sucrose, diatomite, potassium dihydrogen phosphate, clay, sepiolite etc. or
Two or more mixtures.
Another object of the present invention is to provide bactericidal compositions, and preparation prevention plant epiphyte to be used as to cause fungal disease medicine
The application of object, especially as prepare prevention powdery mildew, gray mold, gray mold, graywall, sclerotiniose, scab, anthracnose,
The application of rust, epidemic disease, banded sclerotial blight, damping-off drug.
Compared with prior art, beneficial effects of the present invention are：
(1) present invention is found by experiment that, fluorine chlorine ether bacterium azoles is with fluxapyroxad within the scope of certain quality parts ratio
Compounding, to the powdery mildew on plant, gray mold, leaf mold, graywall, sclerotiniose, scab, anthracnose, rust, epidemic disease, line
It is 1 that the diseases such as blight, damping-off, which have synergistic function, the especially quality parts ratio of the two,:50~50:1 range cooperates with
Synergy is more notable.
(2) quality parts ratio of fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:1、1:2、1:3、1:5、2:3、5:7 pairs of tomatoes
The prevention of gray mold and rice sheath blight disease is synergistic significantly.
(3) compared with single dose, fluorine chlorine ether bacterium azoles is more than the activity of independent component, drop with the activity of fluxapyroxad composition
Low production and application cost, reduces preventing and controlling amount and drug cost.
(4) Bactericidal composite of the present invention compares single dose, overcomes and delayed the generation of drug resistance, alternative routine and is also easy to produce
The pesticide of resistance.
Specific implementation mode
Invention is further described in detail with reference to embodiments, and the preparation method of dosage form is routine in embodiment
Method.
The following desirable embodiment according to the present invention is enlightenment, and by following descriptions, related personnel completely can be
In the range of this invention technological thought, various changes and amendments are carried out.The technical scope of this invention is simultaneously
The content being not limited on specification, it is necessary to determine the technical scope according to the scope of the claims.
(1), example of formulations
Embodiment 1：12% fluorine chlorine ether bacterium azoles fluxapyroxad suspending agent
Fluorine chlorine ether bacterium azoles 6%, fluxapyroxad 6%, polyoxyethylene polyoxypropylene block copolymer 5%, secondary alkyl sulfuric acid
Sodium 5%, isothiazolinone 0.3%, silicone oil 0.2%, xanthans 1.5%, ethylene glycol 3%, deionized water supply 100%, above
Substance is weight percentage.Above-mentioned material is mixed in proportion, be uniformly dispersed through high speed shear, in sand mill be sanded after, i.e.,
12% fluorine chlorine ether bacterium azoles fluxapyroxad suspending agent can be made.
Embodiment 2：30% fluorine chlorine ether bacterium azoles fluxapyroxad suspending agent
Fluorine chlorine ether bacterium azoles 10%, fluxapyroxad 20%, phenylsulfonyl ester 10%, sodium methylene bis-naphthalene sulfonate formaldehyde condensation products
6%, Teepol 5%, Kathon CG Kathon 0.5%, silicone oil 0.2%, xanthans 1.5%, ethylene glycol 3%, deionized water are mended
Foot 100%, the above substance is weight percentage.Above-mentioned material is mixed in proportion, is uniformly dispersed through high speed shear, sand mill
After middle sand milling, you can 30% fluorine chlorine ether bacterium azoles fluxapyroxad suspending agent is made
Embodiment 3：20% fluorine chlorine ether bacterium azoles fluxapyroxad aqueous emulsion
Fluorine chlorine ether bacterium azoles 5%, fluxapyroxad 15%, cyclohexanone 5%, loose base oil 8%, fatty acid polyethylene glycol ester 8%,
Pentaerythrite 3%, ethylene glycol 2%, silicone compound 0.2%, Kathon CG Kathon 0.2%, gelatin 1%, deionized water are supplied
100%, the above substance is weight percentage.Above-mentioned material is mixed in proportion, after high shear agitation is uniform, you can system
Obtain 20% fluorine chlorine ether bacterium azoles fluxapyroxad aqueous emulsion.
Embodiment 4：48% fluorine chlorine ether bacterium azoles fluxapyroxad microemulsion
Fluorine chlorine ether bacterium azoles 8%, fluxapyroxad 40%, cyclohexanone 10%, sec-Butyl Acetate 5%, polyoxyethylene fatty alcohol
Ether 10%, epoxidized linseed oil 3%, Butacide 2%, ethylene glycol 2%, silicone oil 0.3%, deionized water supply 100%, the above substance
It is weight percentage.Above-mentioned material is mixed in proportion, after high shear agitation is uniform, you can 48% fluorine chlorine ether bacterium is made
Azoles fluxapyroxad microemulsion.
Embodiment 5：35% fluorine chlorine ether bacterium azoles fluxapyroxad water dispersible granules
Fluorine chlorine ether bacterium azoles 14%, fluxapyroxad 21%, lauryl sodium sulfate 5%, polyoxyethylene polyoxypropylene block
Copolymer 6%, sodium chloride 3%, soluble starch 0.8%, sepiolite supply 100%, and the above substance is weight percentage.It will
Above-mentioned material mixes in proportion, is uniformly mixed through air-flow crushing, kneading is granulated, after dry screening, you can 35% fluorine chlorine ether is made
Bacterium azoles fluxapyroxad water dispersible granules.
Embodiment 6：24% fluorine chlorine ether bacterium azoles fluxapyroxad wettable powder
Fluorine chlorine ether bacterium azoles 10%, fluxapyroxad 14%, Teepol 10%, alkylnaphthalene sulfonate condensation polymer 5%,
White carbon 5%, kaolin supply 100%, and the above substance is weight percentage.Above-mentioned material is mixed in proportion, mechanical powder
After broken again through air-flow crushing, after mixing, you can be made 24% fluorine chlorine ether bacterium azoles fluxapyroxad wettable powder.
Embodiment 7：27% fluorine chlorine ether bacterium azoles fluxapyroxad wettable powder
Fluorine chlorine ether bacterium azoles 18%, fluxapyroxad 9%, naphthalene sulfonate 10%, di-2-ethylhexylphosphine oxide naphthalene sulfonate 5%, white carbon
5%, diatomite supplies 100%, and the above substance is weight percentage.Above-mentioned material is mixed in proportion, after mechanical crushing again
Through air-flow crushing, after mixing, you can 27% fluorine chlorine ether bacterium azoles fluxapyroxad wettable powder is made.
Embodiment 8：44% fluorine chlorine ether bacterium azoles fluxapyroxad microcapsule suspending agent
Fluorine chlorine ether bacterium azoles 12%, fluxapyroxad 32%, phthalate, cellulose ester 10%, ethyl cellulose 8%, fat
Fatty acid methyl esters 10%, trilaurin polyoxyethylene ether 5%, alkylnaphthalene sulfonate condensation polymer 5%, potassium sorbate 0.3%,
Deionized water complements to 100%, and the above substance is weight percentage.Above-mentioned material is mixed in proportion, polymerisation
Afterwards, you can 44% fluorine chlorine ether bacterium azoles fluxapyroxad microcapsule suspending agent is made.
(2), the embodiment of indoor biological determination of activity
1, fluorine chlorine ether bacterium azoles compounds the indoor toxicity determination test to graw mold of tomato with fluxapyroxad
Fluorine chlorine ether bacterium azoles is measured with fluxapyroxad and the two composition to tomato gray mould using mycelial growth rate method
The influence of germ silk growth.Graw mold of tomato (is isolated from Tianshui of Gansu Province area), it is detached with PDA culture medium,
Purifying, culture, cultivate 7d under 25 DEG C, 90% damp condition, and mycelia covers with and breaks into pure culture biscuits involvng inoculation with 4mm card punch after culture dish
It is spare.On the basis of trial test, fluorine chlorine ether bacterium azoles and fluxapyroxad weight proportion 1:10、1:20、1:30、1:50、1:60、
1:1、1:2、1:3、1:5、2:3、5:7、2:1、3:8、10:1、20:1、30:1、50:1、60:1 and each single dose totally 20 kinds of medicaments
Processing, the mother liquor of each mixed agent and single dose is diluted to 0.125 respectively, 0.25,0.5,0.75,1,2mg/L totally 6 concentration gradients
PDA plate is made, is control with clear water, equal 3 repetitions is often handled, aseptically by pure culture biscuits involvng inoculation in each processing PDA
Behind tablet center, tablet is placed in 25 DEG C of incubator, is cultivated under 90% damp condition, it is straight to wait for that mycelia growth diameter reaches culture dish
(7d or so) investigation result when diameter 50% or so, with SPSS16.0 version softwares calculate each treatment agent virulence regression equation,
Concentration EC in inhibition50, compounding co-toxicity coefficient is calculated using Sun Yunpei's Method.Mycelial growth rate method is used indoors, is measured different
EC of the medicament to bacterial strain50, using co-toxicity coefficient method, the co-toxicity coefficient (CTC) of mixture is calculated, determines the building performance of mixture, tried
Result such as table 1 is tested, circular is as follows：
Using a certain single dose in mixture (EC is generally selected as standard agent50Junior), it is calculated：
Toxicity index (TI)=standard agent EC50/ reagent agent EC50×100
Theoretical toxicity index (TTI)=standard agent toxicity index × standard agent in mixing assembles percentage+
Reagent agent toxicity index × reagent agent percentage in mixing assembles
The EC of actual toxicity index (ATI)=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient (CTC)=survey toxicity index/theoretical toxicity index × 100
Co-toxicity coefficient is classified：CTC>120 mixtures have synergistic function, CTC<80 mixtures have antagonism, 80≤
The mixtures of CTC≤120 have summation action.
2, fluorine chlorine ether bacterium azoles compounds the indoor toxicity determination test to rice sheath blight disease with fluxapyroxad
Mycelia block method is connect using Potted orchard to measure.Fluorine chlorine ether bacterium azoles and fluxapyroxad active compound, with appropriate dimethyl formyl
Amine solvent is configured to the mother liquor of 10000mg/L, is placed in spare in 4 DEG C of refrigerators.Fluorine chlorine ether bacterium azoles and fluxapyroxad weight proportion
1:10、1:20、1:30、1:50、1:60、1:1、1:2、1:3、1:5、2:3、5:7、2:1、3:8、10:1、20:1、30:1、50:1、
60:1 and each single dose totally 20 kinds of chemicals treatments, mass concentration gradient are set as 5 gradients 0.125,0.25,0.5,0.75,1mg/
L, each mass concentration set 3 repetitions.Separately clear water is set as blank control.The potting rice seedling for selecting 3 leaf, 1 heart, growing way consistent, spraying
Naturally dry after processing controls be inoculated with for 24 hours, in the every basin rice seedling base portion center one piece of banded sclerotial blight mycelia of clamping connection for being jetted through medicine
Block, fungus block not contacted with basin soil and water layer.Examination material, which moves in humidistat, after inoculation cultivates, and 26 DEG C of temperature, humidity 80%~
90%, rice growth situation, investigation result when waiting blank controls fully to fall ill after 5d are observed daily, and grade scale uses field medicine
It imitates test rule to carry out, each processing preventive effect is calculated with disease index, data analysis statistical is carried out with SPSS16.0 version softwares,
Find out virulence regression equation, EC50Value, related coefficient.According to Sun Yunpei's Method measure co-toxicity coefficient CTC, test result such as table 2, specifically
Computational methods are as follows：
Using a certain single dose in mixture (EC is generally selected as standard agent50Junior), it is calculated：
Toxicity index (TI)=standard agent EC50/ reagent agent EC50×100
Theoretical toxicity index (TTI)=standard agent toxicity index × standard agent in mixing assembles percentage+
Reagent agent toxicity index × reagent agent percentage in mixing assembles
The EC of actual toxicity index (ATI)=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient (CTC)=survey toxicity index/theoretical toxicity index × 100
Co-toxicity coefficient is classified：CTC>120 mixtures have synergistic function, CTC<80 mixtures have antagonism, 80≤
The mixtures of CTC≤120 have summation action.
1 fluorine chlorine ether bacterium azoles of table compounds the Toxicity Determination to graw mold of tomato with fluxapyroxad
| Reagent agent | Proportioning | EC50(mg/L) | ATI | TTI | CTC |
| Fluorine chlorine ether bacterium azoles (A) | - | 0.48 | --- | --- | --- |
| Fluxapyroxad (B) | - | 1.67 | --- | --- | --- |
| A:B | 1:10 | 1.01 | 47.52 | 35.22 | 134.94 |
| A:B | 1:20 | 1.15 | 41.74 | 32.14 | 129.88 |
| A:B | 1:30 | 1.24 | 38.71 | 31.04 | 124.70 |
| A:B | 1:50 | 1.32 | 36.36 | 30.14 | 120.65 |
| A:B | 1:60 | 1.42 | 33.80 | 29.91 | 113.01 |
| A:B | 1:1 | 0.52 | 92.31 | 64.37 | 143.40 |
| A:B | 1:2 | 0.62 | 77.42 | 52.50 | 147.48 |
| A:B | 1:3 | 0.64 | 75.00 | 46.56 | 161.09 |
| A:B | 1:5 | 0.77 | 62.34 | 40.62 | 153.47 |
| A:B | 2:3 | 0.45 | 106.67 | 57.25 | 186.33 |
| A:B | 5:7 | 0.56 | 85.71 | 58.43 | 146.69 |
| A:B | 2:1 | 0.42 | 114.29 | 76.25 | 149.89 |
| A:B | 3:8 | 0.69 | 69.57 | 48.18 | 144.40 |
| A:B | 10:1 | 0.38 | 126.32 | 93.52 | 135.07 |
| A:B | 20:1 | 0.39 | 123.08 | 96.61 | 127.40 |
| A:B | 30:1 | 0.40 | 120.00 | 97.70 | 122.82 |
| A:B | 1:50 | 0.40 | 120.00 | 98.60 | 121.70 |
| A:B | 60:1 | 0.41 | 117.07 | 98.83 | 118.46 |
As known from Table 1, fluorine chlorine ether bacterium azoles is compounded with fluxapyroxad 50:1~1:Between 50, have to graw mold of tomato
Synergistic effect, co-toxicity coefficient is 120 or more, when fluorine chlorine ether bacterium azoles and fluxapyroxad are compounded 10:1~1:When between 10,
There is apparent synergistic effect to graw mold of tomato, the co-toxicity coefficient of the two compounding is 130 or more, when fluorine chlorine ether bacterium azoles and fluorine
Azoles bacterium amide compounding is than being 1:1、1:2、1:3、1:5、2:3、5:7、2:1、3:It is the most apparent to graw mold of tomato synergy when 8, two
The co-toxicity coefficient of person's compounding is 140 or more, with fluorine chlorine ether bacterium azoles and fluxapyroxad compounding than for 2:When 3, co-toxicity coefficient is most
Greatly 186.33, it is most notable to graw mold of tomato synergy, and fluorine chlorine ether bacterium azoles is 1 with fluxapyroxad compounding ratio:60 and 60:1
When, for the two compounding to graw mold of tomato without synergistic effect, co-toxicity coefficient is less than 120.
2 fluorine chlorine ether bacterium azoles of table compounds the Toxicity Determination to rice sheath blight disease with fluxapyroxad
| Reagent agent | Proportioning | EC50(mg/L) | ATI | TTI | CTC |
| Fluorine chlorine ether bacterium azoles (A) | - | 0.23 | --- | --- | --- |
| Fluxapyroxad (B) | - | 1.21 | --- | --- | --- |
| A:B | 1:10 | 0.68 | 33.82 | 26.37 | 128.26 |
| A:B | 1:20 | 0.82 | 28.05 | 22.87 | 122.67 |
| A:B | 1:30 | 0.88 | 26.14 | 21.62 | 120.88 |
| A:B | 1:50 | 0.91 | 25.27 | 20.60 | 122.71 |
| A:B | 1:60 | 0.98 | 23.47 | 20.34 | 115.41 |
| A:B | 1:1 | 0.26 | 88.46 | 59.50 | 148.66 |
| A:B | 1:2 | 0.31 | 74.19 | 46.01 | 161.27 |
| A:B | 1:3 | 0.38 | 60.53 | 39.26 | 154.18 |
| A:B | 1:5 | 0.41 | 55.56 | 32.51 | 170.90 |
| A:B | 2:3 | 0.29 | 79.31 | 51.40 | 154.29 |
| A:B | 5:7 | 0.25 | 92.00 | 52.75 | 174.39 |
| A:B | 2:1 | 0.21 | 109.52 | 73.00 | 150.03 |
| A:B | 3:8 | 0.39 | 58.97 | 41.10 | 143.50 |
| A:B | 10:1 | 0.18 | 127.78 | 92.64 | 137.93 |
| A:B | 20:1 | 0.18 | 127.78 | 96.14 | 132.90 |
| A:B | 30:1 | 0.19 | 121.05 | 97.39 | 124.30 |
| A:B | 1:50 | 0.19 | 121.05 | 98.41 | 123.01 |
| A:B | 60:1 | 0.20 | 115.00 | 98.67 | 116.55 |
As known from Table 2, fluorine chlorine ether bacterium azoles is compounded with fluxapyroxad 50:1~1:Between 50, have to rice sheath blight disease
Synergistic effect, co-toxicity coefficient is 120 or more, when fluorine chlorine ether bacterium azoles and fluxapyroxad are compounded 10:1~1:When between 10,
There is apparent synergistic effect to rice sheath blight disease, the co-toxicity coefficient of the two compounding is 125 or more, when fluorine chlorine ether bacterium azoles and fluorine
Azoles bacterium amide compounding is than being 1:1、1:2、1:3、1:5、2:3、5:7、2:1、3:It is the most apparent to rice sheath blight disease synergy when 8, two
The co-toxicity coefficient of person's compounding is 140 or more, with fluorine chlorine ether bacterium azoles and fluxapyroxad compounding than for 5:When 7, co-toxicity coefficient is most
Greatly 174.39, it is most notable to rice sheath blight disease synergy, and fluorine chlorine ether bacterium azoles is 1 with fluxapyroxad compounding ratio:60 and 60:1
When, for the two compounding to rice sheath blight disease without synergistic effect, co-toxicity coefficient is less than 120.
(3) field control effectiveness test
1, the field control effectiveness test of fluorine chlorine ether bacterium azoles and fluxapyroxad combination preparation to graw mold of tomato
Test process：The difference of each ingredient of this experimental evidence sets two medicaments dosage respectively, dosing be effectively at
The quality of point fluorine chlorine ether bacterium azoles and fluxapyroxad and.Comparison medicament is 10% fluorine chlorine ether bacterium azole suspending agent and 21% fluorine azoles respectively
Bacterium amide suspending agents and blank clean water experiment.
Test arrangement is fallen ill heavier plot throughout the year in graw mold of tomato, and dispenser is carried out in graw mold of tomato early stage,
Investigation drug effect method after investigating and prevent before dispenser is that each 4 cells of processing repeat, 20 square metres of each plot area,
The 5 points of samplings of each cell, every is investigated two plants, the whole fruits of every plant of investigation.Disease is carried out according to national field trial relevant criterion
Mutual affection grade 3 after dispenser, investigates disease indexs for 7,14 days and calculates preventive effect, and test result is shown in Table 3：
3 fluorine chlorine ether bacterium azoles of table is with fluxapyroxad combination preparation to the field control effectiveness test of graw mold of tomato
By table 3 as it can be seen that the result shows that, fluorine chlorine ether bacterium azoles can be prevented effectively after being compounded with fluxapyroxad by field efficacy
Graw mold of tomato, control effect is superior to the preventive effect of single dose, and preventive effect phase is long.In experiment scope of medication invariably to target crop
Good influence has application value in agricultural is applied.
2, the field control effectiveness test of fluorine chlorine ether bacterium azoles and fluxapyroxad combination preparation to rice sheath blight disease
Test process：The difference of each ingredient of this experimental evidence sets two medicaments dosage respectively, dosing be effectively at
The quality of point fluorine chlorine ether bacterium azoles and fluxapyroxad and.Comparison medicament is 10% fluorine chlorine ether bacterium azole suspending agent and 21% fluorine azoles respectively
Bacterium amide suspending agents and blank clean water experiment.
This experiment is total to dispenser 2 times, is spaced 7d.The another blank control for setting not dispenser.Rice varieties are rich late 347, experimental field
Point Changsha, Hunan Wangcheng area, 30 ㎡ of plot area are repeated 3 times, liquid dosage 450L/hm2.One is investigated before second of dispenser
Secondary, 10d investigates an incidence after second of dispenser, takes 5 points of samplings, every investigation to be connected 5 clumps, investigates 25 Cong Shui altogether
Rice, record total strain number, diseased plant number and disease index, calculates disease index and preventive effect.Severity Scaling takes 0,1,3,5,7,9 grade to be total to
6 ranks
Disease index and control effect are calculated, and (DMRT methods) for statistical analysis using SPSS16.0 version softwares：
Disease index=∑ (the disease number of sheets × typical value at different levels at different levels)/investigation total number of sheets × superlative degree typical value
4 fluorine chlorine ether bacterium azoles of table is with fluxapyroxad combination preparation to the field control effectiveness test of rice sheath blight disease
As can be seen from Table 4, rice sheath blight disease, prevention effect can effectively be prevented after fluorine chlorine ether bacterium azoles and fluxapyroxad compounding
Fruit is superior to the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Claims (10)
1. a kind of bactericidal composition of containing chlorine fluorine ether bacterium azoles and fluxapyroxad, which is characterized in that the fluorine of chlorine containing effective active composition
The quality parts ratio of ether bacterium azoles and fluxapyroxad, the effective active composition fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:50~
50:1, both the effective active composition fluorine chlorine ether bacterium azoles and fluxapyroxad account for the mass percentage 1~80% of composition.
2. the bactericidal composition of a kind of containing chlorine fluorine ether bacterium azoles and fluxapyroxad according to claim 1, it is characterised in that：
The quality parts ratio of fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:30~30:1.
3. the bactericidal composition of a kind of containing chlorine fluorine ether bacterium azoles and fluxapyroxad according to claim 1, it is characterised in that：
The quality parts ratio of fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:20~20:1.
4. the bactericidal composition of a kind of containing chlorine fluorine ether bacterium azoles and fluxapyroxad according to claim 1, it is characterised in that：
The quality parts ratio of fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:10~10:1.
5. the bactericidal composition of a kind of containing chlorine fluorine ether bacterium azoles and fluxapyroxad according to claim 1, it is characterised in that：
The quality parts ratio of fluorine chlorine ether bacterium azoles and fluxapyroxad is 1:1、1:2、1:3、1:5、2:3、5:7、2:1、3:8.
6. the bactericidal composition of a kind of containing chlorine fluorine ether bacterium azoles and fluxapyroxad according to claim 1, it is characterised in that：
The mass percentage that both fluorine chlorine ether bacterium azoles and fluxapyroxad account for composition is 3~50%.
7. the bactericidal composition of a kind of containing chlorine fluorine ether bacterium azoles and fluxapyroxad according to claim 1, it is characterised in that：
The dosage form of the bactericidal composition be suspending agent, microcapsule suspending agent, water dispersible granules, wettable powder, wet seed dressing, missible oil,
Suspension seed-coating agent, aqueous emulsion or microemulsion.
8. the bactericidal composition of a kind of containing chlorine fluorine ether bacterium azoles and fluxapyroxad according to claim 1, it is characterised in that：
The bactericidal composition is applied to the disease on prevention crops.
9. the bactericidal composition of a kind of containing chlorine fluorine ether bacterium azoles and fluxapyroxad according to claim 1, it is characterised in that：
Bactericidal composition application prevention powdery mildew, gray mold, leaf mold, graywall, sclerotiniose, scab, anthracnose, rust,
The diseases such as epidemic disease, banded sclerotial blight, damping-off.
10. the bactericidal composition of a kind of containing chlorine fluorine ether bacterium azoles and fluxapyroxad according to claim 1, feature exist
In：The bactericidal composition application prevention graw mold of tomato and rice sheath blight disease.
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