CN108524724A - A kind of drug and preparation method thereof for treating canker sore - Google Patents
A kind of drug and preparation method thereof for treating canker sore Download PDFInfo
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- CN108524724A CN108524724A CN201810562448.0A CN201810562448A CN108524724A CN 108524724 A CN108524724 A CN 108524724A CN 201810562448 A CN201810562448 A CN 201810562448A CN 108524724 A CN108524724 A CN 108524724A
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- orange peel
- dried orange
- canker sore
- drug
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- 208000020670 canker sore Diseases 0.000 title claims abstract description 35
- 239000003814 drug Substances 0.000 title claims abstract description 33
- 229940079593 drug Drugs 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 38
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 25
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 25
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 25
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 25
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 25
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 25
- 239000010231 banlangen Substances 0.000 claims abstract description 25
- 229940116229 borneol Drugs 0.000 claims abstract description 25
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 25
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 25
- 240000006079 Schisandra chinensis Species 0.000 claims abstract description 24
- 235000008422 Schisandra chinensis Nutrition 0.000 claims abstract description 24
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 23
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 19
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 19
- 239000011718 vitamin C Substances 0.000 claims abstract description 19
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229960001138 acetylsalicylic acid Drugs 0.000 claims abstract description 18
- 241000522254 Cassia Species 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 239000000843 powder Substances 0.000 claims description 24
- 239000000284 extract Substances 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 19
- 239000011265 semifinished product Substances 0.000 claims description 16
- 241000723347 Cinnamomum Species 0.000 claims description 12
- 235000017803 cinnamon Nutrition 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 10
- 229920002774 Maltodextrin Polymers 0.000 claims description 8
- 239000005913 Maltodextrin Substances 0.000 claims description 8
- 229940035034 maltodextrin Drugs 0.000 claims description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 7
- 229930195725 Mannitol Natural products 0.000 claims description 7
- 235000010355 mannitol Nutrition 0.000 claims description 7
- 239000000594 mannitol Substances 0.000 claims description 7
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 6
- 238000001694 spray drying Methods 0.000 claims description 6
- 230000010355 oscillation Effects 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 244000170916 Paeonia officinalis Species 0.000 claims description 2
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 8
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 208000025865 Ulcer Diseases 0.000 description 13
- 231100000397 ulcer Toxicity 0.000 description 12
- 239000000047 product Substances 0.000 description 9
- 210000000214 mouth Anatomy 0.000 description 6
- 210000004400 mucous membrane Anatomy 0.000 description 6
- 235000019640 taste Nutrition 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- -1 crushing Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000001584 soft palate Anatomy 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 1
- 244000241235 Citrullus lanatus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000003467 cheek Anatomy 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003694 hair properties Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 229940037201 oris Drugs 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 230000001720 vestibular Effects 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
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- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention discloses a kind of drugs and preparation method thereof for treating canker sore, include the raw material of following parts by weight：4.6 7.5 parts of 3.6 5.4 parts of vitamin C, 2.2 3.5 parts of aspirin, 2.4 4.5 parts of borneol, 7 9.6 parts of Radix Glycyrrhizae, 35 parts of Chinese yam, 58 parts of Radix Paeoniae Alba, 4.2 6.5 parts of Chinese cassia tree, 46 parts of Schisandra chinensis, 10 14.5 parts of Radix Isatidis, 0.8 1.7 parts of dried orange peel and dark plum.Raw material sources of the present invention are extensive, and Chinese medicine and Western medicine are used cooperatively and use different preparation processes, various products to play synergistic effect in different Chinese medicine, the finished product treatment canker sore cure rate of preparation is high, treatment time is short, will not recur and not have toxic side effect, have a extensive future.
Description
Technical field
The present invention relates to canker sore to cure field, the drug of specifically a kind for the treatment of canker sore.
Background technology
With irregular, more and more people's trouble of the increase of people's operating pressure, the change of eating habit and life
Various diseases are gone up, canker sore is exactly one such.Canker sore is a kind of common disease of cari oris mucosa, betides mouth
The ulcerative damages illness of chamber mucous membrane, canker sore hair in oral cavity any part, be more common in lip inside, tongue, tongue abdomen, cheek stick
The mucous membrane at the positions such as film, vestibular ditch, soft palate, these positions lacks keratinization layer or angling is poor, and men and women, old and young are likely into
For patient groups, but also it is the disease that a kind of cyclical recurrent causes very big pain to patient, severe patient injures pharyngeal
Mucous membrane.
Sharp ache when canker sore is broken out, local cusalgia is apparent, and severe patient can also influence diet, speak, to daily life
Work causes very big inconvenience；It can concurrent halitosis, chronic pharyngitis, constipation, headache, dizziness, nausea, weak, irritated, fever, lymph node
The constitutional symptoms such as enlargement.Stomatocace medicine on the market is that functional component is wanted based on Western medicine at present, although having centainly
Curative effect, but treatment cycle is long, is easy recurrence, side effect is big, this is just that patient brings pain.
Invention content
It is mentioned above in the background art to solve the purpose of the present invention is to provide a kind of drug for treating canker sore
Problem.
To achieve the above object, the present invention provides the following technical solutions：
A kind of drug for treating canker sore, includes the raw material of following parts by weight：3.6-5.4 parts of vitamin C, Ah Si
2.2-3.5 parts of woods, 2.4-4.5 parts of borneol, 7-9.6 parts of Radix Glycyrrhizae, 3-5 parts of Chinese yam, 5-8 parts of Radix Paeoniae Alba, 4.2-6.5 parts of Chinese cassia tree, the five tastes
4.6-7.5 parts of 4-6 parts sub-, 10-14.5 parts of Radix Isatidis, 0.8-1.7 parts of dried orange peel and dark plum.
As a further solution of the present invention：Dried orange peel uses Guangdong dried orange peel, Guangxi dried orange peel or Hunan dried orange peel.
As a further solution of the present invention：The mass fraction of water is 3-5% in Schisandra chinensis.
The preparation method of the drug of the treatment canker sore, is as follows：
The mass fraction that borneol and Chinese cassia tree are dried to water is 2.5-3.5%, crushes respectively and cross 120- by step 1
150 mesh sieve, and obtain borneol powder and ground cinnamon；
Radix Glycyrrhizae, Radix Paeoniae Alba and Schisandra chinensis are added in the water of 8-12 times of its weight and impregnate 30-50 minutes, then exist by step 2
It is decocted 2-4 times in 76-85 degrees Celsius of water, it is 60-75 minutes each, decoction liquor is filtered and merged, Radix Glycyrrhizae decoction liquor, white is obtained
Chinese herbaceous peony decoction liquor and Schisandra chinensis decoction liquor；
Chinese yam and dark plum are added in the ethanol water that mass fraction is 66-75% and use ultrasonic wave by step 3
Oscillation, filtering, centrifugation, separation, obtains Chinese yam alcohol extract and dark plum alcohol extract；
Radix Isatidis and dried orange peel are crushed to 30-50 mesh by step 4, and complex enzyme is then added under 32-45 degrees Celsius carries out
Enzymolysis, sterilizing obtain Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid；
Vitamin C and aspirin are crushed to 60-80 mesh, vitamin C powder and aspirin powder are added by step 5
Enter in the microwave that 120-180W is stirred evenly and be put into Radix Paeoniae Alba decoction liquor and handle 18-25 minutes, obtains the first mixture；
Step 6, by the first mixture, borneol powder, ground cinnamon, Radix Glycyrrhizae decoction liquor, Schisandra chinensis decoction liquor, Chinese yam alcohol extract,
Dark plum alcohol extract, Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid stir evenly in high mixer, obtain the second mixture, and second is mixed
Semi-finished product are obtained after closing object spray drying, crushing, semi-finished product addition auxiliary material is prepared into containing tablet, electuary, capsule or pulvis.
As a further solution of the present invention：The power of supersonic oscillations is 220-260W, frequency 22-26KHz.
As a further solution of the present invention：The mixing velocity of high mixer is 1200-1600rpm.
As a further solution of the present invention：Auxiliary material includes Icing Sugar, mannitol and maltodextrin, semi-finished product, Icing Sugar, sweet dew
The mass ratio of alcohol and maltodextrin is 100:32-36：72-84:30-42.
Compared with prior art, the beneficial effects of the invention are as follows：Raw material sources of the present invention are extensive, and Chinese medicine and Western medicine are coordinated
Different preparation processes, various products is used to play synergistic effect using and by different Chinese medicine, the finished product of preparation treats oral cavity
Ulcer cure rate is high, and treatment time is short, will not recur and not have toxic side effect, have a extensive future.
Specific implementation mode
The technical solution of this patent is described in more detail With reference to embodiment.
Embodiment 1
A kind of drug for treating canker sore, includes the raw material of following parts by weight：3.6 parts of vitamin C, aspirin 2.2
Part, 2.4 parts of borneol, 7 parts of Radix Glycyrrhizae, 3 parts of Chinese yam, 5 parts of Radix Paeoniae Alba, 4.2 parts of Chinese cassia tree, 4 parts of Schisandra chinensis, 10 parts of Radix Isatidis, 0.8 part of dried orange peel
With 4.6 parts of dark plum.Dried orange peel uses Hunan dried orange peel.
The preparation method of the drug of the treatment canker sore, is as follows：
The mass fraction that borneol and Chinese cassia tree are dried to water is 2.8% by step 1, is crushed and is crossed 130 mesh sieve respectively, obtain
To borneol powder and ground cinnamon；
Radix Glycyrrhizae, Radix Paeoniae Alba and Schisandra chinensis are added in the water of 9 times of its weight and impregnate 36 minutes by step 2, then Celsius 79
It is decocted 3 times in the water of degree, 66 minutes every time, filters and merge decoction liquor, obtain Radix Glycyrrhizae decoction liquor, Radix Paeoniae Alba decoction liquor and the five tastes
Sub- decoction liquor；
Chinese yam and dark plum are added in the ethanol water that mass fraction is 68% and are shaken using ultrasonic wave by step 3
It swings, the power of supersonic oscillations is 240W, frequency 25KHz, and filtering, centrifugation, separation obtain Chinese yam alcohol extract and dark plum alcohol extracting
Liquid；
Radix Isatidis and dried orange peel are crushed to 40 mesh by step 4, and complex enzyme is then added under 35 degrees Celsius is digested, and is gone out
Bacterium obtains Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid；
Vitamin C and aspirin are crushed to 60 mesh by step 5, and vitamin C powder and aspirin powder are added
It stirs evenly and is put into the microwave of 135W in Radix Paeoniae Alba decoction liquor and handled 24 minutes, obtain the first mixture；
Step 6, by the first mixture, borneol powder, ground cinnamon, Radix Glycyrrhizae decoction liquor, Schisandra chinensis decoction liquor, Chinese yam alcohol extract,
Dark plum alcohol extract, Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid stir evenly in high mixer, obtain the second mixture, and second is mixed
Semi-finished product are obtained after closing object spray drying, crushing, semi-finished product addition auxiliary material is prepared into containing tablet, electuary, capsule or pulvis.
Embodiment 2
A kind of drug for treating canker sore, includes the raw material of following parts by weight：4.2 parts of vitamin C, aspirin 2.8
Part, 3.3 parts of borneol, 7.8 parts of Radix Glycyrrhizae, 3.9 parts of Chinese yam, 6.6 parts of Radix Paeoniae Alba, 5 parts of Chinese cassia tree, 4.8 parts of Schisandra chinensis, 12.3 parts of Radix Isatidis,
5.6 parts of 1.2 parts of dried orange peel and dark plum.Dried orange peel uses Guangxi dried orange peel.The mass fraction of water is 4.2% in Schisandra chinensis.
The preparation method of the drug of the treatment canker sore, is as follows：
The mass fraction that borneol and Chinese cassia tree are dried to water is 2.8% by step 1, is crushed and is crossed 140 mesh sieve respectively, obtain
To borneol powder and ground cinnamon；
Radix Glycyrrhizae, Radix Paeoniae Alba and Schisandra chinensis are added in the water of 11 times of its weight and impregnate 38 minutes by step 2, then Celsius 82
It is decocted 4 times in the water of degree, 70 minutes every time, filters and merge decoction liquor, obtain Radix Glycyrrhizae decoction liquor, Radix Paeoniae Alba decoction liquor and the five tastes
Sub- decoction liquor；
Chinese yam and dark plum are added in the ethanol water that mass fraction is 72% and are shaken using ultrasonic wave by step 3
It swings, filters, centrifuges, detaches, obtain Chinese yam alcohol extract and dark plum alcohol extract；
Radix Isatidis and dried orange peel are crushed to 50 mesh by step 4, and complex enzyme is then added under 36 degrees Celsius is digested, and is gone out
Bacterium obtains Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid；
Vitamin C and aspirin are crushed to 70 mesh by step 5, and vitamin C powder and aspirin powder are added
It stirs evenly and is put into the microwave of 175W in Radix Paeoniae Alba decoction liquor and handled 24 minutes, obtain the first mixture；
Step 6, by the first mixture, borneol powder, ground cinnamon, Radix Glycyrrhizae decoction liquor, Schisandra chinensis decoction liquor, Chinese yam alcohol extract,
Dark plum alcohol extract, Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid stir evenly in the high mixer of 1350rpm, obtain the second mixing
Object will obtain semi-finished product after the spray drying of the second mixture, crushing, semi-finished product addition auxiliary material be prepared into containing tablet, electuary, glue
Capsule or pulvis.
Embodiment 3
A kind of drug for treating canker sore, includes the raw material of following parts by weight：4.9 parts of vitamin C, aspirin 3.2
Part, 4.2 parts of borneol, 8.8 parts of Radix Glycyrrhizae, 4.7 parts of Chinese yam, 7.5 parts of Radix Paeoniae Alba, 5.8 parts of Chinese cassia tree, 5.5 parts of Schisandra chinensis, Radix Isatidis 13.7
6.9 parts of part, 1.5 parts of dried orange peel and dark plum.Dried orange peel uses Guangdong dried orange peel.
The preparation method of the drug of the treatment canker sore, is as follows：
The mass fraction that borneol and Chinese cassia tree are dried to water is 3.3% by step 1, is crushed and is crossed 130 mesh sieve respectively, obtain
To borneol powder and ground cinnamon；
Radix Glycyrrhizae, Radix Paeoniae Alba and Schisandra chinensis are added in the water of 11 times of its weight and impregnate 38 minutes by step 2, then Celsius 82
It is decocted 3 times in the water of degree, 72 minutes every time, filters and merge decoction liquor, obtain Radix Glycyrrhizae decoction liquor, Radix Paeoniae Alba decoction liquor and the five tastes
Sub- decoction liquor；
Chinese yam and dark plum are added in the ethanol water that mass fraction is 70% and are shaken using ultrasonic wave by step 3
It swings, filters, centrifuges, detaches, obtain Chinese yam alcohol extract and dark plum alcohol extract；
Radix Isatidis and dried orange peel are crushed to 40 mesh by step 4, and complex enzyme is then added under 39 degrees Celsius is digested, and is gone out
Bacterium obtains Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid；
Vitamin C and aspirin are crushed to 70 mesh by step 5, and vitamin C powder and aspirin powder are added
It stirs evenly and is put into the microwave of 140W in Radix Paeoniae Alba decoction liquor and handled 24 minutes, obtain the first mixture；
Step 6, by the first mixture, borneol powder, ground cinnamon, Radix Glycyrrhizae decoction liquor, Schisandra chinensis decoction liquor, Chinese yam alcohol extract,
Dark plum alcohol extract, Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid stir evenly in high mixer, obtain the second mixture, and second is mixed
Semi-finished product are obtained after closing object spray drying, crushing, semi-finished product addition auxiliary material is prepared into containing tablet, electuary, capsule or pulvis,
Auxiliary material includes Icing Sugar, mannitol and maltodextrin, semi-finished product, Icing Sugar, mannitol and maltodextrin mass ratio be 100:32：
72:30。
Embodiment 4
A kind of drug for treating canker sore, includes the raw material of following parts by weight：5.4 parts of vitamin C, aspirin 3.5
Part, 4.5 parts of borneol, 9.6 parts of Radix Glycyrrhizae, 5 parts of Chinese yam, 8 parts of Radix Paeoniae Alba, 6.5 parts of Chinese cassia tree, 6 parts of Schisandra chinensis, 14.5 parts of Radix Isatidis, dried orange peel
1.7 parts and 7.5 parts of dark plum.Dried orange peel uses Guangxi dried orange peel or Hunan dried orange peel.The mass fraction of water is 4.2% in Schisandra chinensis.
The preparation method of the drug of the treatment canker sore, is as follows：
The mass fraction that borneol and Chinese cassia tree are dried to water is 3.4% by step 1, is crushed and is crossed 140 mesh sieve respectively, obtain
To borneol powder and ground cinnamon；
Radix Glycyrrhizae, Radix Paeoniae Alba and Schisandra chinensis are added in the water of 11 times of its weight and impregnate 45 minutes by step 2, then Celsius 82
It is decocted 3 times in the water of degree, 70 minutes every time, filters and merge decoction liquor, obtain Radix Glycyrrhizae decoction liquor, Radix Paeoniae Alba decoction liquor and the five tastes
Sub- decoction liquor；
Chinese yam and dark plum are added in the ethanol water that mass fraction is 74% and are shaken using ultrasonic wave by step 3
It swings, the power of supersonic oscillations is 255W, frequency 24KHz, and filtering, centrifugation, separation obtain Chinese yam alcohol extract and dark plum alcohol extracting
Liquid；
Radix Isatidis and dried orange peel are crushed to 40 mesh by step 4, and complex enzyme is then added under 42 degrees Celsius is digested, and is gone out
Bacterium obtains Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid；
Vitamin C and aspirin are crushed to 70 mesh by step 5, and vitamin C powder and aspirin powder are added
It stirs evenly and is put into the microwave of 160W in Radix Paeoniae Alba decoction liquor and handled 22 minutes, obtain the first mixture；
Step 6, by the first mixture, borneol powder, ground cinnamon, Radix Glycyrrhizae decoction liquor, Schisandra chinensis decoction liquor, Chinese yam alcohol extract,
Dark plum alcohol extract, Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid stir evenly in the high mixer of 1500rpm, obtain the second mixing
Object will obtain semi-finished product after the spray drying of the second mixture, crushing, semi-finished product addition auxiliary material be prepared into containing tablet, electuary, glue
Capsule or pulvis, auxiliary material include Icing Sugar, mannitol and maltodextrin, semi-finished product, Icing Sugar, mannitol and maltodextrin quality it
Than being 100:35：79:38.
Comparative example 1
Using marketed drugs as a comparison case 1.
Patient 500 people of the selection with canker sore, age random distribution, men and women is fifty-fifty, is equally divided into 5 groups, every group
Air ulcer severity is identical, the product of embodiment 1-4 and the product of comparative example 1 is taken to the patient of 1-5 groups respectively, often
It 2 times, be 1.5g every time, and the Cure of patient is observed after three days.Treatment standard：It is effective：Cusalgia mitigates, ulcer surface healing
60% or more, it can normally feed；Recovery from illness：Cusalgia disappears, and ulcer surface heals, can normally feed completely；In vain：Cusalgia is slightly
Mitigate, ulcer surface healing 60% is hereinafter, cannot normally feed.Cure is shown in Table 1.
Table 1
| Recovery from illness/people | Effective/people | In vain/people | Cure rate/% | Effective percentage/% | |
| 1 group | 78 | 22 | 0 | 78 | 100 |
| 2 groups | 73 | 26 | 1 | 73 | 99 |
| 3 groups | 69 | 31 | 0 | 69 | 100 |
| 4 groups | 82 | 17 | 1 | 82 | 99 |
| 5 groups | 12 | 38 | 50 | 12 | 50 |
From table 1 it follows that the cure rate of 1-4 groups and effective percentage are significantly larger than 5 groups of cure rate and have after three days
Efficiency shows that the product of embodiment 1-4 is good for the therapeutic effect of canker sore.
Mr. Wang, man 26 years old.Lip, cheek upper bit ulcer frequent occurrence used other treatment outside the present invention before it
The effect of the drug of canker sore, treatment is less apparent, and healing time is long, and is recurred through normal after curing.Now using implementation
The product of example 1,2 times a day, each 1.5g, canker sore is clearly better after 1 day, is cured after three days, after healing, is grown to it
The observation of time, canker sore do not occur.
It is high certain, man 61 years old suffers from more than 20 day of canker sore, the lip in oral cavity, tongue, cheek, soft palate etc. occur it is multiple round or
Oval type ulcer, surface is greyish white, concavity, clear border.Periphery mucous membrane is red, micro- swollen, local cusalgia, seriously affect feed and
Daily life, once multi-treatment effect was undesirable, after take the product of embodiment 2, three times a day, each 1g, after one day
Cusalgia is substantially reduced, and cusalgia disappears after two days, can normally feed, and ulcer surface heals after 4 days, 1 year no relapse of follow-up.
Liu, man 42 years old start with anxious hair property canker sore for 2008, and with the lip in oral cavity, tongue, cheek etc. mucous membrane occurs
Multiple round or ovum type ulcer, surface is greyish white or red, concavity, clear border.Periphery mucous membrane is red, micro- swollen, local cusalgia,
Feed is influenced, is treated using other drugs, effect is less apparent.Using the product of embodiment 3, a 0.8g, 4 times a day, one
Local cusalgia disappears after day, and ulcer surface is obviously reduced, and ulcer surface heals after three days, and no recurrence was observed during the follow-up period of 6 months.
Mr. Li, male, 16 years old, at oral cavity two nearly more than 10 day of ulcer, and through taking vitamin B2 and water melon frost, outer purpose can paste
Effect unobvious, after the product for using embodiment 4 instead, 3 days wound healings no longer recur in half a year.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiment being appreciated that.
Claims (7)
1. a kind of drug for treating canker sore, which is characterized in that include the raw material of following parts by weight：Vitamin C 3.6-5.4
Part, 2.2-3.5 parts of aspirin, 2.4-4.5 parts of borneol, 7-9.6 parts of Radix Glycyrrhizae, 3-5 parts of Chinese yam, 5-8 parts of Radix Paeoniae Alba, Chinese cassia tree 4.2-
4.6-7.5 parts of 6.5 parts, 4-6 parts of Schisandra chinensis, 10-14.5 parts of Radix Isatidis, 0.8-1.7 parts of dried orange peel and dark plum.
2. it is according to claim 1 treatment canker sore drug, which is characterized in that the dried orange peel using Guangdong dried orange peel,
Guangxi dried orange peel or Hunan dried orange peel.
3. the drug for the treatment of canker sore according to claim 1, which is characterized in that the quality of water point in the Schisandra chinensis
Number is 3-5%.
4. a kind of preparation method of the drug for the treatment of canker sore as described in any one of claims 1-3, which is characterized in that specific
Steps are as follows：
The mass fraction that borneol and Chinese cassia tree are dried to water is 2.5-3.5%, crushes respectively and cross 120-150 mesh by step 1
Sieve, obtains borneol powder and ground cinnamon；
Radix Glycyrrhizae, Radix Paeoniae Alba and Schisandra chinensis are added in the water of 8-12 times of its weight and impregnate 30-50 minutes, then in 76-85 by step 2
Degree Celsius water in decoct 2-4 times, it is 60-75 minutes each, filter and merge decoction liquor, obtain Radix Glycyrrhizae decoction liquor, Radix Paeoniae Alba decoct
Boil liquid and Schisandra chinensis decoction liquor；
Chinese yam and dark plum are added in the ethanol water that mass fraction is 66-75% and are used supersonic oscillations by step 3,
Filtering, centrifugation, separation, obtain Chinese yam alcohol extract and dark plum alcohol extract；
Radix Isatidis and dried orange peel are crushed to 30-50 mesh by step 4, and complex enzyme is then added under 32-45 degrees Celsius is digested,
Sterilizing obtains Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid；
Vitamin C and aspirin are crushed to 60-80 mesh by step 5, vitamin C powder and aspirin powder are added white
It stirs evenly and is put into the microwave of 120-180W in Chinese herbaceous peony decoction liquor and handled 18-25 minutes, obtain the first mixture；
Step 6, by the first mixture, borneol powder, ground cinnamon, Radix Glycyrrhizae decoction liquor, Schisandra chinensis decoction liquor, Chinese yam alcohol extract, dark plum
Alcohol extract, Radix Isatidis enzymolysis liquid and dried orange peel enzymolysis liquid stir evenly in high mixer, obtain the second mixture, by the second mixture
Spray drying obtains semi-finished product after crushing, and semi-finished product addition auxiliary material is prepared into containing tablet, electuary, capsule or pulvis.
5. the preparation method of the drug for the treatment of canker sore according to claim 4, which is characterized in that the ultrasonic wave shakes
The power swung is 220-260W, frequency 22-26KHz.
6. the preparation method of the drug for the treatment of canker sore according to claim 4, which is characterized in that the high mixer
Mixing velocity is 1200-1600rpm.
7. the preparation method of the drug for the treatment of canker sore according to claim 4, which is characterized in that the auxiliary material includes
Icing Sugar, mannitol and maltodextrin, semi-finished product, Icing Sugar, mannitol and maltodextrin mass ratio be 100:32-36：72-
84:30-42。
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| CN110507813A (en) * | 2019-10-12 | 2019-11-29 | 德州学院 | Cure mainly the traditional Chinese medicine reagent and its preparation method of canker sore |
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| CN110507813A (en) * | 2019-10-12 | 2019-11-29 | 德州学院 | Cure mainly the traditional Chinese medicine reagent and its preparation method of canker sore |
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