CN108524625A - 一种补肾益阴胶囊及其制备方法 - Google Patents
一种补肾益阴胶囊及其制备方法 Download PDFInfo
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Abstract
本发明属于中药技术领域，具体涉及一种补肾益阴胶囊及其制备方法，所述补肾益阴胶囊的原材料组成为：阴起石、虎杖叶提取物、牡蛎提取物、亚麻子、阿胶、五灵脂、大枣、核桃粉、淫羊藿。通过使用阴起石、虎杖叶提取物、牡蛎提取物以及多种中草药为主要原料，核桃粉作为辅料的添加，极大地丰富了成品的营养成分，提高产品的营养价值；诸药配伍具有补肾生精，滋阳益阴，固精助育、提高性能力、抗疲劳、防衰老等功效。
Description
技术领域
本发明涉及一种中药技术领域，尤其是涉及一种补肾益阴胶囊及其制备方法。
背景技术
中医认为，肾为先天之本，寓元阴元阳：先天之本是指人立身之本，“人始生，先成精”，而肾藏精，故肾为先天之本。元阴是指阴精，元阳是指元气，元阴元阳在人的生命活动中——从孕育成形到发育壮大过程中起着决定性作用。
肾虚指肾脏精气阴阳不足。肾虚的种类有很多，其中最常见的是肾阴虚、肾阳虚。肾虚的症状：肾阳虚的症状为腰酸、四肢发冷、畏寒，甚至还有水肿，为“寒”的症状；肾阴虚的症状为“热”，主要有腰酸、燥热、盗汗、虚汗、头晕、耳鸣等。现代科学证明，当人发生肾虚时，无论肾阴虚还是肾阳虚，都会导致人的免疫能力的降低。
近年来，各种补肾药品层出不穷，种类繁多，但是普遍存在以下缺陷：补肾效果差；在调理肾虚等症状的同时出现多种其它副作用，比如代谢差、易上火等不足。
中国专利《补肾胶囊》(专利申请号：CN201510370946.1)公开了一种补肾胶囊，由玛咖、肉苁蓉、人参、鹿茸、冬虫夏草、巴戟天、杜仲、桑葚、芡实、山药、熟地、枸杞、何首乌和龙眼肉制备得到，对于治疗肾阴虚表、劳倦内伤、头晕神疲、筋骨无力、腰膝酸软等症具有良好的效果，具有疗效好，副作用小，治愈率高等特点。但是目前的药物普遍存在功能单一，除了补肾之外其它方面的保健功能弱等缺陷。
发明内容
为了解决上述问题，本发明提供了一种补肾益阴胶囊及其制备方法，通过使用阴起石、虎杖叶提取物、牡蛎提取物以及多种中草药为主要原料，核桃粉作为辅料的添加，极大地丰富了成品的营养成分；诸药配伍具有补肾生精，滋阳益阴，固精助育、提高性能力、抗疲劳、防衰老等功效。
本发明可以通过以下技术方案来实现：
一种补肾益阴胶囊，由以下重量份的原材料组成：阴起石10～16份、虎杖叶提取物7～13份、牡蛎提取物15～20份、亚麻子6～10份、阿胶10～16份、五灵脂5～10份、大枣10～15份、核桃粉8～12份、淫羊藿6～10份。
优选地，一种补肾益阴胶囊，由以下重量份的原材料组成：阴起石12～14份、虎杖叶提取物8～12份、牡蛎提取物16～18份、亚麻子7～9份、阿胶12～14份、五灵脂6～8份、大枣12～14份、核桃粉9～11份、淫羊藿7～9份。
优选地，一种补肾益阴胶囊，由以下重量份的原材料组成：阴起石13份、虎杖叶提取物10份、牡蛎提取物17份、亚麻子8份、阿胶13份、五灵脂7份、大枣13份、核桃粉10份、淫羊藿8份。
优选地，所述虎杖叶提取物的制备方法为：将虎杖叶洗净晒干，研成生粉，加入10倍量95％乙醇溶液进行冷浸1～7天，浸取液进行渗滤，收集渗滤液，回收乙醇并浓缩至相对密度为1.30～1.35的稠膏，得虎杖叶提取物。
优选地，所述牡蛎提取物的制备方法为：取牡蛎肉匀浆，加入1.5倍量的蒸馏水，于30℃下超声波辅助提取25min；再于30℃水浴搅拌下提取2h，4000r/min离心5min，取上清液，残渣重复提取两次，合并滤液，减压浓缩至原体积的1/3，冷冻干燥，得牡蛎提取物。
优选地，一种补肾益阴胶囊的制备方法，包括以下步骤：
(1)取阴起石、亚麻子、阿胶、五灵脂、大枣和淫羊藿，加入4～6倍量的水进行煎煮2次，每次煎煮至原重量的20～25％，合并煎煮液；
(2)向步骤(1)所得的煎煮液中加入虎杖叶提取物和牡蛎提取物混合均匀，静置40～48h，取其汁液用文火煎煮至膏状，低温干燥后粉碎，得粉碎物；
(3)将核桃粉与步骤(2)所得的粉碎物混合后填充进胶囊中，即得本发明制备的补肾益阴胶囊。
本发明所述各主要功能成分作用机理如下：
阴起石，阴起石是一种短纤维的石棉类矿石，其多与阳起石伴生。具有养肾益阴、温补命门、治遗精早泄、白带血浊等功效。可用于肾阳虚的阳痿、下焦虚寒、宫冷、症瘕崩漏、腰膝冷痹等。在发明中取其养肾益阴、温补命门、白带血浊之功效。
牡蛎，咸，微寒。归肝、胆、肾经。平肝潜阳，重镇安神，软坚散结，收敛固涩；具有滋阴、养血、补五脏、活血、充肌等功效；用于阴虚阳亢引起的烦躁，失眠、头晕头痛、耳鸣目眩、潮热盗汗等症。可有效治疗虚汗、滞下、遗精，结肿、包块、痰火瘰疬等疾病。
虎杖叶，苦，微涩，微寒。归肝经。叶含异槲皮甙，较多的叶绿醌C和叶绿醌B，其提取物不仅含有丰富的营养物质，还具有平肝潜阳，补肾益阴、祛痰息风等作用。
本发明具备以下有效果：
本发明制备的补肾益阴胶囊通过使用阴起石、虎杖叶提取物、牡蛎提取物以及多种中草药为主要原料，核桃粉作为辅料的添加，极大地丰富了成品的营养成分，提高产品的营养价值；诸药配伍具有补肾生精，滋阳益阴，固精助育、提高性能力、抗疲劳、防衰老等功效。
具体实施方式
为了使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施例，进一步阐述本发明。
实施例1
一种补肾益阴胶囊，由以下重量份的原材料组成：阴起石10份、虎杖叶提取物7份、牡蛎提取物15份、亚麻子6份、阿胶10份、五灵脂5份、大枣10份、核桃粉8份、淫羊藿6份。
所述虎杖叶提取物的制备方法为：将虎杖叶洗净晒干，研成生粉，加入10倍量95％乙醇溶液进行冷浸1～7天，浸取液进行渗滤，收集渗滤液，回收乙醇并浓缩至相对密度为1.30～1.35的稠膏，得虎杖叶提取物。
所述牡蛎提取物的制备方法为：取牡蛎肉匀浆，加入1.5倍量的蒸馏水，于30℃下超声波辅助提取25min；再于30℃水浴搅拌下提取2h，4000r/min离心5min，取上清液，残渣重复提取两次，合并滤液，减压浓缩至原体积的1/3，冷冻干燥，得牡蛎提取物。
一种补肾益阴胶囊的制备方法，包括以下步骤：
(1)取阴起石、亚麻子、阿胶、五灵脂、大枣和淫羊藿，加入4～6倍量的水进行煎煮2次，每次煎煮至原重量的20～25％，合并煎煮液；
(2)向步骤(1)所得的煎煮液中加入虎杖叶提取物和牡蛎提取物混合均匀，静置40～48h，取其汁液用文火煎煮至膏状，低温干燥后粉碎，得粉碎物；
(3)将核桃粉与步骤(2)所得的粉碎物混合后填充进胶囊中，即得本发明制备的补肾益阴胶囊。
实施例2
一种补肾益阴胶囊，由以下重量份的原材料组成：阴起石12份、虎杖叶提取物8份、牡蛎提取物16份、亚麻子7份、阿胶12份、五灵脂6份、大枣12份、核桃粉9份、淫羊藿7份。
实施例3
一种补肾益阴胶囊，由以下重量份的原材料组成：阴起石13份、虎杖叶提取物10份、牡蛎提取物17份、亚麻子8份、阿胶13份、五灵脂7份、大枣13份、核桃粉10份、淫羊藿8份。
实施例4
一种补肾益阴胶囊，由以下重量份的原材料组成：阴起石14份、虎杖叶提取物12份、牡蛎提取物18份、亚麻子9份、阿胶14份、五灵脂8份、大枣14份、核桃粉11份、淫羊藿9份。
实施例5
一种补肾益阴胶囊，由以下重量份的原材料组成：阴起石16份、虎杖叶提取物13份、牡蛎提取物20份、亚麻子10份、阿胶16份、五灵脂10份、大枣15份、核桃粉12份、淫羊藿10份。
对比例1
与实施例1的区别在于，在制备的补肾益阴胶囊中没有添加阴起石。
对比例2
与实施例1的区别在于，在制备的补肾益阴胶囊中没有添加虎杖叶提取物。
对比例3
与实施例1的区别在于，在制备的补肾益阴胶囊中没有添加牡蛎提取物。
功效验证
选择240例有肾功能障碍的患者进行实验，肾功能障碍的症状为：男性的阳痿、腰膝酸软、失眠多梦；女性更年期不适、性冷漠、痛经带下等症状。男女各半，年龄为30-60岁，随机分成8组，每组30例，以上患者分别服用本发明实施例1-5和对比例1-3制备的补肾益阴胶囊，早晚各一粒，7天为一个疗程，6个疗程后观察患者的治疗情况，结果如下表1所示：
疗效评价标准：
显效：男性的阳痿、腰膝酸软、失眠多梦；女性更年期不适、性冷漠、痛经带下等症状几乎消失；有效：以上症状有明显改善；无效：以上症状无改善。
表1各药物的治疗情况
| 组别 | 显效/例 | 有效/例 | 无效/例 | 有效率％ |
| 实施例1 | 23 | 7 | 0 | 100 |
| 实施例2 | 25 | 5 | 0 | 100 |
| 实施例3 | 27 | 3 | 0 | 100 |
| 实施例4 | 22 | 7 | 1 | 96.7 |
| 实施例5 | 20 | 10 | 0 | 100 |
| 对比例1 | 7 | 12 | 11 | 63.3 |
| 对比例2 | 10 | 6 | 14 | 53.3 |
| 对比例3 | 11 | 10 | 9 | 70.0 |
由上表可知，通过实施例1与对比例1的对比可知，在制备的补肾益阴胶囊中添加阴起石，可将肾功能障碍患者得到改善的有效率提高36.7％；通过实施例1与对比例2的对比可知，在制备的补肾益阴胶囊中添加虎杖叶提取物，可将肾功能障碍患者得到改善的有效率提高46.7％；通过实施例1与对比例3的对比可知，在制备的补肾益阴胶囊中添加牡蛎提取物，可将肾功能障碍患者得到改善的有效率提高30.0％。
具体实例：
徐先生，31岁，由于工作压力大、经常加班和应酬。他有着头晕、健忘、失眠多梦、盗汗、耳鸣、腰膝酸软、口干舌燥等症状，经检查为肾功能障碍。服用本发明实施例2制备的补肾益阴胶囊3个疗程后，患者的大部分症状基本消失，还存在轻微的头晕和健忘、以及失眠多梦的症状，继续服用2个疗程后，上述症状全部消失。
杨先生，46岁，头晕、健忘、失眠多梦、盗汗、腰膝酸软等症状，经检查为肾功能障碍。服用本发明实施例3制备的补肾益阴胶囊4个疗程后，患者的大部分症状基本消失，继续服用2个疗程后，上述症状全部消失。
综上可知，在本发明制备的补肾益阴胶囊中加入阴起石、虎杖叶提取物和牡蛎提取物，可显著提高肾功能患者的改善程度，具有滋阳益阴，提高性能力，抗疲劳等功效。
以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对本发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。
Claims (6)
1.一种补肾益阴胶囊，其特征在于，由以下重量份的原材料组成：阴起石10～16份、虎杖叶提取物7～13份、牡蛎提取物15～20份、亚麻子6～10份、阿胶10～16份、五灵脂5～10份、大枣10～15份、核桃粉8～12份、淫羊藿6～10份。
2.根据权利要求1所述的一种补肾益阴胶囊，其特征在于，由以下重量份的原材料组成：阴起石12～14份、虎杖叶提取物8～12份、牡蛎提取物16～18份、亚麻子7～9份、阿胶12～14份、五灵脂6～8份、大枣12～14份、核桃粉9～11份、淫羊藿7～9份。
3.根据权利要求2所述的一种补肾益阴胶囊，其特征在于，由以下重量份的原材料组成：阴起石13份、虎杖叶提取物10份、牡蛎提取物17份、亚麻子8份、阿胶13份、五灵脂7份、大枣13份、核桃粉10份、淫羊藿8份。
4.根据权利要求1～3任一项所述的一种补肾益阴胶囊，其特征在于，所述虎杖叶提取物的制备方法为：将虎杖叶洗净晒干，研成生粉，加入10倍量95％乙醇溶液进行冷浸1～7天，浸取液进行渗滤，收集渗滤液，回收乙醇并浓缩至相对密度为1.30～1.35的稠膏，得虎杖叶提取物。
5.根据权利要求1～3任一项所述的一种补肾益阴胶囊，其特征在于，所述牡蛎提取物的制备方法为：取牡蛎肉匀浆，加入1.5倍量的蒸馏水，于30℃下超声波辅助提取25min；再于30℃水浴搅拌下提取2h，4000r/min离心5min，取上清液，残渣重复提取两次，合并滤液，减压浓缩至原体积的1/3，冷冻干燥，得牡蛎提取物。
6.一种制备如权利要求1～5任一项所述的一种补肾益阴胶囊的方法，其特征在于，包括以下步骤：
(1)取阴起石、亚麻子、阿胶、五灵脂、大枣和淫羊藿，加入4～6倍量的水进行煎煮2次，每次煎煮至原重量的20～25％，合并煎煮液；
(2)向步骤(1)所得的煎煮液中加入虎杖叶提取物和牡蛎提取物混合均匀，静置40～48h，取其汁液用文火煎煮至膏状，低温干燥后粉碎，得粉碎物；
(3)将核桃粉与步骤(2)所得的粉碎物混合后填充进胶囊中，即得本发明制备的补肾益阴胶囊。
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1395271A1 (en) * | 2001-05-23 | 2004-03-10 | Herbal Synthesis Corporation | Herbal compositions for the treatment of mucosal lesions |
| WO2005074415A2 (en) * | 2004-01-15 | 2005-08-18 | Poly-Med, Inc. | Antimicrobial, synthetic, fibrous, and tubular medical devices |
| EP1675617A1 (en) * | 2003-09-30 | 2006-07-05 | Kibow Biotech, Inc. | Compositions and methods for augmenting kidney function |
| CN102429299A (zh) * | 2011-11-01 | 2012-05-02 | 张明 | 一种阿胶功能饮品及生产方法 |
| CN107890557A (zh) * | 2017-12-08 | 2018-04-10 | 湖南康寿制药有限公司 | 用于益气补肾的中药组合物、胶囊及制备方法 |
-
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1395271A1 (en) * | 2001-05-23 | 2004-03-10 | Herbal Synthesis Corporation | Herbal compositions for the treatment of mucosal lesions |
| EP1675617A1 (en) * | 2003-09-30 | 2006-07-05 | Kibow Biotech, Inc. | Compositions and methods for augmenting kidney function |
| WO2005074415A2 (en) * | 2004-01-15 | 2005-08-18 | Poly-Med, Inc. | Antimicrobial, synthetic, fibrous, and tubular medical devices |
| CN102429299A (zh) * | 2011-11-01 | 2012-05-02 | 张明 | 一种阿胶功能饮品及生产方法 |
| CN107890557A (zh) * | 2017-12-08 | 2018-04-10 | 湖南康寿制药有限公司 | 用于益气补肾的中药组合物、胶囊及制备方法 |
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