CN108523141A - 一种肿瘤患者专用的复合特膳食品 - Google Patents
一种肿瘤患者专用的复合特膳食品 Download PDFInfo
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23L33/18—Peptides; Protein hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
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Abstract
本发明涉及一种肿瘤患者专用的复合特膳食品，配方的原料成分以重量份计包括：富硒紫球藻粉100‑1000份，海藻寡糖50‑500份，海洋贝类低聚肽10‑100份，海参氨糖20‑40份，牛磺酸2‑8份，岩藻黄素0.05‑1份，复合维生素1‑8份，钙、铁、锌、镁的无机或有机盐混合物1‑10份；其中，富硒紫球藻粉为用含硒培养基培养后的藻粉；海藻寡糖采用聚合度为3‑10的寡糖；海洋贝类低聚肽采用聚合度为2‑10的蛋白肽；复合维生素为维生素C、维生素E、维生素B1等按比例组成的混合物；本发明产品是一种新型、全面的复合特膳食品，可全面补充肿瘤患者所需的各种营养，能提高肿瘤患者免疫力，优化肠道内菌群，抑制肿瘤细胞的生长和转移。
Description
技术领域：
本发明涉及一种特膳食品，特别是涉及一种肿瘤患者专用的复合特膳食品，属于营养保健食品技术领域。
背景技术：
无论在发达国家还是发展中国家，恶性肿瘤几乎都是死亡率最高的疾病。根据Globocan 给出的统计数据，2012年全球约有1409万恶性肿瘤新增病例，并有820万人死于恶性肿瘤。其中发展中国家的恶性肿瘤死亡率高于发达国家，患病人数占全球的57％，死亡人数高达全球的65％。根据肿瘤患者的特殊体质，配制特殊的易于消化吸收的复合营养食品，有利于提高肿瘤患者的免疫力，改善肿瘤患者的生活质量。
目前，我国市场上针对肿瘤患者食用的特殊膳食食品，主要以补充维生素、矿物质等，并不能提供全面合理的营养，而且价格昂贵，实际作用欠佳，本发明主要以海洋生物原料为主要组分，补充肿瘤患者所需的糖类和蛋白，并配以一定量的维生素和矿物质，全面合理地为肿瘤患者提供必需的营养组分，成本较低，作为医疗的辅助手段帮助患者提高免疫力。
发明内容：
本发明的目的在于克服现有技术的缺点，针对肿瘤患者专用特膳食品领域存在的问题，根据肿瘤患者特殊的生理状态与营养需求，提供一种肿瘤患者专用的复合特膳食品，其含有的富硒紫球藻粉、海藻寡糖、海洋贝类低聚肽、海参氨糖、岩藻黄素等成分不仅可以满足肿瘤患者所需的糖、蛋白等营养，而且能够起到提高机体免疫力、改善患者胃肠道消化能力、保护患者骨关节、抑制肿瘤细胞增殖的功效。
为了实现上述发明目的，本发明所涉及的一种肿瘤患者专用的复合特膳食品，配方的原料成分以重量份计包括：富硒紫球藻粉100-1000份，海藻寡糖50-500份，海洋贝类低聚肽 10-100份，海参氨糖20-40份，牛磺酸2-8份，岩藻黄素0.05-1份，复合维生素1-8份，复合无机盐或有机盐,1-10份；其中，富硒紫球藻粉为用含硒培养基培养后的藻粉；海藻寡糖采用聚合度为3-10的寡糖；海洋贝类低聚肽采用聚合度为2-10的蛋白肽；复合维生素包括1-10重量份维生素C，1-10重量份维生素E，0.5-10重量份维生素B1，0.5-5重量份维生素B2，0.5-10重量份维生素B3，0.5-5重量份维生素B6，0.05-0.5重量份维生素B12；复合无机盐或有机盐,包括5-20重量份钙盐，1-10重量份铁盐，1-10重量份锌盐，1-10重量份镁盐，钙盐选自乳清钙、珊瑚钙；铁盐选自血红素铁、葡萄糖酸亚铁；锌盐选自乳酸锌、葡萄糖酸锌；镁盐选自硬脂酸镁、碳酸镁；
本发明所涉及的肿瘤患者专用的复合特膳食品，其制备方法为：按照上述配方称取原料组分，将富硒紫球藻粉、海藻寡糖、海洋贝类低聚肽、海参氨糖、复合无机盐或有机盐、牛磺酸在搅拌机中于常温下搅拌15-20分钟混匀得混合物，然后于4℃低温下将岩藻黄素和复合维生素加入上述混合物中，再次搅拌15-20分钟混匀，压片成型，微波杀菌法在25-45℃下杀菌2-3小时即制得肿瘤患者专用的复合特膳食品；
本发明产品的服用方法是：在肿瘤患者治疗前、治疗过程中、治疗后均能够服用，每天服用5-50克。
本发明产品是一种主要以海洋植物和动物或其活性组分为原料的食品，配方中所使用的富硒紫球藻粉含有人体必需的微量元素硒，而微量元素硒具有明显的抗癌作用，此外紫球藻粉中含有丰富的多不饱和脂肪酸，能够保护肿瘤患者的心脑血管，预防并发症；海藻寡糖具有调节肠道内益生菌生长、提高机体免疫力等方面的作用，从而能够提高肿瘤患者对营养的消化和吸收能力；海洋贝类低聚肽能够为肿瘤患者提供易被吸收的蛋白肽，补充患者所需的营养；海参氨糖能够提高肿瘤患者的免疫力、修复软骨组织，减少骨关节损伤并发症；牛磺酸具有防治由于肿瘤患者营养不良导致的缺铁性贫血，优化肠道内菌群结构，提高机体免疫力等功效；岩藻黄素具有抗肿瘤、抗炎、保护神经细胞等作用；复合维生素、复合无机盐或有机盐能够补充肿瘤患者日常所需的维生素和盐，维持机体的正常生理功能。因此，本发明产品是一种新型、全面的复合特膳食品，可全面补充肿瘤患者所需的各种营养，提高肿瘤患者的生理机能，增强其免疫力，优化肠道内菌群，抑制肿瘤细胞的生长和转移，防治各种并发症的发生，适合肿瘤患者长期服用。
具体实施方式：
下面结合具体实施例对本发明作进一步的阐述。
实施例1、
本实施例所涉及的肿瘤患者专用的复合特膳食品，其配方由以下质量配比的原料组成：
其中，富硒紫球藻粉为用含硒培养基培养后的藻粉；海藻寡糖采用聚合度为3-10的羊栖菜寡糖；海洋贝类低聚肽采用聚合度为2-10的扇贝蛋白肽；复合维生素中各组分质量为：0.5g 维生素C，0.2g维生素E，0.05g维生素B1，0.05g维生素B2，0.07g维生素B3，0.08g维生素B6，0.05g维生素B12；所述的复合无机盐或有机盐中各组分质量为：2.5g乳清钙，1.5g血红素铁，0.5g乳酸锌，0.5g硬脂酸镁。
本实施例所涉及的肿瘤患者专用的复合特膳食品的制备方法为：按照上述配方称取原料组分，将富硒紫球藻粉、海藻寡糖、海洋贝类低聚肽、海参氨糖、复合无机盐或有机盐、牛磺酸在搅拌机中于常温下搅拌15-20分钟充分混匀得混合物，然后于4℃低温下将岩藻黄素和复合维生素加入上述混合物中，再次搅拌15-20分钟充分混匀，压片成型，微波杀菌法在 25℃下杀菌2小时即制得肿瘤患者专用的复合特膳食品；所述富硒紫球藻粉是含亚硒酸培养基培养的紫球藻经过离心机离心，然后冷冻干燥制得。
产品的服用方法是：在肿瘤患者治疗前、治疗过程中、治疗后均能够服用，每天服用5-50 克。
实施例2、
本实施例所涉及的肿瘤患者专用的复合特膳食品，其配方由以下质量配比的原料组成：
其中，富硒紫球藻粉为用含硒培养基培养后的藻粉；海藻寡糖采用聚合度为3-10的石花菜寡糖；海洋贝类低聚肽采用聚合度为2-10的鲍鱼蛋白肽；复合维生素中各组分质量为：4g 维生素C，2g维生素E、0.5g维生素B1、0.25g维生素B2、0.25g维生素B3、0.8g维生素B6， 0.2g维生素B12；所述的复合无机盐或有机盐中各组分质量为4g珊瑚钙，2g葡萄糖酸亚铁， 2g葡萄糖酸锌，2g碳酸镁。
本实施例所涉及的肿瘤患者专用的复合特膳食品的制备方法为：按照上述配方称取原料组分，将富硒紫球藻粉、海藻寡糖、海洋贝类低聚肽、海参氨糖、复合无机盐或有机盐、牛磺酸在搅拌机中于常温下搅拌15-20分钟充分混匀得混合物，然后于4℃低温下将岩藻黄素和复合维生素加入上述混合物中，再次搅拌15-20分钟充分混匀，压片成型，微波杀菌法在 25℃下杀菌2小时即制得肿瘤患者专用的复合特膳食品；所述富硒紫球藻粉是含亚硒酸培养基培养的紫球藻经过离心机离心，然后冷冻干燥制得。
产品的服用方法是：在肿瘤患者治疗前、治疗过程中、治疗后均能够服用，每天服用5-50 克。
实施例3、
以实施例2的肿瘤患者专用的复合特膳食品进行小鼠实验。
实体瘤模型：将S180细胞在小鼠腹腔内接种，10天后取出小鼠腹水，用生理盐水调整细胞浓度(2×106个/ml)后接种于小鼠右前肢腋窝皮下，0.1ml/只，24小时后，将小鼠随机分为阴性对照组、荷瘤小鼠组和实施例2组，每组10只。将实施例2中的特膳食品配成水溶液，对小鼠进行灌胃喂食(0.2ml/只)，阴性对照组给予正常饮用水，连续喂食10天，末次喂食的次日，称重小鼠，将小鼠处死，取出瘤块，称重。并取腹腔内的巨噬细胞，检测其吞噬中性红的能力。取小鼠血清，检测其淋巴细胞分型。并取出小鼠盲肠内含物与粪便进行肠道菌的计数分析。
按以下公式计算肿瘤抑制率：
肿瘤抑制率(％)＝(阴性对照组的瘤重-实验组的瘤重)/阴性对照组瘤重×100％
实验结果显示，本发明根据肿瘤患者的营养需求，以富硒紫球藻粉等为主要原料制备的肿瘤患者专用的复合特膳食品，不仅能够满足肿瘤患者对于各种营养组分的需求，而且由于含有多种生物活性物质，因此能够提高肿瘤患者的免疫力、优化肠道内菌群、抑制肿瘤细胞的生长和转移，可以全面改善肿瘤患者的生活质量。
Claims (1)
1.一种肿瘤患者专用的复合特膳食品，其特征在于配方的原料成分以重量份计包括：富硒紫球藻粉100-1000份，海藻寡糖50-500份，海洋贝类低聚肽10-100份，海参氨糖20-40份，牛磺酸2-8份，岩藻黄素0.05-1份，复合维生素1-8份，复合无机盐或有机盐1-10份；其中，富硒紫球藻粉为用含硒培养基培养后的藻粉；海藻寡糖采用聚合度为3-10的寡糖；海洋贝类低聚肽采用聚合度为2-10的蛋白肽；复合维生素包括1-10重量份维生素C，1-10重量份维生素E，0.5-10重量份维生素B1，0.5-5重量份维生素B2，0.5-10重量份维生素B3，0.5-5重量份维生素B6，0.05-0.5重量份维生素B12；复合无机盐或有机盐包括5-20重量份钙盐，1-10重量份铁盐，1-10重量份锌盐，1-10重量份镁盐，钙盐选自乳清钙、珊瑚钙；铁盐选自血红素铁、葡萄糖酸亚铁；锌盐选自乳酸锌、葡萄糖酸锌；镁盐选自硬脂酸镁、碳酸镁；其制备方法为：按照上述配方称取原料组分，将富硒紫球藻粉、海藻寡糖、海洋贝类低聚肽、海参氨糖、复合无机盐或有机盐、牛磺酸在搅拌机中于常温下搅拌15-20分钟混匀得混合物，然后于4℃低温下将岩藻黄素和复合维生素加入上述混合物中，再次搅拌15-20分钟混匀，压片成型，微波杀菌法在25-45℃下杀菌2-3小时即制得肿瘤患者专用的复合特膳食品；在肿瘤患者治疗前、治疗过程中、治疗后均能够服用，每天服用5-50克，其具有抗肿瘤效果，能提高肿瘤患者免疫力，优化肠道内菌群，抑制肿瘤细胞的生长和转移。
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