CN108514547A - 用于眼部给药的两部分制剂系统 - Google Patents
用于眼部给药的两部分制剂系统 Download PDFInfo
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- CN108514547A CN108514547A CN201810562582.0A CN201810562582A CN108514547A CN 108514547 A CN108514547 A CN 108514547A CN 201810562582 A CN201810562582 A CN 201810562582A CN 108514547 A CN108514547 A CN 108514547A
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| DK2950648T3 (da) | 2013-02-01 | 2019-12-02 | Ocuphire Pharma Inc | Vandige oftalmiske opløsninger af phentolamin og medicinske anvendelser deraf |
| CA2899342C (en) | 2013-02-01 | 2021-09-21 | Ocularis Pharma, Llc | Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance |
| US20170112936A1 (en) * | 2014-05-23 | 2017-04-27 | Imprimis Pharmaceuticals, Inc. | Pharmaceutical compositions comprising gels and methods for fabricating thereof |
| KR101587412B1 (ko) * | 2014-10-17 | 2016-01-21 | 주식회사 휴온스 | 사이클로스포린 및 트레할로스를 포함하는 안과용 조성물 |
| KR101740869B1 (ko) * | 2016-12-16 | 2017-05-29 | 국제약품 주식회사 | 설파살라진 및 히알루론산을 함유하는 안약 조성물 |
| CN108707212B (zh) * | 2018-05-02 | 2020-01-07 | 上海交通大学 | 一种水溶性共轭聚合物纳米粒子的可控制备方法 |
| JP2022508715A (ja) | 2018-10-15 | 2022-01-19 | オキュフィア・ファーマ・インコーポレイテッド | 緑内障および関連状態の処置のための方法および組成物 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409904A (en) * | 1984-11-13 | 1995-04-25 | Alcon Laboratories, Inc. | Hyaluronic acid compositions and methods |
| WO2001019364A1 (en) * | 1999-09-16 | 2001-03-22 | Horn Gerald D | A method for optimizing pupil size using alpha antagonist |
| CN101874228A (zh) * | 2007-09-26 | 2010-10-27 | 因特瑞有限公司 | 时间指示装置 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4879304A (en) | 1987-05-01 | 1989-11-07 | Angelini Pharmaceuticals Ltd. | Ophthalmic compositions and process for preparing |
| JPS6452722A (en) * | 1987-05-01 | 1989-02-28 | Anjierini Pharmaceut Inc | Ophthalmic composition |
| JPH0558906A (ja) * | 1991-09-06 | 1993-03-09 | Sankyo Co Ltd | シクロスポリン点眼製剤 |
| US5474979A (en) * | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
| CN1185953A (zh) * | 1996-12-27 | 1998-07-01 | 刘伟中 | 富氧舒眼液及其生产工艺 |
| AR002194A1 (es) | 1997-03-17 | 1998-01-07 | Sanchez Reynaldo Alemany | Instrumento computarizado para el analisis del movimiento. |
| WO1999055304A1 (en) | 1998-04-29 | 1999-11-04 | Novartis Ag | Methods and compositions for stabilizing acetylcholine compositions |
| FR2787325B1 (fr) * | 1998-12-17 | 2001-01-26 | Oreal | Nanoemulsion a base d'esters gras de sorbitan oxyethylenes ou non oxyethylenes, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| WO2001041757A1 (en) * | 1999-12-10 | 2001-06-14 | Senju Pharmaceutical Co., Ltd. | Cyclodextrin-containing pharmaceutical composition |
| US6902335B2 (en) * | 2003-05-08 | 2005-06-07 | R.P. Scherer Technologies, Inc. | Hand held dispensing and application apparatus |
| US20060257388A1 (en) * | 2005-05-13 | 2006-11-16 | Julius Knowles | Drug delivery systems for stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof |
| US20080004310A1 (en) * | 2006-06-19 | 2008-01-03 | Applied Pharmacy Services, Inc. | Lyophilized pharmaceutical composition |
| US9561178B2 (en) | 2006-07-25 | 2017-02-07 | Allergan, Inc. | Cyclosporin compositions |
| US20080095754A1 (en) | 2006-10-18 | 2008-04-24 | Burke Susan E | Ophthalmic compositions comprising diglycine |
| CN101528217A (zh) * | 2006-10-18 | 2009-09-09 | 博士伦公司 | 包含二甘氨酸的眼用组合物 |
| DE102007021862A1 (de) | 2007-05-10 | 2008-11-13 | Merck Patent Gmbh | Wässrige pharmazeutische Zubereitung |
| JP5276591B2 (ja) | 2007-08-09 | 2013-08-28 | 千寿製薬株式会社 | ピレノキシン含有二液性点眼剤 |
| CA2702082A1 (en) * | 2007-10-08 | 2009-04-16 | Fovea Pharmaceuticals Sa | Aqueous ophthalmic formulations |
| JP5668476B2 (ja) * | 2007-10-08 | 2015-02-12 | オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物 |
| CN101990437A (zh) * | 2008-01-04 | 2011-03-23 | 阿尔康药品有限公司 | 稳定的环孢菌素水性组合物 |
| US20090221984A1 (en) * | 2008-03-03 | 2009-09-03 | Akram Girgis | Method and apparatus for providing therapeutically effective dosage formulations of lidocaine with and without epinephrine |
| HRP20150097T1 (hr) | 2008-05-07 | 2015-03-27 | The Regents Of The University Of California | Terapijska nadopuna i poboljšanje vlaženja površine oka |
| CN102028697B (zh) * | 2009-09-27 | 2014-01-08 | 上海信谊药厂有限公司 | 含非离子表面活性剂的拉坦前列素滴眼液及制备方法 |
| US20110178147A1 (en) * | 2009-10-20 | 2011-07-21 | Allergan, Inc. | Compositions and methods for controlling pupil dilation |
| US8952051B2 (en) * | 2009-11-05 | 2015-02-10 | Allergan, Inc. | Ophthalmic formulations containing substituted gamma lactams and methods for use thereof |
-
2012
- 2012-07-25 US US13/557,611 patent/US20130029919A1/en not_active Abandoned
- 2012-07-26 JP JP2014522985A patent/JP6271423B2/ja not_active Expired - Fee Related
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- 2012-07-26 CN CN201810562582.0A patent/CN108514547A/zh active Pending
- 2012-07-26 EP EP18151604.8A patent/EP3329896A1/en not_active Withdrawn
- 2012-07-26 CN CN201280039854.XA patent/CN103732202A/zh active Pending
- 2012-07-26 KR KR1020147004872A patent/KR102031997B1/ko not_active Expired - Fee Related
- 2012-07-26 CA CA2843267A patent/CA2843267C/en active Active
- 2012-07-26 EP EP12762425.2A patent/EP2736475A1/en not_active Ceased
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2016
- 2016-04-22 US US15/135,925 patent/US9616017B2/en not_active Expired - Fee Related
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2017
- 2017-04-10 US US15/483,162 patent/US10314887B2/en active Active
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2019
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2020
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5409904A (en) * | 1984-11-13 | 1995-04-25 | Alcon Laboratories, Inc. | Hyaluronic acid compositions and methods |
| WO2001019364A1 (en) * | 1999-09-16 | 2001-03-22 | Horn Gerald D | A method for optimizing pupil size using alpha antagonist |
| CN101874228A (zh) * | 2007-09-26 | 2010-10-27 | 因特瑞有限公司 | 时间指示装置 |
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| US9616017B2 (en) | 2017-04-11 |
| AU2012286857A1 (en) | 2014-02-20 |
| US20160235666A1 (en) | 2016-08-18 |
| AU2017251720A1 (en) | 2017-11-09 |
| JP6271423B2 (ja) | 2018-01-31 |
| CN103732202A (zh) | 2014-04-16 |
| AU2020267145A1 (en) | 2020-12-03 |
| JP2014531401A (ja) | 2014-11-27 |
| CA2843267C (en) | 2020-08-18 |
| US20170209532A1 (en) | 2017-07-27 |
| US10314887B2 (en) | 2019-06-11 |
| EP3329896A1 (en) | 2018-06-06 |
| KR20140054125A (ko) | 2014-05-08 |
| US20130029919A1 (en) | 2013-01-31 |
| AU2019203069A1 (en) | 2019-05-23 |
| WO2013016494A1 (en) | 2013-01-31 |
| KR102031997B1 (ko) | 2019-10-14 |
| US20190290722A1 (en) | 2019-09-26 |
| JP2018062521A (ja) | 2018-04-19 |
| CA2843267A1 (en) | 2013-01-31 |
| EP2736475A1 (en) | 2014-06-04 |
| AU2012286857B2 (en) | 2017-07-27 |
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