CA2843267C - Two part formulation system for ophthalmic delivery - Google Patents
Two part formulation system for ophthalmic delivery Download PDFInfo
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- CA2843267C CA2843267C CA2843267A CA2843267A CA2843267C CA 2843267 C CA2843267 C CA 2843267C CA 2843267 A CA2843267 A CA 2843267A CA 2843267 A CA2843267 A CA 2843267A CA 2843267 C CA2843267 C CA 2843267C
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- 238000009472 formulation Methods 0.000 title description 10
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- 239000013543 active substance Substances 0.000 claims abstract description 74
- 230000004888 barrier function Effects 0.000 claims abstract description 24
- 238000000034 method Methods 0.000 claims abstract description 12
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- 239000002904 solvent Substances 0.000 claims description 37
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- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 25
- 230000002335 preservative effect Effects 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 24
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- MRBDMNSDAVCSSF-UHFFFAOYSA-N phentolamine Chemical group C1=CC(C)=CC=C1N(C=1C=C(O)C=CC=1)CC1=NCCN1 MRBDMNSDAVCSSF-UHFFFAOYSA-N 0.000 claims description 13
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 7
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- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 6
- MKKIWWXKPGIMGN-UHFFFAOYSA-N boric acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OB(O)O.OC(=O)CC(O)(C(O)=O)CC(O)=O MKKIWWXKPGIMGN-UHFFFAOYSA-N 0.000 claims description 6
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 claims description 6
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 5
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 3
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Landscapes
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| PCT/US2012/048263 WO2013016494A1 (en) | 2011-07-26 | 2012-07-26 | Two part formulation system for ophthalmic delivery |
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| CA2899339C (en) | 2013-02-01 | 2021-07-06 | Ocularis Pharma, Llc | Aqueous ophthalmic solutions of phentolamine and medical uses thereof |
| CA2899342C (en) | 2013-02-01 | 2021-09-21 | Ocularis Pharma, Llc | Methods and compositions for daily ophthalmic administration of phentolamine to improve visual performance |
| US20170112936A1 (en) * | 2014-05-23 | 2017-04-27 | Imprimis Pharmaceuticals, Inc. | Pharmaceutical compositions comprising gels and methods for fabricating thereof |
| KR101587412B1 (ko) | 2014-10-17 | 2016-01-21 | 주식회사 휴온스 | 사이클로스포린 및 트레할로스를 포함하는 안과용 조성물 |
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| CN108707212B (zh) * | 2018-05-02 | 2020-01-07 | 上海交通大学 | 一种水溶性共轭聚合物纳米粒子的可控制备方法 |
| AU2019360953A1 (en) | 2018-10-15 | 2021-05-13 | Ocuphire Pharma, Inc. | Methods and compositions for treatment of glaucoma and related conditions |
| JP7670945B2 (ja) | 2018-10-26 | 2025-05-01 | オーパス・ジェネティクス・インコーポレイテッド | 老眼、散瞳、および他の眼障害の治療のための方法および組成物 |
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| JPS6452722A (en) * | 1987-05-01 | 1989-02-28 | Anjierini Pharmaceut Inc | Ophthalmic composition |
| US4879304A (en) | 1987-05-01 | 1989-11-07 | Angelini Pharmaceuticals Ltd. | Ophthalmic compositions and process for preparing |
| JPH0558906A (ja) * | 1991-09-06 | 1993-03-09 | Sankyo Co Ltd | シクロスポリン点眼製剤 |
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| FR2787325B1 (fr) | 1998-12-17 | 2001-01-26 | Oreal | Nanoemulsion a base d'esters gras de sorbitan oxyethylenes ou non oxyethylenes, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
| US6291498B1 (en) * | 1999-09-16 | 2001-09-18 | Gerald Horn | Method for optimizing pupil size using alpha antagonist |
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| US20060257388A1 (en) * | 2005-05-13 | 2006-11-16 | Julius Knowles | Drug delivery systems for stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof |
| US20080004310A1 (en) * | 2006-06-19 | 2008-01-03 | Applied Pharmacy Services, Inc. | Lyophilized pharmaceutical composition |
| US9561178B2 (en) * | 2006-07-25 | 2017-02-07 | Allergan, Inc. | Cyclosporin compositions |
| US20080095754A1 (en) | 2006-10-18 | 2008-04-24 | Burke Susan E | Ophthalmic compositions comprising diglycine |
| CN101528217A (zh) * | 2006-10-18 | 2009-09-09 | 博士伦公司 | 包含二甘氨酸的眼用组合物 |
| DE102007021862A1 (de) | 2007-05-10 | 2008-11-13 | Merck Patent Gmbh | Wässrige pharmazeutische Zubereitung |
| WO2009020145A1 (ja) * | 2007-08-09 | 2009-02-12 | Senju Pharmaceutical Co., Ltd. | ピレノキシン含有二液性点眼剤 |
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| JP5668476B2 (ja) | 2007-10-08 | 2015-02-12 | オーリニア・ファーマシューティカルズ・インコーポレイテッドＡｕｒｉｎｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． | カルシニューリン阻害剤またはｍＴＯＲ阻害剤を含む眼科用組成物 |
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| WO2009088570A1 (en) * | 2008-01-04 | 2009-07-16 | Sirion Therapeutics, Inc. | Stable aqueous cyclosporin compositions |
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| US20110178147A1 (en) * | 2009-10-20 | 2011-07-21 | Allergan, Inc. | Compositions and methods for controlling pupil dilation |
| US8952051B2 (en) * | 2009-11-05 | 2015-02-10 | Allergan, Inc. | Ophthalmic formulations containing substituted gamma lactams and methods for use thereof |
-
2012
- 2012-07-25 US US13/557,611 patent/US20130029919A1/en not_active Abandoned
- 2012-07-26 WO PCT/US2012/048263 patent/WO2013016494A1/en not_active Ceased
- 2012-07-26 EP EP18151604.8A patent/EP3329896A1/en not_active Withdrawn
- 2012-07-26 AU AU2012286857A patent/AU2012286857B2/en not_active Ceased
- 2012-07-26 CN CN201280039854.XA patent/CN103732202A/zh active Pending
- 2012-07-26 CA CA2843267A patent/CA2843267C/en active Active
- 2012-07-26 JP JP2014522985A patent/JP6271423B2/ja not_active Expired - Fee Related
- 2012-07-26 KR KR1020147004872A patent/KR102031997B1/ko not_active Expired - Fee Related
- 2012-07-26 EP EP12762425.2A patent/EP2736475A1/en not_active Ceased
- 2012-07-26 CN CN201810562582.0A patent/CN108514547A/zh active Pending
-
2016
- 2016-04-22 US US15/135,925 patent/US9616017B2/en not_active Expired - Fee Related
-
2017
- 2017-04-10 US US15/483,162 patent/US10314887B2/en active Active
- 2017-10-24 AU AU2017251720A patent/AU2017251720A1/en not_active Abandoned
- 2017-12-27 JP JP2017250920A patent/JP2018062521A/ja active Pending
-
2019
- 2019-05-01 AU AU2019203069A patent/AU2019203069A1/en not_active Abandoned
- 2019-06-10 US US16/436,200 patent/US20190290722A1/en not_active Abandoned
-
2020
- 2020-11-09 AU AU2020267145A patent/AU2020267145A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012286857B2 (en) | 2017-07-27 |
| WO2013016494A1 (en) | 2013-01-31 |
| US10314887B2 (en) | 2019-06-11 |
| JP2014531401A (ja) | 2014-11-27 |
| US20190290722A1 (en) | 2019-09-26 |
| AU2017251720A1 (en) | 2017-11-09 |
| US20170209532A1 (en) | 2017-07-27 |
| EP3329896A1 (en) | 2018-06-06 |
| JP2018062521A (ja) | 2018-04-19 |
| JP6271423B2 (ja) | 2018-01-31 |
| US20160235666A1 (en) | 2016-08-18 |
| CA2843267A1 (en) | 2013-01-31 |
| KR20140054125A (ko) | 2014-05-08 |
| US20130029919A1 (en) | 2013-01-31 |
| US9616017B2 (en) | 2017-04-11 |
| AU2020267145A1 (en) | 2020-12-03 |
| CN108514547A (zh) | 2018-09-11 |
| EP2736475A1 (en) | 2014-06-04 |
| AU2019203069A1 (en) | 2019-05-23 |
| KR102031997B1 (ko) | 2019-10-14 |
| AU2012286857A1 (en) | 2014-02-20 |
| CN103732202A (zh) | 2014-04-16 |
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