CN108514416A - A kind of respiration oxygen consumption real-time monitoring device with upper discharge structure - Google Patents
A kind of respiration oxygen consumption real-time monitoring device with upper discharge structure Download PDFInfo
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- CN108514416A CN108514416A CN201810149643.0A CN201810149643A CN108514416A CN 108514416 A CN108514416 A CN 108514416A CN 201810149643 A CN201810149643 A CN 201810149643A CN 108514416 A CN108514416 A CN 108514416A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0833—Measuring rate of oxygen consumption
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
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Abstract
It is a kind of to carry the respiration oxygen consumption real-time monitoring device with upper discharge structure, capacity slot, oxygen consumption monitoring slot, inlet guide slot, drainage channels are engraved in ontology, the upper surface of ontology is equipped with air inlet and gas outlet；Air inlet is connected to by inlet guide slot with capacity slot；One end that oxygen consumption monitors slot is connected to capacity slot, and the other end is connected to gas outlet；Capacity slot and the junction of oxygen consumption monitoring slot are equipped with protrusion；It is evenly provided with several photo resistance on the slot bottom of oxygen consumption monitoring slot；Photo resistance is sequentially connected in series to form sampling resistor, and connects System of organism signal by resistance detecting circuit；Oxygen consumption, which monitors slot, has tortuous shape；The outlet of drainage channels is connected to capacity slot and inlet guide slot by return water guide groove；Oxygen consumption, which monitors, to be connected between slot and the import of each drainage channels by the guiding device of anti-backflow, and the gap for having between pit and baffle and being connected to oxygen consumption monitoring slot and drainage channels is drained.
Description
Technical field
The present invention relates to a kind of respiration oxygen consumption real-time monitoring devices with upper discharge structure.
Background technology
Anoxic is important pathogenic factor or important one of pathologic process during a variety of disease incidences of body, and high
The problem of primary work, mine tunneling and aerospace must in-flight be studied.It is commonly used in higher medical education experiment each
Kind anoxic experimental model simulates anoxic, and passes through the anoxic experimental model of simulation and carry out physiology, biochemistry, pharmacology, pathology
The research of physiology and clinic etc., to explain the pathologic process of clinical a variety of diseases, explore its effective treatment means etc..
At present in " national institution of higher learning's medical experiment programming textbook ", the classical device of non-narcotic toy anoxic experiment
A closed system is formed frequently with 500ml wide-mouth bottles, the fat tripe suction pipes of 25ml, 50ml graduated cylinders and anoxic bottle, detects the consumption of mouse
Oxygen amount (see Fig. 1, a is anoxic bottle in Fig. 1, b is soda lime, c is fat tripe suction pipe, d is graduated cylinder), or with the wide-mouth of 125-500ml
The closed direct detection hypoxia endurance time of bottle, in visual method number respiratory rate of defined time point.Mouse as experimental subjects, because
Its is small, and respiratory rate again fast (200 times/min~300 time/min), often rotates position, visual method root during anoxic
Originally the respiratory rate that can not accurately count mouse on time, causes experimental result often to be contradicted with expected results, affects experiment
Effect and quality of instruction.
In addition, in above-mentioned conventional oxygen consumption device, mouse breathing consumption oxygen causes the water in graduated cylinder to be moved into fat tripe suction pipe
It is dynamic, cause the anoxic pressure in the bottle to decline, i.e., mouse is the anoxic in subnormal ambient, and oxygen demand measurement result generation system is made to miss
Difference.
Though having mouse breathing transducing amplifier product in recent years, being changed with System of organism signal and usual pressure
Energy device measures mouse breathing frequency, mouse normal pressure acute hypoxia model device and mouse oxygen demand dynamic change in closed environment
The report of measurement device, but can accomplish normal pressure, constant pressure in closed environment and realize oxygen demand and the real-time dynamic of respiratory curve certainly
The dynamic quantitative analysis device traced has not been reported.
Invention content
In order to overcome the disadvantages described above of hypoxia device, it is real that the present invention provides a kind of respiration oxygen consumption with upper discharge structure
When monitoring device, the present invention is on the basis of making non-constraint mouse oxygen demand by oneself, breathing dynamic syndicated monitoring hypoxia device to scarce
Oxygen device, which redesigns, to be transformed, and on the basis of keeping normal pressure, pressure-keeping functions, realizes oxygen demand and the real-time dynamic of respiratory curve certainly
It is dynamic to trace.
Technical proposal that the invention solves the above-mentioned problems is：
A kind of respiration oxygen consumption real-time monitoring device with upper discharge structure, including the horizontal ontology being laid with, described
Body is the acrylic board of water white transparency, and the lower surface of ontology is fitted tightly on smooth barn door；Appearance has been engraved in ontology
Measuring tank, oxygen consumption monitoring slot and inlet guide slot, the upper surface of ontology are equipped with air inlet and the gas outlet for being connected to anoxic bottle；
Air inlet is connected to by inlet guide slot with the capacity slot；One end of the oxygen consumption monitoring slot is connected to capacity slot, and the other end connects
Lead to the gas outlet；The gas outlet is connected by the quick energy converter of height for acquiring respiratory movement data with anoxic bottle, and institute
High quick energy converter is stated with System of organism signal to be connected；
The junction of capacity slot and oxygen consumption monitoring slot is equipped with protrusion, and the protrusion blocks the portion of the entrance of oxygen consumption monitoring slot
Divide cross section；
The length direction for monitoring slot on the upper surface of ontology along oxygen consumption is equipped with scale；Oxygen consumption monitor slot slot bottom on along
The length direction of oxygen consumption monitoring slot is evenly provided with several photo resistance；The photo resistance is sequentially connected in series to form sampling electricity
Resistance, the sampling resistor are connected on a resistance detecting circuit, the output end connection biology of the resistance detecting circuit
Signal acquiring processing system, System of organism signal export animal oxygen demand data according to the data of sampling resistor；
The oxygen consumption monitoring slot has tortuous shape；And oxygen consumption monitoring slot includes several sections of straight troughs being mutually parallel and company
Connect the curved groove of adjacent two straight trough；
Several drainage channels and a return water guide groove are also engraved in ontology, the outlet of drainage channels is led by return water
Slot is connected to capacity slot and inlet guide slot；
Oxygen consumption monitors to be connected to by the guiding device of anti-backflow respectively between slot and the import of each drainage channels, described to lead
Stream device includes baffle and the draining pit that is located on baffle, drains between pit and baffle to have and be connected to oxygen consumption and supervise
Survey the gap of slot and drainage channels；
Draining pit opens up on the body, and baffle is respectively fixedly disposed at curved close to each of drainage channels side
Between slot and drainage channels；It is left end that baffle, which is defined, close to one end of curved groove, is right end close to one end of drainage channels；Water conservancy diversion
The top surface flush of the bottom surface of block and oxygen consumption monitoring slot, the top surface of baffle be gradually ramped up from left end to right end it is oblique
Face, and the left end on the inclined-plane extends at curved groove, the right end on the inclined-plane extends in drainage channels.
Further, the groove depth of capacity slot, oxygen consumption monitoring slot and inlet guide slot is 0.5cm.
Further, air inlet and gas outlet are respectively positioned on the upper left side of ontology, and capacity slot is located at the lower right of ontology.
Further, anoxic bottle and the specific connectivity structure of gas outlet are：The side of the ontology is equipped with connection gas outlet
Translation interface, the other side of the ontology is equipped with the anoxic bottle external tapping of connection anoxic bottle, and translation interface and anoxic bottle are external
Mouth passes through high quick energy converter and is connected to.
Further, the gas outlet and translation interface are detachably connected by connecting tube.
Further, straight trough horizontal extension from left to right on the body, and straight trough and curved groove are vertically connected.
Further, the baffle is wedge type block.
Since the present invention devises baffle 21,22 and draining pit 23,24 so that the ink in capacity slot 05 can weigh
Multiple to use, concrete operations are：Ontology is erect, and oxygen consumption monitoring slot 15 is upward, downward, oxygen consumption monitors in slot 15 capacity slot 05
Water can be flowed by the gap between baffle 21,22 and draining pit 23,24 in drainage channels 06,07, and be passed through successively
Drainage channels 06,07 and return water guide groove flow to for use in capacity slot 05.Breathing oxygen consumption real-time monitoring device is lain in a horizontal plane in again
On desktop, you can tested again, avoid experiment every time and need the trouble for adding water.
Beneficial effects of the present invention are mainly manifested in：
1, test when, the present invention measure oxygen demand fluid column be under horizontality, then fluid column move when, will not be right
Influence is caused stress in hypoxic hypoxia bottle, is solved in conventional oxygen consumption device when mouse breathing consumption oxygen leads to water in graduated cylinder
Mouse anoxic in subnormal ambient caused by when being moved into fat tripe suction pipe, to make oxygen demand measurement result generation system miss
The problem of difference, the present invention effectively increase measurement accuracy.
2, the present invention solves the problems, such as that common classical scarce oxygen consumption device can not monitor breathing and oxygen demand automatically, using light
The principle that pressure oscillation can transmit in closed container caused by electric induction and thorax are shunk solves to use in conventional anoxic experiment
Any time section may be implemented using breathing oxygen consumption real-time monitoring device in the problem of artificial visual method number respiratory rate and oxygen demand
The automatic of hypoxic hypoxia oxygen demand is traced, and the respiratory curve of different type anoxic is traced, and is realized not by analyzing respiratory curve
The comparison of same type anoxic experimental animal respiratory stimulant, mitigates the labor intensity of experiment, improves the accuracy of experimental result.
3, since the oxygen consumption monitoring slot of the present invention has tortuous shape so that when the size of ontology is limited, oxygen consumption prison
Surveying the length of slot can be made longer；So in one timing of range, oxygen consumption, which monitors slot, can have smaller cross-sectional area,
Then the reaction of fluid column will be sensitiveer, to which oxygen consumption monitoring slot just has more accurately measurement accuracy.
4, the present invention is erect, and oxygen consumption monitoring slot is upward, capacity slot flows into the water in oxygen consumption monitoring slot downward, in experiment
Drainage channels can be discharged by the gap between baffle and draining pit, and eventually flow to capacity slot, draining is very convenient,
It also avoids testing the trouble for needing to add water every time simultaneously.Meanwhile guiding device be when can also prevent ontology to be horizontally arranged, capacity slot
Interior liquid flows to capacity slot.
Description of the drawings
Fig. 1 is the structural schematic diagram of the classical device of non-narcotic toy anoxic experiment；
Fig. 2 is the vertical view one for breathing oxygen consumption real-time monitoring device；
Fig. 3 is the internal passage anatomical axis survey one for breathing oxygen consumption real-time monitoring device；
Fig. 4 is the axonometric drawing one for breathing oxygen consumption real-time monitoring device；
Fig. 5 is the axonometric drawing two for breathing oxygen consumption real-time monitoring device；
Fig. 6 is basis《Chinese Pharmacological Bulletin》" dynamic of mouse Whole Oxygen Consumption measures dynamic and surveys by Jiang Zhiwen, Xu Shuxiu etc.
Measurement result calmly "；
Fig. 7 is to carry out the automatic of hypoxic hypoxia oxygen demand using the present invention to trace result.
In figure：01. power interface, 02. power switch, 03. oxygen consumption signaling interface, 04. breath signal interface, 05. capacity
Slot, 06. drainage channels 1, the protrusion of 07. drainage channels 2,08., 09. repair slot, 10~13. repair slots, 14. inlet guide slots,
15. oxygen consumption monitors slot, 16. anoxic bottle external tappings, 17. translation interfaces, 18. gas outlets, 19. air inlets, 20. photo resistance, 21
~22 baffles, 23~24 draining pits.
Specific implementation mode
With reference to attached drawing, a kind of respiration oxygen consumption real-time monitoring device with upper discharge structure, including the horizontal sheet being laid with
Body, the ontology is the acrylic board of water white transparency, and the lower surface of ontology is fitted tightly on smooth barn door；In ontology
Capacity slot 05, oxygen consumption monitoring slot 15 and inlet guide slot 14 are engraved, the upper surface of ontology is equipped with air inlet 19 and for connecting
The gas outlet 18 of logical anoxic bottle；Air inlet 19 is connected to by inlet guide slot 14 with the capacity slot 05；The oxygen consumption monitors slot
15 one end connection capacity slot 05, the other end is connected to the gas outlet 18；The gas outlet 18 is by being used to acquire respiratory movement
The quick energy converter of height of data is connected with anoxic bottle, and the quick energy converter of height is connected with System of organism signal；
Capacity slot 05 and the junction of oxygen consumption monitoring slot 15 are equipped with protrusion, and the protrusion blocks entering for oxygen consumption monitoring slot 15
The partial cross sectional of mouth；
The length direction for monitoring slot 15 on the upper surface of ontology along oxygen consumption is equipped with scale；Oxygen consumption monitors on the slot bottom of slot 15
The length direction that slot 15 is monitored along oxygen consumption is evenly provided with several photo resistance 20；The photo resistance 20 is sequentially connected in series
Sampling resistor is formed, the sampling resistor is connected on a resistance detecting circuit, the output of the resistance detecting circuit
End connection System of organism signal, System of organism signal export animal oxygen consumption according to the data of sampling resistor
Measure data；
The oxygen consumption monitoring slot 15 has tortuous shape；And oxygen consumption monitoring slot 15 includes several sections of straight troughs being mutually parallel
With the curved groove for connecting adjacent two straight trough；
Several drainage channels 06,07 and a return water guide groove are also engraved in ontology, the outlet of drainage channels 06,07 is equal
It is connected to capacity slot 05 and inlet guide slot 14 by return water guide groove；
Oxygen consumption monitors to be connected by the guiding device of anti-backflow respectively between slot 15 and the import of each drainage channels 06,07
Logical, the guiding device includes baffle and the draining pit 23,24 that is located on baffle, drains pit 23,24 and water conservancy diversion
There is the gap of connection oxygen consumption monitoring slot 15 and drainage channels 06,07 between block 21,22；
Draining pit 23,24 opens up on the body, and baffle 21,22 is respectively fixedly disposed at close to drainage channels 19
Between each curved groove and drainage channels 06,07 of side；It is left end that baffle, which is defined, close to one end of curved groove, close to drainage channels
06,07 one end is right end；The top surface flush of the bottom surface of baffle 21,22 and oxygen consumption monitoring slot 15, the top of baffle 21,22
Face is the inclined-plane gradually ramped up from left end to right end, and the left end on the inclined-plane extends at curved groove, the right side on the inclined-plane
End extends in drainage channels 06,07.
Baffle 21,22 can flow to oxygen consumption monitoring slot 15 by barrier liquid when ontology is horizontally arranged from drainage channels 06,07,
Liquid can be guided to be flowed in drainage channels 06,07 from oxygen consumption monitoring slot 15 when ontology is placed vertically again.
Oxygen consumption monitoring slot 15 is good quick to be shown to the breathing of animal in experiment suitable for making the elongated slot of small cross section
Sensitivity, even if the breathing of mouse can also cause the fluid column of ink to generate apparent movement.
The groove depth of capacity slot 05, oxygen consumption monitoring slot 15 and inlet guide slot 14 is 0.5cm.By prolonged and repeated experiment,
It was found that it is that 1cm is optimal selection that the groove depth of oxygen consumption monitoring slot 15, which takes 0.5cm, width, groove depth is excessively high, and laminar flow can occur for ink,
Slot is wide, and the end face of ink fluid column occurs not move concordantly, influences the accurate recording of oxygen demand；Groove depth is excessively shallow, narrow, can lead
It causes tube chamber long, keeps device excessively huge.
Air inlet 19 and gas outlet 18 are respectively positioned on the upper left side of ontology, and capacity slot 05 is located at the lower right of ontology.
Anoxic bottle and the specific connectivity structure of gas outlet are：The conversion that the side of the ontology is equipped with connection gas outlet 18 connects
Mouth 17, the other side of the ontology is equipped with the anoxic bottle external tapping 16 of connection anoxic bottle, and translation interface 17 and anoxic bottle are external
Mouth 16 passes through high quick energy converter and is connected to.
The gas outlet 18 and translation interface 17 are detachably connected by connecting tube, and the connecting leg is silicone tube.
Straight trough horizontal extension from left to right on the body, and straight trough and curved groove are vertically connected.
The baffle 21,22 is wedge type block.
Barn door is laid on pedestal, and the lateral surface of pedestal is equipped with power interface 01, and photo resistance 20 is connect by power supply
Mouth 01 is connected to extraneous power supply, and power interface 01 is furnished with power switch 02；The lateral surface of pedestal is equipped with oxygen consumption signaling interface
03, photo resistance 20 is connected by oxygen consumption signaling interface 03 with System of organism signal；
The quick tonotransducer of height for being connected to anoxic bottle is additionally provided in pedestal, the quick tonotransducer of height passes through breathing
Signaling interface 04 is connected with System of organism signal, and breath signal interface 04 is located on the lateral surface of pedestal.
It is 0.5cm that the width that oxygen consumption monitors slot 15, which is 1cm groove depths, can accommodate the capacity of 45-55ml water in total.
Inlet guide slot 14, capacity slot 05, oxygen consumption monitor hollow out between slot 15, drainage channels 06,07 or are cast with about 5mm*
Rectangle deep and wide 5mm repairs slot 09,10,11,12,13.
Capacity slot 05, oxygen consumption monitoring slot 15, inlet guide slot 14, the drainage channels 06,07 engraved in ontology can both be engraved
It is engraved in body interior, can also be engraved on the lower surface of ontology.But it engraves in body interior, capacity slot 05, oxygen consumption monitoring
Slot 15, inlet guide slot 14, drainage channels 06,07 slot bottom need to be located at the same horizontal plane on；And it engraves in ontology lower surface
When upper, then the slot bottom of each slot was served as by barn door.
When the present invention is horizontal positioned and without outer force effect, in capacity slot 05 ink of 0.5cm thickness surface tension with
It will not be flowed under the action of adhesiveness, so before experiment starts, the water in capacity slot 05 will not be monitored to oxygen consumption in slot 15
Flowing.Meanwhile protrusion has blocked the partial cross sectional of the entrance of oxygen consumption monitoring slot 15 so that oxygen consumption monitors the ink of 15 inlet of slot
The flow resistance of water increases, and further ensures that the ink before experiment starts in capacity slot 05 will not be monitored to oxygen consumption in slot 15
Flowing.
After experiment starts, ink overcomes the resistance of 15 inlet of oxygen consumption monitoring slot to flow under the traction of the negative pressure of anoxic bottle
Oxygen consumption monitors in slot 15, and flows to gas outlet 18 along oxygen consumption monitoring slot 15.The ink in capacity slot 5 is reduced at this time, air inlet
19 by inlet guide slot 14 to 5 make-up gas of capacity slot.
When experiment (ontology is horizontal positioned), guiding device will be encountered when ink flows through when oxygen consumption monitors the curved groove of slot 15, will be led
Stream block 21,22 can prevent the liquid medium in capacity slot 05 from pouring in down a chimney in oxygen consumption monitoring slot 15.Drain the base opening of pit 23,24
The either flush of place plane and oxygen consumption monitoring slot 15, under the effect of gravity, the liquid medium in oxygen consumption monitoring slot 15 will not be filled out
The gap between draining pit 23,24 and baffle 21,22 is filled, therefore, guiding device not will produce oxygen demand measurement result
It influences.
The length of ink fluid column reflects the oxygen demand of experimental animal, and ink fluid column floods photo resistance 20 and causes sampling electricity
The change in resistance of resistance, oxygen consumption monitor photo resistance 20 regularly arranged under slot 15 and can be used for automatic sensing oxygen demand.Its principle is
When stronger using photo resistance light, resistance value is relatively low, then resistance larger feature when dark, using natural light or light as
Transmitting terminal, as receiving terminal, oxygen consumption monitors 20 resistance value of photo resistance flooded by ink fluid column in slot 15 and occurs for photo resistance
Variation.Light signal is converted into electric signal using the resistance detecting circuit of electric bridge form, passes through biochips diagnosis system
System software shows the trend curve of oxygen demand, by detection signal digitlization.
1, use step of the invention is：
1) present invention is erected, and capacity slot 05 is downward, oxygen consumption monitors slot 15 upward；It is connected to 18 He of gas outlet with silicone tube
Translation interface 17；Again consumption is risen to from the black ink that addition was diluted with distilled water into capacity slot 05 in air inlet 19 to water level
Oxygen monitors at 0 scale of slot 15 (i.e. the inlet of oxygen consumption monitoring slot 15).
2) present invention is horizontal positioned on the table, by the phase of breath signal interface 04 and System of organism signal
Channel is answered to be connected；Then oxygen consumption signaling interface 03 is connected with the respective channel of System of organism signal；It finally will be electric
Source interface 01 is connect with power supply.
3) soda lime and mouse are put into anoxic bottle, and cover sealing cover；It will be connected to again with anoxic bottle on sealing cover
Snorkel is connected to by anoxic bottle external tapping 16.
4) startup power supply switch 02, experiment starts.When mouse breathing consumption oxygen in anoxic bottle generates negative pressure, such as
0.5cmH2O columns, the ink in capacity slot 05 can fill up consumption due to the effect of negative pressure to the 15 direction flowing of oxygen consumption monitoring slot
Oxygen capacity makes the pressure in the present invention be constant all the time in -0.5cm H2O columns.Mouse gives off carbon dioxide and by consumption anoxic bottle
The soda lime of placement is absorbed, and therefore, the ml that capacity slot 05 flows to ink in oxygen consumption monitoring slot 15 is the oxygen consumption of mouse
Amount (scale that personal monitoring can monitor 15 surface of slot by oxygen consumption reads oxygen demand)；
When the dilution ink in capacity slot 05 is flowed to oxygen consumption monitoring slot 15, you can flood photo resistance 20, shelter from
Original light impinged upon in photo resistance 20, the ink for flowing into oxygen consumption monitoring slot 15 is more, and the photo resistance 20 being blocked is more
More, resistance detecting circuit can filter out useful signal and application signal control voltage output, by biochips diagnosis
System traces out oxygen demand automatically.
When mouse breathing, the expansion and contraction of lung cause to breathe the pressure oscillation in oxygen consumption real-time monitoring device, pass through height
Quick energy converter is transformed into electric signal and is transmitted to RM6240 System of organism signal, and respiratory curve is traced out with direct current signal,
Accurately dynamic monitoring the pressure in oxygen consumption real-time monitoring device, respiratory rate and amplitude can be breathed, realize anoxic experiment mice
The automatic monitoring of respiratory rate, amplitude and pressure, avoids error caused by personal monitoring.
5) to be tested again, by the present invention erect, and oxygen consumption monitoring slot 15 upward, capacity slot 05 downward, oxygen consumption
Water in monitoring slot 15 can flow to capacity slot 05 by draining the gap between pit 23,24 and drainage channels 06,07.It drains
After flowing into the water in oxygen consumption monitoring slot 15 in experiment, then oxygen consumption real-time monitoring device will be breathed and be horizontally arranged on the table, you can
It is tested again, avoids experiment every time and need the trouble for adding water.
2, experimental result of the invention and advantage explanation
According to《Chinese Pharmacological Bulletin》Jiang Zhiwen, Xu Shuxiu's etc. " dynamic of mouse Whole Oxygen Consumption measures dynamic and measures "
As a result the measurement result (see Fig. 7) of oxygen demand is carried out (see Fig. 6) and using the present invention to be obtained：The oxygen consumption experiment of different experiments room
The capacity of used anoxic bottle is different, and there is a notable difference in the oxygen consumption time-to-live, but oxygen demand curve be in one first rise after under
The two-way curve of drop, oxygen consumption occurs mainly in the front half section time, such as is carried out in oxygen demand measurement first 12 minutes using the present invention
The 71% of total oxygen demand is accounted for, later half time oxygen demand accounts for the 21% of total amount, and is in uniform descent；When illustrating to measure front half section
Between can be obtained the oxygen demand result of difference (obtain) for changing meaning.
Due to present invention System of organism signal recording respiration curve, when can acquire any during anoxic
Between section respiratory rate, amplitude (ventilatory capacity) and oxygen demand, overcome old device visual method number respiratory rate (mouse breathing it is weak and
Soon,>200 times/min, the problem of can not accurately obtaining data on time, even if obtaining the data of respiratory rate, it can not correct and exhale
Inhale the problem of frequency is not necessarily positively correlated with respiratory stimulant) and oxygen demand, it can change routine by promoting the use of the present invention
The way of anoxic operating limit oxygen consumption, the way for making time oxygen consumption rate or minute oxygen demand into obtain experimental result, avoid pole
Limit oxygen consumption murders animal.
The present invention breaks through the recording mode of existing hypoxia device on the basis of succession classical characteristic, it may be said that is that collection is permanent
Pressure, dynamic monitoring respiratory rate, amplitude, oxygen demand and anaerobic environment pressure are the systematization anoxic experimental tool of the whole body, are overcome
The problem of old device in background technology reads oxygen demand data with visual method, and data can not be restored by missing acquisition time just,
And alleviate labor intensity, and it is cheap, make it is simple, be suitable for teaching and scientific research.
Compared with old device, the present invention has following advantage：
The present invention records dynamic oxygen demand with System of organism signal, can acquire any time during anoxic
The oxygen consumption rate of section overcomes old device visual method to read oxygen demand data, misses acquisition time and can not just restore data
Problem, and alleviate labor intensity；The way that conventional anoxic operating limit oxygen consumption can be changed using the present invention makes time consumption into
The way of oxygen rate or minute oxygen demand obtains experimental result, and Limiting Oxygen is avoided to murder animal；It is of particular importance that this
Horizontal fluid column is used when invention experiment, does not interfere with experimental precision.
Content described in this specification embodiment is only enumerating to the way of realization of inventive concept, protection of the invention
Range is not construed as being only limitted to the concrete form that embodiment is stated, protection scope of the present invention also includes art technology
Personnel according to present inventive concept it is conceivable that equivalent technologies mean.
Claims (7)
1. a kind of respiration oxygen consumption real-time monitoring device with upper discharge structure, it is characterised in that：The sheet being laid with including level
Body, the ontology is the acrylic board of water white transparency, and the lower surface of ontology is fitted tightly on smooth barn door；In ontology
Engraved capacity slot, oxygen consumption monitoring slot and inlet guide slot, the upper surface of ontology be equipped with air inlet with for being connected to anoxic bottle
Gas outlet；Air inlet is connected to by inlet guide slot with the capacity slot；One end of the oxygen consumption monitoring slot is connected to capacity slot,
The other end is connected to the gas outlet；The gas outlet passes through the quick energy converter of height and anoxic bottle phase for acquiring respiratory movement data
Even, and the quick energy converter of height is connected with System of organism signal；
The junction of capacity slot and oxygen consumption monitoring slot is equipped with protrusion, and the protrusion blocks the part cross of the entrance of oxygen consumption monitoring slot
Section；
The length direction for monitoring slot on the upper surface of ontology along oxygen consumption is equipped with scale；Oxygen consumption monitors on the slot bottom of slot along oxygen consumption
The length direction of monitoring slot is evenly provided with several photo resistance；The photo resistance is sequentially connected in series to form sampling resistor,
The sampling resistor is connected on a resistance detecting circuit, and the output end of the resistance detecting circuit connects bio signal
Acquisition processing system, System of organism signal export animal oxygen demand data according to the data of sampling resistor；
The oxygen consumption monitoring slot has tortuous shape；And oxygen consumption monitoring slot includes several sections of straight troughs being mutually parallel and connection phase
The curved groove of adjacent two straight troughs；
Several drainage channels and a return water guide groove are also engraved in ontology, the outlet of drainage channels is connected by return water guide groove
Logical capacity slot and inlet guide slot；
Oxygen consumption monitors to be connected to by the guiding device of anti-backflow respectively between slot and the import of each drainage channels, the water conservancy diversion dress
It sets including baffle and the draining pit being located on baffle, has between draining pit and baffle and be connected to oxygen consumption monitoring slot
With the gap of drainage channels；
Draining pit opens up on the body, baffle be respectively fixedly disposed at each curved groove close to drainage channels side with
Between drainage channels；It is left end that baffle, which is defined, close to one end of curved groove, is right end close to one end of drainage channels；Baffle
The top surface flush of bottom surface and oxygen consumption monitoring slot, the top surface of baffle is the inclined-plane gradually ramped up from left end to right end, and
The left end on the inclined-plane extends at curved groove, and the right end on the inclined-plane extends in drainage channels.
2. a kind of respiration oxygen consumption real-time monitoring device with upper discharge structure as described in claim 1, it is characterised in that：
The groove depth of capacity slot, oxygen consumption monitoring slot and inlet guide slot is 0.5cm.
3. a kind of respiration oxygen consumption real-time monitoring device with upper discharge structure as claimed in claim 2, it is characterised in that：
Air inlet and gas outlet are respectively positioned on the upper left side of ontology, and capacity slot is located at the lower right of ontology.
4. a kind of respiration oxygen consumption real-time monitoring device with upper discharge structure as claimed in claim 3, it is characterised in that：
Anoxic bottle and the specific connectivity structure of gas outlet are：Translation interface of the side of the ontology equipped with connection gas outlet, described
The other side of body is equipped with the anoxic bottle external tapping of connection anoxic bottle, and translation interface and anoxic bottle external tapping pass through high quick energy converter
Connection.
5. a kind of respiration oxygen consumption real-time monitoring device with upper discharge structure as claimed in claim 4, it is characterised in that：
The gas outlet and translation interface are detachably connected by connecting tube.
6. a kind of respiration oxygen consumption real-time monitoring device with upper discharge structure as claimed in claim 5, it is characterised in that：
Straight trough horizontal extension from left to right on the body, and straight trough and curved groove are vertically connected.
7. a kind of respiration oxygen consumption real-time monitoring device with upper discharge structure as claimed in claim 6, it is characterised in that：
The baffle is wedge type block.
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| CN110623670A (en) * | 2019-08-16 | 2019-12-31 | 浙江大学 | Split type respiration oxygen consumption real-time monitoring device |
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