CN108498694A - A kind of prepared slices of Chinese crude drugs and preparation method thereof - Google Patents
A kind of prepared slices of Chinese crude drugs and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of prepared slices of Chinese crude drugs and preparation method thereof, belong to drug preparation technique field.The prepared slices of Chinese crude drugs, including following raw material：Sealwort, hawthorn, cassia seed, dried orange peel, honeysuckle, donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin, modified sustained release auxiliary agent, the prepared slices of Chinese crude drugs are by preparing raw slurry, homogenization, pneumatic conveying drying, ultra-fine grinding, preparing coating material, after raw material superfine powder and coating material are mixed after compression moulding made of drying.The prepared slices of Chinese crude drugs that the present invention is prepared have excellent drug absorption efficiency.
Description
【Technical field】
The invention belongs to drug preparation technique fields, and in particular to a kind of prepared slices of Chinese crude drugs and preparation method thereof.
【Background technology】
The prepared slices of Chinese crude drugs are Chinese medicines after processing, can be directly used for the Chinese medicine of tcm clinical practice, including part through the place of production
Chinese medicine slice, the prototype pharmaceutical decocting piece of processing, and the medicine materical crude slice Jing Guo cutting, processing, are the three industries of Chinese medicine industry
One of.
A kind of Chinese patent application document " inferior health prepared slices of Chinese crude drugs and preparation method thereof (application publication number：
CN107320502A a kind of inferior health prepared slices of Chinese crude drugs) " are disclosed, including with component raw material：5-10 grams of sealwort, 15-20 parts of hawthorn,
15-20 grams of cassia seed, 8-12 grams of dried orange peel, 8-10 grams of honeysuckle, preparation method are：Each raw material is weighed, after removing impurity, leaching
Profit, cutting crushing, sweating, rubbing, drying process, are squeezed blocking finally by extrusion equipment, are carried out on blocky tablet
Punching, carries out slice briquetting by slicer, is punched on blocky tablet, and slice packaging, medicinal material are carried out by slicer
Need to be made it is powdered packaging is crushed by grinding device after drying process, which can improve human body and exempt from
Epidemic disease power, relieves fatigue, and reduces blood pressure, and improves function of human body, is infiltrated, turned round using rotating device in preparation method
Infiltration reaches few bubble and moistens more, and medicine is permeable most, rational technology, effectively keeps its drug effect, and sheet and powder is supported to decoct as needed
It is convenient, the utilization rate of each raw medicinal material is improved, cost is reduced, while may additionally facilitate the decomposition of benefit materials in human body, is improved
It absorbs.But its drug release efficiency is low, absorbed efficiency is low in human body, cannot be satisfied the need to drug effect when actually drinking
It asks.
【Invention content】
A kind of prepared slices of Chinese crude drugs of present invention offer and preparation method thereof, it is " a kind of sub- strong in Chinese patent application document to solve
The health prepared slices of Chinese crude drugs and preparation method thereof (application publication number：CN107320502A on the basis of prepared slices of Chinese crude drugs formula disclosed in) ", how
The technical issues of optimizing component, dosage etc., improving the drug release efficiency and absorption efficiency of the prepared slices of Chinese crude drugs.
In order to solve the above technical problems, the present invention uses following technical scheme：
A kind of prepared slices of Chinese crude drugs, including following raw material：Sealwort, hawthorn, cassia seed, dried orange peel, honeysuckle, donkey-hide gelatin, tapioca starch, shell
Glycan, seaweed, soybean lecithin, modified sustained release auxiliary agent；
The modified sustained release auxiliary agent, as unit of parts by weight, including following raw material：15-25 parts of polylactic acid, polyethylene glycol 4-
8 parts, 3-6 parts of shelling element, 2-6 parts of dimethylformamide, 1-4 parts of hydroxyacetic acid, 3-7 parts of hyaluronic acid, 2-8 parts of chitosan oligosaccharide, matter
Measure 1-5 parts of the ethyl alcohol gel solution that score is 15-25%；
The donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin, the modified weight ratio for being sustained auxiliary agent are (5-15):
(4-8):(3-6):(8-16):(6-9)：(10-20).
Further, the donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin weight ratio be 14.9:4.6:
5.2:12.8:8.4:16.7。
Further, as unit of parts by weight, including following raw material：5-10 parts of sealwort, 15-20 parts of hawthorn, cassia seed 15-
20 parts, it is 8-12 parts of dried orange peel, 8-10 parts of honeysuckle, 5-15 parts of donkey-hide gelatin, 4-8 parts of tapioca starch, 3-6 parts of chitosan, 8-16 parts of seaweed, big
6-9 parts of beans lecithin, modified 10-20 parts of auxiliary agent of sustained release.
Further, the modified sustained release auxiliary agent is prepared by following technique：By polylactic acid, polyethylene glycol, shelling element,
Dimethylformamide and hydroxyacetic acid are uniformly mixed, and 20-30min are stirred in 350-650r/min rotating speeds, then in -30~-50
Dry 20-40min in DEG C freeze drier, is subsequently added into hyaluronic acid and chitosan oligosaccharide is uniformly mixed, in 4500-5500r/min
Rotating speed stirs 10-20min, and the ethyl alcohol gel solution that mass fraction is 15-25% is then added and is uniformly mixed, then in 250-
350r/min rotating speeds stir 3-5h, are then collected by centrifugation in 8500-12000r/min rotating speeds, are freeze-dried and are modified after washing
It is sustained auxiliary agent.
The present invention also provides a kind of preparation methods of the prepared slices of Chinese crude drugs, include the following steps：
S1：The medicinal material section that 5-8mm long is cut into after sealwort, hawthorn, cassia seed, dried orange peel and honeysuckle are cleaned, by medicinal material
Section finishes when vapor (steam) temperature is 110-120 DEG C, it is added into medicinal material section after terminating in my 15-20s of fixation time, water-removing
The salt of weight 0.1-0.3%, uniform mixing carry out steam beating after standing 20-30min under the conditions of 130-150 DEG C, finish
Time is 20-25s, and water, which is added, into the medicinal material section after water-removing after cooling is beaten, and raw slurry is made；
S2：Raw slurry prepared by S1 carries out homogenization, and temperature is 80-90 DEG C, homogenization pressure 40-50Mpa, weight
Multiple homogeneous 2-3 times；
S3：Pneumatic conveying drying：Raw slurry after homogeneous is subjected to pneumatic conveying drying, gas inlet temperature by pneumatic drier
It is set as 150-155 DEG C, outlet temperature is set as 42-48 DEG C, and material water ratio is 12-15% after drying, and mixture is made, will
Mixture is crushed using high speed comminuting method, crosses 100-120 mesh screens, and raw material powder is made；
S4：Ultra-fine grinding：Raw material powder is placed in ultrafine crusher, 20-30min is crushed under the conditions of 16-24 DEG C, is crushed
To 600-800 mesh, raw material superfine powder is made；
S5, will donkey-hide gelatin and soybean lecithin mix after be warming up to 80-90 DEG C, keep the temperature 10-20min, be subsequently added into tapioca starch,
Chitosan, seaweed and modified sustained release auxiliary agent are uniformly mixed, and are continuously heating to 100-110 DEG C, 5-10min are kept the temperature, then in 1500-
2500r/min rotating speeds stir 20-40min, are cooled to room temperature to obtain coating material；
S6, the raw material superfine powder that S4 is prepared and the coating material that S5 is prepared are uniformly mixed, are warming up to 90-110
DEG C, 15-35min is kept the temperature, 20-30min is stirred in 850-1050r/min rotating speeds, it is 0.4-0.5cm to be then pressed into thickness, directly
Diameter is the round sheet object of 1-1.3cm, and round sheet object is placed in freeze-day with constant temperature baking oven, is dried at 70-80 DEG C, until product
Water content be 6-7% when take out, the prepared slices of Chinese crude drugs are made
The invention has the advantages that：
(1) by the data of embodiment 1-3 and comparative example 8 as it can be seen that the patient of the edible embodiment 1-3 prepared slices of Chinese crude drugs is to drug
Absorption efficiency significantly improves；Simultaneously by the data of embodiment 1-3 as it can be seen that embodiment 1 is optimum embodiment.
(2) by embodiment 2 and the data of comparative example 1-7 as it can be seen that donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin,
Modified sustained release auxiliary agent plays synergistic effect in preparing the prepared slices of Chinese crude drugs, collaboration improve the drug release efficiency of the prepared slices of Chinese crude drugs with
Absorption efficiency, this may be：The effect of donkey-hide gelatin not only has as Chinese medicine enriches blood enriching yin, moisturizes, hemostasis and with glutinous well
Property, tapioca starch is the starch extracted in a kind of root tuber from tropical plants, since amylopectin forms sediment with straight chain in cassava ative starch
The ratio of powder is up to 80:20, therefore there is very high spike viscosity, as the raw material that stickiness in reinforcement system enhances, with donkey-hide gelatin
Cooperation, can not only improve the molding intensity of the prepared slices of Chinese crude drugs so that tablet keeps definite shape after entering esophagus, makes drug
It is gradually absorbed by the body, effectively increases the absorption efficiency of drug effect, chitosan has higher protein adsorption ability；In degrading enzyme
Under the action of, chitosan has degradability；Chitosan is easy to be processed into line, is suitble to make linear or sheet medical material；Shell
Glycan has affinity and dissolubility, is suitable for producing each analog derivative；Chitosan has higher chemism；Chitosan
Retentiveness is high；In serum, the degradable absorption of chitosan；Chitosan has higher biological degradability；Chitosan has been shown
The height of selectivity inhibits the effect of Streptococcus oralis growth, while having no effect on the growth of other beneficial bacterias, and its is porous
Adsorptivity is donkey-hide gelatin, tapioca starch, seaweed and soybean lecithin provide attachment site so that donkey-hide gelatin, tapioca starch, chitosan, sea
Algae, soybean lecithin can apply to the preparation of the prepared slices of Chinese crude drugs as reinforcement system, improve reinforcement system in prepared slices of Chinese crude drugs system
Reinforcing effect in standby, wherein seaweed have effects that heat-clearing, softening and resolving hard mass, and contain abundant protein, apply to this hair
In the preparation of the bright prepared slices of Chinese crude drugs, the content of prepared slices of Chinese crude drugs protein can not only be effectively supplemented, moreover it is possible to effectively supplement inorganic member
The elements such as plain sodium, potassium, iron, calcium and Anacobin, C and E, biotin and niacin so that the prepared slices of Chinese crude drugs of the invention
Health-care efficacy is more reasonable, and seaweed can be attached to the surface of chitosan so that it is more easy to after entering human body by human body intestines
Road absorbs.The soybean lecithin wherein added contain lecithin, cephalin, etc., tool slows down aging, prevents cardiovascular and cerebrovascular disease etc.
Effect applies in the preparation of the prepared slices of Chinese crude drugs of the present invention, can repair the cell membrane being damaged, and improves cell membrane function, makes
Cell membrane softens and rejuvenation, increases cell activity.Pass through the intake to lecithin, so that it may with improve human body metabolic capability,
The power of regeneration of self-healing ability and antibody tissue enhances the vitality of human body, so that the nutritional ingredient in Chinese medicine tablet
It is fully absorbed by human body.Wherein modified sustained release auxiliary agent is by by polylactic acid, polyethylene glycol, shelling element, dimethylformamide and hydroxyl
Guanidine-acetic acid is uniformly mixed, stirring, then dry in freeze drier, is subsequently added into hyaluronic acid and chitosan oligosaccharide is uniformly mixed,
Then stirring is added ethyl alcohol gel solution and is uniformly mixed, is followed by stirring for, is then centrifuged for collecting, be freeze-dried after washing, using poly-
The degradability and slow release of lactic acid are molten with dimethylformamide and hydroxyacetic acid using polyethylene glycol as film forming matter
Agent, using hyaluronic acid and chitosan oligosaccharide slow release supporting material wherein hyaluronic acid as acid mucopolysaccharide, as good transdermal suction
Accelerating agent is received, the absorption of nutriment can be promoted, and oligosaccharide can promote body intestinal beneficial bacterium to be proliferated, and inhibit harmful bacteria
Growth, therefore the synergistic effect of hyaluronic acid and chitosan oligosaccharide can assign under the premise of improving modified sustained release auxiliary agent slow releasing function
The promotion human body of modification sustained release auxiliary agent makes the ability of absorption of nutrient ingredients under the adhesive effect of ethyl alcohol gel solution
Sustained release auxiliary agent must be modified can keep certain shape after entering human body, due to the suction-operated of polylactic acid so that preparation
Modified sustained release auxiliary agent and the donkey-hide gelatin of addition, tapioca starch, chitosan, seaweed, soybean lecithin are as reinforcement system, with the present invention
The prepared slices of Chinese crude drugs preparation in, further improve the absorption efficiency of prepared slices of Chinese crude drugs nutriment.
(3) by the data of comparative example 9-11 as it can be seen that donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin, modified sustained release
The weight ratio of auxiliary agent is not at (5-15):(4-8):(3-6):(8-16):(6-9)：When in (10-20) range, Chinese medicine drink obtained
The numerical value of the absorption rate score and embodiment 1-3 of piece is very different, and is much smaller than the numerical value of embodiment 1-3, with the prior art (comparison
Example 5) numerical value it is suitable.Donkey-hide gelatin of the present invention, tapioca starch, chitosan, seaweed, soybean lecithin are reinforcement system, embodiment 1-3 controls
By adding donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin, the modified weight for being sustained auxiliary agent when system prepares fluorinated plastic
Than for (5-15):(4-8):(3-6):(8-16):(6-9)：(10-20) is realized and is utilized Colla Corii Asini nourishing blood enriching yin in reinforcement system,
It moisturizes, the effect of hemostasis and its good stickiness, while the spike viscosity of tapioca starch is utilized, reinforcement is used as in donkey-hide gelatin cooperation
In system stickiness enhance system, by using chitosan anti-microbial property and seaweed heat-clearing, softening and resolving hard mass the effect of, greatly
Beans lecithin can improve the metabolic capability of human body, be used as slow release strengthening helping agent by adding modified sustained release auxiliary agent, with donkey-hide gelatin, wood
In the preparation for the prepared slices of Chinese crude drugs that potato powder, chitosan, seaweed, soybean lecithin cooperation apply to the present invention so that in Chinese medicine tablet
Nutritional ingredient fully absorbed by human body.
【Specific implementation mode】
For ease of more fully understanding the present invention, it is illustrated by the following examples, these examples belong to the protection of the present invention
Range, but do not limit the scope of the invention.
In embodiment, the prepared slices of Chinese crude drugs, as unit of parts by weight, including following raw material：5-10 parts of sealwort, hawthorn
15-20 parts, 15-20 parts of cassia seed, 8-12 parts of dried orange peel, 8-10 parts of honeysuckle, 5-15 parts of donkey-hide gelatin, 4-8 parts of tapioca starch, chitosan 3-
6 parts, 8-16 parts of seaweed, 6-9 parts of soybean lecithin, modified 10-20 parts of auxiliary agent of sustained release；
The modified sustained release auxiliary agent is prepared by following technique：By weight by 15-25 parts of polylactic acid, 4-8 parts of poly- second
Glycol, 3-6 part shelling element, 2-6 parts of dimethylformamides and 1-4 parts of hydroxyacetic acids are uniformly mixed, in 350-650r/min rotating speeds
Stir 20-30min, then the dry 20-40min in -30~-50 DEG C of freeze driers, be subsequently added into 3-7 part hyaluronic acids with
2-8 parts of chitosan oligosaccharides are uniformly mixed, and 10-20min is stirred in 4500-5500r/min rotating speeds, and 1-5 parts of mass fractions are then added and are
The ethyl alcohol gel solution of 15-25% is uniformly mixed, and then 3-5h is stirred in 250-350r/min rotating speeds, then in 8500-
12000r/min rotating speeds are collected by centrifugation, and freeze-drying, which obtains being modified, after washing is sustained auxiliary agent.
The preparation method of the prepared slices of Chinese crude drugs, includes the following steps：
S1：The medicinal material section that 5-8mm long is cut into after sealwort, hawthorn, cassia seed, dried orange peel and honeysuckle are cleaned, by medicinal material
Section finishes when vapor (steam) temperature is 110-120 DEG C, it is added into medicinal material section after terminating in my 15-20s of fixation time, water-removing
The salt of weight 0.1-0.3%, uniform mixing carry out steam beating after standing 20-30min under the conditions of 130-150 DEG C, finish
Time is 20-25s, and water, which is added, into the medicinal material section after water-removing after cooling is beaten, and raw slurry is made；
S2：Raw slurry prepared by S1 carries out homogenization, and temperature is 80-90 DEG C, homogenization pressure 40-50Mpa, weight
Multiple homogeneous 2-3 times；
S3：Pneumatic conveying drying：Raw slurry after homogeneous is subjected to pneumatic conveying drying, gas inlet temperature by pneumatic drier
It is set as 150-155 DEG C, outlet temperature is set as 42-48 DEG C, and material water ratio is 12-15% after drying, and mixture is made, will
Mixture is crushed using high speed comminuting method, crosses 100-120 mesh screens, and raw material powder is made；
S4：Ultra-fine grinding：Raw material powder is placed in ultrafine crusher, 20-30min is crushed under the conditions of 16-24 DEG C, is crushed
To 600-800 mesh, raw material superfine powder is made；
S5, will donkey-hide gelatin and soybean lecithin mix after be warming up to 80-90 DEG C, keep the temperature 10-20min, be subsequently added into tapioca starch,
Chitosan, seaweed and modified sustained release auxiliary agent are uniformly mixed, and are continuously heating to 100-110 DEG C, 5-10min are kept the temperature, then in 1500-
2500r/min rotating speeds stir 20-40min, are cooled to room temperature to obtain coating material；
S6, the raw material superfine powder that S4 is prepared and the coating material that S5 is prepared are uniformly mixed, are warming up to 90-110
DEG C, 15-35min is kept the temperature, 20-30min is stirred in 850-1050r/min rotating speeds, it is 0.4-0.5cm to be then pressed into thickness, directly
Diameter is the round sheet object of 1-1.3cm, and round sheet object is placed in freeze-day with constant temperature baking oven, is dried at 70-80 DEG C, until product
Water content be 6-7% when take out, the prepared slices of Chinese crude drugs are made.
Below by more specifically examples illustrate the present invention.
Embodiment 1
A kind of prepared slices of Chinese crude drugs, as unit of parts by weight, including following raw material：9.6 parts of sealwort, 19.4 parts of hawthorn, cassia seed
18.4 parts, it is 9.7 parts of dried orange peel, 8.4 parts of honeysuckle, 14.9 parts of donkey-hide gelatin, 4.6 parts of tapioca starch, 5.2 parts of chitosan, 12.8 parts of seaweed, big
8.4 parts of beans lecithin, modified 16.7 parts of auxiliary agent of sustained release；
The modified sustained release auxiliary agent is prepared by following technique：By weight by 18.4 parts of polylactic acid, 5.7 parts of poly- second two
Alcohol, 4.3 parts of shelling elements, 3.6 parts of dimethylformamides and 2.4 parts of hydroxyacetic acids are uniformly mixed, and are stirred in 498r/min rotating speeds
24min, then the dry 32min in -45 DEG C of freeze driers, is subsequently added into 4.7 parts of hyaluronic acids and 6.2 parts of chitosan oligosaccharide mixing
Uniformly, 15.5min is stirred in 4895r/min rotating speeds, it is mixed that the ethyl alcohol gel solution that 3.2 parts of mass fractions are 16.9% is then added
It closes uniformly, then stirs 4h in 285r/min rotating speeds, be then collected by centrifugation in 10350r/min rotating speeds, be freeze-dried after washing
It is sustained auxiliary agent to modified.
The preparation method of the prepared slices of Chinese crude drugs, includes the following steps：
S1：The medicinal material section that 6.3mm long is cut into after sealwort, hawthorn, cassia seed, dried orange peel and honeysuckle are cleaned, by medicinal material
Section finishes when vapor (steam) temperature is 118 DEG C, its weight is added into medicinal material section after terminating for my 18s of fixation time, water-removing
0.2% salt, uniform mixing carry out steam beating after standing 24min under the conditions of 146 DEG C, and fixation time 23s is cooling
Water is added in medicinal material section after backward water-removing to be beaten, raw slurry is made；
S2：Raw slurry prepared by S1 carries out homogenization, and temperature is 84 DEG C, homogenization pressure 46Mpa, repeats homogeneous
2 times；
S3：Pneumatic conveying drying：Raw slurry after homogeneous is subjected to pneumatic conveying drying, gas inlet temperature by pneumatic drier
153 DEG C are set as, outlet temperature is set as 46 DEG C, and material water ratio is 14.6% after drying, and mixture is made, mixture is adopted
It is crushed with high speed comminuting method, crosses 114 mesh screens, raw material powder is made；
S4：Ultra-fine grinding：Raw material powder is placed in ultrafine crusher, 23min is crushed under the conditions of 21 DEG C, is crushed to 746
Raw material superfine powder is made in mesh；
S5,83 DEG C are warming up to after mixing donkey-hide gelatin and soybean lecithin, keep the temperature 17min, it is poly- to be subsequently added into tapioca starch, shell
Sugar, seaweed and modified sustained release auxiliary agent are uniformly mixed, and are continuously heating to 103 DEG C, 8.5min are kept the temperature, then in 1968r/min rotating speeds
32min is stirred, is cooled to room temperature to obtain coating material；
S6, the raw material superfine powder that S4 is prepared and the coating material that S5 is prepared are uniformly mixed, are warming up to 102 DEG C,
28min is kept the temperature, 24min is stirred in 968r/min rotating speeds, it is 0.47cm, the circular piece of a diameter of 1.2cm to be then pressed into thickness
Round sheet object is placed in freeze-day with constant temperature baking oven by shape object, is dried at 74 DEG C, until the water content of product is taken out when being 6.3%,
The prepared slices of Chinese crude drugs are made.
Embodiment 2
A kind of prepared slices of Chinese crude drugs, as unit of parts by weight, including following raw material：5 parts of sealwort, 20 parts of hawthorn, 15 parts of cassia seed,
12 parts of dried orange peel, 15 parts of donkey-hide gelatin, 4 parts of tapioca starch, 6 parts of chitosan, 8 parts of seaweed, 9 parts of soybean lecithin, is modified and delays 8 parts of honeysuckle
Release 10 parts of auxiliary agent；
The modified sustained release auxiliary agent is prepared by following technique：By weight by 15 parts of polylactic acid, 8 parts of polyethylene glycol, 3
Part shelling element, 6 parts of dimethylformamides and 1 part of hydroxyacetic acid are uniformly mixed, and 20min is stirred in 650r/min rotating speeds, then in-
Dry 20min in 50 DEG C of freeze driers, is subsequently added into 7 parts of hyaluronic acids and 2 parts of chitosan oligosaccharides are uniformly mixed, in 5500r/min
Rotating speed stirs 10min, and the ethyl alcohol gel solution that 5 parts of mass fractions are 15% is then added and is uniformly mixed, then in 350r/min
Rotating speed stirs 3h, is then collected by centrifugation in 12000r/min rotating speeds, and freeze-drying, which obtains being modified, after washing is sustained auxiliary agent.
The preparation method of the prepared slices of Chinese crude drugs, includes the following steps：
S1：The medicinal material section that 5mm long is cut into after sealwort, hawthorn, cassia seed, dried orange peel and honeysuckle are cleaned, by medicinal material section
It finishes when vapor (steam) temperature is 120 DEG C, its weight 0.3% is added into medicinal material section after terminating for my 15s of fixation time, water-removing
Salt, uniform mixing carries out steam beating after standing 20min under the conditions of 150 DEG C, and fixation time 20s, cooling is killed backward
Water is added in medicinal material section after blueness to be beaten, raw slurry is made；
S2：Raw slurry prepared by S1 carries out homogenization, and temperature is 90 DEG C, homogenization pressure 40Mpa, repeats homogeneous
3 times；
S3：Pneumatic conveying drying：Raw slurry after homogeneous is subjected to pneumatic conveying drying, gas inlet temperature by pneumatic drier
150 DEG C are set as, outlet temperature is set as 48 DEG C, and material water ratio is 12% after drying, and mixture is made, mixture is used
High speed comminuting method crushes, and crosses 120 mesh screens, and raw material powder is made；
S4：Ultra-fine grinding：Raw material powder is placed in ultrafine crusher, 30min is crushed under the conditions of 16 DEG C, is crushed to 600
Raw material superfine powder is made in mesh；
S5,90 DEG C are warming up to after mixing donkey-hide gelatin and soybean lecithin, keep the temperature 10min, it is poly- to be subsequently added into tapioca starch, shell
Sugar, seaweed and modified sustained release auxiliary agent are uniformly mixed, and are continuously heating to 110 DEG C, are kept the temperature 5min, then stirred in 2500r/min rotating speeds
20min is mixed, is cooled to room temperature to obtain coating material；
S6, the raw material superfine powder that S4 is prepared and the coating material that S5 is prepared are uniformly mixed, are warming up to 110 DEG C,
15min is kept the temperature, 20min is stirred in 1050r/min rotating speeds, it is 0.5cm, the round sheet of a diameter of 1cm to be then pressed into thickness
Round sheet object is placed in freeze-day with constant temperature baking oven by object, is dried at 80 DEG C, until the water content of product is taken out when being 6%, is made
The prepared slices of Chinese crude drugs.
Embodiment 3
A kind of prepared slices of Chinese crude drugs, as unit of parts by weight, including following raw material：10 parts of sealwort, 15 parts of hawthorn, cassia seed 20
Part, 10 parts of honeysuckle, 5 parts of donkey-hide gelatin, 8 parts of tapioca starch, 3 parts of chitosan, 16 parts of seaweed, 6 parts of soybean lecithin, is modified 8 parts of dried orange peel
It is sustained 20 parts of auxiliary agent；
The modified sustained release auxiliary agent is prepared by following technique：By weight by 25 parts of polylactic acid, 4 parts of polyethylene glycol, 6
Part shelling element, 2 parts of dimethylformamides and 4 parts of hydroxyacetic acids are uniformly mixed, and 30min is stirred in 350r/min rotating speeds, then in-
Dry 40min in 30 DEG C of freeze driers, is subsequently added into 3 parts of hyaluronic acids and 8 parts of chitosan oligosaccharides are uniformly mixed, in 4500r/min
Rotating speed stirs 20min, and the ethyl alcohol gel solution that 1 part of mass fraction is 25% is then added and is uniformly mixed, then in 250r/min
Rotating speed stirs 5h, is then collected by centrifugation in 8500r/min rotating speeds, and freeze-drying, which obtains being modified, after washing is sustained auxiliary agent.
The preparation method of the prepared slices of Chinese crude drugs, includes the following steps：
S1：The medicinal material section that 8mm long is cut into after sealwort, hawthorn, cassia seed, dried orange peel and honeysuckle are cleaned, by medicinal material section
It finishes when vapor (steam) temperature is 110 DEG C, its weight 0.1% is added into medicinal material section after terminating for my 20s of fixation time, water-removing
Salt, uniform mixing carries out steam beating after standing 30min under the conditions of 130 DEG C, and fixation time 25s, cooling is killed backward
Water is added in medicinal material section after blueness to be beaten, raw slurry is made；
S2：Raw slurry prepared by S1 carries out homogenization, and temperature is 80 DEG C, homogenization pressure 50Mpa, repeats homogeneous
2 times；
S3：Pneumatic conveying drying：Raw slurry after homogeneous is subjected to pneumatic conveying drying, gas inlet temperature by pneumatic drier
155 DEG C are set as, outlet temperature is set as 42 DEG C, and material water ratio is 15% after drying, and mixture is made, mixture is used
High speed comminuting method crushes, and sieves with 100 mesh sieve net, and raw material powder is made；
S4：Ultra-fine grinding：Raw material powder is placed in ultrafine crusher, 20min is crushed under the conditions of 24 DEG C, is crushed to 800
Raw material superfine powder is made in mesh；
S5,80 DEG C are warming up to after mixing donkey-hide gelatin and soybean lecithin, keep the temperature 20min, it is poly- to be subsequently added into tapioca starch, shell
Sugar, seaweed and modified sustained release auxiliary agent are uniformly mixed, and are continuously heating to 100 DEG C, are kept the temperature 10min, then stirred in 1500r/min rotating speeds
40min is mixed, is cooled to room temperature to obtain coating material；
S6, the raw material superfine powder that S4 is prepared and the coating material that S5 is prepared are uniformly mixed, are warming up to 90 DEG C, protected
Warm 35min stirs 30min in 850r/min rotating speeds, and it is 0.4cm, the round sheet of a diameter of 1.3cm to be then pressed into thickness
Round sheet object is placed in freeze-day with constant temperature baking oven by object, is dried at 70 DEG C, until the water content of product is taken out when being 7%, is made
The prepared slices of Chinese crude drugs.
Comparative example 1
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare lack in the raw materials of the prepared slices of Chinese crude drugs donkey-hide gelatin,
Tapioca starch, chitosan, seaweed, soybean lecithin.
Comparative example 2
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare in the raw materials of the prepared slices of Chinese crude drugs and lack donkey-hide gelatin.
Comparative example 3
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare in the raw materials of the prepared slices of Chinese crude drugs and lack cassava
Powder.
Comparative example 4
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare that lack shell in the raw materials of the prepared slices of Chinese crude drugs poly-
Sugar.
Comparative example 5
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare in the raw materials of the prepared slices of Chinese crude drugs and lack seaweed.
Comparative example 6
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare in the raw materials of the prepared slices of Chinese crude drugs and lack soybean
Lecithin.
Comparative example 7
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare in the raw materials of the prepared slices of Chinese crude drugs and lack modification
It is sustained auxiliary agent.
Comparative example 8
Using a kind of Chinese patent application document " inferior health prepared slices of Chinese crude drugs and preparation method thereof (application publication number：
CN107320502A) " prepared by the technique of embodiment 1-3.
Comparative example 9
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare 4 parts of donkey-hide gelatin in the raw materials of the prepared slices of Chinese crude drugs,
9 parts of tapioca starch, 2 parts of chitosan, 17 parts of seaweed, 5 parts of soybean lecithin, modified 8 parts of auxiliary agent of sustained release.
Comparative example 10
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare 17 parts of donkey-hide gelatin in the raw materials of the prepared slices of Chinese crude drugs,
9 parts of tapioca starch, 2 parts of chitosan, 18 parts of seaweed, 5 parts of soybean lecithin, modified 22 parts of auxiliary agent of sustained release.
Comparative example 11
It is essentially identical with the preparation process of embodiment 1, have only unlike prepare 16 parts of donkey-hide gelatin in the raw materials of the prepared slices of Chinese crude drugs,
3 parts of tapioca starch, 7 parts of chitosan, 7 parts of seaweed, 11 parts of soybean lecithin, modified 7 parts of auxiliary agent of sustained release.
Indices detection, obtained testing result are carried out to the formula of embodiment 1-3 and the comparative example 1-10 prepared slices of Chinese crude drugs
Such as following table:
As seen from the above table：(1) by the data of embodiment 1-3 and comparative example 8 as it can be seen that eating the embodiment 1-3 prepared slices of Chinese crude drugs
Patient significantly improves the absorption efficiency of drug；Simultaneously by the data of embodiment 1-3 as it can be seen that embodiment 1 is optimum embodiment.
(2) by embodiment 2 and the data of comparative example 1-7 as it can be seen that donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin,
Modified sustained release auxiliary agent plays synergistic effect in preparing the prepared slices of Chinese crude drugs, collaboration improve the drug release efficiency of the prepared slices of Chinese crude drugs with
Absorption efficiency, this may be：The effect of donkey-hide gelatin not only has as Chinese medicine enriches blood enriching yin, moisturizes, hemostasis and with glutinous well
Property, tapioca starch is the starch extracted in a kind of root tuber from tropical plants, since amylopectin forms sediment with straight chain in cassava ative starch
The ratio of powder is up to 80:20, therefore there is very high spike viscosity, as the raw material that stickiness in reinforcement system enhances, with donkey-hide gelatin
Cooperation, can not only improve the molding intensity of the prepared slices of Chinese crude drugs so that tablet keeps definite shape after entering esophagus, makes drug
It is gradually absorbed by the body, effectively increases the absorption efficiency of drug effect, chitosan has higher protein adsorption ability；In degrading enzyme
Under the action of, chitosan has degradability；Chitosan is easy to be processed into line, is suitble to make linear or sheet medical material；Shell
Glycan has affinity and dissolubility, is suitable for producing each analog derivative；Chitosan has higher chemism；Chitosan
Retentiveness is high；In serum, the degradable absorption of chitosan；Chitosan has higher biological degradability；Chitosan has been shown
The height of selectivity inhibits the effect of Streptococcus oralis growth, while having no effect on the growth of other beneficial bacterias, and its is porous
Adsorptivity is donkey-hide gelatin, tapioca starch, seaweed and soybean lecithin provide attachment site so that donkey-hide gelatin, tapioca starch, chitosan, sea
Algae, soybean lecithin can apply to the preparation of the prepared slices of Chinese crude drugs as reinforcement system, improve reinforcement system in prepared slices of Chinese crude drugs system
Reinforcing effect in standby, wherein seaweed have effects that heat-clearing, softening and resolving hard mass, and contain abundant protein, apply to this hair
In the preparation of the bright prepared slices of Chinese crude drugs, the content of prepared slices of Chinese crude drugs protein can not only be effectively supplemented, moreover it is possible to effectively supplement inorganic member
The elements such as plain sodium, potassium, iron, calcium and Anacobin, C and E, biotin and niacin so that the prepared slices of Chinese crude drugs of the invention
Health-care efficacy is more reasonable, and seaweed can be attached to the surface of chitosan so that it is more easy to after entering human body by human body intestines
Road absorbs.The soybean lecithin wherein added contain lecithin, cephalin, etc., tool slows down aging, prevents cardiovascular and cerebrovascular disease etc.
Effect applies in the preparation of the prepared slices of Chinese crude drugs of the present invention, can repair the cell membrane being damaged, and improves cell membrane function, makes
Cell membrane softens and rejuvenation, increases cell activity.Pass through the intake to lecithin, so that it may with improve human body metabolic capability,
The power of regeneration of self-healing ability and antibody tissue enhances the vitality of human body, so that the nutritional ingredient in Chinese medicine tablet
It is fully absorbed by human body.Wherein modified sustained release auxiliary agent is by by polylactic acid, polyethylene glycol, shelling element, dimethylformamide and hydroxyl
Guanidine-acetic acid is uniformly mixed, stirring, then dry in freeze drier, is subsequently added into hyaluronic acid and chitosan oligosaccharide is uniformly mixed,
Then stirring is added ethyl alcohol gel solution and is uniformly mixed, is followed by stirring for, is then centrifuged for collecting, be freeze-dried after washing, using poly-
The degradability and slow release of lactic acid are molten with dimethylformamide and hydroxyacetic acid using polyethylene glycol as film forming matter
Agent, using hyaluronic acid and chitosan oligosaccharide slow release supporting material wherein hyaluronic acid as acid mucopolysaccharide, as good transdermal suction
Accelerating agent is received, the absorption of nutriment can be promoted, and oligosaccharide can promote body intestinal beneficial bacterium to be proliferated, and inhibit harmful bacteria
Growth, therefore the synergistic effect of hyaluronic acid and chitosan oligosaccharide can assign under the premise of improving modified sustained release auxiliary agent slow releasing function
The promotion human body of modification sustained release auxiliary agent makes the ability of absorption of nutrient ingredients under the adhesive effect of ethyl alcohol gel solution
Sustained release auxiliary agent must be modified can keep certain shape after entering human body, due to the suction-operated of polylactic acid so that preparation
Modified sustained release auxiliary agent and the donkey-hide gelatin of addition, tapioca starch, chitosan, seaweed, soybean lecithin are as reinforcement system, with the present invention
The prepared slices of Chinese crude drugs preparation in, further improve the absorption efficiency of prepared slices of Chinese crude drugs nutriment.
(3) by the data of comparative example 9-11 as it can be seen that donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin, modified sustained release
The weight ratio of auxiliary agent is not at (5-15):(4-8):(3-6):(8-16):(6-9)：When in (10-20) range, Chinese medicine drink obtained
The numerical value of the absorption rate score and embodiment 1-3 of piece is very different, and is much smaller than
The numerical value of embodiment 1-3 is suitable with the numerical value of the prior art (comparative example 5).Donkey-hide gelatin of the present invention, tapioca starch, shell are poly-
Sugar, seaweed, soybean lecithin are reinforcement system, when embodiment 1-3 controls prepare fluorinated plastic by add donkey-hide gelatin, tapioca starch,
Chitosan, seaweed, soybean lecithin, the modified weight ratio for being sustained auxiliary agent are (5-15):(4-8):(3-6):(8-16):(6-9)：
The effect of (10-20) is realized and utilized Colla Corii Asini nourishing blood enriching yin in reinforcement system, moisturize, hemostasis and its good stickiness, simultaneously
The spike viscosity of tapioca starch is utilized, enhances system as stickiness in reinforcement system in donkey-hide gelatin cooperation, by using chitosan
The effect of heat-clearing of anti-microbial property and seaweed, softening and resolving hard mass, soybean lecithin can improve the metabolic capability of human body, by adding
Add modified sustained release auxiliary agent as slow release strengthening helping agent, is used with donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin cooperation
Into the preparation of the prepared slices of Chinese crude drugs of the present invention so that the nutritional ingredient in Chinese medicine tablet is fully absorbed by human body.
The above content is it cannot be assumed that present invention specific implementation is confined to these explanations, for the technical field of the invention
Those of ordinary skill for, under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all answers
When being considered as belonging to present invention scope of patent protection determined by the appended claims.
Claims (5)
1. a kind of prepared slices of Chinese crude drugs, which is characterized in that including following raw material：Sealwort, hawthorn, cassia seed, dried orange peel, honeysuckle, donkey-hide gelatin,
Tapioca starch, chitosan, seaweed, soybean lecithin, modified sustained release auxiliary agent；
The modified sustained release auxiliary agent, as unit of parts by weight, including following raw material：15-25 parts of polylactic acid, 4-8 parts of polyethylene glycol,
3-6 parts of shelling element, 2-6 parts of dimethylformamide, 1-4 parts of hydroxyacetic acid, 3-7 parts of hyaluronic acid, 2-8 parts of chitosan oligosaccharide, quality point
Number is 1-5 parts of the ethyl alcohol gel solution of 15-25%；
The donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean lecithin, the modified weight ratio for being sustained auxiliary agent are (5-15):(4-
8):(3-6):(8-16):(6-9)：(10-20).
2. the prepared slices of Chinese crude drugs according to claim 1, which is characterized in that the donkey-hide gelatin, tapioca starch, chitosan, seaweed, soybean
The weight ratio of lecithin is 14.9:4.6:5.2:12.8:8.4:16.7.
3. the prepared slices of Chinese crude drugs according to claim 1, which is characterized in that as unit of parts by weight, including following raw material：Sealwort
5-10 parts, 15-20 parts of hawthorn, 15-20 parts of cassia seed, 8-12 parts of dried orange peel, 8-10 parts of honeysuckle, 5-15 parts of donkey-hide gelatin, tapioca starch 4-8
Part, 3-6 parts of chitosan, 8-16 parts of seaweed, 6-9 parts of soybean lecithin, modified 10-20 parts of auxiliary agent of sustained release.
4. the prepared slices of Chinese crude drugs according to claim 1, which is characterized in that the modified sustained release auxiliary agent is by following technique system
It is standby：Polylactic acid, polyethylene glycol, shelling element, dimethylformamide and hydroxyacetic acid are uniformly mixed, in 350-650r/min rotating speeds
20-30min is stirred, then the dry 20-40min in -30~-50 DEG C of freeze driers, is subsequently added into hyaluronic acid and shell is few
Sugar is uniformly mixed, and 10-20min is stirred in 4500-5500r/min rotating speeds, and it is solidifying that the ethyl alcohol that mass fraction is 15-25% is then added
Sol solution is uniformly mixed, and then stirs 3-5h in 250-350r/min rotating speeds, is then centrifuged and is received in 8500-12000r/min rotating speeds
Collection, freeze-drying, which obtains being modified, after washing is sustained auxiliary agent.
5. a kind of preparation method according to claim 1-4 any one of them prepared slices of Chinese crude drugs, which is characterized in that including following step
Suddenly：
S1：The medicinal material section that 5-8mm long is cut into after sealwort, hawthorn, cassia seed, dried orange peel and honeysuckle are cleaned, medicinal material section is existed
Vapor (steam) temperature finishes when being 110-120 DEG C, its weight is added into medicinal material section after terminating for my 15-20s of fixation time, water-removing
The salt of 0.1-0.3%, uniform mixing carry out steam beating, fixation time after standing 20-30min under the conditions of 130-150 DEG C
For 20-25s, water is added into the medicinal material section after water-removing after cooling and is beaten, raw slurry is made；
S2：Raw slurry prepared by S1 carries out homogenization, and temperature is 80-90 DEG C, homogenization pressure 40-50Mpa, is repeated equal
Matter 2-3 times；
S3：Pneumatic conveying drying：Raw slurry after homogeneous is subjected to pneumatic conveying drying, gas inlet temperature setting by pneumatic drier
It it is 150-155 DEG C, outlet temperature is set as 42-48 DEG C, and material water ratio is 12-15% after drying, and mixture is made, will mix
Material is crushed using high speed comminuting method, crosses 100-120 mesh screens, and raw material powder is made；
S4：Ultra-fine grinding：Raw material powder is placed in ultrafine crusher, 20-30min is crushed under the conditions of 16-24 DEG C, is crushed to
Raw material superfine powder is made in 600-800 mesh；
S5, it is warming up to 80-90 DEG C after mixing donkey-hide gelatin and soybean lecithin, keeps the temperature 10-20min, it is poly- to be subsequently added into tapioca starch, shell
Sugar, seaweed and modified sustained release auxiliary agent are uniformly mixed, and are continuously heating to 100-110 DEG C, 5-10min are kept the temperature, then in 1500-
2500r/min rotating speeds stir 20-40min, are cooled to room temperature to obtain coating material；
S6, the raw material superfine powder that S4 is prepared and the coating material that S5 is prepared are uniformly mixed, are warming up to 90-110 DEG C, protected
Warm 15-35min stirs 20-30min in 850-1050r/min rotating speeds, and it is 0.4-0.5cm, a diameter of 1- to be then pressed into thickness
The round sheet object of 1.3cm, round sheet object is placed in freeze-day with constant temperature baking oven, is dried at 70-80 DEG C, until product is aqueous
Amount is taken out when being 6-7%, and the prepared slices of Chinese crude drugs are made.
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| CN111035660A (en) * | 2020-01-13 | 2020-04-21 | 刘敏 | Polygonal gastric mucosa probiotic powder with good absorption effect |
| CN111110769A (en) * | 2020-01-21 | 2020-05-08 | 蜜拓蜜大健康管理有限公司 | Preparation method of analgesic moxibustion |
| CN111184797A (en) * | 2020-01-21 | 2020-05-22 | 蜜拓蜜大健康管理有限公司 | Medicine formula for meridian moxibustion and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109010371A (en) * | 2018-08-17 | 2018-12-18 | 药圣堂（湖南）制药有限公司 | A kind of donkey-hide gelatin oral preparation and preparation method thereof |
| CN111035660A (en) * | 2020-01-13 | 2020-04-21 | 刘敏 | Polygonal gastric mucosa probiotic powder with good absorption effect |
| CN111110769A (en) * | 2020-01-21 | 2020-05-08 | 蜜拓蜜大健康管理有限公司 | Preparation method of analgesic moxibustion |
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| CN113425766A (en) * | 2021-04-27 | 2021-09-24 | 北京养淬堂生物科学技术研究院有限公司 | Preparation process and application for effectively improving bioavailability and absorption efficiency of traditional Chinese medicine decoction pieces |
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Application publication date: 20180907 |