CN111035660A - Polygonal gastric mucosa probiotic powder with good absorption effect - Google Patents
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Abstract
The application discloses polygonal gastric mucosa probiotic powder with a good absorption effect, which belongs to the technical field of probiotic powder and is formed by mixing medicament particles, wherein the medicament particles comprise an inner core, a slow release layer and slow release bulges, the slow release layer surrounds the periphery of the inner core, the slow release bulges are uniformly arranged on the periphery of the slow release layer, and the slow release bulges are radially arranged from the center of the inner core; the multilayer probiotic powder of the invention effectively improves the efficiency and quality of drug absorption.
Description
Technical Field
The invention relates to the technical field of probiotic powder, in particular to polygonal gastric mucosa probiotic powder with a good absorption effect.
Background
The nutrition of the human body is 100 percent absorbed by intestinal tract; in humans 99% of the toxins enter the human body from the intestinal tract; 84% of viruses in humans enter humans from the intestinal tract; half of the aging of the human body is the brain, and half is the intestinal tract; in western countries 84% of people with malnutrition are caused by intestinal problems. Abnormal intestinal health manifestation: abdominal distension and diarrhea, constipation, inappetence, mouth unclean, easy illness, dark complexion, acne, low mood and the like, and the occurrence of the symptoms indicates that the intestinal tract of people has problems. The disordered intestinal flora may be an important factor in the induction of chronic diseases. Probiotics are living microorganisms beneficial to the health of a host, and a large number of research results show that the probiotics play a role in various health aspects such as the digestive tract, the immunity, the cardiovascular system and the like.
Through retrieval, the Chinese patent with the application number of 201010535819.X discloses probiotic solid powder and a preparation method thereof, wherein the probiotic solid powder is a mixture containing active probiotics and active zeolite, and the content of the active probiotics is 120-500 hundred million CFU/g. The active zeolite mixture comprises the following components in percentage by weight: 30-50% of zeolite, 20-40% of attapulgite clay and 10-30% of bentonite. The probiotic solid powder provides a high-quality and low-cost antibiotic substitute product for the breeding industry, the growth speed of broiler chickens, pigs and fishes is improved by 2.0-15.6% by adding 100-400 million CFU viable bacteria in each gram of feed, the feed conversion rate is improved by 1.1-9.3%, and the diarrhea rate and the death rate of animals can be obviously reduced; the preparation method is simple, the cost is low, the environmental pollution can be reduced, and the obtained product has high bacterium content. One probiotic powder in the above patent has the following disadvantages: the absorption effect is poor.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides the polygonal gastric mucosa probiotic powder with good absorption effect.
The technical scheme adopted by the invention is as follows:
the utility model provides a multilateral stomach mucosa probiotic powder that absorption effect is good, is formed by the medicine particle mixture, and the medicine particle comprises kernel, sustained-release layer and slow release arch, and the periphery at the kernel is enclosed to the sustained-release layer, and the periphery at the sustained-release layer is evenly arranged to the sustained-release arch, and the center of sustained-release arch from the kernel is radial arrangement.
In the embodiment of the invention, the inner core comprises the following raw materials in parts by weight: 50-80 parts of bifidobacterium lactis powder, 20-50 parts of lactobacillus paracasei powder, 8-16 parts of galactooligosaccharide, 4-8 parts of inulin, 2-8 parts of whey powder, 1-5 parts of rhizoma anemarrhenae and 3-9 parts of lotus root starch.
In the embodiment of the invention, the kernel is prepared according to the following process: adding water into lotus root starch, uniformly mixing, heating at 80-120 ℃ for 20-40min, and cooling to room temperature to obtain a material a; and then, uniformly mixing the inulin, the whey powder, the rhizoma anemarrhenae and the water, heating at 80-120 ℃ for 30-50min, filtering to obtain a filtrate, adding the filtrate into the material a, stirring at the rotation speed of 650 plus 850r/min for 30-50min, cooling to room temperature, adding the bifidobacterium lactis powder, the lactobacillus paracasei powder and the galacto-oligosaccharide, uniformly mixing, stirring at the rotation speed of 650 plus 850r/min for 20-40min, and cooling to room temperature to obtain the core. Wherein the addition amount of water can be properly added according to the prior art, so that the materials are uniformly mixed, and the materials are in a paste pill shape.
In the embodiment of the invention, the raw materials of the slow release layer comprise, by weight: 40-50 parts of rice hull powder, 15-25 parts of chitosan, 8-16 parts of donkey-hide gelatin, 4-8 parts of cassava powder, 3-9 parts of seaweed and 8-16 parts of soybean lecithin.
In the embodiment of the invention, the slow release layer is prepared by the following process: uniformly mixing rice hull powder, chitosan and distilled water, uniformly stirring at the speed of 850-1050r/min, then adding donkey-hide gelatin, cassava powder, seaweed and soybean lecithin, stirring for 4-6h at the speed of 280-320r/min in a constant-temperature water bath at the temperature of 65-75 ℃, then cooling to room temperature, carrying out suction filtration to obtain a precipitate, drying the precipitate at the temperature of 45-55 ℃ for 44-52h, and cooling to room temperature to obtain a slow-release layer. Wherein the addition of the distilled water can be properly added according to the prior art, so that the materials are uniformly mixed, and the materials are in a paste pill shape.
In the embodiment of the invention, the raw materials of the slow-release bulges comprise, by weight, 15-25 parts of α -starch, 2-5 parts of sodium glutamate, 3-6 parts of saccharicterpenin, 4-8 parts of spirulina, 3-6 parts of chitosan, 4-8 parts of soybean lecithin, 12-24 parts of polylactic acid and 15-20 parts of ethanol gel.
In the embodiment of the invention, the slow release bulge is prepared by uniformly mixing α -starch, sodium glutamate, saccharicterpenin, spirulina, chitosan and soybean lecithin, stirring at the rotation speed of 350-550 r/min for 20-30min, drying in a freeze dryer at the temperature of-30 to-50 ℃ for 20-40min, adding polylactic acid, uniformly mixing, stirring at the rotation speed of 4500-5500r/min for 10-20min, adding ethanol gel, uniformly mixing, stirring at the rotation speed of 250-350r/min for 3-5h, and centrifuging at the rotation speed of 8500-12000r/min to obtain the slow release bulge.
In the embodiment of the invention, the preparation method of the polygonal gastric mucosa probiotic powder comprises the following steps: spraying a slow release layer on the periphery of the prepared inner core, pouring a plurality of slow release protrusions on the periphery of the slow release layer, drying in a dryer at 45-65 ℃ for 20-40min, forming to obtain medicine particles, and mixing to obtain the polygonal gastric mucosa probiotic powder.
The invention has the beneficial effects that: when the multilateral gastric mucosa probiotic powder with good absorption effect is eaten, the buffering protrusions firstly contact with gastric mucosa and gastric acid and are firstly melted by gastric acid, and when the multilateral gastric mucosa probiotic powder enters the intestinal tract, the stability of adhesion with intestinal villi is improved by the buffering protrusions, the retention time of the inner core in the intestine and stomach is prolonged, the inner core can be exposed in the intestine and stomach after the slow release layer is decomposed by the gastric acid, so that effective medicinal ingredients in the inner core can be released into the intestine and stomach, the release time of medicaments in the inner core in the intestine and stomach is effectively prolonged, the absorption efficiency of the inner core medicaments by the intestine and stomach is effectively improved, and the medicament effect is improved.
Wherein, the viscosity of the rice hull powder in the raw material of the slow release layer is improved because of Mg2+The method is realized by fully exchanging octahedron and tetrahedron layers of cassava flour and chitosan. Because the same charges are carried among the rod crystals to form electrostatic repulsion, the rod crystals are prevented from agglomerating to achieve better dispersion effect, the viscosity is improved, the chitosan is easy to dissolve in a weak acid solvent, the dissolved solution contains amino, the amino inhibits the activity of respiratory enzymes on the surface of bacteria by combining negative electrons to cause bacterial inactivation, meanwhile, because the porosity and a large number of hydroxyl groups on the surface of the chitosan, the donkey-hide gelatin, the cassava powder, the seaweed and the soybean lecithin play a synergistic role in preparing the slow release layer, and the drug release efficiency and the absorption of the slow release layer are improved synergisticallyThe donkey-hide gelatin has the effects of enriching blood, nourishing yin, moistening dryness and stopping bleeding and has good viscosity, the cassava starch is starch extracted from roots of tropical plants, and the ratio of amylopectin to amylose in cassava raw starch is as high as 80:20, so that the cassava starch has high peak viscosity, and the cassava starch is used as a raw material for enhancing the viscosity in a reinforcing system and is matched with the donkey-hide gelatin, so that the forming strength of a slow release layer can be improved, the slow release layer keeps a certain shape after entering an esophagus, the medicine is gradually absorbed by a human body, the absorption efficiency of the medicine effect is effectively improved, and the chitosan has higher protein adsorption capacity; under the action of degrading enzyme, the chitosan has degradability; the chitosan is easy to be processed into lines and is suitable for being made into linear or sheet medical materials; the chitosan has affinity and solubility and is suitable for producing various derivatives; chitosan has higher chemical activity; the water binding capacity of the chitosan is high; in serum, chitosan is easily degraded and absorbed; chitosan has higher biodegradability; the chitosan shows the selective function of highly inhibiting the growth of oral streptococcus, does not influence the growth of other beneficial bacteria, and the porous adsorbability provides attachment sites for the donkey-hide gelatin, the cassava powder, the seaweed and the soybean lecithin, so that the donkey-hide gelatin, the cassava powder, the chitosan, the seaweed and the soybean lecithin can be used as a reinforcing system for preparing traditional Chinese medicine decoction pieces, and the reinforcing effect of the reinforcing system in the preparation of a slow release layer is improved, wherein the seaweed has the effects of clearing heat and softening and resolving hard mass and contains rich protein, and when the seaweed is used for preparing the slow release layer, the content of the protein of the traditional Chinese medicine decoction pieces can be effectively supplemented, the elements such as inorganic elements including sodium, potassium, iron, calcium and the like, vitamins B12, C and E, biotin and nicotinic acid can be effectively supplemented, so that the health-care effect of the probiotic powder is more reasonable, and the seaweed can be attached to the surface of the chitosan, so that the medicine is easier to be absorbed by the intestinal tract of the human body after entering the human body. The added soybean lecithin contains lecithin, cephalin and the like, has the effects of delaying senescence, preventing cardiovascular and cerebrovascular diseases and the like, and can repair damaged cell membranes, improve the functions of the cell membranes, soften and rejuvenate the cell membranes and increase the activity of the cells when being applied to the preparation of the probiotic powder. By passingThe ingestion of lecithin can improve the metabolic capability, the self-healing capability and the regeneration capability of antibody tissues of human bodies and enhance the life vitality of the human bodies, thereby leading the nutrient components in the probiotic powder to be fully absorbed by the human bodies.
The slow release bulge is prepared from α -starch, sodium glutamate, saccharicterpenin, spirulina, chitosan, soybean lecithin, polylactic acid and ethanol gel as raw materials, wherein the sodium glutamate is a sodium salt of glutamic acid and belongs to one of the most abundant naturally-formed nonessential amino acids, and has a freshening effect, and the sodium glutamate is used for preparing the slow release bulge so as to inhibit sharp odor of drug ingredients in the slow release bulge preparation and is matched with α -use of starch and polylactic acid, and the adhesiveness of α -starch is utilized, the sodium glutamate is uniformly dispersed on each attachment site of the preparation in the preparation process, so that nasal medicine smell in an inner core is effectively controlled, the saccharicterpenin is a mixture of triterpenoid saponins extracted from camellia plant seed cakes and saccharides, and is a brown yellow, ashless crystalline, the slow release microcapsule is capable of obviously improving the neuroimmune function and anti-stress effect of an animal body, can clear free radicals, has a function, can regulate a regular function of a triterpene and a carbohydrate, is a mixture of a macrolactin, is prepared from a spirulina, the surface of a spirulina, the polysaccharide is a polysaccharide, the polysaccharide.
Drawings
Fig. 1 is a sectional view of drug particles in polygonal gastric mucosa probiotic powder with good absorption effect according to the invention.
The figures are numbered:
1. a kernel; 2. a sustained release layer; 3. the slow release bulges.
Detailed Description
The technical solutions of the embodiments of the present invention are explained and illustrated below with reference to the drawings of the embodiments of the present invention, but the following embodiments are only preferred embodiments of the present invention, and not all embodiments. Based on the embodiments in the implementation, other embodiments obtained by those skilled in the art without any creative effort belong to the protection scope of the present invention.
In the following description, the appearances of the indicating orientation or positional relationship such as the terms "inner", "outer", "upper", "lower", "left", "right", etc. are only for convenience in describing the embodiments and for simplicity in description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and are not to be construed as limiting the present invention.
Example 1:
as shown in fig. 1, the polygonal stomach mucosa probiotic powder with a good absorption effect provided by the embodiment of the invention is formed by mixing drug particles, wherein the drug particles are composed of an inner core 1, a slow release layer 2 and slow release protrusions 3, the slow release layer 2 surrounds the outer periphery of the inner core 1, the slow release protrusions 3 are uniformly arranged on the outer periphery of the slow release layer 2, and the slow release protrusions 3 are radially arranged from the center of the inner core 1.
The kernel is prepared by the following process: adding 6 parts by weight of lotus root starch into water, uniformly mixing, heating at 100 ℃ for 30min, and cooling to room temperature to obtain a material a; and then uniformly mixing 6 parts of inulin, 5 parts of whey powder, 3 parts of rhizoma anemarrhenae and water, heating at 100 ℃ for 40min, filtering to obtain a filtrate, adding the filtrate into the material a, stirring at the rotating speed of 750r/min for 40min, cooling to room temperature, adding bifidobacterium lactis powder, 35 parts of lactobacillus paracasei powder and 12 parts of galacto-oligosaccharide, uniformly mixing, stirring at the rotating speed of 750r/min for 30min, and cooling to room temperature to obtain the inner core.
The sustained-release layer is prepared by the following process: uniformly mixing 45 parts of rice hull powder, 20 parts of chitosan and distilled water according to parts by weight, uniformly stirring at a speed of 950r/min, then adding 12 parts of donkey-hide gelatin, 6 parts of cassava powder, 6 parts of seaweed and 12 parts of soybean lecithin, stirring for 5 hours at a speed of 300r/min in a constant-temperature water bath at 70 ℃, then cooling to room temperature, carrying out suction filtration to obtain a precipitate, then drying the precipitate at 50 ℃ for 48 hours, and cooling to room temperature to obtain a slow-release layer.
The slow release bulge is prepared by uniformly mixing 20 parts by weight of α -starch, 3.5 parts by weight of sodium glutamate, 4.5 parts by weight of saccharicterpenin, 6 parts by weight of spirulina, 4.5 parts by weight of chitosan and 6 parts by weight of soybean lecithin, stirring for 25min at the rotating speed of 550r/min, drying for 30min in a freeze dryer at the temperature of minus 40 ℃, adding 18 parts by weight of polylactic acid, uniformly mixing, stirring for 15min at the rotating speed of 5000r/min, adding 17 parts by weight of ethanol gel, uniformly mixing, stirring for 4h at the rotating speed of 300r/min, and centrifuging and collecting at the rotating speed of 10500r/min to obtain the slow release bulge.
The preparation method of the polygonal gastric mucosa probiotic powder comprises the following steps: and spraying a slow release layer on the periphery of the prepared inner core, pouring a plurality of slow release protrusions on the periphery of the slow release layer, and finally drying in a drying machine at 55 ℃ for 30min to obtain a medicament particle after molding, and mixing to obtain the polygonal gastric mucosa probiotic powder.
Example 2
As shown in fig. 1, the polygonal stomach mucosa probiotic powder with a good absorption effect provided by the embodiment of the invention is formed by mixing drug particles, wherein the drug particles are composed of an inner core 1, a slow release layer 2 and slow release protrusions 3, the slow release layer 2 surrounds the outer periphery of the inner core 1, the slow release protrusions 3 are uniformly arranged on the outer periphery of the slow release layer 2, and the slow release protrusions 3 are radially arranged from the center of the inner core 1.
The kernel is prepared by the following process: adding water into 3 parts of lotus root starch by weight, uniformly mixing, heating at 120 ℃ for 20min, and cooling to room temperature to obtain a material a; then, 8 parts of inulin, 2 parts of whey powder, 5 parts of rhizoma anemarrhenae and water are uniformly mixed, the mixture is heated for 50min at 80 ℃, then the filtrate is obtained through filtration, the filtrate is added into the material a, the mixture is stirred for 50min at the rotating speed of 650r/min, the mixture is cooled to room temperature, bifidobacterium lactis powder, 20 parts of lactobacillus paracasei powder and 16 parts of galacto-oligosaccharide are added and uniformly mixed, the mixture is stirred for 40min at the rotating speed of 650r/min and then cooled to room temperature, and an inner core is obtained.
The sustained-release layer is prepared by the following process: uniformly mixing 40 parts of rice hull powder, 25 parts of chitosan and distilled water according to parts by weight, uniformly stirring at the speed of 850r/min, then adding 16 parts of donkey-hide gelatin, 4 parts of cassava powder, 9 parts of seaweed and 8 parts of soybean lecithin, stirring for 6 hours at the speed of 280r/min in a constant-temperature water bath at 75 ℃, then cooling to room temperature, carrying out suction filtration to obtain a precipitate, then drying the precipitate at 45 ℃ for 52 hours, and cooling to room temperature to obtain a slow-release layer.
The slow release bulge is prepared by the following process that 15 parts of α -starch, 5 parts of sodium glutamate, 3 parts of saccharicterpenin, 8 parts of spirulina, 3 parts of chitosan and 8 parts of soybean lecithin are uniformly mixed according to the parts by weight, stirred for 30min at the rotating speed of 350r/min, dried for 40min in a freeze dryer at the temperature of-30 ℃, then added with 12 parts of polylactic acid for uniform mixing, stirred for 10min at the rotating speed of 5500r/min, then added with 20 parts of ethanol gel for uniform mixing, stirred for 5h at the rotating speed of 250r/min, and then centrifuged and collected at the rotating speed of 8500r/min to obtain the slow release bulge.
The preparation method of the polygonal gastric mucosa probiotic powder comprises the following steps: and spraying a slow release layer on the periphery of the prepared inner core, pouring a plurality of slow release protrusions on the periphery of the slow release layer, and finally drying in a drying machine at 45 ℃ for 40min to obtain medicament particles after molding, and mixing to obtain the polygonal gastric mucosa probiotic powder.
Example 3
As shown in fig. 1, the polygonal stomach mucosa probiotic powder with a good absorption effect provided by the embodiment of the invention is formed by mixing drug particles, wherein the drug particles are composed of an inner core 1, a slow release layer 2 and slow release protrusions 3, the slow release layer 2 surrounds the outer periphery of the inner core 1, the slow release protrusions 3 are uniformly arranged on the outer periphery of the slow release layer 2, and the slow release protrusions 3 are radially arranged from the center of the inner core 1.
The kernel is prepared by the following process: adding water into 9 parts of lotus root starch by weight, uniformly mixing, heating at 80 ℃ for 40min, and cooling to room temperature to obtain a material a; and then uniformly mixing 4 parts of inulin, 8 parts of whey powder, 1 part of rhizoma anemarrhenae and water, heating at 120 ℃ for 30-min, filtering to obtain a filtrate, adding the filtrate into the material a, stirring at the rotating speed of 850r/min for 30min, cooling to room temperature, adding bifidobacterium lactis powder, 50 parts of lactobacillus paracasei powder and 8 parts of galacto-oligosaccharide, uniformly mixing, stirring at the rotating speed of 850r/min for 20min, and cooling to room temperature to obtain the inner core.
The sustained-release layer is prepared by the following process: mixing 50 parts of rice hull powder, 15 parts of chitosan and distilled water uniformly according to parts by weight, stirring uniformly at a speed of 1050r/min, then adding 8 parts of donkey-hide gelatin, 8 parts of cassava powder, 3 parts of seaweed and 16 parts of soybean lecithin, stirring for 4 hours at a speed of 320r/min in a constant-temperature water bath at 65 ℃, then cooling to room temperature, carrying out suction filtration to obtain a precipitate, then drying the precipitate at 55 ℃ for 44 hours, and cooling to room temperature to obtain a slow-release layer.
The slow release bulge is prepared by uniformly mixing 25 parts by weight of α -starch, 2 parts by weight of sodium glutamate, 6 parts by weight of saccharicterpenin, 4 parts by weight of spirulina, 6 parts by weight of chitosan and 4 parts by weight of soybean lecithin, stirring at the rotating speed of 650r/min for 20min, drying in a freeze dryer at the temperature of 50 ℃ below zero for 20min, adding 24 parts by weight of polylactic acid, uniformly mixing, stirring at the rotating speed of 4500r/min for 20min, adding 15 parts by weight of ethanol gel, uniformly mixing, stirring at the rotating speed of 350r/min for 3h, and centrifuging at the rotating speed of 12000r/min to obtain the slow release bulge.
The preparation method of the polygonal gastric mucosa probiotic powder comprises the following steps: and spraying a slow release layer on the periphery of the prepared inner core, pouring a plurality of slow release protrusions on the periphery of the slow release layer, and finally drying in a drying machine at 65 ℃ for 20min to obtain medicament particles after molding, and mixing to obtain the polygonal gastric mucosa probiotic powder.
Comparative example 1
The probiotic powder is prepared by adopting the process of the embodiment of Chinese patent application document 'a probiotic solid powder and a preparation method thereof (application number: 201010535819. X)'.
Selecting 30 cases from people with stomach diseases and poor digestive functions as testers of the test, randomly dividing the 30 cases into 3 groups, respectively numbering A, B, C, a blank control group and a comparison group for 10 cases in each group, wherein the testers in groups A-C (which sequentially correspond to examples 1-3) take one bag of the polygonal gastric mucosa probiotic powder with good absorption effect prepared in examples 1-3 orally once in the morning and at night each day; blank control group 10 subjects diet as usual daily without any treatment, and comparative example 1 subjects orally took one bag of probiotic powder prepared in comparative example 1 each morning and evening. The test was stopped after 30 days and the effectiveness of the test subjects was counted.
The effective rate is as follows: the number of persons in each group who showed symptoms of poor digestive function as effective/total number of persons in the group;
the probiotic powder of examples 1-3, blank control group, and comparative example 1 were subjected to various index tests, and the obtained test results are as follows:
| experimental groups | Effective rate (%) | Absorption rate/%) |
| Example 1 | 84.6 | 93.6 |
| Example 2 | 81.3 | 86.4 |
| Example 3 | 79.6 | 88.2 |
| Comparative example 1 | 26.1 | 31.5 |
| Blank control group | 15.3 | 12.5 |
Through the data analysis, when the polygonal stomach mucosa probiotic powder with good absorption effect is eaten, the buffering bulges 3 firstly contact with the stomach mucosa and gastric acid and are firstly melted by the gastric acid, and when the polygonal stomach mucosa probiotic powder enters the intestinal tract, the stability of adhesion with intestinal villi is improved by the buffering bulges 3, the retention time of the inner core in the stomach is prolonged, and the inner core can be exposed in the stomach after the slow release layer 2 is decomposed by the gastric acid, so that effective medicinal ingredients in the inner core can be released into the stomach, the release time of medicaments in the inner core in the stomach is effectively prolonged, the absorption efficiency of the inner core medicaments by the stomach is effectively improved, and the medicinal effect is improved.
Wherein, the viscosity of the rice hull powder in the raw material of the slow release layer is improved because of Mg2+The method is realized by fully exchanging octahedron and tetrahedron layers of cassava flour and chitosan. Because the rod crystals have the same charges to form electrostatic repulsion, the rod crystals are prevented from agglomerating to achieve better dispersion effect, the viscosity is improved, the chitosan is easy to dissolve in a weak acid solvent, the dissolved solution contains amino, and the amino inhibits the activity of respiratory enzymes on the surfaces of bacteria by combining negative electrons, so that the bacteria are lostMeanwhile, due to the porosity of the chitosan and a large amount of hydroxyl on the surface, the donkey-hide gelatin, the cassava flour, the seaweed and the soybean lecithin play a synergistic role in preparing the slow release layer, the drug release efficiency and the absorption efficiency of the slow release layer are synergistically improved, the donkey-hide gelatin serving as a traditional Chinese medicine has the effects of enriching blood, nourishing yin, moistening dryness and stopping bleeding and has good viscosity, the cassava flour is starch extracted from the root tuber of a tropical plant, as the ratio of amylopectin to amylose in the cassava native starch is as high as 80:20, the cassava native starch has high peak viscosity and is used as a raw material for enhancing the viscosity in a reinforcing system, the sustained-release layer is matched with the donkey-hide gelatin, so that the molding strength of the sustained-release layer can be improved, the sustained-release layer keeps a certain shape after entering the esophagus, the medicine is gradually absorbed by a human body, the absorption efficiency of the medicine effect is effectively improved, and the chitosan has higher protein adsorption capacity; under the action of degrading enzyme, the chitosan has degradability; the chitosan is easy to be processed into lines and is suitable for being made into linear or sheet medical materials; the chitosan has affinity and solubility and is suitable for producing various derivatives; chitosan has higher chemical activity; the water binding capacity of the chitosan is high; in serum, chitosan is easily degraded and absorbed; chitosan has higher biodegradability; the chitosan shows the selective function of highly inhibiting the growth of oral streptococcus, does not influence the growth of other beneficial bacteria, and the porous adsorbability provides attachment sites for the donkey-hide gelatin, the cassava powder, the seaweed and the soybean lecithin, so that the donkey-hide gelatin, the cassava powder, the chitosan, the seaweed and the soybean lecithin can be used as a reinforcing system for preparing traditional Chinese medicine decoction pieces, and the reinforcing effect of the reinforcing system in the preparation of a slow release layer is improved, wherein the seaweed has the effects of clearing heat and softening and resolving hard mass and contains rich protein, and when the seaweed is used for preparing the slow release layer, the content of the protein of the traditional Chinese medicine decoction pieces can be effectively supplemented, the elements such as inorganic elements including sodium, potassium, iron, calcium and the like, vitamins B12, C and E, biotin and nicotinic acid can be effectively supplemented, so that the health-care effect of the probiotic powder is more reasonable, and the seaweed can be attached to the surface of the chitosan, so that the medicine is easier to be absorbed by the intestinal tract of the human body after entering the human body. The added soybean lecithin contains lecithin, cephalin, etc., and has effect in delaying agingThe probiotic powder has the effects of aging, preventing cardiovascular and cerebrovascular diseases and the like, and can repair damaged cell membranes, improve the functions of the cell membranes, soften and rejuvenate the cell membranes and increase the activity of the cells when being applied to the preparation of the probiotic powder. The ingestion of lecithin can improve the metabolic capability, the self-healing capability and the regeneration capability of antibody tissues of human bodies and enhance the life vitality of the human bodies, thereby leading the nutrient components in the probiotic powder to be fully absorbed by the human bodies.
The slow release bulge is prepared from α -starch, sodium glutamate, saccharicterpenin, spirulina, chitosan, soybean lecithin, polylactic acid and ethanol gel as raw materials, wherein the sodium glutamate is a sodium salt of glutamic acid and belongs to one of the most abundant naturally-formed nonessential amino acids, and has a freshening effect, and the sodium glutamate is used for preparing the slow release bulge so as to inhibit sharp odor of drug ingredients in the slow release bulge preparation and is matched with α -use of starch and polylactic acid, and the adhesiveness of α -starch is utilized, the sodium glutamate is uniformly dispersed on each attachment site of the preparation in the preparation process, so that nasal medicine smell in an inner core is effectively controlled, the saccharicterpenin is a mixture of triterpenoid saponins extracted from camellia plant seed cakes and saccharides, and is a brown yellow, ashless crystalline, the slow release microcapsule is capable of obviously improving the neuroimmune function and anti-stress effect of an animal body, can clear free radicals, has a function, can regulate a regular function of a triterpene and a carbohydrate, is a mixture of a macrolactin, is prepared from a spirulina, the surface of a spirulina, the polysaccharide is a polysaccharide, the polysaccharide.
The above description is only for the preferred embodiment of the present invention and is not intended to limit the scope of the present invention, and all equivalent structural changes made by using the contents of the present specification and the drawings can be directly or indirectly applied to other related technical fields and are included in the scope of the present invention.
Claims (8)
1. The multilateral gastric mucosa probiotic powder with good absorption effect is characterized by being formed by mixing medicament particles, wherein the medicament particles comprise an inner core, a slow release layer and slow release bulges, the slow release layer surrounds the periphery of the inner core, the slow release bulges are uniformly arranged on the periphery of the slow release layer, and the slow release bulges are radially arranged from the center of the inner core.
2. The polygonal gastric mucosa probiotic powder with good absorption effect as claimed in claim 1, wherein the inner core comprises the following raw materials in parts by weight: 50-80 parts of bifidobacterium lactis powder, 20-50 parts of lactobacillus paracasei powder, 8-16 parts of galactooligosaccharide, 4-8 parts of inulin, 2-8 parts of whey powder, 1-5 parts of rhizoma anemarrhenae and 3-9 parts of lotus root starch.
3. A polygonal gastric mucosa probiotic powder with good absorption effect as claimed in claim 2, wherein the inner core is prepared by the following process: adding water into lotus root starch, uniformly mixing, heating at 80-120 ℃ for 20-40min, and cooling to room temperature to obtain a material a; and then, uniformly mixing the inulin, the whey powder, the rhizoma anemarrhenae and the water, heating at 80-120 ℃ for 30-50min, filtering to obtain a filtrate, adding the filtrate into the material a, stirring at the rotation speed of 650 plus 850r/min for 30-50min, cooling to room temperature, adding the bifidobacterium lactis powder, the lactobacillus paracasei powder and the galacto-oligosaccharide, uniformly mixing, stirring at the rotation speed of 650 plus 850r/min for 20-40min, and cooling to room temperature to obtain the core.
4. The polygonal gastric mucosa probiotic powder with good absorption effect as claimed in claim 1, wherein the raw materials of the slow release layer comprise, by weight: 40-50 parts of rice hull powder, 15-25 parts of chitosan, 8-16 parts of donkey-hide gelatin, 4-8 parts of cassava powder, 3-9 parts of seaweed and 8-16 parts of soybean lecithin.
5. The polygonal gastric mucosa probiotic powder with good absorption effect of claim 4, wherein the slow release layer is prepared by the following process: uniformly mixing rice hull powder, chitosan and distilled water, uniformly stirring at the speed of 850-1050r/min, then adding donkey-hide gelatin, cassava powder, seaweed and soybean lecithin, stirring for 4-6h at the speed of 280-320r/min in a constant-temperature water bath at the temperature of 65-75 ℃, then cooling to room temperature, carrying out suction filtration to obtain a precipitate, drying the precipitate at the temperature of 45-55 ℃ for 44-52h, and cooling to room temperature to obtain a slow-release layer.
6. The polygonal gastric mucosa probiotic powder with good absorption effect as claimed in claim 1, wherein the raw materials of the slow release protrusions comprise, by weight, α -25 parts of starch, 2-5 parts of sodium glutamate, 3-6 parts of saccharicterpenin, 4-8 parts of spirulina, 3-6 parts of chitosan, 4-8 parts of soybean lecithin, 12-24 parts of polylactic acid and 15-20 parts of ethanol gel.
7. The polygonal gastric mucosa probiotic powder with good absorption effect as claimed in claim 6, wherein the slow release protrusion is prepared by uniformly mixing α -starch, sodium glutamate, saccharicterpenin, spirulina, chitosan and soybean lecithin, stirring at the rotation speed of 350-.
8. A multilateral gastric mucosa probiotic powder with good absorption effect according to any one of claims 1 to 7, characterized in that the preparation method of the multilateral gastric mucosa probiotic powder comprises the following steps: spraying a slow release layer on the periphery of the prepared inner core, pouring a plurality of slow release protrusions on the periphery of the slow release layer, drying in a dryer at 45-65 ℃ for 20-40min, forming to obtain medicine particles, and mixing to obtain the polygonal gastric mucosa probiotic powder.
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