CN108498462A - A kind of technology of preparing of traditional Chinese powder medicine - Google Patents
A kind of technology of preparing of traditional Chinese powder medicine Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 63
- 239000000843 powder Substances 0.000 title claims abstract description 61
- 238000005516 engineering process Methods 0.000 title claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 23
- 240000006677 Vicia faba Species 0.000 claims abstract description 22
- 235000010749 Vicia faba Nutrition 0.000 claims abstract description 22
- 235000002098 Vicia faba var. major Nutrition 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 21
- 239000003752 hydrotrope Substances 0.000 claims abstract description 21
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 claims abstract description 21
- 238000009835 boiling Methods 0.000 claims abstract description 20
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- 238000000034 method Methods 0.000 claims description 19
- 238000010992 reflux Methods 0.000 claims description 13
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- 238000001035 drying Methods 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 5
- 238000002386 leaching Methods 0.000 claims description 4
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- 239000000654 additive Substances 0.000 claims description 3
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- 239000006071 cream Substances 0.000 claims description 3
- 241000411851 herbal medicine Species 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
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- 238000005119 centrifugation Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 abstract description 19
- 229940079593 drug Drugs 0.000 abstract description 13
- 238000010521 absorption reaction Methods 0.000 abstract description 12
- 239000003651 drinking water Substances 0.000 abstract description 5
- 235000020188 drinking water Nutrition 0.000 abstract description 5
- 239000008187 granular material Substances 0.000 abstract description 5
- 238000002483 medication Methods 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 17
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- 241001465754 Metazoa Species 0.000 description 2
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
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- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
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- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000008236 heating water Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of technology of preparing of traditional Chinese powder medicine, step is：The traditional Chinese medicine formula matched by prescription is prepared medicinal extract by reduced-pressure backflow extraction, handles medicinal extract progress alcohol precipitation to obtain precipitation solution by step 1；Step 2, by the precipitation solution in the step 1 by centrifuging treatment, extracting centrifugal liquid obtains medicinal extract object；Medicinal extract object in the step 2 and 0.5% (quality) brown sugar water are stirred to get the hydrotrope by step 3；Step 4 crushes the broad bean stalk of buying, and broad bean stalk powder is made；Step 5, the hydrotrope made from the step 3 is diluted with pure water, pass through boiling drier finished product with broad bean stalk powder made from the step 4 after dilution, traditional Chinese powder medicine of the present invention both can be by being administered orally after batch mixing, again can be by drinking water administration, absorption rate is high, greatly improves the service efficiency of Chinese medicine, traditional Chinese powder medicine is set to realize a variety of medications simultaneously, having granule can drink water the feature high with absorption rate.
Description
Technical field
The present invention relates to biopharmaceutical technology more particularly to a kind of technologies of preparing of traditional Chinese powder medicine.
Background technology
Currently, traditional Chinese powder medicine is widely used in animal-breeding production practices in the market, the development of traditional Chinese powder medicine is also undergone
One development course, at this stage the preparation process of traditional Chinese powder medicine be generally divided into：1. the pre-treatment of material：Under normal circumstances, powder
Solid material is handled before broken, if it is chemicals, raw material is carried out fully dry；If it is Chinese medicine, then according to medicine
The property of material carries out processing appropriate, such as cleans, is dry, being used after cutting or preliminary crushing etc. for crushing.Bulk pharmaceutical chemicals are crushed
Later, sieved according to the granularity requirements of powder, then with the other compositions drug or auxiliary materials and mixing of recipe quantity, packing, matter
Inspection etc..The granularity of powder is small, dispersion degree is big, therefore it is the key that ensure powder quality to be uniformly mixed.2. crushing：By crushing,
The granularity that solid drugs can be substantially reduced is conducive to each component and is uniformly mixed, and can improve the dissolution rate of insoluble drug.
Crushing operation also will produce influence to the quality of pharmaceutical preparation and drug effect etc., the crystal transfer such as drug or thermal degradation, solid
Grain stick and reunite and the variation etc. of wetability, therefore should attach great importance to.Disintegrating apparatus has mortar, ball mill, impact
Formula pulverizer and fluid energy mill etc. should properly select disintegrating apparatus according to the property of material.3. screening：It sieves to improving material
Mobility and uniformly mixing have great influence.When the grain size of material differs greatly, mobility can be caused to decline, and be difficult to
It is uniformly mixed.Common screening plant has oscillation pulp classifier and rotation vibrating screen.The separative efficiency of rotation vibration sieve apparatus is high, is usually used in
Screening operation in large-scale production.4. mixing：Hybrid manipulation is for the purpose of the uniformity of content.In solid mixing, grain
Son is dispersal unit, it is impossible to obtain being thoroughly mixed for molecular level.Therefore the granularity that each ingredient should be minimized, it is solid to meet
Body mixture it is relatively uniform.And according to the characteristic of component, the dosage of powder and actual appointed condition, select suitable side
Method.Paddling process or polishing can be used in the mixing of a small amount of drug and auxiliary material.There are many factor for influencing mixing efficiency, each group in material
Granule size, shape, density, water content, adhesion and the agglomeration divided can all influence mixed process.It is adopted when large-scale production more
With container fixed and container rotating type mixing machine.Materials are in fixed container intra vane or spiral in container fixed mixing machine
It is mixed under the stirring action of propeller.Container rotating type mixing machine drives material to generate by the turning effort of container itself
Multi-dimensional movement and so that material is mixed.When the mixed proportion of each component is larger, should be progressively increased mixing method using equivalent, i.e., first weigh small
Then isometric other compositions mixing is added in the medicinal powder of dosage, amount increases again successively, until whole mixings, re-sieving mixing
.The powder that low dose of hypertoxic medicine and the diluent of several times amount are mixed " dissipating " again.Extension rate by drug agent
Depending on amount.Must be progressively increased mixing method when preparing scattered again using equivalent.Common diluent has lactose, sucrose, starch, paste in dissipating again
The inert substances such as essence, precipitated calcium carbonate, calcium phosphate, white bole.Sometimes for convenient for observing mixability, a small amount of color can be added
Element.5. divided dose, packaging and storage：The method of divided dose has ocular estimate, gravimetric method and volumetric method etc., and when large-scale production adopts more
Divided dose is carried out with volumetric method.The granularity of powder is small and large specific surface area, is susceptible to deliquescence and lumps, changes colour, degrades or go mouldy
Etc. wild effects, unless otherwise specified, powder should use impermeability packaging material and closed storage, containing volatile medicine or easily
The powder of moisture absorption drug should be sealed and stored.
But these Chinese medicines processed by conventional method are when in use, utilization rate is low, effect is poor, waste is big.
Invention content
The purpose of the present invention is to solve the shortcomings of the prior art and a kind of technology of preparing of traditional Chinese powder medicine is provided, for understand
Certainly traditional Chinese powder medicine absorption rate is low, and using effect is bad, the big problem of the wasting of resources so that traditional Chinese powder medicine both can be by mixed
It is administered orally after material, and can be by drinking water administration, absorption rate is high, greatly improves the service efficiency of Chinese medicine, together
When so that traditional Chinese powder medicine is realized a variety of medications, having granule can drink water the feature high with absorption rate.
In order to achieve the above objectives, the present invention is achieved through the following technical solutions.
A kind of technology of preparing of traditional Chinese powder medicine, it, which is wrapped, expands following steps：
Medicinal extract is prepared by reduced-pressure backflow extraction, by the leaching in the traditional Chinese medicine formula matched by prescription by step 1
Cream carries out alcohol precipitation and handles to obtain precipitation solution；
The volume ratio of medicinal extract and 75% (volume) alcohol is 2 in the alcohol precipitation processing procedure:3, alcohol precipitation temperature is 10 DEG C, alcohol
The heavy time is 24 hours；
Step 2, by the precipitation solution in the step 1 by centrifuging treatment, extracting centrifugal liquid obtains medicinal extract object；
Medicinal extract object in the step 2 and 0.5% (quality) brown sugar water are stirred to get the hydrotrope by step 3；
Step 4 crushes the broad bean stalk of buying, and broad bean stalk powder is made；
Step 5 dilutes the hydrotrope made from the step 3 with pure water, after dilution with made from the step 4
Broad bean stalk powder passes through boiling drier finished product；
The hydrotrope presses 1 with the broad bean stalk powder:50 (mass ratioes) configure.
Further, in the step 1 in reduced-pressure backflow extraction process Chinese herbal medicine prescription dosage and quantity of solvent mass ratio
It is 1:7, refluxing extraction number be 2 times, reflux temperature be 60 DEG C, reflux extracting time be 1 hour, refluxing extraction vacuum degree be-
0.070Mpa。
Further, the water content (quality) of medicinal extract made from the step 1 is 15%~20%.
Further, the time of centrifuging treatment is 15 minutes in the step 2, and rotating speed is 6000 revs/min, single
Secondary additive amount is 6000ml.
Further, the mixing time in the step 3 is 20 minutes, and whipping temp is 25 DEG C, and the rotating speed of stirring is 60
Rev/min.
Further, the mesh number that broad bean stalk crushes in the step 4 is 100 mesh.
Further, in the step 5 hydrotrope with pure water-reducible thinner ratio (volume ratio) be 1:9.
Further, the production method of finished product is in the step 5, by the broad bean stalk powder 20kg in the step 4
It is put into boiling drier, opens boiling drier boiling function switch, the hydrotrope after dilution is dry by top spray injection boiling
In dry machine, the internal diameter of the pipeline that the hydrotrope enters top spray is 5mm, and Ya Li≤0.2Mpa, top spray hole is 50, boiling spray, until
Until the hydrotrope has sprayed, continues fluidized drying and can be obtained within 5 minutes finished product, fluidized drying temperature is 50~70 DEG C.
The technology of preparing of a kind of traditional Chinese powder medicine of the present invention, for low, the using effect that solves traditional Chinese powder medicine absorption rate
It is bad, the big problem of the wasting of resources so that traditional Chinese powder medicine not only can be by being administered orally after batch mixing, but also can be given by drinking-water
Medicine, absorption rate is high, greatly improves the service efficiency of Chinese medicine, while it is a variety of to prescription so that traditional Chinese powder medicine is realized
Method, having granule can drink water the feature high with absorption rate.
Specific implementation mode
With reference to embodiment, the present invention will be further described, but is not limited to the content on specification.
A kind of technology of preparing of traditional Chinese powder medicine, it includes the following steps：
Step 1：Medicinal extract is prepared by reduced-pressure backflow extraction process in the traditional Chinese medicine formula matched by prescription, will be soaked
Cream carries out alcohol precipitation.
Reduced-pressure backflow extraction method is on multi-function extractor plus vacuum system, and solvent (water) is made to boil at a lower temperature
Rise, a kind of Novel extraction method for avoiding heat-sensitive ingredients from being destroyed, extractor for negative pressure state, water temperature at 60 DEG C or more just
It can boil, the advantage is that and protect heat-sensitive ingredients not to be destroyed while and greatly reducing energy consumption.Extraction process：By medicinal material
Medicine materical crude slice or coarse powder are packed into round-bottomed flask, and addition solvent submergence medicinal material surface, bottleneck is installed condenser pipe and vacuum system, led to cold
Condensate, medicinal material are impregnated after a certain period of time, are vacuumized, and after heating water bath reflux extraction to stipulated time, leaching liquid, the dregs of a decoction add newly
Solvent refluxing 2 times, merges each secondary liquid, and recycling design is to get leaching the medicinal extract of concentrate.In extraction process, medicinal material amount with
The ratio between quantity of solvent (mass ratio) is 1:7；Refluxing extraction number is 2 times；Reflux temperature is 60 DEG C；Reflux extracting time is 1 small
When；Vacuum degree is -0.070Mpa.
Medicinal extract made from this step is a kind of semi-solid material of high concentration, and water content (quality) is 15%~20%.
Alcohol deposition method (water alcohol method) means that in Chinese medicine water extracting liquid, ethyl alcohol, which is added, to be made to reach different alcohol contents, some drugs
Ingredient solubility in alcoholic solution, which reduces, is precipitated precipitation, the method for keeping Aqueous extracts refined after separation of solid and liquid.During alcohol precipitation
The volume ratio of medicinal extract and 75% (volume) alcohol is 2:3, alcohol precipitation temperature is 10 DEG C, and the alcohol precipitation time is 24 hours.
Step 2：By the alcohol hypostasis in step 1 by centrifuging, impurity is removed, extracting centrifugal liquid is to get to such as step
One medicinal extract object.15 minutes time is centrifuged, rotating speed is 6000 revs/min, and single additive amount is 6000ml, is centrifuged
Purpose be to allow extract to be separated by solid-liquid separation, number is primary.
Step 3：Medicinal extract object in step 2 and 0.5% (quality) brown sugar water are stirred to get into the hydrotrope, mixing time 20
Minute, whipping temp is 25 DEG C, and the rotating speed of stirring is 60 revs/min.
Step 4：The broad bean stalk of buying is crushed to 100 mesh, moisture is no more than 5% (quality).Broad bean stalk
Rich in nutritional ingredients such as protein, amino acid, trace elements, compared with other agricultural crop straws, broad bean stalk nutritional ingredient contains
Higher is measured, is the high-quality feed raw material of livestock and poultry.
Step 5：The pure water of the hydrotrope made from step 3 is pressed 1:9 (volume ratio dilutions), pure water is distilled water,
It is free from foreign meter, after dilution, returned in system to broad bean stalk powder made from step 4 by boiling drier, the hydrotrope and broad bean stalk
Powder presses 1:50 (mass ratioes) configure.
It is capital equipment using boiling drier, broad bean stalk powder 20kg made from step 4 is put into boiling drier
It is interior, open boiling drier boiling function switch；The hydrotrope is injected by top spray in boiling drier again, the hydrotrope enters top
The internal diameter of the pipeline of spray is 5mm, and Ya Li≤0.2Mpa, 50, top spray hole sprays in boiling, until having sprayed, continuing to boil
Drying 5 minutes is risen, fluidized drying temperature is 50~70 DEG C.
The present invention has following advantages and effect：
1. traditional Chinese powder medicine made from this method brews use for drinking water for animals.
2. traditional Chinese powder medicine made from this method takes full advantage of Chinese material medicine resource, by means such as reduced-pressure backflow, alcohol precipitations, make
Chinese herbal medicine ingredient is uniformly mixed with broad bean stalk powder, is overcome and is wasted big disadvantage when ordinary powder use.
3. traditional Chinese powder medicine made from this method supply animal using when solve the problems, such as that Chinese medicine palatability is poor, addition it is red
The raw materials such as syrup, palatability are good.
It is evenly distributed in animal diets 4. traditional Chinese powder medicine made from this method realizes, it is quantitative more accurate.
The technology of preparing of a kind of traditional Chinese powder medicine of the present invention, for low, the using effect that solves traditional Chinese powder medicine absorption rate
It is bad, the big problem of the wasting of resources so that traditional Chinese powder medicine not only can be by being administered orally after batch mixing, but also can be given by drinking-water
Medicine, absorption rate is high, greatly improves the service efficiency of Chinese medicine, while it is a variety of to prescription so that traditional Chinese powder medicine is realized
Method, having granule can drink water the feature high with absorption rate.
Obviously, the above embodiment of the invention be only to clearly illustrate example of the present invention, and not be
Restriction to embodiments of the present invention.For those of ordinary skill in the art, on the basis of the above description also
It can make other variations or changes in different ways.Here all embodiments can not be exhaustive.It is every to belong to this
Row of the obvious changes or variations that the technical solution of invention is extended out still in protection scope of the present invention.
Claims (8)
1. a kind of technology of preparing of traditional Chinese powder medicine, it is characterised in that：It, which is wrapped, expands following steps：
Step 1, by the traditional Chinese medicine formula matched by prescription by reduced-pressure backflow extraction medicinal extract is prepared, by the medicinal extract into
Row alcohol precipitation handles to obtain precipitation solution；
The volume ratio of medicinal extract and 75% (volume) alcohol is 2 in the alcohol precipitation processing procedure:3, alcohol precipitation temperature is 10 DEG C, when alcohol precipitation
Between be 24 hours；
Step 2, by the precipitation solution in the step 1 by centrifuging treatment, extracting centrifugal liquid obtains medicinal extract object；
Medicinal extract object in the step 2 and 0.5% (quality) brown sugar water are stirred to get the hydrotrope by step 3；
Step 4 crushes the broad bean stalk of buying, and broad bean stalk powder is made；
Step 5 dilutes the hydrotrope made from the step 3 with pure water, after dilution with broad bean made from the step 4
Straw powder passes through boiling drier finished product；
The hydrotrope presses 1 with the broad bean stalk powder:50 (mass ratioes) configure.
2. a kind of technology of preparing of traditional Chinese powder medicine according to claim 1, it is characterised in that：It is depressurized back in the step 1
It is 1 to flow the mass ratio of Chinese herbal medicine prescription dosage and quantity of solvent in extraction process:7, refluxing extraction number is 2 times, and reflux temperature is
60 DEG C, reflux extracting time is 1 hour, and refluxing extraction vacuum degree is -0.070Mpa.
3. a kind of technology of preparing of traditional Chinese powder medicine according to claim 1, it is characterised in that：Step 1 leaching obtained
The water content (quality) of cream is 15%~20%.
4. a kind of technology of preparing of traditional Chinese powder medicine according to claim 1, it is characterised in that：Centrifugation point in the step 2
Time from processing is 15 minutes, and rotating speed is 6000 revs/min, and single additive amount is 6000ml.
5. a kind of technology of preparing of traditional Chinese powder medicine according to claim 1, it is characterised in that：Stirring in the step 3
Time is 20 minutes, and whipping temp is 25 DEG C, and the rotating speed of stirring is 60 revs/min.
6. a kind of technology of preparing of traditional Chinese powder medicine according to claim 1, it is characterised in that：Broad bean straw in the step 4
The mesh number that stalk crushes is 100 mesh.
7. a kind of technology of preparing of traditional Chinese powder medicine according to claim 1, it is characterised in that：The hydrotrope in the step 5
It is 1 with pure water-reducible thinner ratio (volume ratio):9.
8. a kind of technology of preparing of traditional Chinese powder medicine according to claim 1, it is characterised in that：Finished product in the step 5
Production method is that the broad bean stalk powder 20kg in the step 4 is put into boiling drier, opens boiling drier boiling
Functional switch injects the hydrotrope after dilution in boiling drier by top spray, and the internal diameter of the pipeline that the hydrotrope enters top spray is
5mm, Ya Li≤0.2Mpa, top spray hole are 50, boiling spray, until the hydrotrope has sprayed, continue fluidized drying 5 minutes i.e.
Finished product can be obtained, fluidized drying temperature is 50~70 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810475956.5A CN108498462A (en) | 2018-05-17 | 2018-05-17 | A kind of technology of preparing of traditional Chinese powder medicine |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3837957A1 (en) * | 1988-11-09 | 1990-05-10 | Eckes Fa Peter | Method for introducing and distributing a lipophilic substance into liquid water-based foods and stimulants |
| US20040161524A1 (en) * | 2001-06-21 | 2004-08-19 | Yasushi Sakai | Process for producing a plant extract containing plant powder |
| JP2005073557A (en) * | 2003-08-29 | 2005-03-24 | Nippon Flour Mills Co Ltd | Green leaf granule and method for producing the same |
| CN103734427A (en) * | 2013-12-31 | 2014-04-23 | 广州神农生物技术有限公司 | Method of preparing plant bag beverage by taking natural raw materials as adsorptive carrier |
| CN106728261A (en) * | 2017-01-03 | 2017-05-31 | 浙江爱生药业有限公司 | A kind of pharmaceutical composition for treating insomnia |
-
2018
- 2018-05-17 CN CN201810475956.5A patent/CN108498462A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3837957A1 (en) * | 1988-11-09 | 1990-05-10 | Eckes Fa Peter | Method for introducing and distributing a lipophilic substance into liquid water-based foods and stimulants |
| US20040161524A1 (en) * | 2001-06-21 | 2004-08-19 | Yasushi Sakai | Process for producing a plant extract containing plant powder |
| JP2005073557A (en) * | 2003-08-29 | 2005-03-24 | Nippon Flour Mills Co Ltd | Green leaf granule and method for producing the same |
| CN103734427A (en) * | 2013-12-31 | 2014-04-23 | 广州神农生物技术有限公司 | Method of preparing plant bag beverage by taking natural raw materials as adsorptive carrier |
| CN106728261A (en) * | 2017-01-03 | 2017-05-31 | 浙江爱生药业有限公司 | A kind of pharmaceutical composition for treating insomnia |
Non-Patent Citations (1)
| Title |
|---|
| 徐晓俞等: ""蚕豆秸秆综合利用研究进展"", 《福建农业学报》, vol. 30, no. 2, pages 204 - 207 * |
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Application publication date: 20180907 |