CN108498407A - Deep layer skin penetration enhancer and skin care item - Google Patents
Deep layer skin penetration enhancer and skin care item Download PDFInfo
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- CN108498407A CN108498407A CN201810576622.7A CN201810576622A CN108498407A CN 108498407 A CN108498407 A CN 108498407A CN 201810576622 A CN201810576622 A CN 201810576622A CN 108498407 A CN108498407 A CN 108498407A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of deep layer skin penetration enhancer and skin care item, belong to cosmetic technical field.The deep layer skin penetration enhancer is by rose, the extract and 1 of three kinds of natural plants of zest and dried peppermint leaf, 3 butanediols, xanthan gum, hyaluronic acid composition, wherein rose prepares extracting solution using ethanol water as solvent using microwave abstracting, extracting solution dealcoholysis concentration obtains Flos Rosae Rugosae extract, zest and dried peppermint leaf and uses ultrasonic wave extraction by solvent of ethanol water.Skin care item provided by the present invention are with natural extract for main active ingredient, deep skin cell delivery channel is provided for a variety of skin functional components, the effect of keeping cosmetics added ingredient, keratoderma can be penetrated to greatest extent, and Skin Cell target spot is acted on, the performance promotion effective component for filling part nurses effect to the deep layer of skin.
Description
Technical field
The present invention relates to cosmetic technical fields, and in particular to a kind of deep layer skin penetration enhancer and skin care item.
Background technology
Modern female constantly promotes itself love degree, and skin care receives more and more attention, skin care item market and
The developmental research of skin care item constantly heats up.The skin care item of delay skin aging, improvement dermatoglyph and skin-whitening class are to disappear
The favorite of the person of expense, and this kind of skin care item are required to add corresponding functional component, and these functional components are both needed to penetrate skin angle
Matter layer acts on different cell target spots.And current problem is the shielding action due to cuticula, prevent functional component from by
It is effective to absorb, waste the very expensive effective ingredient of price.In order to increase the transdermal absorption factor of functional component, develop
Skin transdermal enhancer, transdermal enhancer are a kind of substances that effect ingredient promoted in cosmetics is permeated and absorbed on the skin.It is transdermal
The mechanism of action of sorbefacient mainly penetrates into skin by reversible change skin texture and reduces substance process
Suffered resistance when skin achievees the purpose that promote systemic Absorption or local treatment.
Existing transdermal transdermal enhancer, such as azone, is mainly applied in terms of medicine more wide based on chemical synthesis
It is general.Unlike field of medicaments, effect ingredient in cosmetics need not enter people's body-internal-circulation, cosmetics institute through skin
With the effect of ingredient act on keratoderma, basal layer and skin corium and play its effect, white-skinned face function ingredient is present in epidermis
In basal layer play its effect, senile-resistant efficacy ingredient act on skin basal cell and skin corium fibroblast in send out
Wave its effect.In order to preferably utilize effect ingredient in cosmetics, various transdermal transdermal enhancers to be used in cosmetics,
In, most representative artificial synthesized transdermal transdermal enhancer is azone.
Currently, some natural percutaneous transdermal enhancers are also gradually used, such as menthol, eucalyptus oil etc..In recent years, natural percutaneous
Sorbefacient with effect good, Small side effects, it is pollution-free the advantages that, just have attracted increasing attention, but current natural
Skin transdermal enhancer has significant limitations to the effect of functional component, cannot especially play a role to the undissolved ingredient of some water, mesh
Preceding many cosmetics are added to chemically synthesized transdermal agent, and chemically synthesized transdermal agent undesirably increases safety
Risk.
Invention content：
There is security risk and natural percutaneous suction for chemical synthesis transdermal agent present in existing effect class cosmetics
It receives agent and has limited shortcoming to functional component, the purpose of the present invention is to provide a kind of deep layer skin penetration enhancers
And skin care item, the deep layer skin penetration enhancer with natural extract be main active ingredient, using the deep layer Transdermal absorption
Skin care item prepared by accelerating agent, can provide deep skin cell delivery channel for a variety of skin functional components, cosmetics is made to be added
The effect of adding ingredient can penetrate keratoderma to greatest extent, and act on the target cell target of skin base layer, skin corium
Point.
To achieve the above object, the technical solution adopted in the present invention is as follows：
A kind of deep layer skin penetration enhancer, is counted in parts by weight, and the raw material for preparing of the accelerating agent includes following component：
3-7 parts of Flos Rosae Rugosae extract；
3-12 parts of fragrant citrus extract；
3-5 parts of mint extract.
The raw material for preparing of the accelerating agent further includes 1,3 butylene glycol 5-20 parts by weight, xanthan gum 0.5-5 parts by weight and transparent
Matter acid 0.5-6 parts by weight.
The preparation process of the Flos Rosae Rugosae extract is：After rose is crushed, it is added in ethanol water and carries out microwave
Extraction, extracting solution obtain the Flos Rosae Rugosae extract after filtering, dealcoholysis and concentration；During microwave abstracting：Rose and second
The weight ratio of alcohol solution is 1：(15-35), microwave abstracting time 8-15min；The content of ethyl alcohol in the ethanol water
For 40-60wt.%.
The preparation process of the fragrant citrus extract is：The ethanol water of concentration 50-90wt.% is added in zest,
The weight ratio of zest and ethanol water is 1：(5-30)；Then ultrasonic wave extraction 20-25min, the extraction of acquisition are used
Liquid obtains the fragrant citrus extract after filtering, dealcoholysis and concentration.
The preparation process of the mint extract is：The ethyl alcohol of concentration 40-60wt.% is added in fresh mint leaf afterwards after cutting
In aqueous solution, the weight ratio of dried peppermint leaf and ethanol water is 1：(5-30)；Then ultrasonic wave extraction 20-25min is used, is obtained
The extracting solution obtained obtains the fragrant citrus extract after filtering, dealcoholysis and concentration.
The accelerating agent is each component mixing that will be prepared in raw material, is heated to 50-100 DEG C, homogeneous after stirring obtains institute
State accelerating agent.Using the deep layer skin penetration enhancer prepare skin care item, including deep layer skin penetration enhancer, effect at
Point and base starting material.
The preparation process of the skin care item is：Functional component is added in the deep layer skin penetration enhancer, is uniformly mixed
After add in the base starting material, be then heated to 50-100 DEG C, skin care item obtained after stirring to homogeneous.
In the skin care item, weight ratio shared by the deep layer skin penetration enhancer is 5-20wt.%, the functional component
Shared weight ratio is 3-15wt.%.
The functional component is being capable of delay skin aging, improvement dermatoglyph or the ingredient for carrying out skin-whitening；It is described
Base starting material is body material in cosmetics, can be selected as needed.
Compared with prior art, the invention has the advantages that：
1, the present invention deep layer skin penetration enhancer is prepared for using natural material completely, be used as cosmetics in effect at
The deep layer cells transport system divided, which can convey multiple efficacies additive, especially not soluble in water to some
Functional component, the performance promotion effective component that can also fill part nurse effect to the deep layer of skin.
2, skin care item provided by the present invention are experiments verify that have good moisturizing effect, even in dehumidifier environment
Under, skin moisture content can also be kept.
3, skin care item provided by the present invention are with natural extract for main active ingredient, rose, zest, thin
Lotus leaf, xanthan gum, hyaluronic acid have high security, validity.
4, it is a variety of skin work(that three kinds of main extracts, which mutually act synergistically, in mid-deep strata skin penetration enhancer of the present invention
The effect of effect ingredient provides deep layer cells transfer passage, keeps cosmetics added ingredient penetrates skin keratin to greatest extent
Layer, and act on cell target spot.
5, mid-deep strata skin penetration enhancer of the present invention has wide range of applications：It can be used for the cream, essence, lotion of cosmetics
Etc. a variety of dosage forms.
Specific implementation mode
The technical solution further illustrated the present invention below by way of specific embodiment.
Embodiment 1：
The present embodiment is to prepare skin cream using deep layer skin penetration enhancer, and detailed process is as follows：
1, the raw material preparation of deep layer skin penetration enhancer, including Flos Rosae Rugosae extract, fragrant citrus extract, peppermint extraction
Object, 1.3 butanediols, xanthan gum and hyaluronic acid.
Flos Rosae Rugosae extract is produced：After rose crushes, the ethanol water extraction of concentration 40wt.%, rose is added
The weight ratio of flower and ethanol water is 1：25；Using Microwave Extraction 8min, extracting solution is successively after filtering, dealcoholysis and concentration
Obtain Flos Rosae Rugosae extract.
Fragrant citrus extract is produced：After fresh zest is broken, the ethanol water extraction of concentration 50wt.% is added,
The weight ratio of zest and ethanol water is 1：20；Using ultrasonic wave extraction 20-25min, extracting solution through filtering, dealcoholysis and
The fragrant citrus extract is obtained after concentration.
Mint extract is produced：After the cutting of fresh mint leaf, the ethanol water extraction of concentration 40wt.% is added, it is thin
The weight ratio of lotus leaf and ethanol water is 1：20；Using ultrasonic wave extraction 25min, extracting solution is through filtering, dealcoholysis and concentration
After obtain the mint extract.
2, deep layer skin penetration enhancer is prepared：
Take 10 weight of 7 parts by weight of Flos Rosae Rugosae extract, 12 parts by weight of fragrant citrus extract and mint extract made above
Part mixing, and 0.9 parts by weight of 10 parts by weight of 1,3-BDO, 1.0 parts by weight of xanthan gum and hyaluronic acid, gained mixture is added
Material is heated to 80 DEG C, and homogeneous after stirring obtains required deep layer skin penetration enhancer.
3, skin cream is prepared：
Functional component is added in deep layer skin penetration enhancer, adds in skin cream basestocks, prepares skin cream, mistake
Journey is as follows：
(1) functional component selected by is tripeptides -7, acts on skin layer floor cells, can improve dermatoglyph, make skin
Skin is beautiful.
By functional component according to functional component：Deep layer skin penetration enhancer=3：It is transdermal that deep layer is added in 10 weight ratio
It is high-speed stirred 5-10 minutes under room temperature, spare in sorbefacient；
(2) the skin cream basestocks group selected becomes：Methyl p-hydroxybenzoate (0.3 part of weight), glycerine (weight 2
Part), octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester (5 parts of weight), isopropyl palmitate (1 part of weight), tristerin (5 parts of weight) and
Hydroxy methacrylate (4 parts of weight), it is 100 parts to add deionized water and mend ad pond om number.
(3) each basestocks ingredient is heated to 60 DEG C, is mixed, be placed in it is fully emulsified in emulsifier, when temperature is down to
At 40 DEG C, the deep layer skin penetration enhancer for having added functional component is added after emulsifying in gained skin cream basestocks, stirring
5-10 minutes, it is made to be uniformly dispersed, that is, obtains the skin cream.
Embodiment 2：
The present embodiment is to prepare facial treatment milk using deep layer skin penetration enhancer, and detailed process is as follows：
1, the raw material preparation of deep layer skin penetration enhancer, including Flos Rosae Rugosae extract, fragrant citrus extract, peppermint extraction
Object, 1.3 butanediols, xanthan gum and hyaluronic acid.
Flos Rosae Rugosae extract is produced：After rose crushes, the ethanol water extraction of concentration 40-60wt.%, rose is added
The weight ratio of rare flower and ethanol water is 1：(15-35)；Using Microwave Extraction 8-15min, extracting solution is successively through filtering, taking off
Flos Rosae Rugosae extract is obtained after alcohol and concentration.
Fragrant citrus extract is produced：After fresh zest is broken, the ethanol water extraction of concentration 50wt.% is added,
The weight ratio of zest and ethanol water is 1：20；Using ultrasonic wave extraction 20-25min, extracting solution through filtering, dealcoholysis and
The fragrant citrus extract is obtained after concentration.
Mint extract is produced：After the cutting of fresh mint leaf, the ethanol water extraction of concentration 40wt.% is added, it is thin
The weight ratio of lotus leaf and ethanol water is 1：20；Using ultrasonic wave extraction 25min, extracting solution is through filtering, dealcoholysis and concentration
After obtain the mint extract.
2, deep layer skin penetration enhancer is prepared：
Take 10 weight of 7 parts by weight of Flos Rosae Rugosae extract, 12 parts by weight of fragrant citrus extract and mint extract made above
Part mixing, and 1,3 butanediol, 12 parts by weight, 0.8 parts by weight of 1.5 parts by weight of xanthan gum and hyaluronic acid, gained mixture is added
Material is heated to 80 DEG C, and homogeneous after stirring obtains required deep layer skin penetration enhancer.
3, facial treatment milk is prepared：
Functional component is added in deep layer skin penetration enhancer, adds in lotion basestocks, prepares facial treatment milk, mistake
Journey is as follows：
(1) functional component selected by is glabridin (Glabridin), acts on skin base layer melanocyte, changes
Kind skin colour skin whitening, keeps skin beautiful.
By functional component according to functional component：Deep layer skin penetration enhancer=3：It is transdermal that deep layer is added in 10 weight ratio
It is high-speed stirred 5-10 minutes under room temperature, spare in sorbefacient；
(2) the lotion basestocks group selected becomes：Methyl p-hydroxybenzoate (0.3 part of weight), glycerine (6 parts of weight),
Octanoic acid/certain herbaceous plants with big flowers acid glycerol three ester (3 parts of weight), isopropyl palmitate (1 part of weight), xanthan gum (1 part), tristerin (weight
Amount 3 parts), jojoba oil (4 parts of weight), add deionized water mend ad pond om number be 100 parts.
(3) each basestocks ingredient is heated to 60 DEG C, is mixed, be placed in it is fully emulsified in emulsifier, when temperature is down to
At 40 DEG C, the deep layer skin penetration enhancer for having added functional component is added after emulsifying in gained lotion basestocks, stirs 5-
10 minutes, it is made to be uniformly dispersed, that is, obtains the facial treatment milk.
Embodiment 3：
The present embodiment is to prepare Essence using deep layer skin penetration enhancer, and detailed process is as follows：
1, the raw material preparation of deep layer skin penetration enhancer, including Flos Rosae Rugosae extract, fragrant citrus extract, peppermint extraction
Object, 1,3 butanediols, xanthan gum and hyaluronic acid.
Flos Rosae Rugosae extract is produced：After rose crushes, the ethanol water extraction of concentration 40wt.%, rose is added
The weight ratio of flower and ethanol water is 1：20；Using Microwave Extraction 8-15min, extracting solution is successively through filtering, dealcoholysis and dense
Flos Rosae Rugosae extract is obtained after contracting.
Fragrant citrus extract is produced：After fresh zest is broken, the ethanol water extraction of concentration 50wt.% is added,
The weight ratio of zest and ethanol water is 1：20；Using ultrasonic wave extraction 20-25min, extracting solution through filtering, dealcoholysis and
The fragrant citrus extract is obtained after concentration.
Mint extract is produced：After the cutting of fresh mint leaf, the ethanol water extraction of concentration 40wt.% is added, it is thin
The weight ratio of lotus leaf and ethanol water is 1：20；Using ultrasonic wave extraction 25min, extracting solution is through filtering, dealcoholysis and concentration
After obtain the mint extract.
2, deep layer skin penetration enhancer is prepared：
Take 10 weight of 7 parts by weight of Flos Rosae Rugosae extract, 12 parts by weight of fragrant citrus extract and mint extract made above
Part mixing, and 1.5 parts by weight of 12 parts by weight of 1,3-BDO, 1.0 parts by weight of xanthan gum and hyaluronic acid, gained mixture is added
Material is heated to 80 DEG C, and homogeneous after stirring obtains required deep layer skin penetration enhancer.
3, Essence is prepared：
Functional component is added in deep layer skin penetration enhancer, adds in Essence basestocks, prepares Essence, mistake
Journey is as follows：
(1) functional component selected by is glabridin (Glabridin), acts on skin base layer melanocyte, changes
Kind skin colour skin whitening, keeps skin beautiful.
By functional component according to functional component：Deep layer skin penetration enhancer=6：It is transdermal that deep layer is added in 15 weight ratio
It is high-speed stirred 5-10 minutes under room temperature, spare in sorbefacient；
(2) the Essence basestocks group selected becomes：Methyl p-hydroxybenzoate (0.3 part of weight), glycerine (weight 6
Part), 1,3-BDO (5 parts of weight), marine algae extract (3 parts of weight), xanthan gum (2.5 parts), allantoin (1 part of weight), then
It is 100 parts that deionized water, which is added, and mends ad pond om number.
(3) each base stock component is heated to 60 DEG C, is mixed, be placed in it is fully emulsified in emulsifier, when temperature is down to
At 40 DEG C, the deep layer skin penetration enhancer for having added functional component is added after emulsifying in gained Essence basestocks, stirring
5-10 minutes, it is made to be uniformly dispersed, that is, obtains the Essence.
Contrast test：
By essence formula of liquid in above example 3 (addition deep layer skin penetration enhancer) and it is not added with deep layer Transdermal absorption
The formula of accelerating agent carries out contrast test, and test method is as follows：
1, prepared by sample：Glabridin (Glabridin) is experiment mark object：
A samples：It is added in essence liquid base material described in 79 parts by weight of example 3,6 parts by weight glabridins (Glabridin)
Deep layer skin penetration enhancer described in 16 parts by weight of example 3 forms A samples；
B samples：Essence liquid base material described in 94 parts by weight of example 3,6 parts by weight glabridins (Glabridin) form B
Sample；
2, it is tested with one-chambered static cell method, repeatedly takes out raw trimestral guinea pig back skin and tested, will be fixed
There is the release pond of experiment skin graft to be mounted on the upside of single compartment, sets drug transdermal agent on isolated experiment skin, in 32 DEG C of water-baths
Middle constant temperature certain time draws and is stirred solution in compartment under experiment skin and is measured, micro- with liquid chromatograph and CR2Ax-2
Machine processor, hplc determination sample room and licoricidin peak value in receiving chamber, CR2Ax-2 computer processors are to peak meter face
Product calculates, and monitors and calculates drug through situation.
3, test result such as the following table 1：
1 glabridin of table (Glabridin) transdermal absorption factor (%)
| Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| A samples | 12.2 | 13.5 | 12.6 | 10.1 | 13.8 | 11,9 | 12.2 | 11.7 | 12.9 | 10,3 |
| B samples | 1.02 | 0.8 | 1.5 | 0.7 | 1.08 | 1.05 | 0.9 | 0.87 | 1.06 | 0.95 |
Embodiment 4：
The present embodiment is to prepare Essence using deep layer skin penetration enhancer, and detailed process is as follows：
1, the raw material preparation of deep layer skin penetration enhancer, including Flos Rosae Rugosae extract, fragrant citrus extract, peppermint extraction
Object, 1.3 butanediols, xanthan gum and hyaluronic acid.
Flos Rosae Rugosae extract is produced：After rose crushes, the ethanol water extraction of concentration 60wt.%, rose is added
The weight ratio of flower and ethanol water is 1：35；Using Microwave Extraction 8-15min, extracting solution is successively through filtering, dealcoholysis and dense
Flos Rosae Rugosae extract is obtained after contracting.
Fragrant citrus extract is produced：After fresh zest is broken, the ethanol water extraction of concentration 50wt.% is added,
The weight ratio of zest and ethanol water is 1：30；Using ultrasonic wave extraction 20-25min, extracting solution through filtering, dealcoholysis and
The fragrant citrus extract is obtained after concentration.
Mint extract is produced：After the cutting of fresh mint leaf, the ethanol water extraction of concentration 40wt.% is added, it is thin
The weight ratio of lotus leaf and ethanol water is 1：20；Using ultrasonic wave extraction 25min, extracting solution is through filtering, dealcoholysis and concentration
After obtain the mint extract.
2, deep layer skin penetration enhancer is prepared：
Take 15 weight of 7 parts by weight of Flos Rosae Rugosae extract, 12 parts by weight of fragrant citrus extract and mint extract made above
Part mixing, and 1.2 parts by weight of 10 parts by weight of 1,3-BDO, 0.9 parts by weight of xanthan gum and hyaluronic acid, gained mixture is added
Material is heated to 80 DEG C, and homogeneous after stirring obtains required deep layer skin penetration enhancer.
3, Essence is prepared：
Functional component is added in deep layer skin penetration enhancer, adds in Essence basestocks, prepares Essence, mistake
Journey is as follows：
(1) functional component selected by is scutellarin (Baicalin), and activation stands the growth of enzyme at fiber No cells, activated end
Metabolism prevents thin fertile aging.Skin base layer melanocyte is acted on, keeps skin beautiful.
A samples：According to functional component：Deep layer skin penetration enhancer=6：Deep layer is added in functional component by 15 weight ratio
It is high-speed stirred 5-10 minutes under room temperature, spare in skin penetration enhancer；
B samples：According to functional component：Deep layer skin penetration enhancer=9：Deep layer is added in functional component by 15 weight ratio
It is high-speed stirred 5-10 minutes under room temperature, spare in skin penetration enhancer；
(2) the Essence basestocks group selected becomes：Methyl p-hydroxybenzoate (0.3 part of weight), glycerine (weight 6
Part), 1,3 butylene glycol (5 parts of weight), marine algae extract (3 parts of weight), xanthan gum (2.5 parts of weight), allantoin (weight 1
Part), it is 100 parts to add deionized water and mend ad pond om number.
(3) each base stock component is heated to 60 DEG C, is mixed, be placed in it is fully emulsified in emulsifier, when temperature is down to
At 40 DEG C, the deep layer skin penetration enhancer for having added functional component is added after emulsifying in gained Essence basestocks, stirring
5-10 minutes, it is made to be uniformly dispersed, that is, obtains the Essence of the Essence respectively containing A samples and the sample containing B.
Contrast test：
Essence formula of liquid in above example 4 is carried out with the formula for being not added with deep layer skin penetration enhancer to having a competition
It tests, uses alternately animal experiment method, test method is as follows：
1, prepared by sample：Scutellarin (Baicalin) is experiment mark object：
A samples：15 weights are added in essence liquid base material described in 79 parts by weight of example 4,6 parts by weight scutellarins (Baicalin)
Deep layer skin penetration enhancer described in part embodiment 4 is measured, A samples are formed；
B samples：15 weights are added in essence liquid base material described in 76 parts by weight of example 4,9 parts by weight scutellarins (Baicalin)
Deep layer skin penetration enhancer described in part embodiment 4 is measured, B samples are formed；
Control sample：9 parts by weight scutellarin (Baicalin) groups are added in essence liquid base material described in 91 parts by weight of example 4
At control sample.
2, solar radiation skin photoage animal experiment evaluation assessment is simulated：
Albino guinea-pig is divided into 3 groups：A samples group, B sample groups；Control sample group：To be not added with the identical of deep layer transdermal delivery system
The skin care item of formula
The hair of net guinea pig back is shaved, each exposure dose of ultraviolet light is：UVA5.67/c ㎡, UVB0.0841/c ㎡, continuously
UV irradiates 16 weeks (cumulative exposure UVA444.1J/c ㎡, UVB6.604j/c ㎡), and the skin of each group animal smear zone is taken to carry out
The detection of indices.
3, light aging animal experiment evaluation result such as table 2-3：
Influence after table 2 long-term UV irradiations to animal skin wrinkle number
| Group | Number of animals | 2 weeks | 4 weeks | 6 weeks | 8 weeks | 10 weeks | 12 weeks | 14 weeks | 16 weeks |
| Control sample | 15 | 0.8 | 3.2 | 4.6 | 5.6 | 5.7 | 5.7 | 6.2 | 6.2 |
| A samples | 15 | 0.4 | 1.1 | 1.6 | 1.7 | 1.9 | 2.1 | 2.3 | 2.6 |
| B samples | 15 | 0.6 | 1.0 | 3.1 | 3.7 | 3.9 | 4.1 |
The influence of the lower dermal pathology of 3 long-term UV of table irradiations
Note：Normal group animal is irradiated without ultraviolet light.
Rose, zest, dried peppermint leaf cooperative effect verification test：
The transdermal facilitation effect of collaboration for three kinds of verification rose, zest, dried peppermint leaf substances carries out following tests：
1, the preparation of sample：
A samples：Flos Rosae Rugosae extract：After rose crushes, the ethanol water extraction of concentration 50wt.%, rose is added
Weight ratio with ethanol water is 2：35；Using Microwave Extraction 8-15min, extracting solution is successively through filtering, dealcoholysis and concentration
After obtain Flos Rosae Rugosae extract.
B samples：Fragrant citrus extract：After fresh zest is broken, the ethanol water extraction of concentration 50wt.% is added, it is fragrant
The weight ratio of orange peel and ethanol water is 2：35；Using ultrasonic wave extraction 20-25min, extracting solution is through filtering, dealcoholysis and dense
The fragrant citrus extract is obtained after contracting.
C samples：Mint extract：After the cutting of fresh mint leaf, the ethanol water extraction of concentration 50wt.%, peppermint is added
The weight ratio of leaf and ethanol water is 2：35；Using ultrasonic wave extraction 20-25min, extracting solution is through filtering, dealcoholysis and concentration
After obtain the mint extract.
2, prepared by control sample：It is experiment functional component with glabridin：
A-1 samples：15 parts of glabridins are added in 85 parts of A samples；
B-1 samples：15 parts of glabridins are added in 85 parts of B samples；
C-1 samples：15 parts of glabridins are added in 85 parts of C samples；
AB samples：15 parts of glabridins are added in 45 parts of A samples and 40 parts of B samples；
AC samples：15 parts of glabridins are added in 45 parts of A samples and 40 parts of C samples；
BC samples：15 parts of glabridins are added in 45 parts of B samples and 40 parts of C samples；
ABC samples：It is added 15 parts of glabridins in 25 parts of A samples, 25 parts of B samples and 35 parts of C samples, it is composition rose, zest, thin
The compound control sample of lotus.
3, test method is as follows：
It is tested with one-chambered static cell method, repeatedly takes out raw trimestral guinea pig back skin and tested, will be fixed with
The release pond for testing skin graft is mounted on the upside of single compartment, sets drug transdermal agent on isolated experiment skin, in 32 DEG C of water-baths
Constant temperature certain time draws and is stirred solution in compartment under experiment skin and is measured, with liquid chromatograph and CR2Ax-2 microcomputers
Processor, hplc determination sample room and licoricidin peak value in receiving chamber, CR2Ax-2 computer processors are to peak meter area
It calculates, monitor and calculates drug through situation.
4, rose, zest, peppermint one kind and three kinds of compounding comparative test result such as the following table 4：
4 glabridin of table (Glabridin) transdermal absorption factor (%)
| Sample | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| A-1 | 1.0 | 0.08 | 0.5 | 0.7 | 0.8 | 0.7 | 0.9 | 0.87 | 1 | 0.75 |
| B-1 | 0.02 | 0.08 | 0.09 | 0.6 | 1.08 | 1.05 | 0.75 | 0.86 | 1.06 | 0.9 |
| C-1 | 1.5 | 1.2 | 0.9 | 1.05 | 1.07 | 1.05 | 0.95 | 0.81 | 1.01 | 0.98 |
| ABC | 13.2 | 11.5 | 10.6 | 11.1 | 11.8 | 13,9 | 13.2 | 13.7 | 12.9 | 10,3 |
5, rose, zest, two kinds of peppermint compound comparative test result such as the following table 5 with three kinds：
5 glabridin of table (Glabridin) transdermal absorption factor (%)
| Sample | 1 | 2 | 3 | 4 | 5 | 6 |
| AB | 2.5 | 2.1 | 1.9 | 2.3 | 1.8 | 2.5 |
| AC | 2.7 | 3.0 | 2.6 | 3.1 | 3.05 | 2.9 |
| BC | 4.5 | 5.1 | 4.62 | 4.8 | 5.1 | 4.7 |
| ABC | 13.2 | 11.5 | 10.6 | 11.1 | 11.8 | 13.9 |
The above experiment illustrates a kind of in three kinds of rose, zest, dried peppermint leaf substances and two kinds of compoundings, does not reach three
Composition compounding rush functional component Transdermal absorption effect, and three kinds of ingredients it is compound after promote functional component Transdermal absorption effect have it is aobvious
Difference is write, the mechanism of action is, rose, zest, peppermint are compound to be had effects that promote three kinds of infiltration, solubilising and moisturizing,
The synergistic effect of three makes to the significant promotion of the transdermal absorption factor of functional component.
Claims (10)
1. a kind of deep layer skin penetration enhancer, it is characterised in that：It counts in parts by weight, the raw material for preparing of the accelerating agent includes such as
Lower component：
3-7 parts of Flos Rosae Rugosae extract；
3-12 parts of fragrant citrus extract；
3-5 parts of mint extract.
2. deep layer skin penetration enhancer according to claim 1, it is characterised in that：The raw material for preparing of the accelerating agent also wraps
Include 1,3 butanediol 5-20 parts by weight, xanthan gum 0.5-5 parts by weight and hyaluronic acid 0.5-6 parts by weight.
3. deep layer skin penetration enhancer according to claim 1, it is characterised in that：The preparation of the Flos Rosae Rugosae extract
Process is：After rose is crushed, it is added in ethanol water and carries out microwave abstracting, extracting solution is after filtering, dealcoholysis and concentration
Obtain the Flos Rosae Rugosae extract；During microwave abstracting：The weight ratio of rose and ethanol water is 1：(15-35),
Microwave abstracting time 8-15min；The content of ethyl alcohol is 40-60wt.% in the ethanol water.
4. deep layer skin penetration enhancer according to claim 1, it is characterised in that：The preparation of the fragrant citrus extract
Cheng Wei：It is added the ethanol water of concentration 50-90wt.% in zest, the weight ratio of zest and ethanol water is
1：(5-30)；Then ultrasonic wave extraction 20-25min, the extracting solution of acquisition is used to obtain the perfume (or spice) after filtering, dealcoholysis and concentration
Orange extract.
5. deep layer skin penetration enhancer according to claim 1, it is characterised in that：The preparation of the mint extract
Cheng Wei：Fresh mint leaf is added in the ethanol water of concentration 40-60wt.% afterwards after cutting, dried peppermint leaf and ethanol water
Weight ratio is 1：(5-30)；Then ultrasonic wave extraction 20-25min is used, the extracting solution of acquisition is after filtering, dealcoholysis and concentration
Obtain the fragrant citrus extract.
6. deep layer skin penetration enhancer according to claim 1 or 2, it is characterised in that：The accelerating agent is will to prepare original
Each component mixing in material, is heated to 50-100 DEG C, homogeneous after stirring obtains the accelerating agent.
7. the skin care item prepared using the deep layer skin penetration enhancer described in claims 1 or 22, it is characterised in that：The skin care
Product include the deep layer skin penetration enhancer, functional component and base starting material.
8. skin care item according to claim 6, it is characterised in that：The preparation process of the skin care item is：It is saturating in the deep layer
Functional component is added in skin sorbefacient, adds after mixing in the base starting material, is then heated to 50-100 DEG C,
Skin care item are obtained after stirring to homogeneous.
9. skin care item according to claim 7, it is characterised in that：In the skin care item, the deep layer skin penetration enhancer
Shared weight ratio is 5-20 parts, and weight ratio shared by the functional component is 3-15 parts.
10. skin care item according to claim 7, it is characterised in that：The functional component be can delay skin aging, change
Kind dermatoglyph or the ingredient for carrying out skin-whitening；The base starting material is body material in cosmetics, can be selected as needed.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111728933A (en) * | 2020-08-15 | 2020-10-02 | 东莞市风雨科技有限公司 | Concealer with spot-lightening and moisturizing functions and preparation process thereof |
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