CN115400068A - Repairing and relieving composition and water, milk and cream containing same - Google Patents
Repairing and relieving composition and water, milk and cream containing same Download PDFInfo
- Publication number
- CN115400068A CN115400068A CN202211212991.0A CN202211212991A CN115400068A CN 115400068 A CN115400068 A CN 115400068A CN 202211212991 A CN202211212991 A CN 202211212991A CN 115400068 A CN115400068 A CN 115400068A
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- 239000008267 milk Substances 0.000 title claims description 13
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Classifications
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- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
- A61K8/585—Organosilicon compounds
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
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- A61Q19/00—Preparations for care of the skin
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- A61Q19/00—Preparations for care of the skin
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- A61Q19/00—Preparations for care of the skin
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The application relates to the field of cosmetics, and particularly discloses a repairing and relieving composition which comprises the following components in percentage by mass: 25-35% of spongy spicules; 32-50% of an anti-inflammatory agent; 24-35% of a allergy-relieving agent; the anti-inflammatory agent comprises a Chuan red peony root extract, and the Chuan red peony root extract accounts for 22-25% of the anti-inflammatory agent by mass; the balance is skin conditioning agent; the allergy relieving agent comprises the following components in percentage by mass: 8-10% of feverfew extract; 9-12% of tea extract; the balance being solvent. The application has the advantages that the stimulation of the spongy bone needles to the skin is reduced, so that the composition has better repairing and relieving effects.
Description
Technical Field
The present application relates to the field of cosmetics, and more particularly, it relates to a rejuvenating and soothing composition and water and creams containing the same.
Background
The spongy spicule is a siliceous or calcareous fibrous material which plays a skeleton support and resists invasion in the sponge and has various structural forms, including single axis, double axis, three axis, multiple axis and the like. Researches find that the spongy bone needle has good optical characteristics and mechanical properties.
Research on the sponge spicule at present focuses on the fields of optical characteristics, nano structures, bionics, medicinal transdermal agents and the like of the sponge spicule. Some natural sponge spicules with high mechanical strength and sharp ends have the function similar to that of micro needles. After the skin is massaged by the sponge spicules, 850 +/-125 micro-channels with the depth of 48.6 +/-13.5 micrometers can be formed on the surface of the skin per square millimeter, the micro-channels can continuously exist for more than 72 hours, a large number of channels can be formed on the surface layer of the skin, macromolecular substances of normal skin cannot permeate through, the macromolecular substances can enter the skin through the micro-channels, the micro-channels can be used in a large area, and the micro-needles have great potential to be used as novel micro-needles for physical permeation promotion of skin drug delivery.
However, when people use the sponge spicule, the phenomena of skin redness, edema and the like are easy to appear in the acupuncture treatment of the skin, the phenomena are gradually resolved after 72 hours, and particularly, redness, itching, dryness and desquamation are easy to appear after facial care, so that the reaction is greater when the stratum corneum is thin. Thus, there is still room for improvement.
Disclosure of Invention
In order to reduce the stimulation of the spongiosa bone to the skin and enable the composition to have better repairing and relieving effects, the application provides a repairing and relieving composition and water, milk and cream containing the composition.
In a first aspect, the present application provides a repair relief composition, using the following technical scheme:
a repairing and relieving composition comprises the following components in percentage by mass:
25-35% of spongy spicules; 32-50% of an anti-inflammatory agent; 24-35% of a allergy-relieving agent;
the anti-inflammatory agent comprises a red paeony root extract, and the red paeony root extract accounts for 22-25% of the anti-inflammatory agent by mass; the balance is skin conditioner;
the allergy relieving agent comprises the following components in percentage by mass:
8-10% of feverfew extract; 9-12% of tea extract; the balance being solvent.
By adopting the technical scheme, the sponge spicules are added to open the skin channel to reach the subcutaneous part, so that the nutrient substances are conveyed, and the absorption rate is increased by hundreds of times; the composition is also beneficial to relieving the blockage of skin pores, accelerating the natural peeling of aged cuticle and shortening the skin renewal cycle; activate microcirculation of skin cells below stratum corneum, and improve metabolism of epidermis.
By adding the feverfew extract, the composition has effects of inhibiting skin induced allergy, enhancing capillary resistance, inhibiting capillary permeability, and resisting inflammation.
By adding the red paeony root extract, the composition has stronger anti-inflammatory effect and can have obvious inhibition effect on hyperfiltration, exudation and edema of capillary vessels and immune inflammation caused by various inflammatory agents.
Because the main components of the tea extract are four types, namely catechin (flavanols), flavone and flavone analogs, anthocyanin and anthocyanin types, phenolic acid and depside acids, and are a complex consisting of more than thirty phenolic substances, the composition has the functions of beautifying the skin, delaying skin aging and the like by adding the tea extract, can remove various free radicals in the body and achieve the effect of resisting oxidation, wherein the tea polyphenol has astringency and can precipitate and denature protein, so the tea extract has strong antibacterial effect.
Therefore, the sponge spicules act on the horny layer of the skin and form a large number of micro-channels which exist continuously, so that the active ingredients in the feverfew extract, the tea extract and the radix paeoniae rubra extract are better promoted to be absorbed by the skin, the stimulation of the sponge spicules to the skin is reduced, and the composition has better effects of repairing and relieving.
Preferably, the pretreatment of the spongy bone needles comprises the following steps:
s1: adding the spongy bone needles into 15-20mol/L NaOH solution, and carrying out ultrasonic treatment for 30-45min; filtering, washing, drying, adding the spongy spicule into 10-15% hydrochloric acid solution, performing ultrasonic treatment for 30-45min, filtering, washing, and drying to obtain activated spongy spicule;
s2: adding the activated spongy spicule into anhydrous ether, adding 3-aminopropyl triethoxysilane at 80-100 ℃, and reacting for 2-3h to obtain a surface-modified spongy spicule;
s3: and (3) placing the sponge spicules with the modified surfaces into 1-2% chitosan solution, and fully mixing to obtain the pretreated sponge spicules.
According to the technical scheme, firstly, a NaOH solution and a hydrochloric acid solution are adopted to activate the spongy bone spicules, so that the activity of silanol groups on the surface of the spongy bone spicules is enhanced, then the activated spongy bone spicules are reacted with 3-aminopropyltriethoxysilane, so that amino groups are connected to the surface of the spongy bone spicules, then the spongy bone spicules subjected to surface modification are mixed in a chitosan solution, so that the amino groups on the surface of the spongy bone spicules are combined with hydroxyl groups in chitosan molecules, and as chitosan has strong adhesion to various active ingredients in a feverfew extract, a tea extract and a radix paeoniae rubra extract, various active ingredients in the feverfew extract, the tea extract and the radix paeoniae rubra extract are more easily absorbed by skin, the stimulation of the spongy bone spicules to the skin is favorably reduced, the skin is not easy to generate the phenomena of redness, edema and the like, so that the effect of comprehensively repairing and beautifying the skin is achieved, and the skin is associated.
Preferably, the mass ratio of the 3-aminopropyltriethoxysilane to the activated spongy spicules is 1: (2-3).
By adopting the technical scheme, the 3-aminopropyltriethoxysilane with a specific proportion is matched with the activated spongy spicules, so that the transdermal effect of the spongy spicules is further improved, and the absorption of various active ingredients in the feverfew extract, the tea extract and the radix paeoniae rubra extract by skin is promoted, so that the composition has better effects of repairing and relieving.
Preferably, the skin conditioning agent comprises the following components in percentage by mass:
36-43% of coastal angelica extract;
phloretin 35-42%.
By adopting the technical scheme, the coastal Chinese angelicaThe extract is rich in ferulic acid, and the ferulic acid contained in the extract can directly reduce H 2 O 2 The content of the active components is combined with membrane phosphatidylethanolamine, and the damage of antagonistic free radicals to tissues, such as oxidation reaction, free radical reaction and the like, is inhibited by directly eliminating the free radicals; the phloretin can inhibit excessive secretion of sebaceous gland, and can be used for treating acne with excessive secretion, inhibiting activity of melanocyte, and treating various skin mottles. Therefore, the coastal angelica extract and the phloretin are matched with each other, so that the repairing and relieving effects of the composition are improved, and the composition has certain whitening and anti-aging effects.
Preferably, the soothing agent also comprises the following components in percentage by mass:
7.5 to 8.5 percent of butanediol;
1,2-pentanediol 4-5%;
1,3-propylene glycol 1-3%;
lecithin 0.3-0.5%;
0.4 to 0.6 percent of magnolol.
By adopting the technical scheme, the substances in the specific proportion are matched with each other, so that the composition has the effects of relieving redness and calming the skin, and is favorable for promoting other substances in the composition to be absorbed and utilized by the skin, so that the composition has better effects of repairing and relieving.
In a second aspect, the present application provides a water containing a remedial soothing composition, using the following technical scheme:
the water containing the repairing and relieving composition comprises the following components in percentage by mass:
phase A: 0.1-0.2% of xanthan gum; 1-3% of glycerol; 2-4% of propylene glycol; carbomer 0.1-0.2%;
phase B: 0.2 to 0.5 percent of p-hydroxyacetophenone;
and C phase: 1,2 hexanediol 0.3-0.6%;
phase D: 0.1 to 0.2 percent of triethanolamine;
phase E: 0.03-4% of a repair soothing composition;
the balance of water.
By adopting the technical scheme, the repairing and relieving composition is added into water, so that the water has better repairing and relieving effects, and the skin is less prone to being damaged.
In a third aspect, the present application provides a milk containing a rejuvenating and soothing composition, using the following technical scheme:
a milk containing a repairing and relieving composition comprises the following components in percentage by mass:
phase A: cetostearyl alcohol 0.4-0.6%; 2.5 to 3 percent of emulsifier; 3-5% of ethylhexyl palmitate; 2-4% of hydrogenated polyisobutene; 3-5% of liquid paraffin; 1-2% of polydimethylsiloxane;
phase B: 4-5% of glycerol; 1-2% of propylene glycol; 0.1 to 0.2 percent of xanthan gum; carbomer 0.1-0.3%; 0.04 to 0.06 percent of sodium hyaluronate;
and C phase: 0.5 to 0.8 percent of p-hydroxyacetophenone; 1,2 hexanediol 0.7-0.9%; 2-5% of propylene glycol;
phase D: 0.03-0.06% of triethanolamine;
phase E: 1-4% of a repair relief composition;
the balance of water.
By adopting the technical scheme, the anti-wrinkle and allergy-relieving composition is added into the milk, so that the milk has better repairing and relieving effects, the stimulation of the spongy bone needles on the skin is favorably relieved, and the skin is quickly repaired.
In a fourth aspect, the present application provides a cream comprising a repair soothing composition, using the following technical scheme:
a cream containing a repairing and relieving composition comprises the following components in percentage by mass:
phase A: cetostearyl alcohol 1.5-2%; 2.5 to 3 percent of emulsifier; 4-5% of ethylhexyl palmitate; 3-4% of hydrogenated polyisobutene; 3-5% of liquid paraffin; 1-2% of polydimethylsiloxane;
phase B: 4-7% of glycerol; 2-4% of propylene glycol; 0.1-0.3% of xanthan gum; carbomer 0.2-0.5%; 0.05 to 0.08 percent of sodium hyaluronate;
and C phase: 0.6 to 0.8 percent of p-hydroxyacetophenone; 1,2-hexanediol 0.5-0.7%; 3-5% of propylene glycol;
phase D: (ii) a 0.1 to 0.3 percent of triethanolamine;
phase E: 1.5-4% of a repair relief composition;
the balance of water.
By adopting the technical scheme, the repairing and relieving composition is added into the cream, so that the skin is not easy to have a condition of redness and allergy, and the skin is better protected.
In summary, the present application includes at least one of the following beneficial technical effects:
1. according to the application, a large number of micro channels which exist continuously are formed in the skin stratum corneum through the sponge spicule, so that various active ingredients in the feverfew extract, the tea extract and the radix paeoniae rubra extract are better promoted to be absorbed by the skin, the stimulation of the sponge spicule to the skin is reduced, and the sponge spicule has better effects of repairing and relieving.
2. The sponge spicules are activated by adopting a NaOH solution and a hydrochloric acid solution, so that the activity of silanol groups on the surface of the sponge spicules is enhanced, the activated sponge spicules are reacted with 3-aminopropyltriethoxysilane, amino groups are connected to the surface of the sponge spicules, the surface-modified sponge spicules are mixed in a chitosan solution, the amino groups on the surface of the sponge spicules are combined with hydroxyl groups in chitosan molecules, and the transdermal effect of the sponge spicules is enhanced, so that various active ingredients in a feverfew extract, a tea extract and a Sichuan red peony root extract are more easily absorbed by the skin, the stimulation of the sponge spicules to the skin is favorably reduced, the skin is not easy to generate the phenomena of redness, edema and the like, the effect of comprehensively repairing and beautifying the skin is achieved, and the beautiful skin is associated.
3. By adopting the mutual matching of the angelica maritima extract and the phloretin, the repairing and relieving effects of the composition are favorably improved, and the composition has certain whitening and anti-aging effects.
Detailed Description
The present application will be described in further detail with reference to examples.
Preparation example 1
An anti-inflammatory agent comprising the following components:
extracts of radix Paeoniae Rubra; and (3) water.
The preparation method of the anti-inflammatory agent comprises the following steps: adding radix Paeoniae Rubra extract and water at room temperature, and stirring at 35r/min for 20min to obtain the antiinflammatory agent.
Preparation example 2
The difference from preparation example 1 is that: equal amount of Angelica maritima extract and phloretin is used to replace water.
The amounts of the components of preparation examples 1-2 are shown in Table 1, and the units of the amounts of the materials in Table 1 are in kg.
TABLE 1
Preparation examples 5 to 8
A soothing agent comprising the following components:
a feverfew extract; a tea extract; butanediol; 1,2-pentanediol; 1,3-propanediol; lecithin; magnolol; and (3) water.
The preparation method of the desensitizer comprises the following specific steps: adding the feverfew extract, the tea extract, the butanediol, 1,2-pentanediol, 1,3-propanediol, the lecithin, the magnolol and water into a stirring kettle, heating to 60 ℃, and stirring all the components at the rotating speed of 40r/min for 15min to be uniform to obtain the sensitizer. The amounts of the components are shown in Table 2, and the unit of each substance in Table 2 is kg.
TABLE 2
Examples 1 to 3
The application discloses a repairing and relieving composition, which comprises the following components:
a sponge spicule; an anti-inflammatory agent; a soothing agent.
The application also discloses a preparation method of the repairing and relieving composition, which comprises the following specific steps: adding spongia, anti-inflammatory agent and soothing agent (specific dosage is shown in table 1) into a stirring kettle respectively, and stirring uniformly at a rotating speed of 50r/min to obtain the repairing and soothing composition.
The components and amounts of the examples 1-3 are shown in Table 3, in kg.
TABLE 3
Example 4
The difference from example 3 is that: the anti-inflammatory agent in the repairing and soothing composition is the anti-inflammatory agent prepared in preparation example 3; the desensitizer is prepared in preparation example 5.
Example 5
The difference from example 3 is that: the anti-inflammatory agent in the repairing and soothing composition is the anti-inflammatory agent prepared in preparation example 4; the desensitizer is prepared in preparation example 6.
Example 6
The difference from example 3 is that:
the pretreatment of the spongy spicule comprises the following steps:
s1: adding spongy spicules into 15mol/L NaOH solution, and carrying out ultrasonic treatment for 30min; filtering, washing, drying, adding the spongy spicules into a 10% hydrochloric acid solution, carrying out ultrasonic treatment for 30min, filtering, washing and drying to obtain activated spongy spicules;
s2: adding the activated spongy spicule into anhydrous ether, adding 3-aminopropyl triethoxysilane at 80 ℃, and reacting for 2h to obtain a surface-modified spongy spicule;
s3: and (3) placing the sponge spicules with the modified surfaces into a 1% chitosan solution, and fully mixing to obtain the pretreated sponge spicules.
Wherein the mass ratio of the 3-aminopropyltriethoxysilane to the activated spongy spicules is 1:2.
example 7
The difference from example 3 is that:
the pretreatment of the spongy spicule comprises the following steps:
s1: adding the spongy spicules into a 20mol/L NaOH solution, and carrying out ultrasonic treatment for 45min; filtering, washing, drying, adding the spongy spicules into 15% hydrochloric acid solution, performing ultrasonic treatment for 45min, filtering, washing, and drying to obtain activated spongy spicules;
s2: adding the activated sponge spicule into anhydrous ether, then adding 3-aminopropyl triethoxysilane at 100 ℃, and reacting for 3h to obtain a surface-modified sponge spicule;
s3: and (3) placing the sponge spicules with the modified surfaces into a 2% chitosan solution, and fully mixing to obtain the pretreated sponge spicules.
Wherein the mass ratio of the 3-aminopropyltriethoxysilane to the activated spongy spicules is 1:3.
comparative example 1
The difference from example 3 is that: equal amounts of water were substituted for the feverfew extract.
Comparative example 2
The difference from example 3 is that: equal amounts of water were substituted for the tea extract.
Comparative example 3
The difference from example 3 is that: equal amount of water is used to replace the radix paeoniae rubrathe extract.
Comparative example 4
The difference from example 3 is that:
a repair and relief composition comprising the following components by mass:
20kg of spongy spicules; 30kg of anti-inflammatory agent; 50kg of allergy relieving agent;
comparative example 5
The difference from example 3 is that:
a repair and relief composition comprising the following components by mass:
38kg of sponge spicules; 55kg of anti-inflammatory agent; 7kg of allergy relieving agent;
experiment 1
The experiment detects the anti-inflammatory effect of the repairing and relieving composition prepared by the method respectively, and the detection method comprises the following steps:
collecting RAW264.7 macrophage in log phase, adjusting cell suspension concentration to 2 × 10 8 Taking 0.4mL of RAW264.7 cell suspension, adding 10 mu L of 200 mu g/mL sample solution to be detected, adding equivalent distilled water into blank control, sequentially adding 0.1mL of Luminol luminescent solution and 0.5 mu L of 125 mu g/L PMA working solution, continuously measuring the chemiluminescence intensity for 20min, automatically recording every 1min,the peak PV of the chemiluminescence intensity was obtained. The inhibition of the respiratory burst of PMA stimulated RAW264.7 cells by the repair relief composition is shown below:
inhibition of macrophage respiratory burst (%) = (1-sample PV/blank PV) × 100%
The greater the rate of inhibition of macrophage respiratory burst, the better the anti-inflammatory effect of the remedial soothing composition.
Experiment 2
The experiment separately detects the anti-allergy effect of the repairing and relieving composition prepared by the method as follows:
the inhibition of hyaluronidase activity was determined by the Elson-Morgan modification.
Sample solutions of examples 1 to 5 and comparative examples 1 to 5 were prepared at a concentration of 1mg/mL, respectively, and were used. Then 0.1mL CaCl with the concentration of 0.25mmol/L is taken 2 Adding 0.5mL hyaluronidase solution (1250U/mL), and keeping the temperature at 37 ℃ for 20min; adding 0.5mL of sample solution, and keeping the temperature at 37 ℃ for 20min; adding 0.5mL of 0.5g/L sodium hyaluronate solution, keeping the temperature at 37 ℃ for 30min, and then standing at normal temperature for 5min; then adding 0.1mL of 0.4mol/L NaOH solution and 0.5mL of acetylacetone solution, placing in a boiling water bath, heating for 15min, and immediately cooling for 5min with cold water; adding 1mL of Ellisib reagent, diluting with 3mL of anhydrous ethanol, mixing, standing for 20min for color development, and measuring light absorption value with ultraviolet visible spectrophotometer.
Hyaluronidase inhibition rate = [1- (A) C -A C0 ）/（A-A 0 ）]×100%
Wherein A is C The absorbance value of the control solution (the sample solution is replaced by acetic acid buffer solution);
A C0 the light absorption value of a blank solution is compared (the sample solution and the enzyme solution are replaced by acetic acid buffer solution);
a is the light absorption value of the sample solution, A 0 The absorbance of the sample blank solution was obtained (the enzyme solution was replaced with acetic acid buffer). The A liquid is scanned in the range of 450nm to 700nm to determine the maximum absorption wavelength.
The greater the hyaluronidase inhibition, the better the anti-allergy effect of the restorative soothing composition.
Experiment 3
In the experiment, in-vitro pigskin is used as an experimental material, the back skin of a non-traumatic pig is selected, a subcutaneous fat layer is removed, hair on the surface of the pigskin is cut to be below 2mm by an electric hair clipper, then a circular sheet with the diameter of 4cm is drilled by a circular puncher, and the thickness of the sheet is trimmed to be not more than 1mm. The knocked-down pigskin sample was cleaned and mounted on a Franz diffusion transdermal cell with its dermal layer facing the receiving cell containing PBS and the stratum corneum exposed in the dosing chamber and mounted with iron clips. 100 μ L of the rejuvenating and soothing compositions prepared in examples 1 to 5 and comparative examples 1 to 5 were added to the administration well, respectively, and then massaged for 2min with the aid of a mini-massager, and transdermal application was performed for 12 hours. Accurately collecting 3mL of receiving solution at regular time (and supplementing 3mL of receiving solution), accurately adding 1mL of ethyl acetate, extracting on shaking table, adding quantitative anhydrous ethanol, measuring absorbance at 274nm, and calculating cumulative permeation amount (μ g/cm) 3 ). The greater the cumulative penetration, the better the transdermal effect of the rejuvenation and soothing composition.
The results of the above experiments are shown in Table 4.
TABLE 4
According to the data of comparative examples 1-3 in table 4, the comparison with the data of example 3 shows that the feverfew extract is not added in comparative example 1, the tea extract is not added in comparative example 2, the red peony root extract is not added in comparative example 3, the feverfew extract, the tea extract and the red peony root extract are simultaneously added in example 3 and are matched with spicule of sponge, the anti-inflammatory effect of the repairing and soothing composition is better than that of comparative examples 1-3 and the anti-allergy effect is higher than that of comparative examples 1-3 in example 3, which shows that the feverfew extract, the tea extract and the red peony root extract are simultaneously added and are matched with the spicule of sponge, the anti-inflammatory and anti-allergy effects of the repairing and soothing composition are improved, and the irritation of the skin of the spicule of sponge is reduced, so that the skin is not easy to have the phenomena of reddening and edema.
As can be seen from the comparison of the data of comparative examples 4-5 in Table 4 with the data of example 3, the amounts of each of the components of comparative examples 4-5 are outside the ranges as defined herein, and the anti-inflammatory and anti-allergic effects of the repair relief composition are not as good as those of example 3, indicating that the amounts of the components also affect the performance of the repair relief composition, and therefore, the amounts of each of the components of the repair relief composition are within the ranges as defined herein, and thus, the efficacy of the repair relief composition is enhanced.
According to the comparison of the data of the examples 6 to 7 in the table 4 with the data of the example 3, the sponge spicules are pretreated in the examples 6 to 7 on the basis of the example 3, and the 4h cumulative penetration rate of the examples 6 to 7 is higher than that of the example 3, which shows that the pretreatment of the sponge spicules by the method is beneficial to improving the transdermal effect of the sponge spicules, so that various active ingredients in the feverfew extract, the tea extract and the red peony root extract are more easily absorbed by the skin, and further, the stimulation of the sponge spicules on the skin is reduced, so that the skin is not easily subjected to the phenomena of redness, edema and the like.
Experimental example 1
The experimental example discloses water containing a repairing and relieving composition, which comprises the following components in parts by mass:
phase A: 96.17kg of water; 0.1kg of xanthan gum; 1kg of glycerol; 2kg of propylene glycol; carbomer 0.1kg;
phase B: 0.2kg of p-hydroxyacetophenone;
and C phase: 1,2-hexanediol, 0.3kg;
phase D: 0.1kg of triethanolamine;
phase E: 0.03kg of a repair and relief composition;
repair relief composition the repair relief composition prepared in example 3 was used.
This experimental example also discloses a method for preparing water containing a repair soothing composition, comprising the steps of:
s1: adding 96.17kg of water, 0.1kg of xanthan gum, 1kg of glycerol, 2kg of propylene glycol and 0.1kg of carbomer in the phase A component into an emulsifying pot in sequence, heating to 85 ℃, stirring at the rotating speed of 35r/min for dissolving, stirring at constant temperature for 30min, and dispersing until the components are uniform;
s2: cooling to 65 deg.C, adding 0.2kg of p-hydroxyacetophenone in phase B and 0.1kg of triethanolamine in phase D into emulsifying pot, and stirring at 28 r/min;
s3: reducing the temperature to 42 ℃, then adding 0.3kg of 1,2-hexanediol in the C phase into an emulsifying pot, and stirring uniformly at a constant temperature of 25 r/min;
s4: reducing the temperature to 40 ℃, then adding the repairing and relieving composition in the phase E into an emulsifying pot, and stirring uniformly at a constant speed of 20 r/min;
s5: and (4) reducing the temperature to 35 ℃, filtering and discharging after the inspection is qualified.
Experimental example 2
The differences from the experimental example 1 are:
water containing a rejuvenating and soothing composition, comprising the following components in mass:
phase A: 87.3kg of water; 0.2kg of xanthan gum; 3kg of glycerol; 4kg of propylene glycol; carbomer 0.2kg;
phase B: 0.5kg of p-hydroxyacetophenone;
and C phase: 1,2-hexanediol 0.6kg;
phase D: 0.2kg of triethanolamine;
phase E: repair relief composition 4kg of the repair relief composition prepared in example 3 was used.
Experimental example 3
The experimental example discloses a milk containing a repairing and relieving composition, which comprises the following components in parts by mass:
phase A: cetearyl alcohol 0.4kg; ARLACEL170 kg; 0.6kg of methyl glucose sesquistearate; 0.9kg of PEG-20 methyl glucose sesquistearate; 3kg of ethylhexyl palmitate; 2kg of hydrogenated polyisobutene; 3kg of liquid paraffin; 1kg of polydimethylsiloxane;
phase B: water 78.63kg; 4kg of glycerol; 1kg of propylene glycol; 0.1kg of xanthan gum; carbomer 0.1kg; 0.04kg of sodium hyaluronate;
and C phase: 0.5kg of p-hydroxyacetophenone; 1,2-hexanediol, 0.7kg; 2kg of propylene glycol;
phase D: 0.03kg of triethanolamine;
phase E: 1kg of repairing and relieving composition;
repair relief composition the repair relief composition prepared in example 3 was used.
The experimental example also discloses a preparation method of the milk containing the repair and relief composition, which comprises the following steps:
s1: sequentially adding 78.63kg of water, 4kg of glycerol, 1kg of propylene glycol, 0.1kg of xanthan gum, 0.1kg of carbomer and 0.04kg of sodium hyaluronate into a main emulsifying pot, heating to 90 ℃, stirring at the rotating speed of 35r/min for dissolving, and keeping the temperature for 30min;
s2: adding the phase A into an oil pan, heating to 80 ℃, uniformly stirring at the rotating speed of 25r/min, and preserving heat for 30min;
s3: after heat preservation, pumping the phase A into a main emulsifying pot, homogenizing for 3min, and stirring uniformly at the rotating speed of 35 r/min;
s4: reducing the temperature to 65 ℃, then sequentially adding 0.5kg of p-hydroxyacetophenone in the phase C, 0.7kg of 1,2-hexanediol, 2kg of propylene glycol and 0.03kg of triethanolamine in the phase D into a main emulsifying pot, and uniformly stirring at the rotating speed of 30 r/min;
s5: reducing the temperature to 40 ℃, adding the repairing and relieving composition in the phase E into an emulsifying pot, and stirring uniformly at a constant temperature of 25 r/min;
s6: and (4) reducing the temperature to 35 ℃, filtering and discharging after the inspection is qualified.
Experimental example 4
The difference from experimental example 3 is that:
a milk containing a repairing and relieving composition comprises the following components in parts by mass:
phase A: 0.6kg of cetearyl alcohol; ARLACEL170 kg; 1kg of methyl glucose sesquistearate; 1kg of PEG-20 methyl glucose sesquistearate; 5kg of ethylhexyl palmitate; 4kg of hydrogenated polyisobutene; 5kg of liquid paraffin; 2kg of polydimethylsiloxane;
phase B: water 62.08kg; 5kg of glycerol; 2kg of propylene glycol; 0.2kg of xanthan gum; 0.3kg of carbomer; 0.06kg of sodium hyaluronate;
and C phase: 0.8kg of p-hydroxyacetophenone; 1,2-hexanediol, 0.9kg; 5kg of propylene glycol;
phase D: 0.06kg of triethanolamine;
phase E: repair and soothing composition 4kg of the repair and soothing composition prepared in example 3 was used.
Experimental example 5
The experimental example discloses a cream containing a repairing and relieving composition, which comprises the following components in parts by mass:
phase A: cetearyl alcohol 1.5kg; ARLACEL170 kg; 0.6kg of methyl glucose sesquistearate; 0.9kg of PEG-20 methyl glucose sesquistearate; 4kg of ethylhexyl palmitate; 3kg of hydrogenated polyisobutene; 3kg of liquid paraffin; 1kg of polydimethylsiloxane;
phase B: 72.95kg of water; 4kg of glycerol; 2kg of propylene glycol; 0.1kg of xanthan gum; carbomer 0.2kg; 0.05kg of sodium hyaluronate;
and C phase: 0.6kg of p-hydroxyacetophenone; 1,2-hexanediol 0.5kg; 3kg of propylene glycol;
phase D: 0.1kg of triethanolamine;
phase E: 1.5kg of a repairing and relaxing composition;
repair relief composition the repair relief composition prepared in example 3 was used.
This experimental example also discloses a method for preparing a cream containing a restorative and soothing composition, comprising the steps of:
s1: adding 72.95kg of water, 4kg of glycerol, 2kg of propylene glycol, 0.1kg of xanthan gum, 0.2kg of carbomer and 0.05kg of sodium hyaluronate into a main emulsifying pot in sequence, heating to 90 ℃, stirring at the rotating speed of 35r/min for dissolving, and keeping the temperature for 30min;
s2: adding the phase A into an oil pan, heating to 80 ℃, uniformly stirring at the rotating speed of 25r/min, and preserving heat for 30min;
s3: after heat preservation, pumping the phase A into a main emulsifying pot, homogenizing for 3min, and stirring uniformly at the rotating speed of 35 r/min;
s4: cooling to 65 ℃, then sequentially adding 0.6kg of p-hydroxyacetophenone, 0.5kg of 1,2-hexanediol, 3kg of propylene glycol and 0.1kg of triethanolamine in the phase D into the main emulsifying pot, and uniformly stirring at the rotating speed of 30 r/min;
s5: reducing the temperature to 40 ℃, adding the repairing and relieving composition in the phase E into an emulsifying pot, and stirring uniformly at a constant temperature of 25 r/min;
s6: and (4) reducing the temperature to 35 ℃, filtering and discharging after the inspection is qualified.
Experimental example 6
The difference from experimental example 5 is that:
a cream containing a repair and soothing composition comprises the following components in parts by mass:
phase A: 2kg of cetearyl alcohol; ARLACEL170 kg; 1kg of methyl glucose sesquistearate; 1kg of PEG-20 methyl glucose sesquistearate; 5kg of ethylhexyl palmitate; 4kg of hydrogenated polyisobutene; 5kg of liquid paraffin; 2kg of polydimethylsiloxane;
phase B: 56.32kg of water; 7kg of glycerol; 4kg of propylene glycol; 0.3kg of xanthan gum; carbomer 0.5kg; 0.08kg of sodium hyaluronate;
and C phase: 0.8kg of p-hydroxyacetophenone; 1,2-hexanediol, 0.7kg; 5kg of propylene glycol;
phase D: triethanolamine 0.3kg
Phase E: 4kg of a repairing and relieving composition;
repair relief composition the repair relief composition prepared in example 3 was used.
Experiment 4
The experiment respectively detects the irritation of the water, the milk and the cream prepared in the experimental example to the skin, and the method comprises the following steps:
30 test volunteers aged 35-50 years and marked 3X 3cm inside the left and right arms 2 Test area, then at 2.0. + -. 0.1mg sample/cm 2 The test samples prepared in examples 1 to 6 were each applied uniformly to the test area and the skin was massaged with a finger or with the aid of a tool (massager). After one month of application by the volunteers, the skin test effect of the test area and the blank control area was observed, and each area was measured 3 times in parallel. The results are shown in Table 5.
TABLE 5
As can be seen from the results of experiments 1-6 in Table 5, the addition of the rejuvenating and soothing composition to water or milk or cream all did not cause skin irritation.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.
Claims (8)
1. A repair relief composition characterized by: the composite material comprises the following components in percentage by mass:
25-35% of spongy spicules; 32-50% of an anti-inflammatory agent; 24-35% of a allergy-relieving agent;
the anti-inflammatory agent comprises a red paeony root extract, and the red paeony root extract accounts for 22-25% of the anti-inflammatory agent by mass; the balance is skin conditioning agent;
the allergy relieving agent comprises the following components in percentage by mass:
8-10% of feverfew extract; 9-12% of tea extract; the balance being solvent.
2. A remedial soothing composition according to claim 1, characterized by: the pretreatment of the spongy spicule comprises the following steps:
s1: adding the spongy bone needles into 15-20mol/L NaOH solution, and carrying out ultrasonic treatment for 30-45min; filtering, washing, drying, adding the spongy spicule into 10-15% hydrochloric acid solution, performing ultrasonic treatment for 30-45min, filtering, washing, and drying to obtain activated spongy spicule;
s2: adding the activated spongy spicule into anhydrous ether, adding 3-aminopropyl triethoxysilane at 80-100 ℃, and reacting for 2-3h to obtain a surface-modified spongy spicule;
s3: and (3) placing the sponge spicules with the modified surfaces into 1-2% chitosan solution, and fully mixing to obtain the pretreated sponge spicules.
3. A remedial soothing composition according to claim 2, characterized in that: the mass ratio of the 3-aminopropyltriethoxysilane to the activated spongy spicules is 1: (2-3).
4. A remedial soothing composition according to claim 1, characterized by: the skin conditioner comprises the following components in percentage by mass:
36-43% of coastal angelica extract;
phloretin 35-42%.
5. A remedial soothing composition according to claim 1, characterized by: the allergy relieving agent also comprises the following components in percentage by mass:
7.5 to 8.5 percent of butanediol;
1,2-pentanediol 4-5%;
1,3-propylene glycol 1-3%;
lecithin 0.3-0.5%;
0.4 to 0.6 percent of magnolol.
6. A water containing a remedial soothing composition according to any of claims 1 to 5 wherein: the composite material comprises the following components in percentage by mass:
phase A: 0.1-0.2% of xanthan gum; 1-3% of glycerol; 2-4% of propylene glycol; carbomer 0.1-0.2%;
phase B: 0.2 to 0.5 percent of p-hydroxyacetophenone;
and C phase: 1,2 hexanediol 0.3-0.6%;
phase D: 0.1 to 0.2 percent of triethanolamine;
phase E: 0.03-4% of a repair soothing composition;
the balance of water.
7. A milk containing a rejuvenating composition as claimed in any one of claims 1 to 5, characterized in that: the composite material comprises the following components in percentage by mass:
phase A: cetostearyl alcohol 0.4-0.6%; 2.5 to 3 percent of emulsifier; 3-5% of ethylhexyl palmitate; 2-4% of hydrogenated polyisobutene; 3-5% of liquid paraffin; 1-2% of polydimethylsiloxane;
phase B: 4-5% of glycerol; 1-2% of propylene glycol; 0.1-0.2% of xanthan gum; carbomer 0.1-0.3%; 0.04 to 0.06 percent of sodium hyaluronate;
and C phase: 0.5 to 0.8 percent of p-hydroxyacetophenone; 1,2 hexanediol 0.7-0.9%; 2-5% of propylene glycol;
phase D: 0.03-0.06% of triethanolamine;
phase E: 1-4% of a repairing and relieving composition;
the balance of water.
8. A cream comprising the repair and soothing composition of any of claims 1-5, wherein: the composite material comprises the following components in percentage by mass:
phase A: cetostearyl alcohol 1.5-2%; 2.5 to 3 percent of emulsifier; 4-5% of ethylhexyl palmitate; 3-4% of hydrogenated polyisobutene; 3-5% of liquid paraffin; 1-2% of polydimethylsiloxane;
phase B: 4-7% of glycerol; 2-4% of propylene glycol; 0.1-0.3% of xanthan gum; carbomer 0.2-0.5%; 0.05 to 0.08 percent of sodium hyaluronate;
and C phase: 0.6 to 0.8 percent of p-hydroxyacetophenone; 1,2-hexanediol 0.5-0.7%; 3-5% of propylene glycol;
phase D: (ii) a 0.1 to 0.3 percent of triethanolamine;
phase E: 1.5-4% of a repair relief composition;
the balance of water.
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